Inorganic Chemistry Frontiers
·
2023
·Vol. 11
·期 1
·172-185
·
IF 7
Kejie Li,Mengmeng Dai,Zuoling Fu,Zhiying Wang,Hanyu Xu,Rong Wang
Fluorides have garnered tremendous attention in rare-earth-doped fluorescent probes owing to their low phonon energy and excellent optical transparency. However, the latest generation of fluorides, LiYF4, is plagued by extremely complex and uncontrollable synthesis methods, which greatly restricts its further exploration and application. Herein, a straightforward one-step method for the synthesis LiYF4:Ln3+ with micron-sized cones and nano-spheres is reported. Astonishingly, self-sensitized luminescence was achieved under multi-wavelength excitation when Er3+ was singly doped. LiYF4:Yb3+,Er3+ demonstrated superior luminescence intensity to those of commercial green phosphors (NaYF4:Yb3+,Er3+); this ultra-efficient photoluminescence was confirmed from the crystal structure, electronic band properties, morphological analysis and Debye temperature calculations. Further, by constructing cross-relaxation between the Ce3+ and Er3+ ions (4I11/2 + 2F5/2 → 4I13/2 + 2F7/2), the specific four-peak emission (SFPE) intensity of Er3+ in NIR-IIb was significantly increased, further enhancing the relative sensitivity of thermally coupled temperature sensing based on SFPE. Subsequently, non-thermally coupled temperature sensing based on SFPE was also achieved through the construction of phonon-assisted energy transfer between Ho3+ 5I6 and Er3+ 4I13/2. In summary, this paper not only puts forward theoretical and experimental arguments for the use of LiYF4 to replace the conventional NaYF4, but also substantiates the extraordinary prospects of LiYF4 as a temperature-sensitive fluorescent probe in nanomedicine.
研究领域:
材料科学
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纳米医学
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DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Baoxia Liu,Yaoyao Zhang,Yuanqiang Hao,Xu Zhu,Yintang Zhang,Yanli Zhou,Hongliang Tan,Maotian Xu
This study developed a novel luminescent assay for kinase activity using metal–organic coordination polymer nanoparticles (Tb/ATP-Zn) as the probe. Tb/ATP-Zn, self-assembled by adenosine triphosphate (ATP), Zn2+, and Tb3+, is non-luminescent. Protein kinase A (PKA) can catalyze the transformation of ATP within Tb/ATP-Zn nanoparticles to adenosine diphosphate (ADP), which in turn effectively sensitizes the luminescence of Tb3+. Based on this mechanism, Tb/ATP-Zn can realize the facile luminescent “turn-on” sensing of protein kinase activity without the use of external ATP and substrate peptide. Under optimized conditions, the fluorescence intensities of Tb/ATP-Zn at 550 nm are linear with the PKA activity within a range of 0.3–1.5 U·μL–1. The LOD (S/N = 3) of this method is down to 0.001 U·μL–1. The presented assay also features high selectivity, long-term stability, fast response, and convenient operation. Furthermore, Tb/ATP-Zn was successfully employed for monitoring PKA activity in cell lysis solutions. Probe Tb/ATP-Zn is thus expectable to be a powerful tool for the practical study of PKA in relevant biological events.
研究领域:
生物化学
·
分子生物学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2014
·
IF 2.291
Tianshu Chu,Huiping Liu,Yangyi Yang,Hongming Wang,Yunsong Hu,Yi Wang,Minghao Yu,Seik Weng Ng
A strong green-light-emitting Tb complex [Tb 2 (csal) 6 (H 2 O) 4 ]·4H 2 O ( 1 ) (Hcsal = 4-chlorosalicylicacid) has been synthesized. The structure was determined by single crystal X-ray diffraction. 1 exhibits a discrete dinuclear structure which is further assembled into a 3D supramolecular network by hydrogen bonding and aromatic π−π stacking interactions. This complex was used to detect ethylenediamine (EDA), triethylamine (TEA) and ethanolamine (EOA), the relationship between luminescence intense of 1 and concentrate of EDA or TEA can be fitted in Stern–Volmer equation. The results indicate that 1 is a promising probe for detecting amines with high selectivity and sensitivity.
研究领域:
化学
·
材料科学
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 44
·期 4
·1446-1454
·
IF 3.069
Jin Xiao Li,Qing Lin Guan,Yu Wang,Zi Xin You,Yong Heng Xing,Feng Ying Bai,Li Xian Sun
A facile strategy was used to construct a series of composite materials with color-tunable and white light emission by encapsulating 1,3,6,8-tetrakis(p-benzoic acid)pyrene (H4TBAPy) into framework material [Eu(MCTCA)1.5(H2O)2]·1.75H2O (Eu-MCTCA), which is synthesized based on Eu(NO3)3·6H2O and 5-methyl-1-(4-carboxylphenyl)-1H-1,2,3-triazole-4-carboxylic acid (H2MCTCA). A slight adjustment of the emission color can be easily fulfilled by simply altering the concentration of H4TBAPy or regulating the excitation wavelength. Notably, white light emitting Eu-MCTCA@H4TBAPy can be realized by encapsulating H4TBAPy with a concentration of 0.75 mM, when the excitation wavelength is 350 nm. Furthermore, based on the favorable luminescence and stable structure of Eu-MCTCA@H4TBAPy in water or organic solvents, Eu-MCTCA@H4TBAPy can be used as a potential luminescent probe for detecting Fe3+, Cr2O72− and colchicine.
