Advanced Optical Materials
·
2020
·Vol. 8
·期 12
·1902118
·
IF 8.286
Fan Fang,Mengjia Liu,Wei Chen,Hongcheng Yang,Yizun Liu,Xiang Li,Junjie Hao,Bing Xu,Dan Wu,Kun Cao,Wei Lei,Peter Müller-Buschbaum,Xiao Wei Sun,Rong Chen,Kai Wang
Quantum dots (QDs) are promising for being used in advanced displays due to their outstanding emission properties. Herein, a novel encapsulation method for QDs is reported and ultra-stable QDs@SiO 2 @Al 2 O 3 luminescent microspheres (QLuMiS) are obtained by combining a sol–gel method for the intermediate SiO 2 layer with a fluidized powder atomic layer deposition (ALD) for the outer Al 2 O 3 layer. The rich hydroxyl coverage on the QDs@SiO 2 surface provides abundant chemisorption sites, which are beneficial for the deposition of Al 2 O 3 in the ALD process. Simultaneously, the water-oxygen channels in the SiO 2 layer are blocked by the Al 2 O 3 layer, which protects the QDs against deterioration. Consequently, the QLuMiS exhibit an excellent stability with 86% of the initial light conversion efficiency after 1000 h of blue light aging under a light power density of 2000 mW cm −2 . Such stability is significantly better than that of QDs@Al 2 O 3 and QDs@SiO 2 samples. Moreover, under this strong irradiation aging condition with blue light, the extrapolated lifetime (L50) of QLuMiS is 4969 h, which is ten times longer than that of QDs@SiO 2 and is the best record as far as is known. Finally, a prototype of a QLuMiS-based cellphone screen with a wide color gamut of 115% NTSC is demonstrated.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanophotonics
·
2016
·Vol. 5
·期 4
·565-572
·
IF 4.333
Wei Chen,Kai Wang,Junjie Hao,Dan Wu,Jing Qin,Di Dong,Jian Deng,Yiwen Li,Yulong Chen,Wanqiang Cao
In this research, we have developed an approach by incorporating quantum dots (QDs) with red emission into mesoporous silica microspheres through a non-chemical process and obtained luminescent microspheres (LMS). Owing to the lattice structure of LMS, QDs were effectively protected from intrinsic aggregation in matrix and surface deterioration by encapsulant, oxygen and moisture. The LMS composite has therefore maintained large extent luminescent properties of QDs, espe-cially for the high quantum efficiency. Moreover, the fabricated white light emitting diode (WLED) utilizing LMS and YAG:Ce yellow phosphor has demonstrated excellent light performance with color coordinates around (x = 0.33, y = 0.33), correlated color temperature between 5100 and 5500 K and color rendering index of Ra = 90, R9 = 95. The luminous efficiency of the WLED has reached up to a new record of 142.5 lm/W at 20 mA. LMS provide a promising way to practically apply QDs in lightings and displays with high efficiency as well as high stability.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
ANALYST
·
2016
·Vol. 141
·期 18
·5366-5373
·
IF 4.033
Jie Tang,Yingying Su,Dongyan Deng,Lichun Zhang,Na Yang,Yi Lv
Using probes based on persistent luminescence nanoparticles (PLNPs) is a promising methodology for direct imaging analysis of bio-molecules. In the present work, SrMgSi2O6:Eu0.01,Dy0.02 persistent luminescence microspheres have been synthesized via a simple template method and sunlight could successfully excite their luminescence. Further, a new probe was established based on turn-off of the persistent luminescence emission for detection and optical imaging of dopamine (DA). Mechanistic studies indicated that when the synthesized PL microspheres themselves are alkaline, the PL of the SrMgSi2O6:Eu0.01,Dy0.02 microspheres can be efficiently quenched by DA through electron transfer in the presence of ambient O2. The approach exhibited high convenience by only homogeneously mixing DA and the SrMgSi2O6:Eu0.01,Dy0.02 microspheres. Meanwhile, other phenols, ascorbic acid (AA), and uric acid (UA) were tested and had little interference to the dopamine detection. The current strategy showed the linear range of PL intensity versus concentration was 1.0 × 10−5–1.0 × 10−3 M for DA with a detection limit of 0.78 μM (S/N = 3) and it was successfully applied for imaging and detection of DA in human urine with quantitative recovery (99.6–102.5%).
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2020
·Vol. 13
·期 2
·440
·
IF 3.057
Youxiong Zheng,Yan Tang,Jianwei Yu,Lan Xie,Huiyou Dong,Rongsheng Deng,Fuhua Jia,Bingxin Liu,Li Gao,Junyuan Duan
Building novel functional nanomaterials with a polymer is one of the most dynamic research fields at present. Here, three amphiphilic block copolymers of 8-hydroxyquinoline derivative motifs (MQ) with excellent coordination function were synthesized by Reversible Addition-Fragmentation Chain Transfer Polymerization (RAFT) polymerization. The coordination micelles were prepared through the self-assembly process, which the MQ motifs were dispersed in the hydrophobic polystyrene (PSt) blocks and hydrophilic Poly(N-isopropylacrylamide (PNIPAM)) blocks, respectively. The dual-emission micelles including the intrinsic red light emission of quantum dots (QDs) and the coordination green light emission of Zn2+-MQ complexes were built by introducing the CdSe/ZnS and CdTe/ZnS QDs in the core and shell precisely in the coordination micelles through the coordination-driven self-assembly process. Furthermore, based on the principle of three primary colors that produce white light emission, vinyl carbazole units (Polyvinyl Carbazole, PVK) with blue light emission were introduced into the hydrophilic PNIPAM blocks to construct the white light micelles that possess special multi-emission properties in which the intrinsic red light emission of QDs, the coordination green light of Zn2+-MQ complexes, and the blue light emission of PVK were synergized. The dual and multi-emission hybrid micelles have great application prospects in ratiometric fluorescent probes and biomarkers.
