Current Drug Delivery
·
2024
·Vol. 22
·期 4
·479-491
·
IF 2.8
Teng Guo,Chenming Zhang,Yuling Chen,Yihan Wu,Zhenda Liu,Yongtai Zhang,Nianping Feng
BackgroundAdding a suitable surfactant can enhance the transdermal permeability of transethosomes while also leveraging its functionality as a functional material. In this study, transethosomes were prepared using D-α-tocopherol acid polyethylene glycol succinate (TPGS) as edge activators for transdermal delivery of curcumin (Cur).MethodsThe TPGS-mediated curcumin-loaded transethosomes (Cur@TES) were prepared and formulated optimally, and the optimized formulations were characterized for their morphology, particle size, entrapment efficiency (EE) and drug loading (DL). The stability and deformability of Cur@TES were investigated, while the transdermal delivery of Cur@TES was investigated through in vitro transdermal assays and fluorescence imaging. A mouse ear swelling model was performed to determine the anti-inflammatory effect of Cur@TES.ResultsCur@TES appeared round or elliptical in shape. The particle size, EE and DL for the optimized formulation were observed as 131.2 ± 7.2 nm, 97.68 ± 2.26%, and 6.58 ± 0.62%, respectively. X-ray diffraction analysis confirmed the formation of disordered structures in the inner core of the vesicles. Moreover, Cur@TES system demonstrated better stability and deformability compared to the curcumin-loaded ethosomes (Cur@ES). In vitro transdermal experiments demonstrated that Cur@TES significantly increased the amount of drug retained in the skin (P<0.05). Fluorescence imaging confirmed that the skin distribution was distinctly enhanced with the delivery by TPGS mediated transethosomes. In addition, Cur@TES showed a significant inhibitory effect on Inflammatory swelling in the mouse ear-swelling model.ConclusionTPGS-mediated transethosomes exhibit significant transdermal advantages and enhanced anti-inflammatory effects, providing a new perspective for the transdermal delivery of curcumin.
研究领域:
药剂学
·
生物医学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Wenxin Jiang,Jing Wang,Dan Yuan,Zhiming Gao,Bing Hu,Yanlei Li,Yuehan Wu
Agarose microgels were prepared with bottom-up approach, and emulsifying properties of agarose microgels were investigated. Physical properties of microgels are varied with agarose concentration, and further affect the emulsifying performance of microgels. Enhanced surface hydrophobicity index and decreased particle size of microgels were recorded with the increasing of agarose concentration, which were conducive to emulsifying properties of microgels. Improved interfacial adsorption of microgels was evidenced by Dynamic surface tension and SEM. However, microscopic morphology of microgel at O/W interface indicated that increasing agarose concentration could weaken the deformability of microgels. The influence of external conditions (pH and NaCl) on the physical properties of microgels were investigated, and their effects on emulsion stability were evaluated. Compared with acidification, NaCl was appeared to be more destructive to emulsion stability. Results indicated acidification and NaCl could decrease surface hydrophobicity index of microgels, but there was differentiation in the variation of particle size. It was inferred that deformability of microgels could make contribution to the stability of emulsion. This study verified that microgelation was a feasible scheme to improve the interfacial properties of agarose, and the influence of agarose concentration, pH, and NaCl on the emulsifying performance of microgels was investigated.
研究领域:
食品科学
·
材料科学
·
界面化学
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Shuwen Tan,Xiaojia Xu,Ting Zhang,Min Li,Xiaoyan Liu,Per M. Claesson,Yu Fang
Microgels have been widely used for stabilizing emulsions due to their softness and stimulus responsiveness. Although ultrastable emulsions have been prepared by microgel nanoparticles, the role of electrostatic interactions on emulsion stability is still a controversial topic and further investigation of the effect of microgel deformability is required. In the present study, neutral poly(N-vinylcaprolactam) (PVCL) and charged poly(N-vinylcaprolactam)-co-methacrylic acid (P(VCL-co-MAA)) microgels were synthesized and further used as emulsifiers to stabilizing emulsion. The P(VCL-co-MAA) microgel has a swelling ratio larger than that of the PVCL microgel in water. The nanomechanical properties of the microgels in water were characterized by atomic force microscopy with using the tip of different radii. The result reveals that the P(VCL-co-MAA) microgel is more deformable than the PVCL counterpart. Stability tests of the emulsions showed that below the volume phase transition temperature (VPTT) of the microgels, both microgel types can stabilize the emulsions under various conditions. Unexpectedly, most of the emulsions still remain stable above the VPTT. Further increasing the temperature to 60 °C, P(VCL-co-MAA) microgel emulsions remained stable at a pH value above the pKa of MAA while the emulsion was unstable below the pKa. However, phase separation occurs in PVCL microgel-stabilized emulsions at 60 °C. These results demonstrate that electrostatic repulsion and deformability of the microgels can enhance the emulsion stability, providing insights into the rational design and preparation of ultrastable Pickering emulsions.
