CHEMISTRY & BIODIVERSITY
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2024
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IF 2.3
Yue Lu,Ming-Hua Duan,Xue Zhao,Yang Zhang,Yu Yang,Rui Xu,Ya-shuai Kang,Zi-Lin Wang,You-Zhi Zhang,Chang-Wei Li
Six previously unreported papulacandins, namely pestiorosins A–F (1–6), were isolated from the fermentation products of the fungus Pestalotiopsis rosea YNJ21 isolated from the fruitbody of Amanita exitialis. The structures of these compounds, along with a known compound called pestiocandin (7), were determined using MS, NMR data, and modified Mosher's method. All compounds exhibited significant antifungal activity against Candida albicans, with MIC values ranging from 0.06 to 2.00 μg/mL. In terms of cytotoxicity assays, compounds 3 and 6 demonstrated moderate inhibitory activity against human breast cancer MCF-7 cells with IC50 values of 24.50 and 16.83 μM, respectively. On the other hand, compound 7 displayed similar levels of inhibitory activity against mice microglial BV2 cells with an IC50 value of 24.51 μM.
研究领域:
微生物学
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药物化学
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天然产物研究
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY & BIODIVERSITY
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2024
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IF 2.3
Yu-Ting Wang,Yuan Dong,Fang Wang,Shuai-Ming Zhu,Yang Zhang,Yu Yang,Rui Xu,Cai-Hong Dong,You-Zhi Zhang,Chang-Wei Li
Four previously undescribed caryophyllene sesquiterpenoids ( 1 – 4 ) along with one known drimane sesquiterpenoid ( 5 ) were isolated from the fermentation products of the mushroom Hypholoma capnoides 819. The structures of 1–4 with rare tricyclic skeleton (6/5/4) or bicyclic skeletons (9/4) were determined on the basis of comprehensive spectroscopic data analysis, calculated NMR, ORD data, and their biosynthetic pathways. Compounds 1–5 only showed very weak cytotoxicity toward mouse microglial cells (BV2), breast cancer cells (MCF-7), and human lung cancer cells (A549) at 40 µM. In addition, none of the compounds demonstrated antibacterial activity against Staphylococcus aureus or Escherichia coli at 128 µg/mL. Graphical Four previously undescribed caryophyllene sesquiterpenoids (1–4) along with one known drimane sesquiterpenoid (5) were isolated from the fermentation products of the mushroom Hypholoma capnoides 819.
研究领域:
天然产物化学
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药物化学
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微生物学
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产品关联
DOI
PubMed
高影响因子
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
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2024
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IF 2
Shanshan Tang,Jia Zhao,Chang Liu,Dezhi Huang,Jing Tian,Yi Yang
Coprinus comatus is an edible mushroom and its fermented product possesses antioxidant activity. In this study, to further enhance the antioxidant activity and improve the reusability of the strain, calcium alginate hydrogel was used as the carrier for embedding and immobilizing Coprinus comatus. The effects of CaCl2 concentration, sodium alginate concentration, microsphere diameter, and the amount of magnetic particle on the antioxidant activity of fermented products were investigated. The results showed that the magnetic immobilized microsphere prepared by 2.50% CaCl2, 2.00% sodium alginate and 0.50% Fe3O4 had the best fermentation antioxidant activity (EC50 was 0.43 ± 0.01 mg/mL) when the diameter was 5 mm, which increased by 24.56% compared to the initial activity. Besides, the microsphere showed strong reusability, the antioxidant activity was still better than the free strain after being used five times. This study not only enhanced the antioxidant activity of Coprinus comatus fermented product through immobilization, but also provided an effective method for microbial fermentation.
研究领域:
微生物学
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食品科学
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产品关联
DOI
PubMed
高影响因子
Chinese Journal of Natural Medicines
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2022
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IF 3.887
Jun-Jie ZHU,Qi-Sen HUANG,Sheng-Quan LIU,Wei-Jia DING,Ya-Hong XIONG,Chun-Yuan LI
Four new diphenyl ethers, named epicoccethers K−N ( 1 − 4 ), were purified from the fermentation medium of a fungus Epicoccum sorghinum derived from Myoporum bontioides , and identified through HR-ESI-MS and NMR spectral analysis. Except that compound 1 showed moderate antifungal activity against Penicillium italicum and Fusarium graminearum , the other three compounds showed stronger activity against them than triadimefon. All of them showed moderate or weak antibacterial activity towards Staphylococcus aureus and Escherichia coli with O6 and O78 serotypes except that 3 was inactive to E. coli O6.
