Pharmaceutics
·
2019
·Vol. 11
·期 10
·539
·
IF 4.773
You Xu,Yiyue Guo,Yuqi Yang,Yingying Meng,Xuejun Xia,Yuling Liu
Deformable nanovesicles have been extensively investigated due to their excellent ability to penetrate biological barriers. However, suffering from serious physical and chemical instabilities, the wide use of deformable nanovesicles in medical applications is still limited. Moreover, far less work has been done to pursue the lyophilization of deformable nanovesicles. Here, we aimed to obtain stable deformable nanovesicles via freeze-drying technology and to uncover the underlying protection mechanisms. Firstly, the density of nanovesicles before freeze-drying, the effect of different kinds of cryoprotectants, and the types of different reconstituted solvents after lyophilization were investigated in detail to obtain stable deformable nanovesicles based on insulin-phospholipid complex (IPC-DNVs). To further investigate the underlying protection mechanisms, we performed a variety of analyses. We found that deformable nanovesicles at a low density containing 8% lactose and trehalose in a ratio of 1:4 (8%-L-T) have a spherical shape, smooth surface morphology in the lyophilized state, a whorl-like structure, high entrapment efficiency, and deformability after reconstitution. Importantly, the integrity of IPC, as well as the secondary structure of insulin, were well protected. Accelerated stability studies demonstrated that 8%-L-T remained highly stable during storage for 6 months at 25 °C. Based on in vivo results, lyophilized IPC-DNVs retained their bioactivity and had good efficacy. Given the convenience of preparation and long term stability, the use of combined cryoprotectants in a proper ratio to protect stable nanovesicles indicates strong potential for industrial production.Keywords:deformable nanovesicles;combination;cryoprotectant;mechanism;insulin
研究领域:
药剂学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Linlin Hu,Xudong Zhang,Bing Li,Mihan Jin,Xiaohui Shen,Zongwu Luo,Zhanyuan Tian,Lizhi Yuan,Junkai Deng,Zhengfei Dai,Jiangxuan Song
Although silicon has the highest theoretical capacity among the existing anode materials, its practical application is highly hindered by huge interface stress arising from large volume change upon cycling. Herein, an efficient energy-dissipation engineering was harnessed on high-capacity silicon anodes through a synergized “static” (chemically crosslinking) and “dynamic” (physically crosslinking) binder. In this dual network, the disassociation of non-covalent hydrogen bonds greatly facilitates the dispersion and release of unfavorable stress, while the permanent chemical bonding network enables a deformable network to sustain the electrode structure. Such a strategy effectively avoids both materials and electrodes deterioration and promises a better Si-based anode: a high areal capacity of 2 mAh cm −2 with capacity retention of 91.3% after 200 cycles. Meanwhile, the energy-dissipation mechanism was further clarified by temperature-dependent FTIR and finite element simulations.
研究领域:
材料科学
·
电化学
·
锂离子电池
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xueqi Li,Ziqiang Shang,Yaoxing Wang,Jiuqing Liu,Yanjun Xie,Jian Li,Yiqi Liu,Wentao Gan
Magnetic soft robots composed of stimuli-responsive materials are promising for biomedical engineering applications; however, typical responsive materials are fabricated with nondegradable polymeric substrates. In this study, we report a flexible, biodegradable, and magnetically sensitive cellulose film (M-film) that can be utilized for magnetically controllable soft robots (M-robots) with programmable locomotion, cargo delivery, and remote wireless operation functions. The M-film with good foldability, origami, and magnetic properties is synthesized by a simple paper-making process using cellulose nanofibers, additive sodium alginate, and BaFe12O19 particles. Through the following origami–magnetization process, the M-robot with multimodal movements is designed: climbing over the obstacles in the walking environment; additionally, this process can complete various cargo transport tasks by clawing, rolling, and flipping. This approach expands the precise controllability and manipulability of environmentally friendly cellulose nanomaterials beyond the known applications and opens the prospects of their implementation in stimuli-responsive robots, wireless control electronics, and intelligent devices.
研究领域:
材料科学
·
生物医学工程
·
机器人学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Advances
·
2023
·Vol. 4
·期 4
·1196-1201
·
IF 5
Yuanyuan Chen,Yunqi Shi,Min Liang,Huiliang Wang
Shape deformable hydrogels have wide potential applications in soft robotics, artificial muscles, manipulators and flexible devices. The development of simple, facile and efficient methods for preparing shape deformable hydrogels is of significant importance for their practical applications. In this work, we proposed a novel strategy to transform isotropic hydrogels into shape deformable hydrogels by altering the surface areas and hence the swelling behaviours of hydrogels. Simple scratching and photolithography patterning methods are employed to introduce grooves or projections on the surface of hydrogels. By controlling the density and direction of scratches, or the width, density, height and direction of the stripes, the degree and direction of the bending and twisting of the hydrogel can be adjusted. Taking the advantages of the photolithography method, more precise and complex patterns can be introduced onto hydrogel samples with different shapes; therefore, more complex shape deformations from 2D to 3D can be achieved. The strategy of changing surface area to endow isotropic hydrogels with shape deformation behaviour can be applied to a wide variety of hydrogels and many methods can be employed; therefore, it is of great significance for many practical applications.
