Radical sulfonylation with sulfur dioxide surrogates
Sulfur dioxide is a toxic atmospheric pollutant, primarily emitted from the combustion of sulfur-containing fossil fuels. The development of clean and cost-effective chemical processes for capturing SO2 has garnered significant interest from both industry and academia. On the other hand, sulfonyl-derived functional groups occupy a significant position in pharmaceuticals, agrochemicals and materials science. As versatile building blocks, sulfonyl groups can be utilized in a variety of bond-forming reactions in modern organic chemistry. Thus, the direct synthesis of these SO2-containing compounds from SO2 under mild conditions represents a more atom-efficient and greener approach. Owing to the troublesome issue of using toxic and malodorous gaseous SO2, sulfonylation reactions involving diverse SO2 surrogates provide an efficient and promising method for the synthesis of SO2-containing compounds. Since 2014, radical-mediated SO2 insertion strategies have attracted significant attention. By using photocatalysis, electrochemistry, transition-metal catalysis, and thermal initiation, significant progress has been made toward radical sulfonylation with SO2 surrogates. This review highlights the advances from the past decade that provide readers with essential tools for designing and implementing radical sulfonylation using SO2 surrogates in organic synthesis.
危险品化学品经营许可证（带存储）