JOURNAL OF NANOPARTICLE RESEARCH
·
2017
·Vol. 19
·期 12
·1-11
·
IF 2.02
Chen Daquan,Song Xiaoyan,Wang Kaili,Guo Chunjing,Yu Yueming,Fan Huaying,Zhao Feng
In this article, in order to enhance the bioavailiability and tumor targeting of curcumin (Cur), the oligosaccharides of hyaluronan conjugates, folic acid-oligosaccharides of hyaluronan-acetal-menthone 1,2-glycerol ketal (FA-oHA-Ace-MGK) carried oHA as a ligand to CD44 receptor, double-pH-sensitive Ace-MGK as hydrophobic moieties, and FA as the target of folate receptor. The structure characteristics of this smart response multifunctional dual-targeting nano-sized carrier was measured by fourier-transform infrared (FT-IR) and nuclear magnetic resonance ( 1 H–NMR). Cur, an anticancer drug, was successfully loaded in FA-oHA-Ace-MGK micelles by self-assembly. The measurement results of transmission electron microscopy (TEM) presented that the Cur-loaded micelles were spherical in shape with the average size of 166.3 ± 2.12 nm and zeta potential − 30.07 mV. Much more encapsulated Cur could be released at mildly acidic environments than at pH 7.4, from the Cur-FA-oHA-Ace-MGK micelles. Cytotoxicity assay indicated that non-Cur loaded micelles mostly had no cytotoxicity to MCF-7 cells and A549 cells, and Cur-loaded micelles had significantly lower survival rate than Cur suspension in the same concentration, which proved that the drug-loaded micelles can effectively inhibit tumor cell growth. The targeting of CD44 receptors and folate receptors was proved in vitro cellular uptake assay. These results showed the promising potential of FA-oHA-Ace-MGK as an effective nano-sized carrier for anti-tumor drug delivery.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Jie Mao,Yang Li,Tong Wu,Conghui Yuan,Birong Zeng,Yiting Xu,Lizong Dai
To precisely deliver drug molecules at a targeted site and in a controllable manner, there has been great interest in designing a synergistical drug delivery system that can achieve both surface charge-conversion and controlled release of a drug in response to different stimuli. Here we outline a simple method to construct an intelligent drug carrier, which can respond to two different pH values, therefore achieving charge conversion and chemical-bond-cleavage-induced drug release in a stepwise fashion. This drug carrier comes from the self-assembly of a block copolymer-DOX conjugate synthesized through a Schiff base reaction between poly(2-(diisopropylamino)ethyl methacrylate-b-poly(4-formylphenyl methacrylate-co-polyethylene glycol monomethyl ether methacrylate) (PDPA-b-P(FPMA-co-OEGMA)) and DOX. The surface charge of the BCP-DOX micelles reversed from negative to positive when encountering a weakly acidic environment due to the protonation of PDPA segments. In vitro cellular uptake measurement shows that the cellular uptake and internalization of the BCP-DOX micelles can be significantly enhanced at pH ∼ 6.5. Moreover, this drug carrier exhibits a pH-dependent drug release owing to the cleavage of the imine bond at pH < 5.5. With this dual-pH responsive feature, these micelles may have the ability to precisely deliver DOX to the cancer cells.
研究领域:
生物材料
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Kunjie Wang,Xianrong Liu,Yanan Li,Yunsi Wang,Riming Hu,Bingxin Liu,Peng Zhang,Benhua Xu,Yongcheng Li
Ensuring Ruthenium-based (Ru) catalysts with high metal utilization is a potential and challenging strategy for designing and constructing high catalytic activity electrocatalysts for hydrogen evolution reaction (HER). Herein, Ruthenium single atoms (SA) and Ruthenium nanoparticles (NPs) are simultaneously anchored on hierarchically porous carbon via the self-templates method for the first time. Benefiting from the synergetic effect of hierarchically porous carbon and the coexistence of Ru SA and Ru NPs, the Ru/C-800 shows attractive HER catalytic activity in acidic and alkaline solutions, with low overpotentials to drive the current density of 10 mA cm −2 and the smallest Tafel slope. Density functional theory (DFT) results reveal that the coexistence of Ru SA and Ru NPs can positively affect charge distribution and charge transfer kinetics, and reduce the hydrogen adsorption and water dissociation free energy. This work provides a novel self-templating strategy for synthesizing high catalytic activity catalysts in a wide pH range.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2015
