APPLIED CLAY SCIENCE
·
2022
·
IF 5.907
Fayang Guo,Dabao Li,Jeremy B. Fein,Jingcheng Xu,Yingwei Wang,Qiaoyun Huang,Xingmin Rong
Reactions occurring at silicate minerals play a significant role in controlling phenolic endocrine disrupting chemicals' bioavailability and mobility. However, the underlying molecular mechanisms for BPA (bisphenol A) and BPS (bisphenol S) onto montmorillonite (MMT) remain poorly understood. To decipher the molecular-level interfacial configuration and dominant reaction mechanism, batch experiments, X-ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), X-ray photoelectron spectroscopy (XPS) measurements, and density functional theory (DFT) calculations were performed. Our batch adsorption experiments showed that MMT exhibits a higher adsorption capacity for BPS than for BPA. The XRD analysis also suggested that BPA and BPS could enter the interlayer of MMT. FTIR and XPS results revealed that The Ca atoms and the oxygen atoms in the SiO 4 tetrahedra were involved in BPA and BPS adsorption process via non-covalent interactions. The electrostatic potential calculations suggested that the sulfonyl O site and the hydroxyl H site on the BPS molecule are more favorable for interacting with the MMT surface than the hydroxyl O and H sites of the BPA molecule. DFT calculations further confirmed that stronger binding of BPS than BPA onto the (001) surface and the interlayer of MMT. BPA tends to form Ca ion bridges through hydroxyl groups onto MMT. In contrast, BPS prefers to form Ca ion bridges onto MMT through its sulfonyl group and form hydrogen bonds via hydroxyl groups. This study provides new insights into the molecular-scale interactions that control BPA and BPS adsorption onto an important and environmentally-relevant clay mineral, and which affect the fate and behavior of BPA and BPS in soil systems.
研究领域:
环境科学
·
分子生物学
✓ 已验证
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Yang Liu,Yuanyuan Wang,Jie Ma,Runping Han
ABSTRACT In this study, peanut shell was modified using β-cyclodextrin (β-CD) and citric acid to improve the adsorption capacity for removal of lead ion (Pb 2+ ) and bisphenol S (BPS) from solution in batch mode. Scanning electron microscopy, Fourier-transform infrared spectroscopy, elemental analysis, X-ray fluorescence analysis, specific surface area analysis, thermogravimetric analysis, etc were used to characterize the adsorbent before and after modification. The results showed that the adsorbent was successfully modified. The adsorption results of Pb 2+ and BPS on β-CD-PS indicated that acidic conditions were not conducive to the adsorption of Pb 2+ , the adsorption of BPS basically remained unchanged at pH 2~7, and alkaline conditions were not conducive to the adsorption. The presence of salt had a negative effect on Pb 2+ , but had no effect on the adsorption of BPS. The Langmuir and Koble–Corrigan models could predict the equilibrium adsorption process of Pb 2+ while Temkin and Koble–Corrigan models could describe the equilibrium adsorption process of BPS. The adsorption quantity from experiments is 89.6 mg·g –1 for Pb 2+ and 16.2 mg·g –1 for BPS at 293 K, respectively. The adsorption process of Pb 2+ was consistent with the pseudo-first-order and Elovich models, indicating the presence of ion-exchange in the adsorption process; the adsorption of BPS was consistent with the pseudo-second-order model, indicating that chemisorption was the main rate-controlling step. Thermodynamic studies indicated that the adsorption of Pb 2+ was a spontaneous and endothermic reaction with increasing entropy, while the adsorption of BPS was a spontaneous and exothermic reaction with decreasing entropy. 0.1 mol·L –1 HNO 3 could desorb and regenerate the β-CD-PS adsorbed Pb 2+ for three times, and 75% C 2 H 5 OH had a better desorption and regeneration effect for BPS loaded β-CD-PS. β-CD-PS can effectively remove the lead ion and BPS from mixtures and the study can provide the basis for the effective utilization of peanut shell in environmental remediation.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
BIORESOURCE TECHNOLOGY
·
2024
·
IF 9.7
Mingdong Chang,Ji-Hang Jiang,Jianqiao Wang,Ru Yin,Qiaoyu Li,NaNa Wang,Pengfei Xiao,Li-Wei Zhou,Tangfu Xiao
Bisphenol S (BPS) has attracted much attention as an emerging hazardous contaminant due to its endocrine disruption and oncogenic effects. Although white-rot fungi have remarkable bioremediation capabilities for some bisphenols, little is known about their performance in BPS degradation. In this study, the newly discovered Phlebia acerina S-LWZ20190614-6 exhibited high capacity to degrade BPS. To further explore the mechanism of BPS degradation by P. acerina S-LWZ20190614-6, the whole-genome background and degradation pathways were investigated. Five low-toxicity metabolites were detected during the BPS biodegradation process, and a strong correlation was found between this biodegradation process and the interactions between BPS and ligninolytic enzymes. Moreover, transcriptomic analysis revealed that genes related to DNA replication and repair, ABC transporters, and fatty acid metabolism were involved in this BPS degradation process. Overall, this study provides insights into the achievement of BPS biodegradation by white-rot fungi.