研究领域:
材料科学
·
软体机器人技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2022
·
IF 4.855
Jin Zhao,Ji-Dong Liu,Haixia Shen,Min Guo,Qing Li,Cai-Feng Wang,Chang Liu,Su Chen
The hydrogel artificial muscle has demonstrated enormous potential in various applications, such as soft robotics and actuators. However, the poor mechanical properties have always limited the practical applications of hydrogels. Here, we designed a Zr4+ coordinated and vinyl hybrid silica nanoparticle (VSNP) grafted poly(acrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic acid) (VSNP@poly(AM-co-AMPS)-Zr4+) via frontal polymerization (FP). Benefiting from the synergistic effect of the polymer–nanocomposite interaction (VSNP nanocomposite) and metal ion–ligand interactions (Zr4+–sulfonate group coordination), the mechanical properties of hydrogels can be extremely improved. In addition, a deformable hydrogel with gradient structure and swelling ratio was designed through introducing Zr4+ to one side of the hydrogel, which can serve as an artificial muscle to accomplish multiple moving activities, such as bending and grabbing. This work offers an easy-to-perform strategy to construct mechanically strong hydrogels, which might promote the development of artificial muscle materials.
研究领域:
材料科学
·
软体机器人
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yun Zhao,Shuo Chen,Mengxin Guan,Bin Ding,Jianyong Yu,Jianhua Yan
The high reactivity of Li-anodes and the easily separated solid-state interface are two hurdles for constructing stable solid-state Li-metal batteries (SSLBs). Herein, we report a 3D mixed ion–electron conductive (MIEC) Li anode with deformable molten interphase of poly(Ɛ-caprolactone) electrolytes that is highly efficient towards constructing stable SSLBs. The 3D Li anode is fabricated by integrating a Li foil with a MIEC film via a facile hot-rolling process, in which the MIEC frame is composed of Li 0.33 La 0.56 TiO 3 particle attached carbon nanofibers . We propose that the chemical reactions between Li 0.33 La 0.56 TiO 3 and Li facilitates Li-nucleation inside the MIEC frame and thus enables fast stress relaxation and reduces volume fluctuations, while the molten interphase works as a binder to integrate the anodes and electrolytes without delamination during cycling. As a result, the symmetrical batteries run stably for 1200 h at 45 ℃, and the 3D Li/LiFePO 4 full batteries achieve a capacity of 134 mA h g −1 at 1C with a high-capacity retention of 98 % after 250 cycles, showing appealing commercial prospect.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 30
·e54105
·
IF 3
Yan Zhou,Xiaolin Pu,Lu Liu,Lei Wang
The conventional filtration loss reducers, which help reduce the invasion into the formation, often make the rheology of the oil-based drilling fluid difficult to control. In this paper, the new type of porous deformable polymeric particle was synthesized as filtration loss reducer (FLR), through dispersion polymerization using acrylamide and stearyl methacrylate. Fourier transform infrared spectroscopy, differential scanning calorimeter, thermogravimetric analysis, contact angle apparatus, nitrogen adsorption/desorption techniques and scanning electron microscope have been carried out to confirm the chemical structure of the FLR. The results illustrated that FLR is a hydrophobic porous solid particle with deformability. The oil-based drilling fluid loaded with FLR retains high temperature resistance up to 180°C and the density of 2.2 g/cm 3 . The FLR help reduced the filtration loss to 3.2 mL, smaller than their counterparts, and synthesized FLR has small impact on the rheology of drilling fluids.
研究领域:
材料科学
·
石油工程
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITE STRUCTURES
·
2021
·
IF 5.407
Wentong Yang,Xiaoming Qi,Jiawen Sun,Laiming Yu,Yubing Dong,Yaqin Fu,Yaofeng Zhu
In this work, a novel deformable honeycomb sandwich composite felt (DCF) was fabricated through dipping method that using polyester felt (PET-F) as matrix, water-borne epoxy resin mixed with self-made microwave absorbent as microwave absorbing coating. The DCF with honeycomb-like sandwich structure possesses enhanced mechanical properties and excellent microwave absorption (MA) performance. In addition, the components of coating also endow DCF with shape memory behavior which makes it more suitable for various scenarios. The minimum reflection loss of the DCF with the optimal comprehensive performance can reach −55.90 dB with the thickness of only 1.4 mm and the effective absorption bandwidth is 4.87 GHz. The excellent MA performance of DCF is attributed to the well impedance matching and strong loss characteristics, which is closely related to moderate conductive network, multiple loss mechanism and special structural. This work may have reference significance for the practical application of MA materials.
