Materials
·
2025
·Vol. 18
·期 7
·1452
·
IF 3.2
Jiangfeng Wang,Wanjun Zhao,Chen Shen,Yapeng Ou,Qingjie Jiao
High-energy boron-based fuel aluminum-diboride (AlB2) has attracted much attention in the field of solid propellants. However, the low reactivity of AlB2hindered its further application. In this study, highly reactive AlB2@hydroxyl-terminated perfluoropolyether alcohol (AlB2@HTPFA) composites with a core–shell structure were prepared by coating AlB2with functionalized fluoropolymers by using a facile one-step in situ polymerization method. AlB2@HTPFA composites with varying polymer contents (0, 5, 10, and 15 wt%) were obtained. The in situ polymerization strategy enables precise control over the polymer coating thickness and interfacial interactions, which is critical for optimizing the reactivity and thermal stability of composites. The morphology and structure were characterized, and the microcore–shell structure of AlB2@HTPFA was obtained. Compared with raw AlB2, the combustion efficiency of coated fuel increased by 4.1%, 5.6%, and 7.5%, respectively, with varying polymer contents. Meanwhile, the reactivity of AlB2@HTPFA (5 wt%) was 0.65 MPa/s, which is ~1.5 times that of AlB2. Additionally, the ignition and combustion characteristics of AlB2@HTPFA were investigated by laser ignition experiments with potassium perchlorate (KP) as an oxidant. The results revealed that AlB2@HTPFA/KP composites showed a greatly reduced combustion duration compared to uncoated AlB2. The ignition and combustion enhancement mechanism of AlB2@HTPFA was proposed. During the ignition process, the existence of HTPFA can result in a pre-ignition reaction, thus raising its reaction activity. This work provided a promising candidate for high-energy fuel that can be used in energetic materials.
研究领域:
材料科学
·
燃烧学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Chuan Huang,Zhijian Yang,Yanchun Li,Baohui Zheng,Qilong Yan,Lifeng Guan,Guan Luo,Shangbin Li,Fude Nie
Nano-aluminum, as a potential replacement of micro-aluminum, has attracted significant research interests in energetic fields due to its high reactivity. However, the intrinsic high surface area of nanoparticles drives nano-aluminum encounter challenges in handling process and prone to large aggregation, significantly impeding the further application of nano-aluminum. In this work, nano-aluminum based microspheres incorporating hexanitrohexaazaisowurtzitane (CL-20) are directly fabricated by electrospray deposition. These as-prepared microspheres were in high monodispersity and their size ranges from 8 to 16 μm. The surface morphology of such microspheres was adjustable by using different polymers as binder. Thermal behavior results show that CL-20 has no appreciable effect on the reactivity of nano-aluminum while the fluoropolymer binder (F2314) facilitates the oxidation of nano-aluminum. Nevertheless, the presence of CL-20 can significantly enhance the reactivity of nano-aluminum in the combustion behavior tests, where electrosprayed microspheres exhibit outstanding performance in comparison to physical mixed sample, presenting a high pressurization rate, peak pressure and short burning time. These excellent properties are possibly attributed to their uniform microstructure. Therefore, the use of electrospray method can offer a promising strategy to fabricate the microstructure controllable microspheres.
研究领域:
材料科学
·
能源领域
✓ 已验证
产品关联
DOI
高影响因子
XENOBIOTICA
·
2021
·
IF 1.908
Min Tian,Shenzhi Zhou,Wei Li,Jiaru Li,Lan Yang,Ying Peng,Jiang Zheng
Aegeline (AGL) is a natural alkaloidal amide mainly isolated from the leaves and fruits of tropical plant Aegle marmelos, with multiple pharmacological activities.As one component of several dietary supplements, AGL caused a series of acute and chronic liver injuries. Nevertheless, the mechanisms of AGL-induced hepatotoxicity remain unclear. This study was conducted to identify reactive metabolite(s), to determine related metabolic pathways, and define the possible association of the bioactivation with AGL cytotoxicity.A demethylation metabolite (M1) and a GSH conjugate (M2) were detected in rat liver microsomal incubations containing AGL and GSH. The two metabolites were both found in bile of rats and rat primary hepatocytes after AGL administration.Recombinant P450 enzyme incubations showed that CYP2C19 was the principal enzyme catalysing this metabolic activation.Ticlopidine, a selective inhibitor of CYP2C19, decreased the formation of M1 and M2 in hepatocytes and attenuated the susceptibility of hepatocytes to the cytotoxicity of AGL. The results suggest that AGL was metabolized to a p-quinone methide intermediate which could in part participate in AGL-induced cytotoxicity.
