ANALYTICA CHIMICA ACTA
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2025
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IF 6
Yuling Li,Weiran Zhao,Xiang Xiang,YunLei Hu,Xiaoqiang Zhang,Wenjian Sun,Xiaoxuan Liu
Background Perturbed lipid metabolism in cellular environment plays an essential role in the progression of peripheral neuropathy, such as Charcot-Marie-Tooth disease type 1A (CMT1A). Current deep-profiling of lipidome still has certain limitations for high-throughput analysis of clinical samples, such as low sensitivity, extensive requirement of instrument modification, technician-dependent pretreatment and lack of method-adapted data-processing software. Results Herein, a new generation aza-Prilezhaev aziridination (APA) reagent has been designed for coupling with high-resolution liquid chromatography mass spectrometry (LC-MS) to conduct comprehensive untargeted deep lipidomics of CMT1A disease. It facilitates large-scale lipid structural annotations over a wide polarity range in a single run with high-sensitivity. With the developed method, an extensive library containing information on retention time, m / z , and MS/MS down to C=C location levels for 393 unsaturated lipids of CMT1A was created. Significant disease-related differences in C=C isomer profiles were observed from the comparison of plasma between CMT1A patients (N=9) and controls (N=8). Specifically, 40 different lipids were identified, predominantly comprising n-6, n-7, and n-9 C=C positional isomers. Significance This innovative methodology would offer substantial potential to enhance diagnosis and therapeutic strategies for CMT1A and other diseases based on lipid isomerization information.
研究领域:
神经病学
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脂质组学
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代谢组学
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分子诊断学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2019
·Vol. 99
·期 7
·3548-3554
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IF 2.422
Wen Nie,Kezhou Cai,Yuzhu Li,Zehui Tu,Bing Hu,Cunliu Zhou,Conggui Chen,Shaotong Jiang
BACKGROUND The characteristics of carcinogenic polycyclic aromatic hydrocarbons (PAHs) produced from various fatty acids, as important components of fats and oils, at high temperature are still little known. The reason is because the existing data are from experiments conducted in complex food systems. In this study, 12 PAHs produced from nine fatty acids, representing saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs), were investigated in a model system heated at 98, 165 and 240 °C. RESULTS SFAs can with difficulty be pyrolyzed to generate PAHs at 98 °C, but small amounts of PAHs were determined in MUFAs (44.97 µg kg −1 ) and PUFAs (177.73 µg kg −1 ). When the temperature reached 165 °C, there were totals of 27.59, 142.8 and 449.68 µg kg −1 PAHs assayed in SFAs, MUFAs and PUFAs, respectively. The amounts of PAHs generated from SFAs, MUFAs and PUFAs at 240 °C were higher when compared with those of the 165 °C group ( P < 0.05). With an increase of heating temperature, the proportion of PAHs with four to five rings increased. Under the same heating conditions, the concentration of PAHs in fatty acids increased with an increase in the number of double bonds. CONCLUSIONS More PAHs, especially carcinogenic ones with four to five rings, will be produced in fatty acids heated at higher temperature. The content of PAHs generated from fatty acids increased with an increase in the number of double bonds. This study will increase the understanding of the production characteristics of PAHs from various fatty acids under heating condition. © 2019 Society of Chemical Industry
研究领域:
食品科学
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毒理学
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化学
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产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2024
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IF 12.7
Tao Shou,Qingsheng Dong,Dexian Yin,Shikai Hu,Xiuying Zhao,Liqun Zhang