研究领域:
环境科学
·
微生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Environmental Science & Technology Letters
·
2021
·
IF 7.653
Wenjuan Zhang,Yue Gao,Cheng Chen,Aijing Li,Xuerui Ma,Yong Liang,Xinglei Yao,Maoyong Song,Guibin Jiang
Bisphenol S (BPS) is a bisphenol A (BPA) replacement that is widely present in the environment and in humans. The association between obesity and BPS has been reported in epidemiological studies; however, the obesogenic effect and related mechanism of BPS remain poorly understood. In this study, high-resolution microcomputed tomography analysis showed that the volume of visceral fat was significantly increased in BPS-treated mice. Moreover, BPS showed a higher potency to induce visceral fat formation in mice than BPA at the exposure concentration of 5 mg/kg/day for 14 days. Nontargeted metabolomic analysis showed that BPS exposure induced multiple metabolic disorders in the livers of BPS-treated mice. Interestingly, the body weight and volumes of visceral fat returned to normal by co-treatment with succinate in BPS-treated mice, suggesting that succinate might be the key molecule for the link between BPS and visceral obesity. Our findings highlight that BPS may act as an environmental obesogen to promote obesity.
研究领域:
环境科学
·
代谢生物学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Yan Wang,Tao Yang,Jing Chen,Shaobin Wen,Die Li,Bingyu Wang,Qiang Zhang
A novel ferrocene-based nanofiltration membrane is prepared to combine filtration and photo-Fenton reaction for water treatment. Membranes containing ferrocene groups are successfully fabricated via an integration of layer-by-layer interfacial polymerization and ion exchange reaction. Rejection performance towards bisphenol S (BPS) increases with the growth of the interfacial polymerization layer, and the optimal membrane shows the highest rejection rate of 98.1%. For the optimal photo-Fenton system with H 2 O 2 , UV and ferrocene-based membrane (PS/HTCC-3/FcSO 3 ), the degradation rate of k is 0.092 min −1 , which is 1.8 times higher than that of the system with only H 2 O 2 and UV. Meanwhile, the salinity of BPS in the optimal system is 2 times higher than that of the system with H 2 O 2 and UV. After the heterogeneous photo-Fenton process, PS/HTCC-3/FcSO 3 can reject 65.6% of the BPS degradation by-products based on the variation of total organic carbon (TOC). In addition, quenching experiments prove that ·OH is the primary active radical, and the yield of ·OH in the optimal system is the highest compared with the system with H 2 O 2 and UV. The outstanding performance of ferrocene-based membrane demonstrates its potential for micropollutants treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED GEOCHEMISTRY
·
2024
·
IF 3.1
Yanting Pan,Feng Zhang,Ziyang Zhou,Feng Jiang,Xiaoming Wang,Hui Yin,Wenfeng Tan,Xionghan Feng
A series of cobalt-doped FeS (x% Co–FeS) nanoparticles , prepared via a hydrothermal method, were introduced as catalysts for generating radicals from peroxymonosulfate (PMS) to degrade the endocrine disrupter bisphenol S (BPS) in wastewater. The kinetic results revealed that only a small amount of Co doping (7% At.) could greatly improve the efficiency of PMS activation by FeS, leading to the rapid degradation of BPS (0.21min −1 vs. 0.0046 min −1 ), and no secondary pollution caused by Co leaching. Notably, exceptional activation was observed over a wide pH range from 4 to 11. Moreover, various background ions (NO 3 − , Cl − , CO 3 2− ) and temperatures (10.0–55.0 °C) minimally affected BPS degradation, suggesting excellent applicability in different sewage environments. Furthermore, quenching experiments, coupled with electron paramagnetic resonance technology, identified singlet oxygen ( 1 O 2 ) and sulfate radicals (SO 4 •- ) as the primary reactive oxygen species responsible for BPS degradation. Due to the selectivity of 1 O 2 and the high redox potential of SO 4 •- , this technology had excellent anti-interference and degradation ability. In six repeated batch experiments, the catalysts showed favorable cyclability and stability due to Co(II)/Co(III) cycling mediated by structural S 2− . These results provided insights into the potential applications of modifying natural FeS-type minerals as a promising heterogeneous catalyst for environmental restoration.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2016