研究领域:
材料科学
·
化学工程
·
软物质物理
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Ruihan Xiang,Baibin Yang,Qiannan Yu,Kefei Wang,Caihong Wang,Yong Wu,Shuai Tan
Developing hydrogel electrolytes with excellent deformability and desirable conductivity is of paramount importance in improving flexible solid-state aqueous energy devices. Herein high-alkali contained poly (sodium acrylate) hydrogel electrolytes with high conductivities, soft deformability, and considerable freezing resistance are designed and developed for flexible Zn-air batteries. The electrolytes are simply prepared by swelling a high content of 5 M KOH solutions within a homogenous crosslinked poly (sodium acrylate) network. The homogenous crosslinked networks in the electrolytes ensure robust fracture toughness (600 J m −2 ) during diverse deformation, while the high content of KOH solutions (80 wt%) enable soft feature of low Young’s modulus (1.4 kPa), desirable ion conductivity (246 mS cm −1 ), and anti-freezing performance (<-30 °C) for the electrolytes. Based on these, the derived Zn-air batteries show satisfactory energy density (0.1 W cm −2 ), multiple flexibility, and wide operating temperatures (−30 °C to r.t.), which are practically applied as flexible energy-consuming devices in different situations. The work here provides a promising approach to develop desirable hydrogel electrolytes for various alkaline energy devices.
研究领域:
材料科学
·
能源技术
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Wenbin Jin,Jingjing Wang,Hai Wan,Yuan Liang,Shuohan Huang,Yuwei Chen,Peng Wei,Qun Shao,Yanping Wang,Yong He,Yumin Xia
With the rapid development of marine transportation, frequent oil leakage will inevitably occur. Therefore, oil–water separation had become an important research topic. The polyoxymethylene (POM) microfiber is a potential oil–water separation material with very good chemical stability, hydrophobicity, and lipophilicity, as well as unique microfiber recyclability and deformability. In this paper, the POM microfiber (PMF) was prepared using a method inspired by natural bamboo cellulose. PMF can be directly used for oil adsorption with a maximum of 19.5 times of oil adsorption capacity (OAC). The water contact angle (WCA) in oil of POM microfiber membrane (PMFM) can reach 160° and the oil–water separation efficiency was more than 99%. In addition, the recyclability allowed the PMF to repeatedly separate the oil–water mixture, and the deformability ensured that it can be used in various oil–water separation situations with different shapes. Moreover, only deionized water was used in the top-bottom preparation strategy of PMF without any chemical reagents. Therefore, this eco-friendly strategy had important implications for the preparation of microfiber materials.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
Soft Matter
·
2015
·Vol. 11
·期 46
·9038-9044
·
IF 4.029
Lianying Wu,Ziqiao Hu,Guangming Chen,Zhibo Li
A convenient green preparation method has been developed to achieve layered double hydroxide (LDH)/polymer nanocomposite (NC) hydrogels. In contrast to previous publications using toxic organic solvent of formamide or methanol in LDH exfoliation or anion exchange, the interlayer anion exchange and exfoliation of LDH are completed in one step with the help of an amino acid (L-serine). The LDH/polyacrylamide (PAM) NC hydrogels are achieved by a convenient exfoliation–adsorption in situ polymerization method. The exfoliation of LDH is characterized by dynamic light scattering and transmission electron microscopy. Interestingly, the developed NC hydrogels reveal ultrahigh deformability and extraordinary stretchability, confirmed by qualitative images and qualitative tensile and compression tests. The molecular mechanism for the ultrahigh deformability and extraordinary stretchability is discussed by crosslinking density, inter-crosslinking molecular weight and swelling tests. We believe that the findings reported herein will deepen our understanding towards the chemistry of network soft materials including gels, and further widen the applications of polymer hydrogels in mechanical devices such as artificial muscles, biomedical devices and drug delivery systems.