研究领域:
药理学
·
毒理学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chemistry-An Asian Journal
·
2022
·Vol. 17
·期 13
·e202200141
·
IF 4.839
Shuai-Cong Huo,Yao Li,De-Xiang Zhang,Qi Zhou,Ying Yang,Herbert W. Roesky
Graphical A series of digermylenes R(EGeL) 2 (L=CH[C(Me)N(Ar)] 2 , Ar=2,6- i Pr 2 C 6 H 3 ; E=O, R=1,3-C 6 H 4 ( 1 ), 1,4-C 6 H 4 ( 2 ), Me 2 C(CH 2 ) 2 ( 3 ); E=NH, R=1,4-C 6 H 4 ( 4) , 1,4-C 6 H 10 , ( 5 ); E=C(O)O, R=1,3-C 6 H 4 ( 6 )) were synthesized by the nucleophilic addition of diphenols, diol, diamines and dicarboxylic acids, respectively, with L′Ge (L′=HC[C(CH 2 )N(Ar)]C(Me)N(Ar), Ar=2,6- i Pr 2 C 6 H 3 ). Treatment of the obtained digermylene 1,3-C 6 H 4 (OGeL) ( 1 ) with sulfur, selenium, and CuX (X=Cl, Br, I, C 6 F 6 ) is also explored. A series of digermylenes R(EGeL) 2 (L=CH[C(Me)N(Ar)] 2 , Ar=2,6- i Pr 2 C 6 H 3 ; E=O, R=1,3-C 6 H 4 ( 1 ), 1,4-C 6 H 4 ( 2 ), Me 2 C(CH 2 ) 2 ( 3 ); E=NH, R=1,4-C 6 H 4 ( 4) , 1,4-C 6 H 10 ( 5 ); E=C(O)O, R=1,3-C 6 H 4 ( 6 )) were synthesized by the reactions of L′Ge (L′=HC[C(CH 2 )N(Ar)]C(Me)N(Ar), Ar=2,6- i Pr 2 C 6 H 3 ) with selected diphenols, diol, diamines, and o -/ m -phthalic acids, respectively. Treatment of digermylene 1,3-C 6 H 4 (OGeL) 2 ( 1 ) with sulfur, selenium and CuX (X=Cl, Br, I) led to the formation of 1,3-C 6 H 4 [OGe(S)L] 2 ( 8 ), 1,3-C 6 H 4 [OGe(Se)L] 2 ( 9 ), and (CuX) 2 [1,3-C 6 H 4 (OGeL) 2 ] 2 (X=Cl ( 10 ), Br ( 11 ), I ( 12 )), respectively. The obtained products were characterized by melting point, elemental analysis, FT-IR, 1 H and 13 C NMR spectroscopy, and single-crystal X-ray diffraction.
研究领域:
无机化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Yuwei Xie,Qi Jiang,Yilin Zhang,Kaiting Zhang,Jifei Hou,Mingbao Feng
Homogeneous solar/oxidant systems have emerged as cost-effective treatments for removing organic micropollutants and disinfecting pathogenic bacteria in water. However, detailed discussions regarding the effectiveness and mechanisms for water decontamination and disinfection have not been conducted yet. This paper reviewed and compared the decontamination and disinfection performance of homogeneous solar/oxidant systems, including solar-activated hydrogen peroxide, peroxydisulfate, peroxymonosulfate, chlorine, peracetic acid, ferrate, and periodate. The activation mechanisms of different oxidants by sunlight are summarized, where oxidants were activated under solar irradiation to produce multiple reactive species to remove micropollutants and inactivate bacteria. Notably, different reactive species promoted different conversion pathways for micropollutants, and the in silico toxicity predictions suggested the non-overlooked transformation-derived risks from the degradation products of micropollutants. Furthermore, the economic cost analysis of all solar/oxidant systems studied suggested that the overall costs were acceptable, while some other factors in practical applications needed to be reconsidered. Finally, research perspectives on solar-based oxidation technologies in terms of water decontamination and disinfection were provided. In summary, this review facilitates an understanding of the fundamental principles and oxidizing mechanisms of different solar/oxidant systems in water and wastewater treatment.