·Vol. 23
·期 9
·8976-8984
·
IF 2.76
Guo Huiying,Li Hao,Liang Ni,Chen Fangyuan,Liao Shaohua,Zhang Di,Wu Min,Pan Bo
Bisphenol S (BPS), a new bisphenol analog, is considered to be a potential replacement for bisphenol A (BPA), which has gained concern because of its potentially adverse health impacts. Therefore, studies are needed to investigate the environmental fate and risks of this compound. In this study, the adsorption of BPS and four structural analogs on multi-walled carbon nanotubes (MWCNTs) and graphite (GP) were investigated. When solid-phase concentrations were normalized by the surface areas, oxygen-containing functional groups on the absorbents showed a positive impact on phenol sorption but inhibited the sorption of chemicals with two benzene rings. Among BPS analogs, diphenyl sulfone showed the lowest sorption when hydrophobic effects were ruled out. Chemicals with a butterfly structure, formed between the two benzene rings, showed consistently high sorption on MWCNTs, independent of the substituted electron-donating or accepting functional groups. This study emphasizes the importance of chemical conformation on organic, contaminant sorption on engineered, carbonaceous materials.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Qingwei Gao,Jing Ding,Guanshu Zhao,Qingliang Zhao,Lili Li,Xiaoshan Zhao,Lingjun Bu,Shiqing Zhou,Shan Qiu
Sulfate radical-based advanced oxidation processes had been widely applied in the water treatment. In this study, a novel solar-assisted electrooxidation process (SEOP) to activate peroxymonosulfate (PMS) or peroxydisulfate (PDS) was conducted for the degradation of bisphenol S (BPS). The SEOP with persulfate (PS) demonstrated its synergistic effect for BPS degradation, compared with the electrooxidation/PS and the solar process. The hydroxyl radical, sulfate radical ( SO 4 · - ), and singlet oxygen were regarded as primary active species in BPS degradation in SEOP with PS. The transition structure complex ( persulfate* ) on the anode promoted the efficiency of BPS degradation via the non-radical mechanism. The activation of PMS and PDS in SEOP was dominated through radical and non-radical mechanism, respectively. To effectively supplement experimental work with quantum chemical calculation, density function theory (DFT) showed that the active sites mainly focused on the phenol ring of BPS. The energy barrier calculation indicated that BPS was more susceptible to be attacked by SO 4 · - through electron transfer. BPS was mainly degraded by ring-opening, substitution, addition, C–C bond breaking, and decarboxylation reactions. Furthermore, the effective decrease in bio-toxicity of BPS intermediates in SEOP with PS was predicted. Experiments under various current densities, initial concentration of PS, electrolyte, and humic acid suggested the feasibility of SEOP with PS. BPS was degraded with lower energy consumption (0.18 kWh·m −3 ·order − 1 ) in SEOP with PMS than that in SEOP with PDS (0.30 kWh·m −3 ·order − 1 ) and without PS (0.38 kWh·m −3 order − 1 ), respectively. The SEOP with PS poses the feasible, convenient, and economic potential for the degradation of refractory pollutants.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Nuanfei Zhu,Kuijing Yuan,Dinghui Xiong,Fengxiang Ai,Kun Zeng,Biying Zhao,Zhen Zhang,Hongjun Zhao
Dietary intake is an important exposure pathway of environmental bisphenols including bisphenol S (BPS, a typical emerging organic pollutant). However, available data on the occurrence and risk assessment of BPS in food samples are limited due to the lack of high-throughput analytical methods. Herein, based on H 2 O 2 inducing fluorescence turn-off signals, a sensitive and high-throughput fluorescence enzyme-linked immunosorbent assay (FELISA) was developed for BPS investigation in beverages. In this system, the fluorescence of copper nanoclusters in ZIF-8 (CuNCs-CS@ZIF-8) could be quenched with the presence of H 2 O 2 owing to the strong oxidation, being served as signal amplification in FELISA. Meanwhile, the aggregation-induced emission (AIE) fluorescence enhancement of CuNCs-CS through the conformational locking of ZIF-8 provided an effective strategy to overcome the intrinsic limitations of FELISA including high background, serious fluorescence quenching