·Vol. 17
·期 10
·1-10
·
IF 2.184
Chen Daquan,Wang Guohua,Song Weiguo,Zhang Qiang
Most anticancer drugs cannot kill cancer stem cells (CSCs) effectively, which lead to the failure of anticancer chemotherapy, such as relapse and metastasis. In this study, we prepared a multifunctional oligosaccharides of hyaluronan (oHA) conjugates, oHA-histidine-menthone 1,2-glycerol ketal (oHM). The oHM conjugates possess pH-sensitive menthone 1,2-glycerol ketal (MGK) as hydrophobic moieties and oHA as the target of CD44 receptor. Anticancer drugs, curcumin(Cur) and paclitaxel(PTX), were loaded into oHM micelles via self-assembly. Then, oHM micelles were mineralized through controlled deposition of inorganic calcium and phosphate ions on the nanoparticular shell via a sequential addition method to fabricate the “nano-eggs.” The formed nano-eggs had a smaller size (120.6 ± 4.5 nm) than oHM micelles (158.6 ± 6.4 nm), indicating that mineralization made the appearance of compact nanoparticles. Interestingly, when the nano-eggs were put into the acidic conditions (pH 6.5), their outer shell(inorganic minerals) will be destroyed with the larger size, while the “nano-eggs” were stable under pH 7.4. For both nano-eggs and oHM micelles, the Cur and PTX were released in a sustained manner depending on the pH of the solution. However, the nano-eggs showed much lower released than the oHM micelles due to the dissolution of the inorganic minerals and pH-sensitive ketal at mildly acidic environments (pH 6.5). In vivo study, the nano-eggs could get to the tumor site more effectively than oHM micelles. CSCs were sorted by a side population assay from MDA-MB-231 breast cancer cell lines over-expressing CD44 receptors. Antitumor activity was also evaluated on MDA-MB-231 xenografts in nude mice. The antitumor efficacy indicated that nano-eggs with co-delivery of Cur and PTX produced the strongest antitumor efficacy, and nano-eggs showed strong activity against cancer stem cells. These double pH-sensitive nano-eggs may provide a promising strategy for drug delivery to both cancer cells and cancer stem cells.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Kunjie Wang,Yanan Li,Dongxu Yang,Yunsi Wang,Fuan Wei,Bingxin Liu,Peng Zhang,Benhua Xu,Yongcheng Li
Coupling noble metals on molybdenum disulfide (MoS 2 ) has emerged as a promising strategy for triggering inert basal plane and boosting hydrogen evolution reaction (HER) performances. Herein, ultrafine Ru nanoparticles (NPs) are decorated on vertical 2H MoS 2 nanosheets via a facile hydrothermal method. Benefiting from new active site centers triggered by ultrafine Ru NPs and vertically grown 2H MoS 2 nanosheets on carbon cloth (CC), Ru 0.15 @2H MoS 2 exhibits impressive HER performances in dual pH media, with low overpotentials of 20 and 111 mV and small Tafel slope of 67.6 and 76.3 mV dec ‑1 in alkaline and acid solutions to drive a current density of 10 mA cm -2 . DFT calculation results prove that ultrafine Ru NPs decorated on 2H MoS 2 nanosheets endow Ru 0.15 @2H MoS 2 with low hydrogen adsorption free energy and fast charge transfer kinetics. This work provides an effective and simple method for designing MoS 2 -based catalysts with high catalytic activity to decorate precious metal in a wide pH medium.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Zilong Han,Peng Wang,Guoyong Mao,Tenghao Yin,Danming Zhong,Burebi Yiming,Xiaocheng Hu,Zheng Jia,Guodong Nian,Shaoxing Qu,Wei Yang
As one of the most promising drug delivery carriers, hydrogels have received considerable attention in recent years. Many previous efforts have focused on diffusion-controlled release, which allows hydrogels to load and release drugs in vitro and/or in vivo. However, it hardly applies to lipophilic drug delivery due to their poor compatibility with hydrogels. Herein, we propose a novel method for lipophilic drug release based on a dual pH-responsive hydrogel actuator. Specifically, the drug is encapsulated and can be released by a dual pH-controlled capsule switch. Inspired by the deformation mechanism of Drosera leaves, we fabricate the capsule switch