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Wenting Shen,Jiang Xu,Lizhong Zhu
Sulfidized nanoscale zerovalent iron (SNZVI) with improved reactivity and selectivity has shown great potential for environmental remediation. However, it is unclear if SNZVI could be applied for the remediation of soil washing solution, and how a soil-washing surfactant affects the reactivity and selectivity of SNZVI. Here, we assess the impact of Triton X-100 (TX-100) on the reactivity and selectivity of a sulfidized commercial NZVI toward tetrabromobisphenol A (TBBPA). While sulfidation of NZVI improved its reactivity and electron efficiency toward TBBPA, TX-100 could further improve these promoting effects, which was 8–21 and 4–7 times higher than those without TX-100, respectively, depending on TX-100 concentration. Because TX-100 could induce the solubilization of TBBPA, sorb onto the SNZVI surface, and favor the subsequent sorption and degradation of TBBPA. SNZVI performance for successive treatments of TBBPA contaminated water was also greatly improved by TX-100. Moreover, washing the TBBPA-contaminated soil with TX-100 could efficiently extract the TBBPA, and almost all of the TBBPA in the soil washing solution could be efficiently degraded by SNZVI. These results suggest that TX-100 is a good additive to SNZVI for improving its performance, and SNZVI coupled with TX-100 can be a promising technology for the remediation of TBBPA-contaminated soil.
研究领域:
环境科学
·
土壤修复
·
地下水修复
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Guozhang Gu,Huaiyang Cai,Yutao Wang,Chen Tang,Guoxiang Zou,Jinchun Li,Rong Yang
Achieving both super toughness and flame retardancy in polylactic acid (PLA) materials hinges on resolving the interface compatibility issues between flame retardants, toughening agents, and PLA, as well as overcoming potential antagonisms between these components. Here, we present an approach employing hyperbranched structures to simultaneously enhance the toughness and flame retardancy of PLA materials. Our strategy involved the reactive blending of PLA with a quaternary bio-based phosphorus-containing copolyester (PPE) featuring side hydroxyl groups and hexamethylene glycidyl cyclotriphosphazene (HGCP). The multi-epoxy groups of HGCP reacted with the hydroxyl and carboxyl groups present in PPE and PLA, resulting in the formation of hyperbranched PLA-PPE copolymers. The hyperbranched copolymers provided great interfacial compatibilization and low viscosity, synergistically promoting the melt-dripping flame-retardant mechanism facilitated by PPE, aiding in the rapid removal of heat and combustible material from the pyrolysis zone. Consequently, the PLA/PPE/HGCP blends exhibited super toughness, achieving a maximum notched impact strength of 70.2 kJ/m 2 . Additionally, the blends demonstrated a 27 % LOI and can pass the UL-94 V-0 rating. Moreover, all the blends are biodegradable in a Proteinase K solution. This research underscores the efficacy of utilizing hyperbranched structures as a promising strategy for the development of PLA materials with simultaneous enhancement of processability, toughness, and flame retardancy.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER COMPOSITES
·
2019
·Vol. 41
·期 4
·1500-1506
·
IF 2.268
Jie Li,Jinfeng Wang,Shuang Yang,Yang Cao,Fang Yang,Jinchuan Wu