研究领域:
材料科学
·
化学工程
·
生物医学工程
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DOI
高影响因子
DRUG DELIVERY
·
2020
·
IF 4.902
Yuqi Yang,Yiyue Guo,You Xu,Yingying Meng,Xing Zhang,Xuejun Xia,YuLing Liu
Deformable nanovesicles (DNVs) have been used in the buccal delivery of biomacromolecules due to their ability to enhance drug penetration. However, no breakthroughs have been made until now due to limited understanding of the factors affecting in vivo buccal delivery. In this study, we designed a series of DNVs, based on an insulin–phospholipid complex (IPC-DNVs), to investigate the influence of drug dose, buccal administration methods, and key quality characteristics of IPC-DNVs for buccal delivery. IPC-DNVs showed a non-linear dose–response relationship between 8 and 12 IU. There was no significant effect of drug delivery site (sublingual mucosa/buccal mucosa) or ligation time (15 or 30 min) on buccal absorption of IPC-DNVs. However, the area above the curve of reduction in blood glucose level overtime (AAC0–6h) for oral mucosa administration was significantly higher than that for buccal mucosa administration. Increasing the drug concentration in IPC-DNVs led to a decrease in AAC0–6h. This might be due to local leakage of DNVs, while squeezing through biological barriers with high concentration of insulin, thus hindering the subsequent delivery of DNVs. IPC-DNVs, measuring 80–220 nm in size, did not significantly affect AAC0–6h. However, when the size was increased to approximately 400 nm, AAC0–6h decreased, thus suggesting that IPC-DNVs with reasonable size were more effective. Additionally, increased deformability of IPC-DNVs might cause drugs to leak easily, thus reducing the promoting effect of buccal absorption. Our results clarified the effect of characteristics of IPC-DNVs on buccal delivery in vivo and provided meaningful support for the design of dosage form of DNVs.
研究领域:
药剂学
·
生物医学工程
·
药物传递系统
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Wenxin Jiang,Wei Xiang,Wei Lu,Dan Yuan,Zhiming Gao,Bing Hu,Yanlei Li,Yuehan Wu,Zhengpeng Feng
Hexadecyltrimethylammonium bromide complexed alginate-Ca 2+ microgels (C/AMGs) were developed as emulsifiers, which shown remarkably improved emulsifying performance than non-complexed alginate-Ca 2+ microgels (AMGs) in previous study. This work focus on the impact of deformability on the emulsifying performance of C/AMGs. By regulating alginate concentration (1.0–4.0 wt%), microgels with different deformability were prepared. Deformability was proved to have great influence on the emulsifying performance of C/AMGs, which was evaluated by Langmuir trough measurements, emulsion appearance, centrifugation stability, digestive behavior, and oxidative stability. Particle size and SEM images indicated microgels prepared with lower alginate concentration are more deformable. C/AMGs (2.0 wt%) exhibits the best emulsifying performance, which could be ascribed to the appreciated deformability and mechanical strength . Digestive behavior and oxidative stability of alginate-Ca 2+ microgel (2.0 wt%) stabilized emulsions were further investigated. Compared with alginate-Ca 2+ microgel (2.0 wt%) stabilized emulsions, C/AMGs (2.0 wt%) stabilized emulsions shown delayed lipid digestion and lower POV. Results of this work supporting that Mickering mechanism have potential in fabricating functional emulsions based on natural polysaccharides .
研究领域:
食品科学
·
生物材料学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2021
·Vol. 36
·期 9
·1835-1845
·
IF 3.089
Chen Changsong,Wu Yihua,Zhu Zhi-Gang,Shih Wan Y.,Shih Wei-Heng
Abstract All-inorganic perovskite materials have many advantages such as adjustable emission range, narrow emission peaks, and good crystallinity, which have attracted widespread interest. They can be used as solar cells, LEDs, photodetectors, displays, and other optoelectronic devices. However, poor environmental stability is the major factor limiting its applications. We introduced a Poly(styrene-ethylene-butylene-styrene) SEBS polymer to create perovskite/SEBS composite films which have excellent stability even in the water environment. Besides, due to the elastic nature of SEBS, the composite films exhibited good mechanical deformability and could maintain most of its fluorescence intensity after being stretched hundreds of times. A WLED device was constructed by stacking CsPbBr 3 /SEBS films and CsPbI 3 /SEBS films over a blue LED. The WLED performed well with color rendering index of 82.6 with chromaticity coordination (0.35, 0.36) and color temperature 4784 K. Graphic Abstract
In order to create a stable and flexible photoluminescent material, we combined a
poly(styrene-ethylene-butylene-styrene) (SEBS) polymer and cesium lead-halide
nanocrystals forming a flexible photoluminescent composite. The composite films
show both good environment stability and excellent flexibility.
