MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
·
2021
·
IF 5.234
Cheng Zhang,Jilai Xue,Xuan Liu,Haipeng Li,Zengjie Wang,Xiang Li,Ying Liu
The deformation and structure stability of graphite cathodes are of importance for its service lifetime. The time dependence and coupling of deformation, elastoplastic property change and microstructure evolution of graphite cathodes were investigated under constant pressure at 940 °C. The deformations from early expansion transiting to the rapid and latter steady creep were found with increased hardness and modulus, in parallel with decreasing interplanar spacing of graphite (002) planes ( d 002 ) and increasing crystallite size along c -axis of graphite lattice ( L c ). The inner fracture among (002) planes may be related to the kink bands structure in graphite. It is clarified that no Na–C intercalation compounds get involved in change of graphite lattice. The crystallite size along a -axis ( L a ) can play an important role in structure stability with deformation-hardening effect on elastoplastic property and pinning effect on creep resistance. The deformation mechanism and the influencing factors on long-term structure stability of graphite cathode are also discussed in detail.
研究领域:
材料科学
·
固体力学
✓ 已验证
DOI
高影响因子
Smart Materials and Structures
·
2024
·Vol. 33
·期 7
·075031
·
IF 3.7
Huilong Jiang,Jincheng Lei,Zishun Liu
Thermo-sensitive hydrogel is a smart soft material that undergoes significant volume deformation in response to temperature changes, making it highly applicable in soft smart actuators. However, traditional thermo-sensitive hydrogel bilayer structures are often characterized by slow response rates and limited unidirectional bending capabilities. To overcome these limitations, a new thermo-sensitive hydrogel bilayer structure with faster response and bidirectional deformation is proposed in this work. This structure consists of two active thermo-sensitive hydrogel layers with different thermo-sensitive effect, in which one shrinks and the other swells when the temperature changes. The hydrogels with the fastest temperature response are identified by optimizing the monomer fraction and used to create the bilayer structure. The deformation states of the dual thermo-sensitive hydrogel bilayer structure are controlled by regulating the phase state of the both layers, resulting in different deformation patterns under varied temperature in experiments. We have established a model to describe the deformation of the bilayer structure. Finally, the capability of the bilayer structure to mimic human body movements and the blooming and wilting of flowers is demonstrated. This work reveals the deformation mechanism for a novel dual thermo-sensitive hydrogel bilayer structure, which holds great significance for the advancement of soft smart actuators.
研究领域:
材料科学
·
软体机器人
·
智能材料
✓ 已验证
DOI
高影响因子
Soft Robotics
·
2025
·
IF 6.1
Chenlong Tang,Hui Ma,Shiyu Wu,Hui Zhang,Wenquan Chen,Yang Zhou,Kun Wei,Xiaojian Li,Fuzhou Niu,Ping Liu,Yuping Duan,Guangli Liu,Tingting Luo,Runhuai Yang
Programmable deformation hydrogel robots have garnered significant attention in biomedical fields due to their ability to undergo large-scale reversible deformation. As clinical demand rises, there is a need for hydrogel robots that are easy to process and operate, and can undergo programmable deformation. Here, we propose a method to fabricate single-layer programmable deformation hydrogel robots in one step using a high-precision digital light processing 3D printing system. Two kinds of deformable elements with different structure distribution on the top and bottom sides are produced by using two kinds of focused light with varying intensities. By combining these deformable elements, we create four basic modules with different and fixed deformable shapes. The desired shape deformation in hydrogel robots can be achieved by programming the combination of these four basic modules. The hydrogel robots exhibit reversible repeat deformation under near-infrared light stimulation. We validate our approach by fabricating several scaffolds using combinations of the four basic modules, demonstrating the feasibility of programming deformation and the potential application of these scaffolds in pipeline movement. This research provides the feasibility for the simple programming deformation of hydrogel robots and offers a novel approach for fabricating programmable deformation hydrogel robots in biomedical fields.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Horizons
·
2023
·Vol. 10
·期 5
·1726-1736
·
IF 13.3
Tianyi Ji,Wei Gong,Jie Zhou,Yangmin Jing,Ruizhe Xing,Bingjie Zhu,Kerui Li,Chengyi Hou,Qinghong Zhang,Yaogang Li,Hongzhi Wang
Rarely are bionic robots capable of rapid multi-dimensional deformation and object identification in the same way as animals and plants. This study proposes a topological deformation actuator for bionic robots based on pre-expanded polyethylene and large flake MXene, inspired by the octopus predation behavior. This unusual, large-area topological deformation actuator (easily reaching 800 cm2 but is not constrained to this size) prepared by large-scale blow molding and continuous scrape coating exhibits different distribution states of molecular chains at low and high temperatures, causing the actuator's deformation direction to change axially. With its multi-dimensional topological deformation and self-powered active object identification capabilities, the actuator can capture objects like an octopus. The contact electrification effect assists the actuator to identify the type and size of the target object during this multi-dimensional topological deformation that is controllable and designable. This work demonstrates the direct conversion of light energy into contact electrical signals, introducing a new route for the practicality and scaling of bionic robots.
