FOOD CHEMISTRY
·
2025
·
IF 9.8
Yating Zhong,Keying Zhang,Xinru Wang,Haibo Liang,Ying Yu,Manli Guo,Yujuan Cao,Bixia Lin
It is important to develop sensitive and accurate methods for the detection of tetracycline (TC). For this purpose, a dual emission probe Eu-DPA/BDC-(OH) 2 was developed based on the green fluorescence of the ligand 2, 5-dihydroxyterephthalic acid (BDC-(OH) 2 ), and the red fluorescence of Eu 3+ sensitized by another ligand 2, 6-pyridine dicarboxylic acid (DPA). TC was able to quench the fluorescence of ligand BDC-(OH) 2 at 545 nm by the internal filter effect (IFE), and coordinate with Eu 3+ to enhance the fluorescence at 625 nm by the antenna effect (AE). I 625 /I 545 showed a linear relationship with TC concentration with an LOD at 55 nM. At the same time, the fluorescence color of Eu-DPA/BDC-(OH) 2 changed from green to yellow to red with the increase of TC concentration. On this basis, the RGB method was also developed for the visual detection of TC with an LOD at 0.2 μM. These methods have been successfully applied for the detection of TC in fish feed and pork with recovery rates of 93 % -110 %, indicating excellent applicability in the detection of real samples.
研究领域:
分析化学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2023
·Vol. 15
·期 7
·2014
·
IF 5.4
Fang Luo,Ting Zhong,Ying Chen,Qianqian Guo,Ling Tao,Xiangchun Shen,Yanhua Fan,Xingjie Wu
Dual-ligand targeting drug delivery nanoplatforms are considered a promising tool for enhancing the specificity of chemotherapy. However, serious off-target delivery has been observed in current dual-ligand targeting nanoplatforms, as each ligand can independently recognize receptors on the cell membrane surface and guide drug nanocarriers to different cells. To overcome this barrier, a dual-ligand synergistic targeting (DLST) nanoplatform is developed, which can guide chemotherapy treatment specifically to cancer cells simultaneously overexpressing two receptors. This nanoplatform consists of a singlet oxygen (1O2) photosensitizer-loaded nanocarrier and a drug-loaded nanocarrier with1O2responsiveness, which were, respectively, decorated with a pair of complementary DNA sequences and two different ligands. For cancer cells overexpressing both receptors, two nanocarriers can be internalized in larger quantities to cause DNA hybridization-induced nanocarrier aggregation, which further activates1O2-triggered drug release under light irradiation. For cells overexpressing a single receptor, only one type of nanocarrier can be internalized in a large quantity, leading to blocked drug release due to the ultrashort action radius of1O2. In vivo evaluation showed this DLST nanoplatform displayed highly specific tumor treatment with minimized long-term toxicity. This is a highly efficient drug delivery system for DLST chemotherapy, holding great potential for clinical applications.Keywords:synergistic targeting;specific treatment;drug delivery;controlled release;tumor chemotherapy
研究领域:
生物医学工程
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纳米医学
·
肿瘤学
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DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 30
·10584-10593
·
IF 4
Xue Wen,Wenjun Zhang,Cong Ding,Zhongfa Li,Chengyue Xin
Metal–organic frameworks (MOFs) are a unique class of multifunctional hybrid crystals that have been successfully utilized in diverse ranges of applications. However, since MOFs are prone to aqueous degradation, the development of stable luminescent MOF platforms in aqueous media is still a huge challenge. Here, a novel dual-ligand Eu3+/DUT-52-COOH composite is prepared based on the luminescent DUT-52 prototype structure via a dual-ligand strategy and a post-synthetic modification (PSM) method. The functionalized Eu3+/DUT-52-COOH material exhibits dual emission and good photothermal stability in aqueous media. Thus, Eu3+/DUT-52-COOH is developed as a ratiometric luminescent sensor to achieve highly selective and sensitive detection of Cu2+ and Cr2O72− in aqueous solutions and has a low detection limit of 3.43 μM and 25.7 nM, respectively. This work is one of the few cases of detecting Cu2+ and Cr2O72− in aqueous media based on a DUT-52, and the detection signals can be observed by the bare eye without using sophisticated analytical instruments. The possible sensing mechanism is discussed in detail. The results obtained in this project may provide broad prospects for developing smart sensing systems to accomplish highly efficient, easily operable and quantitative intelligent recognition of Cu2+ and Cr2O72−.