研究领域:
高分子化学
·
纳米材料科学
·
生物标记物研究
✓ 已验证
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2023
·
IF 8.6
Gan Zhang,Ganggang Zhang,Xiaocui Lai,Liu Su,Weihua He,Weihua Lai,Shengliang Deng
Conventional fluorescent microspheres (CFMs) have the disadvantages of low photoluminescence intensity (aggregation-caused quenching) and poor antibody conjugation. Herein, we achieved the improved performance of lateral flow immunoassay (LFIA) based on the high-fluorescent property of aggregation-induced emission fluorescent microspheres (AIEFMs) and biofriendly antibody coupling strategy of the polydopamine (PDA) layer. Although the PDA layer quenches the fluorescence intensity of AIEFM by Förster resonance energy transfer (FRET), quenching can be effectively controlled by ingenious adjusting of the thickness of the PDA. The PDA-coated AIEFM (AIEFM@PDA), which not only retained the strong fluorescence of AIEFM but also improved the antibody coupling efficiency and reproducibility of LFIAs, was successfully applied in sandwich and competitive LFIAs for the highly sensitive detection of pathogenic bacteria (Escherichia coli O157:H7) and antibiotics (enrofloxacin). In comparison with the CFM method, the proposed AIEFM@PDA-LFIA for the detection of E. coli O157:H7 and enrofloxacin could enhance the sensitivity by 40 times and 20 times, respectively. In addition, AIEFM@PDA-LFIA was further used for the detection of E. coli O157:H7 in river water, apple juice, and milk with satisfactory recoveries from 82.24 to 123.02% and enrofloxacin in pork, chicken, fish, and beef with satisfactory recoveries from 75.67 to 120.89%. The proposed AIEFM@PDA-LFIA showed excellent potential in rapid detection applications.
研究领域:
生物化学
·
医学检测
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Jiawei Chen,Xinhui Shu,Xiaoyue Xiao,Gan Zhang,Sha Yu,Juan Peng,Weihua Lai
The sensitivity of lateral flow immunoassays (LFIAs) is largely determined by the choice of antibody and labeling material. In this study, monoclonal antibodies (mAbs) against sildenafil were developed, and mAb-3C11 was selected for LFIA development based on its sensitivity and matrix tolerance. Additionally, aggregation-induced emission fluorescent microspheres (AIEFMs) were synthesized as the signal label. Combining the high performance antibody with the outstanding label, the LFIA@AIEFMs showed good sensitivity, with a limit of detection of 0.15 ng mL −1 , which is 4.4 times lower than that of LFIA using commercially available dyed latex microspheres. LFIA@AIEFMs was successfully applied to sildenafil detection, yielding recovery rates between 78.8 % and 130.4 % (coefficient of variation <15 %). Results were consistent with LC-MS analysis, confirming the robustness and practical applicability of the developed LFIA.
研究领域:
分析化学
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Zongyou Chen,Yanyan Tang,Ping Guo,Wei Zhang,Juan Peng,Yonghua Xiong,Bingfeng Ma,Weihua Lai
High fluorescence intensity microspheres such as aggregation-induced emission fluorescence microspheres (AIEFM) have improved the sensitivity of lateral flow immunoassay (LFIA). The preparation of immune probes in LFIA usually adopts the chemical coupling strategy with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide for antibody coupling, which has the problems of low coupling efficiency, tedious coupling process, and poor repeatability. A biocompatible metal-phenolic network (MPN), which contains large amounts of phenols and galloyl groups, could easily, quickly, and stably couple with antibodies. Herein, we proposed a strategy based on MPN modification on ultrabright AIEFM surface as a novel label for the rapid detection of carbendazim. The limit of detection of AIEFM@MPN-LFIA was 0.019 ng/mL, which was 4.9 times lower than that of AIEFM-LFIA. In spiked samples, the average recoveries of AIEFM@MPN-LFIA ranged from 80% to 118% (coefficient of variation <13.45%). Therefore, AIEFM@MPN was a promising signal label that could improve the detection performance of LFIA.
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Liwen Hu,Zhenzhen Chen,Ting Li,Xianlong Ye,Qi Luo,Weihua Lai
Antibodies and labels were typically non-oriented conjugated in conventional immunochromatographic assays (ICAs). In this work, a C-terminal cysteine-tagged recombinant protein A (rPA) was conjugated in an oriented manner onto aggregation-induced emission fluorescence microsphere (AIEFM). The Fc fragment of anti-enrofloxacin monoclonal antibody (anti-ENR mAb) was then conjugated onto the rPA. The resulting oriented mAb-AIEFM probe was used in an ENR-ICA for the rapid detection of ENR , a widely abused animal drug. The ENR-ICA with the oriented probe saved 66.7% of anti-ENR mAb and 25% of ENR-bovine serum albumin, and had a limit of detection of 0.035 ng/mL, compared with 0.079 ng/mL for the non-oriented probe. The corresponding linear ranges of the ENR-ICA based on the oriented and non-oriented probes were 0.25–10 ng/mL and 0.1–2.5 ng/mL, respectively. This novel ICA based on the oriented probe has the potential to be used for sensitive and rapid detection in food safety.
研究领域:
分析化学
·
生物化学
·
食品科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）