研究领域:
材料科学
·
仿生学
·
智能机器人
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DELIVERY
·
2020
·
IF 4.902
Yuqi Yang,Yiyue Guo,You Xu,Yingying Meng,Xing Zhang,Xuejun Xia,YuLing Liu
Deformable nanovesicles (DNVs) have been used in the buccal delivery of biomacromolecules due to their ability to enhance drug penetration. However, no breakthroughs have been made until now due to limited understanding of the factors affecting in vivo buccal delivery. In this study, we designed a series of DNVs, based on an insulin–phospholipid complex (IPC-DNVs), to investigate the influence of drug dose, buccal administration methods, and key quality characteristics of IPC-DNVs for buccal delivery. IPC-DNVs showed a non-linear dose–response relationship between 8 and 12 IU. There was no significant effect of drug delivery site (sublingual mucosa/buccal mucosa) or ligation time (15 or 30 min) on buccal absorption of IPC-DNVs. However, the area above the curve of reduction in blood glucose level overtime (AAC0–6h) for oral mucosa administration was significantly higher than that for buccal mucosa administration. Increasing the drug concentration in IPC-DNVs led to a decrease in AAC0–6h. This might be due to local leakage of DNVs, while squeezing through biological barriers with high concentration of insulin, thus hindering the subsequent delivery of DNVs. IPC-DNVs, measuring 80–220 nm in size, did not significantly affect AAC0–6h. However, when the size was increased to approximately 400 nm, AAC0–6h decreased, thus suggesting that IPC-DNVs with reasonable size were more effective. Additionally, increased deformability of IPC-DNVs might cause drugs to leak easily, thus reducing the promoting effect of buccal absorption. Our results clarified the effect of characteristics of IPC-DNVs on buccal delivery in vivo and provided meaningful support for the design of dosage form of DNVs.
研究领域:
药剂学
·
生物医学工程
·
药物传递系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science Advances
·
2022
·Vol. 8
·期 18
·
IF 14.957
Yi Pan,Zhenyu Yang,Chang Li,Sammer Ul Hassan,Ho Cheung Shum
The healthy functioning of the plants’ vasculature depends on their ability to respond to environmental changes. In contrast, synthetic microfluidic systems have rarely demonstrated this environmental responsiveness. Plants respond to environmental stimuli through nastic movement, which inspires us to introduce transformable microfluidics: By embedding stimuli-responsive materials, the microfluidic device can respond to temperature, humidity, and light irradiance. Furthermore, by designing a foldable geometry, these responsive movements can follow the preset origami transformation. We term this device TransfOrigami microfluidics (TOM) to highlight the close connection between its transformation and the origami structure. TOM can be used as an environmentally adaptive photomicroreactor. It senses the environmental stimuli and feeds them back positively into photosynthetic conversion through morphological transformation. The principle behind this morphable microsystem can potentially be extended to applications that require responsiveness between the environment and the devices, such as dynamic artificial vascular networks and shape-adaptive flexible electronics.
