Polymers
·
2020
·Vol. 12
·期 1
·239
·
IF 3.426
Jie Wen,Xiaopeng Zhang,Mingwang Pan,Jinfeng Yuan,Zhanyu Jia,Lei Zhu
Commonly synthetic polyethylene glycol polyurethane (PEG–PU) hydrogels possess poor mechanical properties, such as robustness and toughness, which limits their load-bearing application. Hence, it remains a challenge to prepare PEG–PU hydrogels with excellent mechanical properties. Herein, a novel double-crosslinked (DC) PEG–PU hydrogel was fabricated by combining chemical with physical crosslinking, where trimethylolpropane (TMP) was used as the first chemical crosslinker and polyphenol compound tannic acid (TA) was introduced into the single crosslinked PU network by simple immersion process. The second physical crosslinking was formed by numerous hydrogen bonds between urethane groups of PU and phenol hydroxyl groups in TA, which can endow PEG–PU hydrogel with good mechanical properties, self-recovery and a self-healing capability. The research results indicated that as little as a 30 mg·mL−1TA solution enhanced the tensile strength and fracture energy of PEG–PU hydrogel from 0.27 to 2.2 MPa, 2.0 to 9.6 KJ·m−2, respectively. Moreover, the DC PEG–PU hydrogel possessed good adhesiveness to diverse substrates because of TA abundant catechol groups. This work shows a simple and versatile method to prepare a multifunctional DC single network PEG–PU hydrogel with excellent mechanical properties, and is expected to facilitate developments in the biomedical field.Keywords:tannic acid;double crosslinking;polyurethane hydrogel;mechanical properties;multifunction
研究领域:
材料科学
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化学工程
·
生物医学工程
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xingyu Yi,Rui Zhou,Liang Liu,Shirong Xu,Hong Sun,Kenji Ogino,Yimin Fan
Formaldehyde (FO) and nanochitin suspension (DEChN) were combined to synthesize stable hydrogels via ice-templated chemical/physical crosslinking. The synthesis process involved the mixing of formaldehyde and nanochitin, followed by ammonia-induced gas phase coagulation to achieve dual crosslinking, thereby enhancing the mechanical properties of the hydrogels. The chemically crosslinked hydrogel exhibited a storage modulus of 680.05 Pa, whereas the demonstrated an approximately 5-times increase in storage modulus of 3110.34 Pa for DEChN(5)/FO(1), along with a reduced surface area and improved structural stability. Filtration experiments revealed that the dual-crosslinked hydrogel achieved nearly complete removal of microplastics (∼3 μm in diameter), with a flux of 8.22 mL cm −2 h −1 , outperforming both the chemically (5.05 mL cm −2 h −1 ) and physically (3.01 mL cm −2 h −1 ) crosslinked samples. This enhanced performance was attributed to the larger pore size and robust channel structure in dual crosslinked hydrogels. The nanochitin hydrogels offered a more straightforward fabrication process, superior filtration efficiency, and cost-effectiveness, highlighting their scalability for practical water purification systems.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
PubMed
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2019
·
IF 2.367
Jing Zhou,Yuanyuan Chen,Mengmeng Luo,Fen Deng,Sen Lin,Wencan Wu,Guqiang Li,Kaihui Nan
Objective: This study was aimed to develop sustained drug release from levofloxacin (LF)-loaded chitosan (CS) microspheres for treating ophthalmic infections.Significance: Dual cross-linked CS microspheres developed by the spray-drying technique displays significantly higher level of sustained drug release compared with non-cross-linked CS microspheres.Methods: LF-loaded CS microspheres were prepared using the spray-drying technique, and then solidified with tripolyphosphate and glutaraldehyde as dual cross-linking agents. The microspheres were characterized by surface morphology, size distribution, zeta potential, encapsulation efficiency, and drug release profiles in vitro. The drug quantification was verified and analyzed by high-performance liquid chromatography (HPLC). The structural interactions of the CS with LF were studied with Fourier transform infrared spectroscopy. The effect of various influencing excipients in the formulation of the dual cross-linked CS microspheres on drug encapsulation efficiency and the drug release profiles were extensively investigated.Result: The microspheres demonstrated high encapsulation efficiency (72.4 ∼ 98.55%) and were uniformly spherical with wrinkled surface. The mean particle size was between 1020.7 ± 101.9 and 2381.2 ± 101.6 nm. All microspheres were positively charged (zeta potential ranged from 31.1 ± 1.32 to 42.81 ± 1.55 mV). The in vitro release profiles showed a sustained release of the drug and it was remarkably influenced by the cross-linking process.Conclusion: This novel spray-drying technique we have developed is suitable for manufacturing LF-loaded CS microspheres, and thus could serve as a potential platform for sustained drug release for effective therapeutic application in ocular infections.
