Chao Huang,Yunjia Xu,Ruizhi Tang,Shujuan Ma,Bolin Gong,Junjie Ou
Particles with asymmetric morphology or surface chemical identity (Janus) are of great interest in the field of materials due to their special composition and structure. However, it is still a challenge to prepare particles with dual asymmetry via simple and convenient synthesis strategies. Herein, micron-sized dual-asymmetry Janus particles were prepared via photo-induced seeded swelling polymerization within 30 min. By controlling the polarity of the organic solvent (porogenic reagent), Janus particles with various morphologies were fabricated. The particles with convex surfaces, such as dumbbell-shaped, snowman-shaped, and golf-shaped morphologies, were obtained in the polar porogenic system, while the concave surface particles, such as bowl-shaped and ball-in-bowl, were acquired in the non-polar porogenic system. Mushroom-shaped and pinecone-shaped particles were generated in the binary porogenic system. Particularly, snowman-shaped, bowl-shaped, and pinecone-shaped particles were characterized by confocal laser scanning microscopy, exhibiting asymmetric chemical identity. They could be easily modified into amphiphilic solid surfactants for emulsifying oil–water incompatible mixtures with a definite interfacial orientation. This strategy provides a possibility for the simple and rapid preparation of dual Janus particles with asymmetric morphology and chemical identity, which are expected to be produced on a large scale.
Simin Wu,Jiandong Han,Xiukai Guo,Zilong Rao,Kexin Zhang,Daping Quan,Ying Bai
The lack of endothelial layer hinders the use of decellularized corneal stroma in keratoplasty, resulting in adverse effects, such as non-specific protein adsorption and corneal oedema after implantation, which leads to rapid failure of the ophthalmic implants. In this study, superhydrophilic poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) was gently introduced to the porcine-derived decellularized corneal stroma matrix (pDCSM), aiming to resist undesirable biofilm adsorption within the ocular environment. After complete decellularization, the pDCSM was first methacrylated by the integration of methacrylic anhydride. Consecutively, PMPC was only grafted from the back surface (endothelium side) of the methacrylated pDCSM through surface-initiated free radical polymerization. This one-side surface-modified pDCSM not only retained good optical transmittance and mechanical properties that were comparable to the untreated pDCSM, but both surfaces of the same artificial cornea also showed non-cytotoxicity and good biocompatibility. Moreover, the PMPC-grafted back surface exhibited considerable antifouling properties that resisted both protein and cell adhesion. Consequently, such Janus-like artificial cornea holds great promise in future ophthalmic applications, which may serve as a springboard for the design of versatile decellularized extracellular matrix based biomedical implants with Janus-like properties. Graphical Surface initiated PMPC grafting on the back side of decellularized corneal stromal matrices resulted in Janus-like scaffolds for potential ophthalmic applications.
危险品化学品经营许可证（带存储）