研究领域:
植物学
·
微流控技术
·
材料科学
·
仿生工程
·
光子器件
✓ 已验证
DOI
高影响因子
Current Drug Delivery
·
2024
·Vol. 22
·期 4
·479-491
·
IF 2.8
Teng Guo,Chenming Zhang,Yuling Chen,Yihan Wu,Zhenda Liu,Yongtai Zhang,Nianping Feng
BackgroundAdding a suitable surfactant can enhance the transdermal permeability of transethosomes while also leveraging its functionality as a functional material. In this study, transethosomes were prepared using D-α-tocopherol acid polyethylene glycol succinate (TPGS) as edge activators for transdermal delivery of curcumin (Cur).MethodsThe TPGS-mediated curcumin-loaded transethosomes (Cur@TES) were prepared and formulated optimally, and the optimized formulations were characterized for their morphology, particle size, entrapment efficiency (EE) and drug loading (DL). The stability and deformability of Cur@TES were investigated, while the transdermal delivery of Cur@TES was investigated through in vitro transdermal assays and fluorescence imaging. A mouse ear swelling model was performed to determine the anti-inflammatory effect of Cur@TES.ResultsCur@TES appeared round or elliptical in shape. The particle size, EE and DL for the optimized formulation were observed as 131.2 ± 7.2 nm, 97.68 ± 2.26%, and 6.58 ± 0.62%, respectively. X-ray diffraction analysis confirmed the formation of disordered structures in the inner core of the vesicles. Moreover, Cur@TES system demonstrated better stability and deformability compared to the curcumin-loaded ethosomes (Cur@ES). In vitro transdermal experiments demonstrated that Cur@TES significantly increased the amount of drug retained in the skin (P<0.05). Fluorescence imaging confirmed that the skin distribution was distinctly enhanced with the delivery by TPGS mediated transethosomes. In addition, Cur@TES showed a significant inhibitory effect on Inflammatory swelling in the mouse ear-swelling model.ConclusionTPGS-mediated transethosomes exhibit significant transdermal advantages and enhanced anti-inflammatory effects, providing a new perspective for the transdermal delivery of curcumin.
研究领域:
药剂学
·
生物医学工程
✓ 已验证
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Libo Zhu,Zhen Zhang,Quanjun Liu
With the development in DNA self-assembly technology, DNA origami nanostructures have been widely applied in biomedical research. Solid-state nanopores represent an emerging single-molecule sensing platform for studying nanostructures with arbitrary dimensions and physical characteristics, including DNA origami. Here, we employed relatively narrow silicon nitride nanopores to detect the deformation and translocation of DNA origami nanoplates with dimensions of approximately 60 × 54 nm. We performed translocation experiments using three nanopore diameters that are all smaller than the plat dimensions. Analysis of current blockade signals and the representative events reveals three types of translocation orientations for the nanoplates. Furthermore, by studying the electrical signal characteristics (current change and dwell time) for the different diameter pores, we obtained information about the translocation behaviors for the DNA nanoplates through different constrictions. Our investigation provides an approach to analyze the deformation and translocation of DNA origami structures.