研究领域:
药剂学
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眼科感染治疗
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DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 23
·5116
·
IF 4.967
Bingchao Duan,Minghui Yang,Quanchao Chao,Lan Wang,Lingli Zhang,Mengxing Gou,Yuling Li,Congjun Liu,Kui Lu
In this study, an egg white dual cross-linked hydrogel was developed based on the principle that the external stimulus can denature proteins and cause them to aggregate, forming hydrogel. The sodium hydroxide was used to induce gelation of the egg white protein, subsequently introducing calcium ions to cross-link with protein chains, thereby producing a dual cross-linked hydrogel. The characteristics of the dual cross-linked hydrogels—including the secondary structure, stability, microstructure, swelling performance, texture properties, and biosafety—were investigated to determine the effects of calcium ion on the egg white hydrogel (EWG) and evaluate the potential application in the field of tissue engineering. Results showed that calcium ions could change the β-sheet content of the protein in EWG after soaking it in different concentrations of CaCl2solution, leading to changes in the hydrogen bonds and the secondary structure of polypeptide chains. It was confirmed that calcium ions promoted the secondary cross-linking of the protein chain, which facilitated polypeptide folding and aggregation, resulting in enhanced stability of the egg white dual cross-linked hydrogel. Furthermore, the swelling capacity of the EWG decreased with increasing concentration of calcium ions, and the texture properties including hardness, cohesiveness and springiness of the hydrogels were improved. In addition, the calcium cross-linked EWG hydrogels exhibited biocompatibility and cell-surface adhesion in vitro. Hence, this work develops a versatile strategy to fabricate dual cross-linked protein hydrogel with biosafety and cell-surface adhesion, and both the strategy and calcium-egg white cross-linked hydrogels have potential for use in bone tissue engineering.Keywords:egg white hydrogel;dual cross-linking;metal ions;secondary structure;biocompatibility
研究领域:
生物材料学
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组织工程学
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DOI
PubMed
高影响因子
CELLULOSE
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2019
·Vol. 26
·期 16
·8645-8654
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IF 3.917
Xu Haiyu,Liu Yan,Xie Yuanyuan,Zhu Enwen,Shi Zhuqun,Yang Quanling,Xiong Chuanxi
Abstract Hydrogels are mostly used in biomedical sciences such as tissue engineering, drug delivery, and in vitro diagnostics. Nanocellulose hydrogels have multiple advantages because of their biodegradability, non-toxic properties, high water content and inherent biocompatibility. Moreover, 2,2,6,6-tetramethylpiperidinyl-1-oxyl(TEMPO)-oxidized cellulose nanofibrils (TOCNs) are completely individualized cellulose nanofibrils which have high aspect ratios, high elastic moduli, high strengths, high thermal stability, large surface areas, and large numbers of carboxylate groups on their surfaces. Here, the doubly cross-linked (DC) nanocellulose hydrogels with both ionic and chemical crosslinks were prepared and exhibited more improvement in mechanical properties than singly cross-linked nanocellulose hydrogels. The singly Fe 3+ cross-linked nanocellulose hydrogel and chemically cross-linked nanocellulose hydrogel were broken at stresses of 117 kPa (strain = 80%) and 17 kPa (strain = 40%), respectively. The DC nanocellulose hydrogel exceeded a compressive strength of 450 kPa and a compressive strain of 90% without cracking. This greatly expands the application of nanocellulose hydrogels. Additionally, these nanocellulose hydrogels had good optical transparency and high swelling degree to meet the needs of practical applications. These DC nanocellulose hydrogels have great application prospects in the field of biomedical materials. Graphic abstract
研究领域:
生物材料学
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生物医学工程
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DOI
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2017
·Vol. 55
·期 11
·1920-1928
·
IF 2.952
Yawen Huang,Shengbo Zhang,Huan Hu,Xiaonan Wei,Hongtao Yu,Junxiao Yang
Low dielectric photopatternable materials have aroused much interest owing to their potential application as alternatives of conventional photoresists. Although a number of photosensitive groups have been established to construct photopatternable materials for many years, it is still a challenge to introduce them into polymer chains via a facile and control polymerization technique, such as living free radical polymerization. In this work, on the basis of the photoactive silaycyclobutene moiety, a new monomer, 1-methyl-1-(4-vinylphenyl) silacyclobutane (1-MVPSCB), was synthesized and demonstrated successful to conduct atom transfer radical polymerization (ATRP). Subsequently, the copolymerization of 1-MVPSCB with 4-vinylbenzocyclobutene (4-VBCB) and styrene produced a kind of benzocyclobutene/silacyclobutane double-crosslinked polymer (BS-DCP) with controlled benzocyclobutene/silacyclobutane ratios and low polydispersity index. Owing to the UV/thermally dual crosslinked structure, BS-DCP possesses photapatternability, high dimensional stability and low dielectric constant (2.37 at 10 MHz). These properties make BS-DCP a potential photoresist that could be directly used as interconnected dielectrics. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55 , 1920–1928