Polylactic acid (PLA) is a biobased plastic with biodegradability, biocompatibility, and high-strength properties; however, its inherent brittleness limits its widespread application. Toughness can be improved by physical blending, chemical copolymerization, and reactive blending of PLA with flexible components. As highly engineered block polymers, polyurethanes (PUs) can improve the toughness of PLA through physical blending or in situ polymerization. However, current research on PU-toughened PLA is hindered by poor compatibility, toughening, and dependence on petrochemical resources. Therefore, to address these issues, we developed a novel biobased millable polyurethane (PO3G-MPU) containing unsaturated double bonds and used it to toughen PLA via peroxide-initiated dynamic vulcanization. The results showed that balancing toughness and strength is possible, with the notched impact strength and tensile strength of the prepared PLA/MPU blends reaching 59.01 kJ/m 2 and 43.97 MPa, respectively. The massive shear yielding and plastic deformation of the PLA matrix induced by the crosslinked PO3G-MPU were responsible for the main toughening mechanism. These results provide a new perspective on research on PU-toughened PLA.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2015
·Vol. 6
·期 20
·3858-3864
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IF 5.52
Wenwen Xue,Lisheng Zhang,Haizhen Chen,Jinggang Wang,Haining Na,Jin Zhu
Polyurethanes (TPUs) containing carbon–carbon double bonds are synthesized for use as novel materials with the ability to form functionalizable ultrafine fibers via electrospinning. By adjusting the molecular structure, a series of TPU products with different amounts of carbon–carbon double bonds are obtained. After investigating the reactivity of the TPU with 1H,1H,2H,2H-perfluorooctanethiol, all of the TPU samples exhibit effective functionalizability. The more carbon–carbon double bonds contained in the molecular structure, the stronger the functionalizability. Besides, these TPUs can easily form uniform ultrafine fibers via electrospinning. Upon comparison, the functionalizability of the electrospun fibers is similar to that observed in the bulk TPU materials. This work suggests a feasible methodology to produce a functionalized ultrafine fibrous carrier. Accordingly, TPU containing carbon–carbon double bonds is expected to be exploited as a fibrous carrier of solid catalysts in the future.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 24
·
IF 1.768
Dandan Zhang,Hongbo Liang,Jiang Bu,Lei Xiong,Shengmei Huang,D. D. Zhang,H. B. Liang,J. Bu,L. Xiong,S. M. Huang
In this study, epoxidized soybean oil was modified to prepare acrylated epoxidized soybean oil (AESO) and vinyl/acrylate ended soybean oil (VASO), which were blended with mercaptopropyl polyhedral oligomericsilsequioxane (POSS-SH) to prepare UV curable thiol-acrylate and thiol-ene-acrylate hybrid coatings. Photopolymerization processes of the coatings were measured and the results showed that addition of POSS-SH obviously increased the conversion of double bond. The physical and mechanical properties of all cured samples were investigated, which indicated that the pencil hardness, tensile strength, and fracture toughness were significantly improved by POSS-SH. Moreover, with increasing POSS-SH content, the water contact angles of cured samples were increased, and the water resistance was greatly improved. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42095.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Guangjia Lv,Dehai Li,Yihong Bao,Yajuan Qin,Xuan Zhang,Fei Xu,Kexue Zhu,Yutong Zhang,Yanjun Zhang
This study investigates the influence of weakly polar methoxy groups and nonpolar carbon–carbon double bonds in phenolic acids (PAs) on the physicochemical characteristics and digestibility of cassava starch (CS) using vanillic acid (VA), syringic acid (SA), ferulic acid (FA), and sinapic acid (EA). Both methoxy groups and carbon–carbon double bonds are shown to modify molecular phase distributions, reduce the energy gap ( ΔE ), and increase electron localization. These changes enhance the overall hydrophobicity and activity of PAs, thereby enhancing their ability to bind with starch and form hydrogen bonds. Additionally, methoxy groups and carbon‑carbon double bonds can enhance the crystallinity of the complex, reduce gelatinization viscosity, improve thermal stability, and reduce digestibility. Notably, EA, with the most methoxy groups and carbon–carbon double bonds, exhibits the lowest ΔE (3.9105 eV), the highest resistant starch content (47.79 ± 0.60 %), and the most significant reduction in glycemic-index (GI) (71.52 ± 0.54 %). Finally, carbon–carbon double bonds demonstrate a more pronounced effect than methoxy groups in improving the physicochemical properties and digestibility of starch, confirming the substantial potential of nonpolar molecular groups in improving starch characteristics. These findings provide valuable insights for starch modification techniques and the development of low GI food products.