研究领域:
微生物学
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天然产物化学
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药理学
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产品关联
DOI
PubMed
高影响因子
Green Energy & Environment
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2020
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IF 6.395
Jiajun Liu,Kui Wu,Zhengke Li,Wensong Li,Yuqing Ning,Weiyan Wang,Yunquan Yang
The great challenge in the aldol condensation of tailored fermentation products (acetone–butanol–ethanol, ABE) into energy intensive fuels is to develop a suitable catalyst with high activity and low–cost. In this study, Co, Ni, and Co–Ni supported on Mg–Al oxide catalysts were prepared and their pore diameters were enlarged via adding active carbon as a hard template into Mg–Al hydrotalcite. During the aldol condensation reaction, the catalyst activity was enhanced after enlarging the pore diameter and Co–Ni bimetal supported catalyst presented the highest activity, which was resulted from that the electron transfer between Co and Ni in Co–Ni alloy enhanced the dehydrogenation activity and large pore lowered the mass transfer resistance. After optimizing the reaction conditions, acetone conversion and the total selectivity of C 5 –C 11 desired products in the aldol condensation of ABE reached up to 76% and 90%, respectively. The stability study showed that the activity was decreased with the increase of reaction number because of the oxidation of metallic Co and Ni, but this could be solved via a simple hydrogen reduction method.
研究领域:
催化化学
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能源科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2010
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IF 2.879
Corjan van den Berg,Floor Boon,Mark Roelands,Paul Bussmann,Earl Goetheer,Dirk Verdoes,Luuk van der Wielen
Most fermentation products have a feedback inhibiting effect on the host organism. In situ product recovery (ISPR) can be a means to overcome this product inhibition in fermentations. Particles such as solvent impregnated resins or capsules can be valuable tools for product recovery based on extraction. To evaluate, which kind of particle will be feasible for a certain kind of fermentation product an evaluation is presented here. Furthermore, an assessment is made what the impact is of ISPR for enhancing productivities in relatively non-inhibiting (lactic acid), fairly inhibiting (phenol) and severely inhibiting (erythromycin) fermentation products. A process containing solvent impregnated resins or capsules is evaluated based on enhanced productivities and cost-effectiveness. It is shown that applying these particles inside a fermentor can result in a decrease in ±30% of total manufacturing costs for pharma-intermediate production.
研究领域:
生物工程
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生物化学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2025
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IF 2.1
Yuanxin Zhao
Isobutanol is a promising biofuel that can be produced via fermentation. However, its separation from water is challenging due to the formation of an azeotrope during distillation. This study investigates the effects of K3PO4 concentration and temperature on the phase separation of isobutanol–water azeotropes. Results show that increasing salt concentration significantly enhances isobutanol recovery and dehydration efficiency, while temperature has a relatively minor effect. Isobutanol recovery exceeded 99.9% and dehydration ratios surpassed 90% at higher salt concentrations, with minimal influence from temperature. The water content in the isobutanol-rich phase decreases sharply with salt addition, and the solubility of isobutanol in the aqueous phase shows a strong logarithmic decline. A good linear fit (R2 > 0.997) confirms the reliability of the correlation. These findings demonstrate that salting-out using K3PO4 is a highly effective strategy for improving the separation of fermentation-based isobutanol.
研究领域:
生物化工
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分离科学
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生物能源
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工业微生物学
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过程工程
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2023
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IF 6
Jia-wei Luo,Shan Xiao,Bo Wang,Yan-xue Cai,Ji-hui Wang
A new fermented food by utilizing pineapple by-products and whey protein as the matrix via co-fermentation with strains of lactic acid bacteria and yeast is developed. We investigated its impact on human well-being, focusing on the bioavailability and physiological viability of the resulting pineapple–whey protein fermented product (PWF) under simulated human gastrointestinal conditions. We evaluated PWF's potential as a prebiotic using in vitro fermentation assays, revealing that its probiotic components effectively reached the colon and functioned without hindrance. This transit triggered significant release of phenolic compounds, establishing an antioxidant-rich environment during simulated digestion. In vitro fermentation experiments showcased PWF's capacity to induce short-chain fatty acid production in the intestines, alongside its ability to influence the microbial community composition. Additionally, we explored how PWF-induced alterations in the gut microbiota might impact human health. The results suggested that PWF could potentially enhance metabolic pathways in the intestinal microbiota, thereby fostering a more favorable microbial ecosystem.
研究领域:
食品科学
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微生物学
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营养学
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2019
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IF 3.714
Ru-yi Li,Shaoman Wang,David Julian McClements,Yin Wan,Cheng-mei Liu,Gui-ming Fu
Small molecules with beneficial biological activities can be generated by controlled fermentation of natural food products. In this study, the fermentation products of tannic acid by Aspergillus carbonarius FCYN212 were isolated and identified. Two major chemical structures were obtained: gallic acid (GA) and 3,4,6-tri- O -galloyl- d -glucose (TGG). GA and TGG exhibited stronger free radical scavenging ability and ferric-reducing power than butylated hydroxyanisole (BHA). Additionally, TGG demonstrated significant dose-dependent enzyme inhibitory activities against α-amylase and α-glucosidase with IC 50 values of 334.6 ± 8.9 and 46.5 ± 1.6 μM, respectively. Notably, TGG was a mixed type inhibitor of α-amylase and α-glucosidase according to a Dixon plot. This study revealed the antioxidant and enzyme inhibitory potential of TGG isolated from a fermented extract of tannic acid. TGG may therefore serve as an antioxidant and antidiabetic ingredient in functional or medical foods.
研究领域:
食品科学
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生物化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）