研究领域:
材料科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Qingming Bao,Mingming Bao,Hai Xiao,Tsogzolmaa Ganbold,Shuqin Han,Huricha Baigude
The simultaneous delivery of CpG oligonucleotide along with short interfering RNA (siRNA) has the potential to significantly boost the anticancer impact of siRNA medications. Our previous research demonstrated that Curdlan nanoparticles functionalized with adenosine are capable of selectively delivering therapeutic siRNA to cancerous cells through endocytosis mediated by adenosine receptors. Herein, we synthesized a dual-ligand-functionalized Curdlan polymer (denoted by CuMAN) to simultaneously target tumor cells and tumor-associated macrophages (TAMs). CuMAN nanoparticles containing CpG and siRNA demonstrated enhanced uptake by B16F10 tumor cells and bone marrow-derived macrophages, which are facilitated by AR on tumor cells and mannose receptor on macrophages. This led to increased release of pro-inflammatory cytokines in both in vitro and in vivo settings. The synergistic effect of CpG on TAMs and RNAi on tumor cells mediated by the CuMAN nanoparticle not only suppressed the tumor growth but also strongly inhibited the lung metastasis. Our findings indicate that the CuMAN nanoparticle has potential as an effective dual-targeting delivery system for nucleic acid therapeutics.
研究领域:
生物医学工程
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肿瘤免疫学
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Chanez Maouche,Yongying Wang,Chao Cheng,Wenlong Wang,Yi Li,Waqar A. Qureshi,Pengwei Huang,Ali Amjad,Yazhou Zhou,Juan Yang
Iron-nitrogen-carbon (Fe N C) catalysts derived from zeolitic-imidazolate frameworks (ZIFs) are worldwide accepted to be the most promising candidates for the oxygen reduction reaction (ORR), but the insufficient stability, the low FeN x exposure and poor density restrict their ORR activity. Here, we demonstrate a strategy to synthesize FeN x sites embedded in a micro/mesoporous N, S co-doped graphitic carbon (Fe N C/MUS) by tuning the ligand linkers via the addition of 2-undecylimidazole as a co-ligand in ZIF precursors, and optimizing the electronic structure of Fe center by an in-situ addition of thiourea molecules as sulfur (S) source. 2-undecylimidazole offered an open porous structure to incorporate more FeN x , while the S-doping increased the density of FeN x . Besides, 2-undeclyimidazole cooperatively with S-doping caused favorable changes into the catalyst structure, particularly improved the exposure and density of FeN x sites and doubled the Brunauer-Emmetter-Teller surface area to 1132 m 2 g −1 contrasted to the pristine Fe N C/M (544 m 2 g −1 ). Fe N C/MUS displayed an accelerated ORR activity with a higher half-wave potential of 0.86 V (vs. reversible hydrogen electrode (RHE)) than that of Pt/C (0.84 V) in addition of a longer durability with a 11 % of activity decay after 30 000 s in alkaline media. This work offers a new insight to design optimal ZIFs precursor and a facile electron withdrawing S-doping strategy for efficient electrocatalysis .
研究领域:
材料科学
·
电化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Kexin Huang,Zhongyun Yang,Ling Liu,Xue Yang,Youjun Fan,Miaolan Sun,Chengzhou Liu,Wei Chen,Jun Yang
We herein propose a dual ligand coordination strategy for deriving puissant non-noble metal electrocatalysts to substitute valuable platinum (Pt)-based materials toward oxygen reduction reaction (ORR), a key reaction in metal-air batteries and fuel cells. In brief, cobalt ions are firstly double-coordinated with proportionate 2-methylimidazole (2-MeIm) and benzimidazole (BIm) to obtain drum-like zeolitic imidazolate frameworks (D-ZIFs), which are then carbonized to output the final Co, N co-doped porous carbon (Co–N–PC D ) catalyst inheriting the drum-like morphology of D-ZIFs. The Co–N–PC D is featured by mesopores and exhibits superb electrocatalytic behavior for ORR. Impressively, the half-wave potential of Co–N–PC D catalysts is 0.886 V with finer methanol-tolerance and stability than those of commercial Pt/C. Additionally, a zinc-air battery assembled from the Co–N–PC D displays an open-circuit voltage of 1.413 V, comparable to that of commercial Pt/C (1.455 V), suggesting the potentials of Co–N–PC D in practical energy conversion devices.