研究领域:
材料科学
·
光电技术
·
纳米技术
·
光子学
✓ 已验证
DOI
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 36
·期 9
·2305032
·
IF 29.4
Waner Lin,Ziya Wang,Yingtian Xu,Zhixian Hu,Wenyu Zhao,Zhihao Zhu,Zhenglong Sun,Guoxing Wang,Zhengchun Peng
The perception of object's deformability in unstructured interactions relies on both kinesthetic and cutaneous cues to adapt the uncertainties of an object. However, the existing tactile sensors cannot provide adequate cutaneous cues to self-adaptively estimate the material softness, especially in non-standard contact scenarios where the interacting object deviates from the assumption of an elastic half-infinite body. This paper proposes an innovative design of a tactile sensor that integrates the capabilities of two slow-adapting mechanoreceptors within a soft medium, allowing self-decoupled sensing of local pressure and strain at specific locations within the contact interface. By leveraging these localized cutaneous cues, the sensor can accurately and self-adaptively measure the material softness of an object, accommodating variations in thicknesses and applied forces. Furthermore, when combined with a kinesthetic cue from the robot, the sensor can enhance tactile expression by the synergy of two relevant deformation attributes, including material softness and compliance. It is demonstrated that the biomimetic fusion of tactile information can fully comprehend the deformability of an object, hence facilitating robotic decision-making and dexterous manipulation.
研究领域:
机器人学
·
触觉感知
·
仿生传感器
·
软体机器人
·
材料属性估计
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2021
·Vol. 10
·期 20
·2100985
·
IF 9.933
Yuanyuan Jia,Peiliang Shen,Tao Yan,Weijia Zhou,Jia Sun,Xin Han
Robust isolation of cancer stem cells (CSCs) in a high-throughput, label-free manner is critical for understanding tumor heterogeneity and developing therapeutic strategies targeting CSCs. Cell-mechanics-based microfluidic sorting systems provide efficient and specific platforms for investigation of stem cell-like characteristics on the basis of cell deformability and cell-substrate adhesion properties. In the present study, a microfluidic tandem mechanical sorting system is developed to enrich CSCs with high flexibility and low adhesive capacity. In the integrated microfluidic system, cancer cells are driven by hydrodynamic forces to flow continuously through two featured devices, which are functionalized with sequentially variable microbarriers and surface-coated fluid mixing microchannels, respectively. Collected deformable and low-adhesive cancer cells exhibit enhanced stem cell-like properties with higher stemness and metastasis capacity both in vitro and in vivo, compared with each single device separation. Using these devices, bioactive natural compound screening targeting CSCs is performed and a potent therapeutic compound isoliquiritigenin from licorice is identified to inhibit the lung cancer stem cell phenotype. Taken together, this microfluidic tandem mechanical sorting system can facilitate drug screening targeting CSCs and the analysis of signals regulating CSC function in drug resistance.
研究领域:
生物医学工程
·
癌症生物学
·
药理学
·
细胞生物学
·
药物发现
✓ 已验证
DOI
PubMed
高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Zhaoxia Luo,Liqun Zhang,Yongri Liang,Shipeng Wen,Li Liu
To achieve high deformation under a low electric field intensity is still a big challenge for the dielectric elastomers (DE) potentially used in artificial electronic skin and artificial muscles. Herein, poly-dopamine (PDA) modified 1D barium titanate (BT@PDA) nanofibers and 2D MXene nanosheets with high aspect ratio and large dipole moment were fabricated, and introduced into TPU elastomers. Results showed that the interfacial polarization and micro-capacitor structure formed by MXene sheets lead to the high dielectric constant, and high dielectric loss of MXene/TPU composites with low modulus. The interfacial polarization caused by BT@PDA nanofibers resulting in high dielectric constant and low dielectric loss of BT@PDA/TPU composites with high modulus. Combing the advantages of the two fillers, the MXene/BT@PDA/TPU composites showed high dielectric constant, low dielectric loss, low modulus. The electrical sensitivity factor of 0.5 wt% MXene/5 wt% BT@PDA/TPU composite (11.38) was much higher than the sum of that of 0.5 wt% MXene/TPU (1.73) and 5 wt% BT@PDA/TPU (4.35) composites at a low filler content, showing the 0.5 wt% MXene/5 wt% BT@PDA/TPU dielectric composite had a large deformation under a low electric field. This work can provide an effect strategy to design DE nanocomposites with good deformation performance.
研究领域:
材料科学
·
纳米技术
·
电气工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）