HIGH PERFORMANCE POLYMERS
·
2023
·
IF 2.1
Junjie Zhou,Kangkang Guo,Fan Wang,Yaping Zhu,Huimin Qi
Herein, the catalytic effects of aromatic amines with different structures on the room temperature curing of bisphenol E cyanate (BECy) have been studied using differential scanning calorimetry (DSC) and Fourier transform infrared (FT-IR) spectroscopy. Our results revealed that the mixed amine comprised of aniline and N,N-dimethyl-p-phenylenediamine (AN/NNDPA) bearing primary amino groups in its structure was a highly effective catalyst for the room temperature curing of cyanate esters. When the cyanate ester and mixed amine were combined at a molar ratio of 100:5 and cured at room temperature for 5 days, the curing degree of BECy resin reached 79.7%. The room temperature curing mechanism of the BECy-AN/NNDPA system was investigated using pyrolysis gas chromatography-mass spectrometry (PY GC-MS). Our results showed that the formation reactions of the intermediate structure and cyclotrimerization reactions occurred during the room-temperature curing process. The activation energies of BECy and different aromatic amine systems at different heating rates were determined using non-isothermal DSC. The results further demonstrated the catalytic effect of AN/NNDPA on the cyanate ester curing reaction. BECy-AN/NNDPA cured at room temperature has suitable heat resistance and a 5% weight loss temperature (Td5) of 361°C.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Biology-Basel
·
2025
·Vol. 14
·期 8
·992
·
IF 3.5
Kaicheng Gu,Lindong Yang,Yi Jiang,Zhiqiang Wang,Jiannan Chen
Simple SummaryBisphenol E (BPE), a typical endocrine disruptor, is widely present in various environmental media. Using zebrafish as a model, this study systematically evaluated the toxic effects of BPE on embryonic development and the nervous system. By integrating a network toxicology analysis and molecular docking techniques, the neurotoxic mechanism was revealed: BPE inhibits the activity of NOS3/PKG, blocks the transmission of the cGMP/PKG signaling pathway, and ultimately induces neurotoxic damage. This research advances the understanding of endocrine disruptor toxicity by providing novel experimental evidence and delivers key theoretical pillars for building a health risk assessment system targeting environmental pollutants.As typical environmental hormones, endocrine-disrupting chemicals (EDCs) have become a global environmental health issue of high concern due to their property of interfering with the endocrine systems of organisms. As a commonly used substitute for bisphenol A (BPA), bisphenol E (BPE) has been frequently detected in environmental matrices such as soil and water in recent years. Existing research has unveiled the developmental and reproductive toxicity of BPE; however, only one in vitro cellular experiment has preliminarily indicated potential neurotoxic risks, with its underlying mechanisms remaining largely unelucidated in the current literature. Potential toxic mechanisms and action targets of BPE were predicted using the zebrafish model via network toxicology and molecular docking, with RT-qPCRs being simultaneously applied to uncover neurotoxic effects and associated mechanisms of BPE. A significant decrease (p< 0.05) in the frequency of embryonic spontaneous movements was observed in zebrafish at exposure concentrations ≥ 0.01 mg/L. At 72 hpf and 144 hpf, the larval body length began to shorten significantly from 0.1 mg/L to 1 mg/L, respectively (p< 0.01), accompanied by a reduced neuronal fluorescence intensity and a shortened neural axon length (p< 0.01). By 144 hpf, the motor behavior in zebrafish larvae was inhibited. Through network toxicology and molecular docking, HSP90AB1 was identified as the core target, with the cGMP/PKG signaling pathway determined to be the primary route through which BPE induces neurotoxicity in zebrafish larvae. BPE induces neuronal apoptosis and disrupts neurodevelopment by inhibiting the cGMP/PKG signaling pathway, ultimately suppressing the larval motor behavior. To further validate the experimental outcomes, we measured the expression levels of genes associated with neurodevelopment (elavl3,mbp,gap43,syn2a), serotonergic synaptic signaling (5-ht1ar,5-ht2ar), the cGMP/PKG pathway (nos3), and apoptosis (caspase-3,caspase-9). These results offer crucial theoretical underpinnings for evaluating the ecological risks of BPE and developing environmental management plans, as well as crucial evidence for a thorough comprehension of the toxic effects and mechanisms of BPE on neurodevelopment in zebrafish larvae.
研究领域:
环境毒理学
·
神经毒理学
·
发育生物学
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分子生物学
·
生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Zhao-Xi Zhou,Yuewei Li,Jie Zhong,Zhen Luo,Cui-Ran Gong,Yang-Qing Zheng,Shuqiang Peng,Li-Ming Yu,Lixin Wu,Ying Xu
As the 3D printing technology is getting more and more popular and useful, demands for materials for 3D printing have increased significantly. Cyanate ester (CE) resin possesses the characteristics of high heat distortion temperature and high glass transition temperature, outstanding mechanical properties, low dielectric constant, and excellent water uptake. However, CE resin has not been widely used in 3D printing of UV curing because it is difficult for photopolymerizable groups to graft onto the chains of CE resin. On the other hand, the glass transition temperature (Tg) of the homopolymer of the tris(2-hydroxyethyl)isocyanurate triacrylate (THEICTA) outclasses that of other acrylates. Although THEICTA is particularly advantageous to prepare a UV-curing prepolymer with high glass transition temperature, it also cannot be directly used for fabricating heat-resistant 3D-printed parts because it is solid and adding diluents will reduce the thermal stability of printed objects. This study is unique in producing 3D-printed materials, in which the THEICTA tactfully dissolves in low viscosity (about 100 mPa·s under 25 °C) bisphenol E cyanate (BECy) without sacrificing two kinds of bulk material properties. In the process of 3D printing, the carbon–carbon double bonds from THEICTA are cured by radical polymerization. Postprinting thermal treatment transforms three cyanate groups to a triazine ring structure. Additionally, the two kinds of structures are interpenetrating. The high-performance 3D-printing material has potential in fields ranging from space flight and aviation to the automotive and electronic industry.
研究领域:
材料科学
·
化学工程
·
增材制造
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）