The effect of hydroxyapatite (HA) particle shape on the reactivity of HA surfaces was investigated by selecting the rod-shaped (r-HA) and spherical HA particles (s-HA) to coinitiate the ring-opening polymerization of d , l -lactide (DLLA) used stannous octoate (Sn(Oct) 2 ) as the catalyst, respectively. It was found that both s-HA and r-HA could be grafted with PDLLA and the reactivity of s-HA was higher than that of r-HA according to the results from FTIR, NMR, TGA and BET method. The potential mechanism was that the shape of HA particles determined the crystal faces exposed to participate in graft reaction clarified by performing X-ray diffraction detections and Materials Studio analysis. The primary crystal faces were (211) and (112) for s-HA yet (002) and (300) for r-HA. These findings suggested that the shape of HA particles might influence their reactivity, which might provide a new way to improve the graft ratio of polymers so as to prepare HA/polymer composites with strong interfacial strength by selecting or designing the shape of the HA particles.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yajie Chen,Wei Ren,Zilong Zheng,Ganggang Wu,Bin Hu,Junhong Chen,Jiaxin Wang,Chunpei Yu,Kefeng Ma,Xinli Zhou,Wenchao Zhang
The development of nanothermites with adjustable reactivity has always been the research hotspot in the field of energetic materials, and its key issue is to control the interfacial contact extent and diffusion length between fuel and oxidizer. Here, the 3DOM CuO/Al, 3DOM CuO/Al-NPs and CuO-NPs/Al-NPs nanothermites, which show a gradual decrease in contact extents between reactants, were firstly prepared simultaneously using magnetron sputtering, P4VP self-assembly and ultrasonic mixing, respectively. The DSC thermograms show that the heat release of the 3DOM CuO/Al (sputtering 200 nm Al) can reach 2541.4 J/g, much larger than either value of the prepared 3DOM CuO/Al-NPs and CuO-NPs/Al-NPs. The activation energies of these CuO/Al systems also exhibit the similar results as the heat releases. However, the 3DOM CuO/Al-NPs can lead to the highest combustion pressure (24.6 MPa), the shortest pressure rise time (0.067 ms), and the fastest pressurization rate (647.98 GPa/s), followed orderly in corresponding values by the CuO-NPs/Al-NPs and 3DOM CuO/Al. All data indicate that the contact extent between CuO and Al plays a great effect on the overall reactivity, and their differences in structure and volume are responsible for the diverse combustion pressure performance. Furthermore, the presence of reaction voids between components can promote the O diffusion to enhance the continuous mass and heat transfer for an efficacious reaction. Hence, it is believed that similar methods can be used to improve the contact extent and diffusion length between fuels and oxidants so as to achieve an adjustment in reactivity for various nanothermites.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
XENOBIOTICA
·
2021
·
IF 1.908
Xiaojiao Zheng,Xu Wang,Zifang Ding,Wei Li,Ying Peng,Jiang Zheng
Deferiprone (DFP) is a metal chelating agent generally used to treat patients with thalassaemia, due to iron overload in clinical settings.Studies have revealed that long-term use of DFP can induce hepatotoxicity, however, mechanisms of its toxic action remain unclear. The present studies are aimed to characterize the reactive metabolite of DFP, to define the metabolic pathway, and to determine the P450 enzymes participating in the bioactivation.A demethylation metabolite (M1) was observed in rat liver microsomal incubations. Additionally, a glutathione (GSH) conjugate (M2) and an N-acetylcysteine (NAC) conjugate (M3) were detected in microsomal incubations fortified with DFP and GSH/NAC.Biliary M2 and urinary M3 were respectively found in animals administered DFP.CYP2A6 enzyme dominated the catalysis to bioactivate DFP.