研究领域:
材料科学
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电化学
·
能源转换
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产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Shaokang Su,Wei Zhang,Ying Xie,Lihong Qi,Song Wang,Limin An,Kai Pan
Cobalt phosphide has been widely used in various catalytic reactions due to its excellent catalytic activity and stability. In contrast to the conventional synthesis of Co2P nanorods using expensive and toxic trioctylphosphine (TOP), this study employs a dual-ligand strategy to prepare iron-atom-doped monodisperse Co2P nanorods. The strategy involves the use of triphenylphosphite (TPOP) as a cost-effective and relatively less toxic strong ligand, alongside hexadecylamine (HDA) as a weaker ligand. The resultant atom-doped Co2P nanorods exhibited a large aspect ratio, providing a plentiful supply of active sites for electrocatalytic hydrogen evolution. In both alkaline and acidic electrolytes, achieving a current density of 10 mA cm–2 required overpotentials of 91 and 141 mV, respectively, with the optimal Co:Fe molar ratio of 1:0.2. The introduction of Fe atoms through doping increased the electron density at the Co atom sites, thereby enhancing H adsorption. This research offers a cost-effective and relatively low-toxicity method for the controlled fabrication of monodisperse transition-metal phosphide nanorods, enabling efficient catalytic reactions.
研究领域:
材料科学
·
催化化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Jin-Juan Xing,Ping-Ping Sun,Yu-Hang Zhang,Xian-Yi Zhao,Fa-Nian Shi
ABSTRACT Three Co (III) complexes based on double ligands {[Co(2,2’-bpy)(2,5-HPda) (2,5-Pda)]Cl·2H 2 O, namely Co-1; [Co(2,2’-bpy)(2,5-Pda) 2 ]·2H 2 O, namely Co-2; [Co(2,2’-bpy)(2,5-HPda)(2,5-Pda)]NO 3 ·H 2 O, namely Co-3} were synthesized by hydrothermal methods. Single crystal X-ray diffraction (XRD), X-ray photoelectron spectrometer (XPS) and energy dispersive spectrometer (EDS) were applied to confirm the components of the three complexes and the oxidation states of the central atom. Optical micrograph, powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR) and ultraviolet-visible spectrum (UV-vis) were used to characterize these complexes. The thermal stabilities of the three complexes were further evaluated by thermo gravimetric analysis (TG). Afterwards, Co-3 was calcined under a flow of nitrogen at 420 °C for 2 h and the composites (C(N,O)/Co x O y ) were formed. When the composites were used as electrode materials for supercapacitors, the results showed an excellent specific capacitance of 544 F·g −1 in 6 M KOH solution at a current density of 2 A·g −1 . The cycle tests showed that the specific capacitance retained well after 2000 cycles at 20 A·g −1 current density.
研究领域:
材料化学
·
能源科学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Shan Pu,Chengyan Xia,Lan Wu,Kailai Xu
In this study, polyvinylpyrrolidone (PVP) supported and cysteine (Cys) modified copper nanoclusters (Cys-PVP-CuNCs) with high fluorescence intensity have been synthesized and used to establish a simple and sensitive assay for the determination of trace Sn 4+ . The presence of Sn 4+ can lead to fluorescence quenching based on the aggregation of PVP-CuNCs caused by the coordination of Sn 4+ and oxygen atoms. For Cys-PVP-CuNCs, the ligand Cys can transfer electrons to the metal center of the cluster, resulting in strong fluorescence enhancement of CuNCs and intensification of fluorescence quenching after interaction with Sn 4+ , which is conducive to more sensitive visual detection. The proposed assay allows for the detection of Sn 4+ in a linear range from 5 μg L −1 to 100 μg L −1 , with a detection limit as low as 4.5 μg L −1 at a signal-to-noise ratio of 3. Moreover, under UV light, the obvious fluorescent color change can be observed by naked eyes at Sn 4+ concentration ranging from as low as 5 μg L −1 to 200 μg L −1 . Benefiting from the high sensitivity of this assay, satisfactory test results have been obtained when using only 10 mg of canned food samples with rapid digestion. The proposed Cys-PVP-CuNCs fluorescent probe shows excellent stability, simple operation, good selectivity, and high sensitivity, and thus it is expected to be used in the real-time field detection of Sn 4+ .