研究领域:
材料科学
·
分析化学
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产品关联
DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2024
·
IF 4.1
Yuxiang Jiao,Yifei Li,Huaijun Tang,Shanglan Xian,Yonghui He,Long Wang,Jinghao Zhang
Herein, a cationic iridium(III) complex [(ppy) 2 Ir(IPP)]PF 6 (ppy: 2-phenylpyridine; IPP: 2-(1 H -imidazo[4,5- f ][1,10]phenanthrolin-2-yl)phenol) was synthesized. Under the excitation of 328 nm (λ ex = 328 nm) UV light, this complex emitted bright yellow orange light (500 ∼ 700 nm, λ em,max = 582 nm), the Stokes shift was up to 254 nm, mainly due to excited-state intramolecular proton transfer (ESIPT) occurring in its ancillary ligand IPP. [(ppy) 2 Ir(IPP)]PF 6 was very sensitive to Ni 2+ , which was caused by the ESIPT being hindered by the coordination of [(ppy) 2 Ir(IPP)]PF 6 with Ni 2+ . Its bright yellow orange light disappeared within 1 min when Ni 2+ (1.0 equiv.) was added in its solution (in DMSO/H 2 O, v/v = 999/1), therefore, it can be used for “turn-off” chemiluminescent detection of Ni 2+ . The recognition of [(ppy) 2 Ir(IPP)]PF 6 to Ni 2+ was not interfered by many common metal ions (such as Na + , K + , Li + , Mg 2+ , Al 3+ , Ca 2+ , Fe 3+ , Ag + , Zn 2+ , Hg 2+ , Co 2+ , Pb 2+ , Mn 2+ , Ba 2+ or Cr 3+ ), however, Cu 2+ was an interfering metal ion, but its interference can be completely masked by thiourea. The detection limit was as low as 3.31 × 10 −7 mol∙L -1 (0.331 μM). The Job’s plot analysis revealed that the stoichiometry of [(ppy) 2 Ir(IPP)]PF 6 with Ni 2+ was 1:1, its detecting mechanism based on ESIPT effect was demonstrated by 1 H NMR spectra and density functional theory (DFT) calculation.
研究领域:
化学
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2014
·
IF 5.825
Jing Li,Laizhong Chen,Wenxiao Wu,Wei Zhang,Zhao Ma,Yanna Cheng,Lupei Du,Minyong Li
To find an approach that can image the hydrolysis activity of aminopeptidase N (APN) both in vitro and in vivo, three bioluminescent probes have been well designed and synthesized herein. All of them can be recognized and hydrolyzed by APN to produce bioluminescence emission in the presence of firefly luciferase. To the best of our knowledge, they are the first bioluminescent probes for imaging APN in deep tissues and living animals.
研究领域:
生物化学
·
分子影像学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Xueru Zhang,Jiarong Guo,Wei Tang,Xinrui Duan
Based on the chemical structure and luminescence mechanism of luminol, the synthesis of luminol analogues has been widely studied. However, luminol and its derived reagents are still suffering from some drawbacks, such as short luminescence time and weak intensity. Herein, we designed and synthesized a novel hydroxyphenyl benzothiazole-based phthalhydrazide derivative DAH-AMPH, which has a hydroxyphenyl benzothiazole structure as a strong fluorescent site and a cyclic phthalhydrazide structure as a chemiluminescence (CL) emitting site. DAH-AMPH exhibited excellent CL properties in the DAH-AMPH/UHP/hemin CL system for hemin detection with a wide linear range of 0.1 nM to 20.0 nM and low LOD as 3 pM. It performed good selectivity in bloodstain imaging on different substrate materials. DAH-AMPH/UHP/hemin CL system supplied a powerful tool for trace detection of bloodstain. Moreover, as a new CL substrate to HRP, DAH-AMPH showed high sensitivity (0.8 pg/mL of LOD) in the DAH-AMPH/UHP/SPTZ/MORP/HRP CL system indicating a bright prospect for the use of DAH-AMPH in heme-containing peroxidase detection.
研究领域:
分析化学
·
法医学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Pharmaceutical Analysis
·
2021
·
IF 4.769
Yingai Sun,Yuqi Gao,Chunchao Tang,Gaopan Dong,Pei Zhao,Dunquan Peng,Tiantian Wang,Lupei Du,Minyong Li
In recent years, various methods for detecting exogenous and endogenous hypochlorite have been studied, considering its essential role as a biomolecule. However, the existing technologies still pose obstacles such as their invasiveness, high costs, and complicated operation. In the current study, we developed a glow-type chemiluminescent probe, hypochlorite chemiluminescence probe (HCCL)-1, based on the scaffold of Schaap's 1,2-dioxetane luminophores. To better explore the physiological and pathological functions of hypochlorite, we modified the luminophore scaffold of HCCL-1 to develop several probes, including HCCL-2, HCCL-3, and HCCL-4, which amplify the response signal of hypochlorite. By comparing the luminescent intensities of the four probes using the IVIS® system, we determined that HCCL-2 with a limit of detection of 0.166 μM has enhanced sensitivity and selectivity for tracking hypochlorite both in vitro and in vivo.