研究领域:
食品科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS D-APPLIED PHYSICS
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2023
·Vol. 56
·期 38
·384002
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IF 3.4
Yushun Zhao,Yufan Xu,Gilbert Teyssèdre,Jianyi Xue,Yanning Zhao,Bin Du
Epoxy insulators in gas insulated switchgear and gas insulated transmission lines tend to accumulate surface charges, leading to insulation flashover. Improving the surface trap characteristics of epoxy materials, which can accelerate the surface charge dissipation of epoxy insulators, is a promising method to improve the surface insulation performance. The surface trap characteristics of epoxy materials are strongly influenced by the chemical groups in the acid anhydride molecules. In this work, by quantum chemical calculations and isothermal surface potential decay tests, taking six organic anhydrides that differ only in the methyl and carbon–carbon double bonds, we find the modulation laws of methyl and carbon–carbon double bonds on the charge trap depth within and between molecular chains. The regulation mechanism is revealed from the microscopic perspectives of electron energy structure and electron cloud offset. The changes of surface charge trap depth of epoxy materials are primarily attributed to the changes in the spatial distribution of the electron cloud density between and on the valence bonds caused by the interaction between the electron-donating methyl group and the electron-absorbing carbon–carbon double bond.
研究领域:
材料科学
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化学
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产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
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2023
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IF 5.2
Miaomiao Chen,Hailong Xu,Huili Zhao,Wei Bai,Min Ji
Selective hydrogenation of C C double bond in α, β-unsaturated carbonyl compounds is of great significance in the production of fine chemicals, and the design and preparation of hydrogenation catalysts with high selectivity is the key to realize the industrialization of this reaction. Controlling and adjusting the steric hindrance between substrate molecules and active center of catalysts is an effective strategy to achieve high selectivity. In this work, the spatially hindered “Frustrated Lewis pairs” (FLPs) was used as the active component and metal-organic frameworks (MOFs) materials with a certain window size were used as the catalyst support. We designed and synthesized a heterogeneous hydrogenation catalyst B(C 6 F 5 ) 3 /DO-MIL-101 by immobilizing FLP onto metal-organic frameworks (MIL-101). Characterizations and catalytic performance tests revealed that the catalytically active species B(C 6 F 5 ) 3 /DO was confined in MIL-101 nanocavities via Cr–O coordination bond. The resulting B(C 6 F 5 ) 3 /DO-MIL-101 catalyst not only realized the recycling of FLP, but also showed excellent catalytic activity and high selectivity in the selective hydrogenation of C C double bond in α, β-unsaturated carbonyl ketones. It should be noted that the steric hindrance between FLP and substrate molecules, as well as the shape selectivity of MOFs nanocages, are the principal factors for the high selectivity of the catalyst.
研究领域:
化学工程
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材料科学
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催化化学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2020
·Vol. 137
·期 34
·48982
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IF 2.52
Jian Yang,Tong Zhang,Yue Yin,Wenhong Jiang,Yunzhe Du,Xiaofei Zhu,Bo Jiang,Yudong Huang
Reactive group content was a key parameter in polymer curing process. However, the conventional methods to measure the curing were destructive and time consuming. In this article, near-infrared spectra technology had been applied for reactive group analysis of the photothermal curing silicone to achieve rapid nondestructive and quantitative detection. The calibration model was developed about epoxy value and CC double bond value, with determination coefficient ( R 2 ) of 0.9631 and 0.9689. Root mean square error of prediction were 0.0179 and 0.0143 by partial least square regression. The optimized calibration model was used to predict the content of epoxy value and CC double bond value in the photothermal curing process, it proved that the silicone resin cured under UV-radiation and heat. This novel method provided a promising approach to analysis the curing mechanism and quality parameters of resin.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 56
·45420-45425
·
IF 3.84
Xiuchun Li,Cailin Liu,Kezhen Gou,Haijun Yang,Xianyan Ren,Bihui Peng
Pt/SDB hydrophobic catalysts, platinum supported on a cross-linked styrene-divinyl benzene copolymer (SDB), were prepared by an impregnating method. The results indicated that the content of the residual double bonds was positively proportional to the amount of divinyl benzene (DVB) and negatively proportional to the amount of initiator. When the molar ratio of DVB to St was 1 : 1, the content of the residual double bonds reached a highest value of 1.248 mmol g−1. The influences of the contents of residual double bonds on the loading amounts of Pt, as well as the catalytic activity and stability of Pt/SDB catalysts were investigated. Performance tests demonstrated that the loading amounts of Pt increased correspondingly, as the contents of residual double bonds increased. Moreover, Pt/SDB with a higher content of residual double bonds generally had a higher column efficiency and a better stability. Interestingly, the column efficiencies of Pt/SDB with a highest content of residual double bond were all above 90% under all experiment conditions.