研究领域:
材料科学
·
聚合物化学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Jiajun Qin,Ming Li,Ming Yuan,Xinglei Shi,Jiliang Song,Yiyan He,Hongli Mao,Deling Kong,Zhongwei Gu
The metal gallium has enormous promise in fighting infections by disrupting bacterial iron metabolism via a “Trojan horse” trick. It is well worth trying to study the potential of gallium-mediated hydrogel for treating infected wounds. Herein, on the basis of a conventional gelation strategy of sodium alginate combined with metal ions, Ga3+ has been innovatively given a dual role in a dual-cross-linked hydrogel. It acts nor only as a cross-linking agent to form a hydrogel material but also as a therapeutic agent to slow-release and continuously treat infected wounds. Further photo-cross-linking is introduced to improve the mechanical properties of the hydrogel. Thus, a new gallium ionic- and photo-dual-cross-linked alginate hydrogel, with broad-spectrum antimicrobial activity and strengthened mechanical performance, for the treatment of infected wounds is reported. The morphology, degradability, swelling behavior, rheological properties, and gallium release kinetics together indicated the homogeneous and the strengthened mechanical performance of this hydrogel but did not impede the release of gallium ions. Interestingly, in vitro and in vivo results also demonstrated its favorable biocompatibility, reduced bacterial growth, and accelerated infected wound healing, making the gallium-incorporated hydrogel an ideal antimicrobial dressing.
研究领域:
材料科学
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生物医学工程
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制药学
·
伤口护理
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DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2019
·Vol. 57
·期 22
·2228-2234
·
IF 2.591
Changhong Lin,Dekun Sheng,Xiangdong Liu,Shaobin Xu,Fance Ji,Li Dong,Yan Zhou,Yuming Yang
A dual crosslinked self-healing polyurethane was prepared with robust mechanical properties through the dynamic reversible pyridine-Fe 3+ coordination bonds and Diels–Alder (DA) covalent bonds dual crosslinking strategy. Moreover, the mechanical properties and self-healing ability of polyurethane can be tuned readily by different ratio of the coordination bonds and DA bonds. Under external load, the coordination bonds serve as sacrificial bonds are broken to dissipate energy, the DA bonds can keep the shape of sample. With the coordination bonds participation, the damaged samples can be healed under moderate heating treatment or with the aid of FeCl 3 solution. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57, 2228–2234
研究领域:
高分子化学
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材料科学
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自修复材料
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功能高分子
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智能材料
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2022
·Vol. 223
·期 10
·2100467
·
IF 2.996
Yun Liu,Yongmei Liu,Zhiyun Yang,Xiaoling Chen,Yansheng Zhao
Conductive hydrogels show broad prospects in wearable electronic devices. However, the conductive hydrogel cross-linked only by chemical bonds has the shortcomings of being hard and brittle, easy to break under pressure. In order to solve these problems, the MPASP-PAA/Fe 3+ composite conductive hydrogel is prepared by the method of physical and chemical double crosslinking using modified polyaspartic acid (MPASP) as the chemical crosslinking agent and FeCl 3 as the physical crosslinking agent. Compared with traditional chemical crosslinking agents such as N ′ N -methylene bisacrylamide, the MPASP can not only increase mechanical properties of the conductive hydrogel, but also improve the biodegradability and biocompatibility. At the same time, FeCl 3 as a physical crosslinking agent can also enhance the conductivity and toughness of the conductive hydrogel. When MPASP and Fe 3+ content are 2.5 wt% and 0.75 mol%, respectively, the MPASP-PAA/Fe 3+ composite conductive hydrogel exhibits high conductivity (0.12 S m −1 ), sensitivity (4.93), and stretchability (329%). In addition, its compressive strength is as high as 1081.39 KPa. The flexible strain sensor assembled by the MPASP-PAA/Fe 3+ composite conductive hydrogel can not only monitor human joint movements such as elbow and wrist bending, but also detect subtle vibrations such as vocalization and swallowing.