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jialong Pang,Yali Liu,Chuanfang Zhao,Jiawen Li,Mengting Ran,Baiyi Zu,Xincun Dou
The structural modification of metal–organic frameworks (MOFs) is of vital importance in many fields, especially in sensing with enhanced performance, while the efficient synthesis of functionalized MOF nanoparticles toward small molecule detection remains challenging. Here, a general cellulose nanofibril (CNF)-induced in situ one-step strategy was proposed for the synthesis of dual-ligand-functionalized europium-based MOF (EuMOF@CNF) nanoparticles under an effective regulation of the crystallization kinetics in hydrothermal synthesis. Based on the unique dual-ligand structure, the obtained EuMOF featured a tunable antenna effect and laid a good foundation for fluorescence-sensing materials. Benefiting from the superior self-assembly properties of CNFs and the tunable antenna effect of EuMOF@CNF, flexible sensing films were constructed, showing excellent mechanical properties (72 MPa for stress and 3.8% for strain) and tunable luminescence properties and achieving instant (1 s) and sensitive fluorescence sensing of sarin analogue vapor with a significantly low limit of detection (LOD, 2.8 ppb) and robust selectivity against a wide range of common interferents (>14 types), especially independent of common acids. We believe that this pioneering design of EuMOF with tunable antenna effects would positively advance the development of high-performance MOF-based fluorescent materials and devices.
研究领域:
材料科学
·
化学传感器
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Haijiao Jia,Mengqi Cheng,Ran Zhao,Pingyi Zheng,Fangfang Ren,Yaqin Nan,Mengting Huang,Youxin Li
An effective palladium nanocatalyst (Fe3O4@SiO2–FPBA–DTPA–Pd) was proposed and prepared, which was immobilized on magnetic silica with ethylenediamine pentaacetic acid and formylphenylboronic acid as biligands. A series of characterizations showed that Fe3O4@SiO2–FPBA–DTPA–Pd was 5–15 nm and contained 1.44 mmol/g Pd2+/Pd0. It was stable below 232.7 °C, and its saturation magnetization value was 21.17 emu/g which was easily recycled by a magnet. Its catalytic ability was evaluated through 7 Suzuki reactions and 15 Heck reactions. Results showed that the yields of 14 reactions catalyzed by Fe3O4@SiO2–FPBA–DTPA–Pd were more than 90%, while were better than those of the other two immobilized Pd catalysts on a single diethyltriamine pentaacetic acid (DTPA) group or boronic acid group. Moreover, Fe3O4@SiO2–FPBA–DTPA–Pd showed good reusability in both Suzuki and Heck reactions. In two model Suzuki and Heck reactions, after seven cycles, its yields were still above 95% without significant loss, which exceeded those of many reported catalysts; therefore, it has great potential in future large-scale industrial production.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 192
·期 1
·1-11
·
IF 5.3
Chen Xueke,Huang Tongfu,Wang Xin,Wu Chunyan,Yi Fei,Wan Ziqiang,Zou Bao,Xiong Wei,Liao Fusheng,Fan Hao,Yin Zhaojiang
The ultrahigh-sensitive detection of H 2 S is reported using a novel dual-ligand metal–organic framework (MOF) electrochemiluminescence (ECL) sensor. By combining tetrakis(4-carboxyphenyl) porphyrin (TCPP) and 1,3,6,8-tetrakis(4-carboxyphenyl) pyrene (TBAPy) as ligands and employing zirconium as the metal source, a spindle-shaped Zr-PyTCPPMOF was successfully designed and synthesized. Notably, the multiple nitrogen structures of porphyrin provided abundant binding sites for sulfur (S), further enhancing the ECL signal of Zr-PyTCPPMOF. The sensor shows a good linear relationship in the 0.01–100 μM range, with a detection limit reaching 1.18 nM (S/N = 3). When analyzing actual serum samples, the recovery was between 96.6 and 106.2%. Ultimately, the dual-ligand ECL platform based on Zr-PyTCPPMOF achieved trace detection of H 2 S, which is expected to provide reliable technical support for early environmental monitoring and disease diagnosis. Graphical abstract
研究领域:
分析化学
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）