研究领域:
生物化学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2024
·
IF 5.5
Ximeng Shi,Yumeng Wang,Jiaoyang Yu,Yating Yang,Zecheng Jin,Hanghang Wang,Dalei Wu,Wei Chen,Jianming Guo,Yinan Zhang
Comprehensive Summary The detection of critical endogenous species, such as bacteria in microenvironments in the body, requires better imaging tools for visualization and monitoring of biological events. Bioluminescence imaging is the most popular strategy for obtaining real-time in living cells and organisms. Herein, we introduced a nitroaryl group on the C-3 position and a hydroxy group at the C-6 phenyl ring on furimazine to report the first bioluminescent probe ( 7 ) based on NanoLuc-furimazine bioluminescent pair for the detection of nitroreductase in bacteria. The probe, which possessed up to 560-fold intensity increase with a low detection limit of 16 ng/mL of nitroreductase, has the most efficient uncage efficiency in comparison with other bioluminescent congeners, thus enabling highly selective and sensitive visualization of NTR activity in a panel of clinical priority pathogens. Additionally, imaging of the recombinant strain as well as the NTR from mouse feces indicated the potential of this probe in the application of different mouse disease models.
研究领域:
生物化学
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分子生物学
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医学影像学
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DOI
高影响因子
LUMINESCENCE
·
2020
·Vol. 35
·期 4
·601-607
·
IF 1.855
Xiao Liu,Dong Chen,Chenchen Wang,Nianjuan Tian,Zhiqiang Li,Ying Zhang,Zhi-Jun Ding
Highly selective detection of Bacillus anthrax spores has attracted worldwide attention because Bacillus anthrax spores not only are harmful to the health of human beings and animals, but also can be used as biological warfare agents. Here, we report a simple platform by mixing EuCl 3 ·6H 2 O and sodium polyacrylate in aqueous solution and further investigate its luminescence response towards Bacillus anthrax biomarker dipicolinic acid (DPA) as a turn-on luminescence probe. Importantly, our probe has good sensitivity, lower detection limit, excellent selectivity as well as great anti-interference ability due to the great luminescence enhancement of Eu 3+ . Moreover, a test paper is constructed to realize the purpose of portable detection. These results indicate that our probe is an excellent candidate for sensing DPA.
研究领域:
生物化学
·
分析化学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROSCOPY LETTERS
·
2025
·
IF 1.6
Yuting Jiang,Deyan Tai,Zhiyuan Xiao,Jinshui Liu
A ratiometric luminescent probe for detecting Bi(III) in water using a functionalized Eu(III) coordination polymer was developed. The raw materials guanosine monophosphate (GMP), Eu(III), and 2,6-pyridine dicarboxylic acid (DPA) were used to synthesize the GMP-Eu-DPA polymer, which contained Eu(III) coordinated with GMP and DPA and gave red emission at a wavelength of 614 nm when excited at a wavelength of 282 nm. Adding Bi(III) decreased the intensity of luminescence of the GMP-Eu-DPA coordination polymer at 614 nm and caused a GMP–Bi complex that strongly luminesced at 373 nm under excitation at 282 nm to form. Under optimal conditions, the luminescence intensity ratio I373/I614 had a good linear relationship with the Bi(III) concentration in the range 1.0–230 μM, and the detection limit was low (0.6 μM). The dual emission reverse rate of change luminescent probe can eliminate environmental influences, making the proposed detection method highly selective. This method has been successfully used to detect Bi(III) in water samples.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Shaozhen Jing,Xiaolei Wu,Xueliang Wang,Daniel Shiu-Hin Chan,Tsun-Yin Li,Chun-Yuen Wong,Chung-Hang Leung,Wanhe Wang,Jing Wang
Background Boron-containing drugs are widely used in anti-inflammatory, anti-bacterial, anti-tumor and other applications, thus it is important to develop methods for their detection. However, the sensitive detection of delanzomib through its boronic group remains challenging because of steric hindrance and interference from its own fluorescence. Results We report an iridium(III) complex containing the 1,2-dione group for the detection of delanzomib for the first time. The complex shows significantly decreased luminescence at 580 nm upon addition of delanzomib in aqueous solution. Complex 1 has good selectivity and sensitivity for delanzomib with a linear relationship in the range of 1 – 30 μM and a limit of detection (LOD) of 0.628 μM and a limit of quantification (LOQ) of 1 μM. Furthermore, complex 1 is successfully applied for the monitoring of delanzomib in health-related samples. Significance This study provides a solid basis for the advancement of analytical tools for the monitoring of boron-containing drugs.
研究领域:
分析化学
·
药学
·
生物医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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