with a double-layer structure that is made of two kinds of pH-responsive hydrogels. Two layers are covalently bonded together through silane coupling agents. They can bend collaboratively in a basic or acidic environment to achieve the “turn on” motion of the capsule switch. By incorporating an array of parallel elastomer stripes on one side of the hydrogel bilayer, various motions (e.g., bending, twisting, and rolling) of the hydrogel bilayer actuator were achieved. We conducted an in vitro lipophilic drug release test. The feasibility of this new drug release method is verified. We believe this dual pH-responsive actuator-controlled drug release method may shed light on the possibilities of various drug delivery systems.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yihang Xue,Dahai Zeng,Yuying Meng,Bing Du,Haifang Xie,Lei Ma,Yufeng Wang,Qingsheng Gao
Atomic transition metal-nitrogen (M-N x ) active sites dispersed on carbon matrix have emerged as highly promising electrocatalysts for energy conversion systems, owing to their maximized metal center utilization and excellent conductivity of the carbon substrate. However, conventional symmetric M-N 4 configurations often exhibit limited hydrogen evolution reaction (HER) activity in alkaline due to the inferior water dissociation capacity. In this work, isolated Co single atoms anchored on N -doped hollow carbon substrates (Co SA /NHCs) are successfully fabricated by the pyrolysis of Co 2+ -containing polypyrrole (Co-PPY) precursor, and the subsequent removal of embedded Co particles. Thanks to the high density of atomically distributed asymmetric Co-N 4 moieties, which facilitate efficient water activation and optimal adsorption of the active hydrogen (H*), the synthesized Co SA /NHCs electrocatalysts show remarkable HER activity and stability in alkaline electrolyte. Besides, they can effectively electrolyze HER in acidic medium, undergoing the Volmer-Heyrovsky pathway. Remarkably, Co SA /NHC-800, pyrolyzed at 800 °C, requires small overpotentials of 230 and 228 mV to achieve the current density of −10 mA cm −2 in 1.0 M KOH and 0.5 M H 2 SO 4 solutions, respectively. Moreover, it displays small Tafel slopes, high Faradic efficiencies (∼100 %) and superior long-term stability. This study paves a strategic approach for designing high-performance single-atom electrocatalysts through asymmetric structural engineering.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Shunyu Shen,Qian Zhang,Weijia Guo,Gaojie Jiao,Yawen Wang,Han Wang,Kai Shao,Zhenjie Wang,Caicai Li,Xianyun Peng,Qingfeng Sun
The exploration of non-Pt catalysts that are highly efficient, durable, and cost-effective for the hydrogen evolution reaction (HER) is crucial for enhancing the energy efficiency of water splitting technologies. In this study, we fabricated an electrocatalyst comprising RuP2 nanoparticles decorated on N, P codoped cellulose nanofibers (CNFs)-derived carbon networks (RuP2/NPC) through a simple mixing-pyrolysis strategy. Specifically, the CNFs, which are rich in oxygen-containing functional groups, not only serve as dispersants to prevent the restacking of graphene oxide (GO) and the aggregation of RuP2 nanoparticles, thereby exposing more active sites, but also form a conductive network with GO to facilitate electron transport. Moreover, density functional theory (DFT) calculations indicate that the integration of NPC regulates the electronic structure of RuP2, resulting in a nearly thermoneutral ΔGH* at the Ru site of RuP2/NPC and making the HER process more feasible. Consequently, the synthesized catalyst exhibits excellent catalytic activity, achieving low overpotentials of 41 mV in 0.5 M H2SO4 and 52 mV in 1.0 M KOH to drive a current density of 10 mA cm–2, while maintaining robust stability. Notably, RuP2/NPC also demonstrates promising performance in alkaline seawater electrolysis, requiring an overpotential of merely 108 mV to support the same level of current density. This research significantly advances the application of CNFs-derived carbon materials in hydrogen production and contributes to the high-value utilization of forestry resources, thereby providing an inspiring avenue for the advancement of efficient and sustainable energy conversion technologies.
