Petroleum Science
·
2023
·
IF 5.6
Fan Ding,Xin Jin,Tao Shen,Shan-Shan Mao,Qing Zhao,Mang-Lai Gao
Wettability is an important surface property that deserves to further explore the factors on its alteration. Series of bis -N-heterocyclic quaternary ammonium salts with different spacer length and N-heterocyclic headgroups (morpholinium (BMMB, BMMD and BMMH), piperidinium (BPMH) and piperazinium (BMPMH)) have been synthesized and employed for altering the wettability of vermiculite and its derivates (Vts) treated by Li + -saturated heating method. The results of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TG-DTG), scanning electron microscopy (SEM) and N 2 adsorption/desorption isotherms indicate that all of the bis -N-heterocyclic quaternary ammonium salts have been successfully inserted into the vermiculite layers, leading to the organic monolayer. The results of capillary rise tests combined with Lipophilic to Hydrophilic Ratio ( LHR ) values unveil the wettability alteration of the organo-Vts. As the layer charge decreases, the hydrophilicity of the organo-Vts gradually increases, which is probably caused by the decline in binding sites. As the result of the change in spacer length of modifier, the wetting properties of morpholinium-based organo-Vts change in order of BMMD-Vts > BMMH-Vts > BMMB-Vts, and difference in N-heterocyclic headgroups leads to the sequence of wettability: BMPMH-Vts > BPMH-Vts > BMMH-Vts. Layer charge of Vt, spacer length and the type of the N-heterocyclic headgroup of modifier have the synergistic effect on the regulation of the wettability.
研究领域:
材料科学
·
表面化学
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DOI
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2019
·
IF 3.407
Wen-Jing Wu,Wei-Feng Tang,Ming-Hui Xiang,Jianshe Yan,Xiumei Cao,Chang-Hui Zhou,Yan Chang,Jing Xi,Yi-Yi Cao,Yang Luan,Xin-Yu Zhang
1-Chloro-2-hydroxy-3-butene (CHB) is a possible metabolite of 1,3-butadiene, a carcinogenic air pollutant . To demonstrate its formation in vivo, it is desirable to develop a practical biomarker and the corresponding analysis method. CHB can undergo alcohol dehydrogenase- and cytochromes P450 enzymes (P450)-mediated oxidation to yield 1-chloro-3-buten-2-one (CBO), which readily forms glutathione conjugates. We hypothesized that CBO-derived mercapturic acids , which are the expected biotransformed products of CBO-glutathione conjugates, could be used as CHB biomarkers. Thus, in the present study, we investigated the in vivo biotransformation of CHB into CBO-derived mercapturic acids. Because the reaction of CBO with N -acetyl- l -cysteine yields two products, 1,4- bis ( N -acetyl- S -cysteinyl)-2-butanone (NC1) and 1-chloro-4-( N -acetyl- S -cysteinyl)-2-butanone (NC2), we first developed an isotope dilution LC/ESI − -MS-MS method to quantitate urinary NC1 and NC2, and then determined their concentrations in urine of C57BL/6 mice and Sprague-Dawley rats administered CHB. Since no NC2 was detected in samples, the LC/ESI − -MS-MS method was optimized specifically for NC1. NC1 was enriched through solid phase extraction with the recovery being 75–82%. The limits of detection and quantitation were 6.8 and 34 fmol/0.1 mL for mouse urine, and 4.5 and 7.1 fmol/0.1 mL for rat urine, respectively. In urine of animals before CHB administration, no NC1 was detected; in mice administered CHB at 10 and 30 mg/kg, and rats at 5 and 15 mg/kg, NC1 was detected and its concentrations in urine from animals given higher doses were 3–6 fold higher than those given lower doses. Moreover, the NC1 concentrations in urine during 0–8 h were 4–6 fold and 10–11 fold higher than those during 8–24 h for mice and rats, respectively. The results demonstrated that CHB could be in vivo biotransformed into NC1, which could be used as a practical CHB biomarker.
研究领域:
毒理学
·
分析化学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2022
·Vol. 331
·期 4
·1731-1740
·
IF 1.754
Kubota Masahiko,Wu Hao,Kim Seong-Yun
A N’-N’ -di-n-hexyl-thiodiglycolamide and 2,2’-[(2-ethylhexyl)imino]bis[ N,N -bis(2-ethylhexyl)acetamide] impregnated porous silica-based adsorbent was prepared for enhancing the adsorption of palladium ions from simulated high-level liquid waste. The adsorbent exhibited a relatively fast palladium response and selectivity without the use of additional modification reagents. Palladium ions were adsorbed over a wide nitric acid range of 0.6−5 M and a broad temperature range of 288−323 K. The uniform distribution of adsorbed palldium ions onto the study adsorbent was confirmed by PIXE. Successful recovery of more than 90% of the palladium ions was achieved using 0.1 M thiourea via separation by column experiments. Based on the obtained data, it is expected that the prepared adsorbent can be used for the practical separation of palladium ions from high-level liquid waste.