研究领域:
化学工程
·
催化材料
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Chao Lin,Ting Lü,Dongming Qi,Zhihai Cao,Yangyi Sun,Yiting Wang
In situ free-radical polymerization in the presence of inorganic nanoparticles (NPs) continues to attract intense research interest for the preparation of nanocomposites. In this study, in situ solution polymerization of methyl methacrylate (MMA) in the presence of pristine or surface-modified SiO2 NPs has been successfully carried out. The effects of SiO2 NPs on the initiator decomposition and polymerization rates, as well as the final polymerization conversions, have been systematically investigated. Specifically, the influences of silicon hydroxyl (SiOH), double bonds, and an in situ generated graft layer on the particle surface on initiator decomposition and the in situ polymerization process have been studied in detail. On this basis, a mechanistic rationale for the influence of surface groups on SiO2 NPs on the in situ solution polymerization is proposed. During the in situ polymerization process, the SiOH on the surface of the SiO2 NPs not only accelerates the decomposition of benzoyl peroxide and increases its ineffective consumption, but also enhances the wastage of radicals through chain-transfer reaction. However, when the SiO2 surface bears reactive double bonds, the in situ generated grafted polymer layer is effective in preventing the initiator and free radicals from contacting the SiOH to any considerable extent, thereby enhancing the polymerization rate and the final monomer conversion. The results of this study may also lay down scientific and theoretical foundations for developing more organic–inorganic hybrid nanocomposites through in situ free radical polymerization.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
·
2024
·
IF 7.4
Yanheng He,Tianwei Zhang,Ming Zeng,Hao Duan,Bing Zhang,Jianying Yu
To prepare SBS modified asphalt (SMA) waterproofing membrane with excellent self-healing performance, in this paper, four self-healing agents (ASHA-A, ASHA-B, ASHA-C, ASHA-D) with acylhydrazone bonds and carbon-carbon double bonds (C C) were synthesized, and were used to prepare self-healing SMA waterproofing membranes (SSMA-A, SSMA-B, SSMA-C, SSMA-D). The effects of ASHAs with different structures on the structure, high and low temperature properties, joint peel strength and self-healing performance of SSMAs were investigated. The Fourier transform infrared spectroscopy and fluorescence microscope results showed that acylhydrazone bonds of ASHAs were introduced into the chains of SBS molecules, and the SBS in SSMAs occurred crosslinking through the C C of ASHAs and SBS, the crosslinked network structures of SBS in SSMA-C and SSMA-D were denser and more complete because ASHA-C and ASHA-D contained more C C involved in the crosslinking reaction. The softening point and low temperature flexibility of SSMAs were enhanced by the formation of the SBS crosslinked network structure, and the optimum dosage of ASHAs was 0.6%. The joint peel strength of SSMA-A, SSMA-B, SSMA-C and SSMA-D increased by 26.68%, 31.25%, 49.52% and 56.97% compared to SMA. The introduction of acylhydrazone bonds with reversible fracture and rearrangement significantly improved the crack self-healing performance of SMA, the impermeability times of SMA, SSMA-A, SSMA-B, SSMA-C and SSMA-D were 13.28 min, 37.29 min, 42.53 min, 53.34 min and 59.67 min after self-healing at 40℃ for 8 h, which indicated that ASHA-D with benzene ring and multiple C C had the best improvement in self-healing performance of SMA.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）