研究领域:
材料科学
·
能源化学
·
理论计算
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 4
·621
·
IF 4.329
Xiao Wang,Shi Li,Yuanyuan Tu,Jiwen Hu,Zhenzhu Huang,Shudong Lin,Xuefeng Gui
The pH-responsive membrane is a new wastewater treatment technology developed in recent years. In this paper, a novel film with intelligent pH-responsiveness was first prepared by blending functional gates comprised of hydrolyzed aramid nanofibers (HANFs) into aramid nanofiber (ANF) membranes via a vacuum filtration method. Those as-prepared membranes exhibited dual pH-responsive characteristics, which were featured with a negative pH-responsiveness in an acidic environment and a positive pH-responsiveness in basic media. These dual pH-responsive membranes also exhibited a high tensile strength which could still reach 55.74 MPa (even when the HANFs content was as high as 50 wt%), a high decomposition temperature at ~363 °C, and good solvent resistance. The membranes described herein may be promising candidates for a myriad of applications, such as the controlled release of drugs, sensors, sewage treatment, etc.Keywords:aramid nanofiber;hydrolyzed aramid nanofiber;vacuum filtration;dual pH-responsive characteristic;high strength
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
PEST MANAGEMENT SCIENCE
·
2022
·Vol. 79
·期 3
·969-979
·
IF 4.462
Linhuai Li,Jun Cen,Lingling Huang,Ling Luo,Guangqi Jiang
BACKGROUND The development of stimulus-responsive and photothermally controlled-release microcapsule pesticide delivery systems is a promising solution to enhance the effective utilization and minimize the excessive use of pesticides in agriculture. RESULTS In this study, an AVM@CS@TA-Fe microcapsule pesticide delivery system was developed using avermectin as the model drug, chitosan and tannic acid as the wall materials, and tannic acid–Fe complex layer as the photothermal agent. The optical microscope, scanning electron microscope, transmission electron microscope, and Fourier-transform infrared spectroscope were used to characterize the prepared microcapsule. The slow-release, UV-shielding, photothermal performance, and nematicidal activity of the microcapsule were systematically investigated. The results showed that the system exhibited excellent pH-responsive and photothermal-sensitive performances. In addition, the UV-shielding performance of the delivery system was improved. The photothermal conversion efficiency ( η ) of the system under the irradiation of near-infrared (NIR) light was determined to be 14.18%. Moreover, the nematicidal activities of the system against pine wood nematode and Aphelenchoides besseyi were greatly increased under the irradiation of light-emitting diode (LED) simulated sunlight. CONCLUSION The release of the pesticide-active substances in such a pesticide delivery system could be effectively regulated with the irradiation of NIR light or LED-simulated sunlight. Thus, the developed pesticide delivery system may have broad application prospects in modern agriculture fields. © 2022 Society of Chemical Industry.
研究领域:
农业科学
·
材料科学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2017
·
IF 3.684
Hongyao Ding,Xin Ning Zhang,Si Yu Zheng,Yihu Song,Zi Liang Wu,Qiang Zheng
As a promising structural material, various tough hydrogels have been developed in recent years by incorporating different kinds of noncovalent bonds as the energy-dissipating segments. Among these systems, it is challenging to use hydrogen bonds due to their instability in aqueous environment. Here we report a tough hydrogel of poly(1-vinylimidazole- co -acrylic acid) (P(VI- co -AAc)) reinforced by the robust hydrogen bonds between imidazole and carboxylic acid groups. The hydrogels with different composition possess excellent mechanical performances, with tensile breaking stress, breaking strain, Young's modulus , and tearing fracture energy being 0.3–1.8 MPa, 920–1400%, 0.1–0.7 MPa, and 0.7–5.6 kJ/m 2 , respectively, which are well maintained over a wide pH range (3 ≤ pH ≤ 10). The high stability of hydrogen bonds should be rooted in the strong proton donor-acceptor pair. However, when pH ≤ 2 or pH ≥ 11, the gels become highly swelled due to the dissociation of imidazole and carboxylic acid groups, respectively, accompanying with dramatic decrease in mechanical properties . The tough hydrogels also show temperature- and deformation rate-dependent mechanical properties , as well as shape memory and self-recovery abilities, due to the dynamic nature of noncovalent bonds. Such hydrogels with remarkable mechanical properties and dual pH-responsiveness should find applications in load-bearing soft actuators, flexible electronics, etc.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Tao Liao,Chang Liu,Jun Ren,Hui Chen,Ying Kuang,Bingbing Jiang,Jianli Chen,Zhengguang Sun,Cao Li
To enhance drug utilization and reduce their side effects, the strategy of “tumor-triggered targeting” was introduced to fabricate dual-pH-sensitive chitosan (CHI)/mesoporous silica nanoparticle (MSN)-based anticancer drug delivery system (DDS) in this work. Model drug doxorubicin hydrochloride (DOX) was loaded in MSN, which was modified with benzimidazole (Bz) group. Then chitosan- graft - β -cyclodextrin (CHI- g -CD) was applied as the “gatekeeper” to cover MSN through host-guest interaction between β -CD and Bz. After being coated with targeting peptide adamantane-glycine-arginine-glycine-aspartic acid-serine (Ad-GRGDS), methoxy poly(ethylene glycol) benzaldehyde (mPEG-CHO) was finally grafted on CHI through the pH-sensitive benzoic imine bond. Due to the dynamic protection of PEG, the obtained carriers were “stealthy” at pH 7.4, but could reveal the shielded targeting peptide and the positive charge of CHI in the weakly acidic environment achieved a “tumor-triggered targeting”. Inside cancer cells, the interaction between β -CD and Bz group could be destroyed due to the lower pH, resulted in DOX release. Both in vitro and in vivo studies proved the DDS could targeting induce cancer cell apoptosis, inhibit tumor growth, and reduce the cytotoxicity of DOX against normal cells. It is expected that the system named DOX@MSN-CHI-RGD-PEG could be a potential choice for cancer therapy.
研究领域:
生物医学工程
·
药学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）