in the detection of real samples. Thus, the integration of AIE building blocks into porous ZIF-8 showed obvious advantages in enhancing the analytical performance of FELISA. Under optimized conditions, satisfactory results with good accuracy were achieved in this proposed FELISA, which was applied for the systematic investigation of BPS in foods and further health risk assessments. The results after 100 beverages analysis displayed an average detection frequency of 55%, and the detected concentration of BPS ranged from below the limit of quantification (LOQ) to 12.08 ng/mL with a mean value of 1.717 ng/mL. Besides, the estimated daily intake (EDI) of BPS was calculated to be 0.05449–4.483 ng/kg-bw/day, in which milk–tea drinks contributed to the majority of BPS daily intake (mean EDI = 4.483 ng/kg-bw/day). And the hazard quotient (HQ) according to EDI values indicated that BPS exposure in beverages might not make a considerable impact on human health.
研究领域:
环境科学
·
食品科学
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
Animals
·
2023
·Vol. 13
·期 24
·3832
·
IF 3
Hongmei Xu,Yueyue Li,Qiao Li,Zifeng Ma,Shi Yin,Honghong He,Yan Xiong,Xianrong Xiong,Daoliang Lan,Jian Li,Wei Fu
Simple SummaryIn recent years, authoritative journals have consistently reported DHODH’s critical role in resistance to ferroptosis, significantly advancing the research on related mechanisms. Nevertheless, the nucleotide sequence of the yakDHODHgene remains unknown, and its involvements in ferroptosis processes in yak cells remain elusive. Therefore, in the present study, we cloned the coding region of the yakDHODHgene, and revealed its high conservation in mammals. Furthermore, by using a bisphenol S (BPS)-induced ferroptosis model, we confirmed the role of theDHODHgene in mitigating ferroptosis in yak skin fibroblasts (YSFs) derived from a three-mouth-old fetus. This study offers theoretical support for further exploring the functions of the yakDHODHgene and partially elucidating the molecular mechanisms underlying ferroptosis.AbstractDihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme ofde novobiosynthesis of pyrimidine. Although the involvement of DHODH in resisting ferroptosis has been successively reported in recent years, which greatly advanced the understanding of the mechanism of programmed cell death (PCD), the genetic sequence of the yakDHODHgene and its roles in ferroptosis are still unknown. For this purpose, we firstly cloned the coding region sequence ofDHODH(1188 bp) from yak liver and conducted a characterization analysis of its predictive protein that consists of 395 amino acids. We found that the coding region of the yakDHODHgene presented high conservation among species. Second, the expression profile of theDHODHgene in various yak tissues was investigated using RT-qPCR. The results demonstrated thatDHODHwas widely expressed in different yak tissues, with particularly high levels in the spleen, heart, and liver. Third, to investigate the involvement ofDHODHin regulating ferroptosis in cells, yak skin fibroblasts (YSFs) were isolated from fetuses. And then, bisphenol S (BPS) was used to induce thein vitroferroptosis model of YSFs. We observed that BPS decreased the cell viability (CCK8) and membrane potential (JC-1) of YSFs in a dose-dependent manner and induced oxidative stress by elevating reactive oxygen species (ROS). Simultaneously, it was evident that BPS effectively augmented the indicators associated with ferroptosis (MDA and BODIPY staining) and reduced GSH levels. Importantly, the co-administration of Ferrostatin-1 (Fer), a potent inhibitor of ferroptosis, significantly alleviated the aforementioned markers, thereby confirming the successful induction of ferroptosis in YSFs by BPS. Finally, overexpression plasmids and siRNAs of the yakDHODHgene were designed and transfected respectively into BPS-cultured YSFs to modulateDHODHexpression. The findings revealed thatDHODHoverexpression alleviated the occurrence of BPS-induced ferroptosis, while interference ofDHODHintensified the ferroptosis process in YSFs. In summary, we successfully cloned the coding region of the yakDHODHgene, demonstrating its remarkable conservation across species. Moreover, using BPS-induced ferroptosis in YSFs as the model, the study confirmed the role of theDHODHgene in resisting ferroptosis in yaks. These results offer valuable theoretical foundations for future investigations into the functionality of the yakDHODHgene and the underlying mechanisms of ferroptosis in this species.Keywords:yak;DHODHgene;fetal fibroblasts;ferroptosis;Bisphenol S