研究领域:
化学工程
·
核废物处理
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产品关联
DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Hongxu Chen,Fangbo Zhao,Zhiguo Li,Jingyun Ge,Caixu Wang,Liu Yang
In dye/salt separation of textile industry wastewater, bio-fouling holds negative effects on separation ability of loose nanofiltration (LNF) membrane. A novel ultra-high in-situ anti-bacterial LNF membrane was firstly fabricated through interfacial polymerization (IP) using a synthetic aqueous monomer of 1,2-bis ( N -aminoethyl imidazoline) ethane (BAIE) and a commercial organic monomer of 1,3,5-tris(bromomethyl)benzene (TBB) in this work. Notably, the BAIE-TBB LNF membrane containing anti-bacterial imidazole structures by IP process could prevent the loss of anti-bacterial modifiers and keep the imidazole structures loaded meanly. It showed significant anti-bacterial performance for Escherichia coli and Staphylococcus aureus . Moreover, the fabricated BAIE-TBB LNF membrane with 0.1 wt% TBB (M-0.1) exhibited an ultra-high water permeance of 157.1 LMH/bar, a high Congo Red (CR, 100 ppm) rejection of 99.6 %, and a low NaCl (1000 ppm) rejection of 1.5 %, due to its relatively loose functional layer. For the salt/dye mixed solution, M-0.1 presented excellent separation performance with a CR/NaCl separation factor (α 246.3), and still exhibited good salt/dye separation performance under high salt concentration. With excellent water permeability, dye/salt separation, and anti-bacterial properties, BAIE-TBB LNF membrane holds great application potential in dye/salt separation.
研究领域:
环境工程
·
膜科学
·
水处理
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产品关联
DOI
高影响因子
POLYMER
·
2020
·
IF 4.231
Zhefu Wu,Dongsheng Li,Guangming Yan,Han Wang,Suilin Liu,Jie Yang,Gang Zhang
2,6-bis( N -pyrazolyl) pyridine (BPP) with tridentate N 3 group is successfully incorporated into copolymer via solution polycondensation in this work. With assembly of different metal ions , the supramolecules could be shape-memorized or fluorescence-responsive. The tridentate N 3 group in BPP fragment is found to enhance the fluorescence intensity of BPP-Eu 3+ films and affinity to the metal ions, supported by inter-fragmented charge transfer theory (IFCT) and wavefunction analysis. The heat-resistance of supramolecules is improved by incorporation of zinc ions and the T g could be changed from 150.5 °C up to 201.7 °C. The average binding strength (BDE) of N –Zn 2+ in NMP solvation model is −5.03 kcal/mol, which is flexible enough to maintain the dynamic properties discussed in this study.
研究领域:
材料科学
·
化学
·
高分子科学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Hongxu Chen,Fangbo Zhao,Xiaohui Zhang,Hee-Deung Park,Zhiguo Li,Liu Yang
ABSTRACT Bio-fouling is a key issue for the nanofiltration operation. In this study, 1, 2-bis ( N -aminoethyl imidazoline) ethane (BAIE) firstly was used as a novel bisimidazoline aqueous monomer to prepare the anti-bacterial nanofiltration (NF) membranes. A novel nanofiltration (BAIE-TMC NF) membrane with in-situ anti-bacterial structure and anti-fouling property was fabricated via interfacial polymerization (IP) with trimesoyl chloride (TMC), basing on a polyethersulfone (PES) substrate. Protonated imidazole endowed the surface of BAIE-TMC NF membrane with weak electronegativity, and its salt rejection sequence was MgSO 4 > Na 2 SO 4 > MgCl 2 > NaCl > LiCl. Meantime, the BAIE-TMC NF membrane with 0.5 wt% BAIE (M-0.5) exhibited a high rejection for bivalent ions, with a high MgSO 4 rejection (94.7%). Notably, BAIE-TMC NF membrane containing an in-situ anti-bacterial imidazole structure showed significant anti-fouling and anti-bacterial properties. After BSA or HA filtration process, the flux recovery rates of all BAIE-TMC NF membranes were higher than 95%, and M-0.5 exhibited high inhibition performance against Escherichia coli (98.5%) and Staphylococcus aureus (98.4%). Furthermore, M-0.5 exhibited excellent long-term separation stability during the three weeks separation experiment. BAIE can serve as an effective aqueous monomer for fabricating in-situ anti-bacterial and anti-fouling NF membrane to achieve the rejection of organic pollutant and bivalent ions.
研究领域:
环境工程
·
材料科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Hao Zhang,Li Yang,Mengxiao Han,Yaobao Han,Zhilin Jiang,Qing Zheng,Jun Dong,Tingting Wang,Zhen Li
The currently available immune checkpoint therapy shows a disappointing therapeutic efficacy for glioblastoma multiforme (GBM), and it is of great importance to discover better immune checkpoints and develop innovative targeting strategies. The discovered metabolic immune checkpoint ecto-5-nucleotidase (CD73) in a tumor contributes to its immune evasion due to the dysregulation of extracellular adenosine (ADO), which significantly inhibits the function of antitumor T cells and increases the activity of immunosuppressive cells. Herein, we drastically inhibit the expression of CD73 to reduce the production of ADO by using versatile Au@Cu2–xSe nanoparticles (ACS NPs). ACS NPs can decrease the expression of CD73 by alleviating the tumor hypoxia through their Fenton-like reaction to weaken the ADO-driven immunosuppression for enhancing antitumor T cell infiltration and activity of GBM. The copper ions (Cu2+) released from ACS NPs can chelate with disulfide, leading to the formation of cytotoxic bis(N,N-diethyldithiocarbamate)-copper complex (CuET), which can be combined with radiotherapy to recruit more antitumor T cells to infiltrate into the tumor site. Based on the inhibition of CD73 to promote the infiltration and activity of antitumor T cells, a cascade of enhancing GBM immunotherapy effects can be achieved. The significant increase in CD8+ T and CD4+ T cells within the tumor and the memory T cells in the spleen effectively reduces tumor size by 92%, which demonstrates the excellent efficacy of immunotherapy achieved by a combination of metabolic immune checkpoint CD73 inhibition with chemoradiotherapy. This work demonstrates that modulation of CD73-mediated tumor immunosuppression is an important strategy of improving the outcome of GBM immunotherapy.
研究领域:
肿瘤学
·
免疫治疗
·
纳米技术
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）