研究领域:
材料科学
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生物医学工程
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柔性电子
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产品关联
DOI
高影响因子
POLYMER TESTING
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2022
·
IF 4.931
Ying Chen,Jie Li,Jiawei Lu,Meng Ding,Yi Chen
PVA hydrogels with high strength and toughness are fabricated by dual physical and chemical cross-linking. The best comprehensive mechanical properties can be achieved by reaction at room temperature followed with freeze-thaw and annealing treatment. Besides, the mechanical properties of PVA hydrogel increased first and then decreased with the increase of molecular weight or mass fraction. By changing the reaction solvent, the mechanical properties of PVA hydrogel could also be effectively adjusted. Therefore, the influences of various factors on the mechanical properties of PVA hydrogel can be obtained.
研究领域:
生物材料
·
高分子科学
·
组织工程
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生物医学工程
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软物质物理
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药物递送系统
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Zhongzheng Xu,Mingwei Zhao,Ning Sun,Xiangjuan Meng,Ziteng Yang,Yuxin Xie,Fei Ding,Yunbo Dong,Mingwei Gao,Yining Wu,Lin Li,Caili Dai
The gel with dually crosslinked polymer network (DPN) based on supramolecular interaction and chemical crosslinking usually has excellent temperature and shear resistance. The gel fracturing fluid with DPN will provide a new working fluid strategy for the efficient development of deep/ultra-deep oil and gas. Herein, a delayed crosslinking gel fracturing fluid with DPN is reported, which is formed by a supramolecular enhanced polymer containing catechol groups and a multisite organic zirconium delayed crosslinker. The gel breaker and cleanup additive are optimized, and the gel breaking liquid is uniform and had high surface/interface activity. The gel fracturing fluid has excellent delayed crosslinking ability, temperature resistance and shear resistance. It can be crosslinked to the hanging state within 233 s, and the residual viscosity is 71 mPa·s after shearing at 200 °C. The delayed crosslinking behavior and mechanism of gel fracturing fluid are further analyzed by viscoelastic rheological experiment and gelation kinetics calculation. Before reaching the temperature threshold of chemical crosslinking (70 °C), the system is dominated by supramolecular polymer network (SPN). After reaching 70 °C, the addition of chemical crosslinking makes SPN become DPN. The Avrami kinetic calculation results show that the gel growth mode at 70 °C changes from multi-dimensional diffusion growth to one-dimensional linear rapid growth. In addition, the final one-dimensional linear rapid growth stage of gelation is not controlled by temperature. The temperature mainly affected the multidimensional growth stage of gelation.
研究领域:
石油工程
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材料科学
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化学工程
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DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 75
·47767-47774
·
IF 3.108
X. M. Ma,R. Li,J. Ren,X. C. Lv,X. H. Zhao,Q. Ji,Y. Z. Xia
To address the poor mechanical performance of conventional thermo-responsive poly(N-isopropylacrylamide) (pNIPAM) hydrogels, methacryloyl covalently-modified chitosan (methacryloylchitosan, MACS) was conceived as the chemical macro-cross-linker and employed cooperatively with chitosan, as the physical macro-cross-linker, to construct dually macro-cross-linked pNIPAM hydrogels for the first time. The employed MACS was synthesized through acylation of chitosan using methacrylic acid activated by N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) and N-hydroxy-succinimide (NHS). The influence of the preparation conditions, including the solids content, the dosage and component of the cross-linkers as well as the amount of the initiator, on the mechanical performance and swelling/deswelling properties of the obtained hydrogels was investigated systematically. The prepared dual-cross-linked pNIPAM hydrogels exhibit high mechanical strength, manifested in the achieved compressive stress of 8.75 MPa at 98% strain and tensile strength of 0.105 MPa. The high recovery efficiency (beyond 95%) from cyclic tensile tests reveals the good recoverability of these hydrogels. Moreover, they exhibit excellent thermo-responsiveness, to be more specific, rapid deswelling rates, i.e., most can release 50% of the absorbed water in ∼10 minutes on the temperature jump across the phase transition temperature. In particular, the deswelling rate increases with the increase of either the cross-linkers or MACS. The prominent mechanical performance and rapid responsiveness of the novel pNIPAM hydrogels is highly conductive for their future applications.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）