研究领域:
药理学
·
毒理学
·
临床医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PLoS Pathogens
·
2024
·Vol. 20
·期 7
·e1012431
·
IF 5.5
Xiaoyu Liu,Nemat O. Keyhani,Hong Liu,Yue Zhang,Yuxian Xia,Yueqing Cao
Reactive carbonyl and oxygen species (RCS/ROS), often generated as metabolic byproducts, particularly under conditions of pathology, can cause direct damage to proteins, lipids, and nucleic acids. Glyoxal oxidases (Gloxs) oxidize aldehydes to carboxylic acids, generating hydrogen peroxide (H 2 O 2 ). Although best characterized for their roles in lignin degradation, Glox in plant fungal pathogens are known to contribute to virulence, however, the mechanism underlying such effects are unclear. Here, we show that Glox in the insect pathogenic fungus, Metarhizium acridum , is highly expressed in mycelia and during formation of infection structures (appressoria), with the enzyme localizing to the cell membrane. MaGlox targeted gene disruption mutants showed RCS and ROS accumulation, resulting in cell toxicity, induction of apoptosis and increased autophagy, inhibiting normal fungal growth and development. The ability of the MaGlox mutant to scavenge RCS was significantly reduced, and the mutant exhibited increased susceptibility to aldehydes, oxidative and cell wall perturbing agents but not toward osmotic stress, with altered cell wall contents. The Δ MaGlox mutant was impaired in its ability to penetrate the host cuticle and evade host immune defense resulting in attenuated pathogenicity. Overexpression of MaGlox promoted fungal growth and conidial germination, increased tolerance to H 2 O 2 , but had little to other phenotypic effects. Transcriptomic analyses revealed downregulation of genes related to cell wall synthesis, conidiation, stress tolerance, and host cuticle penetration in the Δ MaGlox mutant. These findings demonstrate that MaGlox -mediated scavenging of RCS is required for virulence, and contributes to normal fungal growth and development, stress resistance.
The ability of organisms to detoxify reactive metabolic byproducts is crucial for normal development, stress resistance, and where applicable, pathogenesis. Here, using the insect pathogenic fungus, Metarhizium acridum , we show that a glyoxal oxidase acts to detoxify cellular reactive carbonyl species (RCS) as well as leading to decreased reactive oxygen species (ROS) levels by alleviating aldehydes accumulation which can trigger ROS production. Mutants deficient in MaGlox showed increased levels of RCS/ROS leading to increased autophagy and apoptosis, resulting in impaired fungal growth, development, and reduced virulence. These findings link Glox mediated RCS/ROS detoxification to cell degradation/turnover processes and cell death, impacting fungal pathogenicity and development.
研究领域:
微生物学
·
真菌学
·
病理学
·
细胞生物学
·
植物病理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Yujun Cheng,Peng Hu,Tianwei Hao
The sulfur precursor-induced sulfidation effectively enhances the nanoscale zerovalent iron (nZVI) reactivity. However, due to the batch-to-batch variation in synthesis and reaction conditions, the sulfur precursor that confers superior reactivity to sulfidized nZVI (S-nZVI) and its application potential are undetermined. This study evaluated the impact of six sulfur precursors (Na 2 S, Na 2 S 2 O 4 , S 0 , Na 2 S 2 O 3 , K 2 S 6 , and sulfate reduction effluent [a sulfide-containing effluent]) on the reactivity, toxicity, and colloidal stability of S-nZVI. The reactivity enhancement induced by sulfidation of the different sulfur precursors was inconsistent and dependent on the contaminant. In the removal of trichloroethylene (TCE) and hexavalent chromium Cr(VI) in aqueous solution, S-nZVI, with a high Fe 0 content, hydrophobicity, and electron transfer properties (i.e., S-nZVI Na2S and S-nZVI Na2S2O3 ), yielded relatively high capacities. In the removal of tetracycline (TC) by S-nZVI, the performance was relatively unaffected by the sulfur precursors. The toxicity evaluation demonstrated that S-nZVIs showed a limited toxicity (less than 0.35-log) to Escherichia coli ( E. coli ) in simulated groundwater. Despite sulfidation marginally improving the colloidal stability of nZVI—by reducing the interparticle forces—, the S-nZVI particle settling was observed, within 60 min, at the bottom of the vial containing the suspension. Overall, none of the sulfur precursors was manifestly preferable to the others. Na 2 S, Na 2 S 2 O 3 , and SR-effluent were recommended for use in low sulfur content post-sulfidation processes considering the material performances and costs. These findings contribute to the understanding of the effect of the sulfur precursors on the reactivity and application potential of S-nZVI, thereby providing guidance for tuning S-nZVI properties and selecting suitable sulfur precursors for specific in situ remediation scenarios.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）