研究领域:
分子生物学
·
细胞生物学
·
遗传学
✓ 已验证
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2025
·
IF 8
Xincong Su,Li Kai,Xiaowen Han,Rongzhi Wang,Xiao Yang,Xuedong Wang,Jin Yan,Qiuhui Qian,Zejun Wang,Huili Wang
Bisphenol S (BPS) and Bisphenol F (BPF), as alternatives to bisphenol A (BPA), are recognized for their endocrine-disrupting properties, but their combined immune toxicity mechanisms remain poorly understood. This study systematically evaluates the individual and joint immune toxicity effects of BPS and BPF through ADMET predictions, transgenic zebrafish models, and molecular docking analyses. The results indicate that equal effect concentration BPS and BPF act through distinct immune pathways: BPS primarily targets macrophages to mediate immune responses, while BPF significantly stimulates neutrophil proliferation and induces a stronger inflammatory response through chemokine signaling. Molecular docking studies show that BPF binds more stably to pro-apoptotic protein Mapk8 and oxidative stress-related protein Hsp90aa1, leading to significantly higher levels of apoptosis and reactive oxygen species (ROS) compared to BPS. The similarity of modes of action (MOA)between BPS and BPF based on relevant immune indicators calculated and experimentally is about 0.3; this quantitative result also proves that modes of action differ widely. Nonetheless, most of the indicators showed superimposed effects in the combined experiments, and it is noteworthy that the oxidative stress indicators (SOD, MDA) showed synergistic effects, suggesting that BPS and BPF, which have very different modes of action, are able to be risk assessed using an additive model with respect to immunity, but may exhibit synergistic risks with respect to oxidative stress. This research demonstrates that BPS and BPF induce immune toxicity via different molecular targets and pathways and highlights the need to account for their synergistic effects in risk assessments. These findings provide important insights into the immune toxicity mechanisms of BPA substitutes and the potential risks of combined exposures.
研究领域:
环境科学
·
毒理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2025
·
IF 5.4
Rong Tian,Jia-Xin Li,Naihao Lu
As a replacement of bisphenol A, bisphenol S (BPS) is commonly used in the wrappers and food containers of daily life. Epidemiological studies demonstrate a close link between BPS exposure and vascular diseases, where the biological activities of BPS remain scarcely known. Herein, the effects of BPS on endothelial function as well as the underlying mechanism were investigated in human umbilical vein endothelial cells (HUVECs) and mouse arteries. It was found that exposure of BPS dose-dependently induced endothelial dysfunction (i.e., decline of nitric oxide (NO) formation) in HUVECs, accompanied by the increase of reactive oxygen species (ROS) production and loss of mitochondria membrane potential. Mitochondria-specific antioxidant (Mito-Tempol) or superoxide scavenger (tiron) abolished the harmful effects of BPS, while superoxide dismutase (SOD)-specific siRNA exhibited negative influence, suggesting that mitochondrial ROS was responsible for BPS-induced endothelial dysfunction and SOD was a sensitive target of BPS. Consistently, plasma NO formation and endothelium-dependent vasodilation was significantly impaired in mice exposed to dietary BPS. In addition, the binding of bovine serum albumin (BSA, the most abundant protein in blood) to BPS considerably alleviated ROS formation and endothelial dysfunction in HUVECs. BPS primarily interacted with Sudlow site I of albumin to generate BSA-BPS complex through static mechanism, in which the hydrogen bonds and electrostatic forces played important roles. Altogether, dietary exposure to emerging BPS would disrupt vascular homeostasis via the induction of mitochondrial ROS formation and consequent endothelial dysfunction, highlighting the detoxification impact of albumin protein on the hazardous effects of environmental pollutants.
研究领域:
环境科学
·
心血管生物学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）