研究领域:
生物物理学
·
纳米技术
·
单分子检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 3
·433
·
IF 4.967
Chuanbo Liu,Shutian Liu,Conglin Dong,Chengqing Yuan,Xiuqin Bai
Reducing the deformation of polymer matrix materials can decrease the fluctuation of coefficient of friction (COF), and friction-induced vibration and its amplitudes. HDPE composites with T-ZnOw as a fixed strengthening filler were modified with the addition of Si3N4particles at different concentrations. The COFs, wear rates, micro-morphologies, and friction-induced vibrations were obtained by conducting sliding tests against carbon steel balls in an aqueous environment at a low velocity and high load. The mechanism of the reduction in frictional fluctuation due to the addition of Si3N4particles was revealed through the frictional responses. The results demonstrated that 4 wt% addition of Si3N4in HDPE can enhance the strain–stress property and improve the lubrication by forming a lubricating film. Therefore, the surface deformation and the fluctuations of COFs and its vibrations were reduced. The aggregation phenomenon and reduced strain–stress response at a high concentration of Si3N4disrupted the positive fluctuating reduction, and resulted in a rough surface with severe tearing and cracking deformations. Additionally, it led to fluctuating wear behaviors with high COF and vibrations. The results obtained in this study can elucidate the effects of adding Si3N4particles to enhance lubrication in polymer composites. Additionally, the results provide a new research method for designing and manufacturing polymer-based composites with low friction-induced fluctuations.Keywords:HDPE composite;Si3N4;surface deformation;fluctuation reduction
研究领域:
材料科学
·
摩擦学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Zheng Wang,Feng Xu,Di Wu,Wei Huang,Zhiqin Chu,Yuan Lin
Cells need to migrate through confined spaces during processes such as embryo development and cancer metastasis. However, the fundamental question of how confinement size and surrounding rigidity collectively regulate the migration capability of cells remains unclear. Here, by utilizing maskless photolithography with a digital micromirror device (DMD), a microchannel with precisely controlled width and wall stiffness (similar to those exhibited by natural tissues) is fabricated. We find that increasing the rigidity of the confining wall leads to a more reduced nuclear volume but has no detectable influence on the myosin expression level in the cells. More interestingly, a biphasic trend of the cell speed is observed, with the migration velocity reaching its minimum at an intermediate wall rigidity of ∼10 kPa. A motor-clutch-based pulling race model is then proposed, which suggests that such biphasic dependence is due to the fact that a very soft channel wall will result in small deformation of the nucleus and consequently reduced cell-wall friction, while larger myosin-based crawling force can be triggered by a stiff confining boundary, both leading to a relatively high migration speed. These findings could provide critical insights into novel strategies for controlling the movement of cells and the design of high-performance biological materials.
研究领域:
细胞生物学
·
生物力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Mofan Li,Donghai Yang,Lei Tian,Haotian Liu,Liangyu Cai,Limin He
Combining a magnetic field with an electric field offers a promising approach for enhancing oil–water separation, yet its underlying mechanisms are not fully understood. We systematically investigated the dynamic deformation of salt-containing water droplet suspended in oil under an electric–magnetic coupling field. Integrating high-speed camera experiments with molecular dynamics simulations, we found that the dynamic response amplitude of droplet is reduced compared to a single electric field. Our analysis suggests that ions deflect under electric–magnetic coupling, affecting ion enrichment and water molecule polarization, thereby weakening droplet tip charge and induced electric forces, which suppresses droplet deformation. Increasing the electric capillary number and ion concentration enhances suppression, whereas improving the electric field frequency to 500 Hz almost eliminates this suppression effect. Notably, the degree of droplet deformation inhibition remains consistent across different viscosity ratios. These research findings offer insights for designing dehydrators to intensify oil–water separation.
研究领域:
物理学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MULTIPHASE FLOW
·
2019
·
IF 2.829
Xin Huang,Limin He,Xiaoming Luo,Haoran Yin,Donghai Yang
Deformation and coalescence behaviors of water droplets in viscous fluid under a direct current electric field are investigated with experiments and numerical simulations. An electro-hydrodynamic model is developed based on fluid dynamics equations and electrostatic equations. A coupled level set and volume of fluid method is proposed to capture the dynamic interface. The numerical results are validated to be in good accordance with classic results in the literature. The effects of electric capillary number Ca and viscosity ratio λ on droplet deformation and coalescence are systematically analyzed. Two different droplet response modes are obtained, namely overdamping response and underdamping response. The conversion of response modes is discussed with the ( Ca, λ ) phase diagram. Moreover, the distributions of electric field and flow field before and after the droplets contact are compared and analyzed. Numerical results show the time evolution of liquid bridge is dominated by the interfacial tension and viscosity of continuous phase. The electric stress is extremely weak at the liquid bridge and has a slight influence on evolution of liquid bridge. The correlation formula between dimensionless liquid bridge radius and conical angle during the growth of liquid bridge is regressed. These results are helpful for the optimization of electro-coalescence process.
研究领域:
流体力学
·
电动力学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）