研究领域:
材料科学
·
电磁学
✓ 已验证
DOI
高影响因子
DRUG DELIVERY
·
2020
·
IF 4.902
Yuqi Yang,Yiyue Guo,You Xu,Yingying Meng,Xing Zhang,Xuejun Xia,YuLing Liu
Deformable nanovesicles (DNVs) have been used in the buccal delivery of biomacromolecules due to their ability to enhance drug penetration. However, no breakthroughs have been made until now due to limited understanding of the factors affecting in vivo buccal delivery. In this study, we designed a series of DNVs, based on an insulin–phospholipid complex (IPC-DNVs), to investigate the influence of drug dose, buccal administration methods, and key quality characteristics of IPC-DNVs for buccal delivery. IPC-DNVs showed a non-linear dose–response relationship between 8 and 12 IU. There was no significant effect of drug delivery site (sublingual mucosa/buccal mucosa) or ligation time (15 or 30 min) on buccal absorption of IPC-DNVs. However, the area above the curve of reduction in blood glucose level overtime (AAC0–6h) for oral mucosa administration was significantly higher than that for buccal mucosa administration. Increasing the drug concentration in IPC-DNVs led to a decrease in AAC0–6h. This might be due to local leakage of DNVs, while squeezing through biological barriers with high concentration of insulin, thus hindering the subsequent delivery of DNVs. IPC-DNVs, measuring 80–220 nm in size, did not significantly affect AAC0–6h. However, when the size was increased to approximately 400 nm, AAC0–6h decreased, thus suggesting that IPC-DNVs with reasonable size were more effective. Additionally, increased deformability of IPC-DNVs might cause drugs to leak easily, thus reducing the promoting effect of buccal absorption. Our results clarified the effect of characteristics of IPC-DNVs on buccal delivery in vivo and provided meaningful support for the design of dosage form of DNVs.
研究领域:
药剂学
·
生物医学工程
·
药物传递系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Jian Chen,Youlong Hua,Binjie Jin,Zhan Zhu,Mengru Zhang,Yuhua Zhang,Renan Jin,Xiao Liang,Ruijue Cao,Xinben Hu,Xingkun Man,Li Xi,Baochun Guo,Bingfeng Ju,Qian Zhao
Couplant is indispensable for ultrasound examinations. However, shape adaptability and operational feasibility, which are both crucial, cannot be provided conjointly by existing couplants due to their either liquid or solid form. Here an ideal couplant composed of fibers and dynamically cross-linked polysilicone is reported, which exhibits a unique solid-to-fluid transition upon application of stress exceeding a threshold. Together with the acoustically transparent feature, the particularity of the stress-triggered fluidity allows conformal adapting to arbitrary geometries under stress exertion and stable preserving for long-term and reliable ultrasound examination after stress release. Steeply curved geometries and pressure-sensitive tissues, which are extremely challenging for the state-of-the-art ultrasound modalities, are successfully graphed or treated. This couplant integrates the merits of liquids and solids, providing new opportunities for various ultrasound in industrial and medical fields.
研究领域:
生物医学工程
·
超声医学
·
材料科学
·
柔性电子
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xiao-Fang Hou,Xu-Man Chen,Hari Krishna Bisoyi,Qi Qi,Tianchi Xu,Dongzhong Chen,Quan Li
Developing an artificial dynamic nanoscale molecular machine that dissipatively self-assembles far from equilibrium is fundamentally important but is significantly challenging. Herein, we report dissipatively self-assembling light-activated convertible pseudorotaxanes (PRs) that show tunable fluorescence and enable deformable nano-assemblies. A pyridinium-conjugated sulfonato-merocyanine derivative (EPMEH) and cucurbit[8]uril (CB[8]) form the 2EPMEH ⊂ CB[8] [3]PR in a 2:1 stoichiometry, which phototransforms into a transient spiropyran containing 1:1 EPSP ⊂ CB[8] [2]PR when exposed to light. The transient [2]PR thermally relaxes (reversibly) to the [3]PR in the dark accompanied by periodic fluorescence changes that include near-infrared emission. Moreover, octahedral and spherical nanoparticles are formed through the dissipative self-assembly of the two PRs, and the Golgi apparatus is dynamically imaged using fluorescent dissipative nano-assemblies.
研究领域:
化学
·
纳米技术
·
分子机器
·
材料科学
·
生物物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Materials Letters
·
2021
·
IF 8.312
Jiaxue Zhang,Qianying Lu,Yanyan Li,Tingyu Li,Ming-Hui Lu,Yan-Feng Chen,Desheng Kong
Stretchable optoelectronics represent an emerging technology featuring soft mechanical properties. The advancements in this active area rely on the development of compliant electronic materials. Currently, the deformable forms of light-emitting devices often exhibit double-side emissions due to the lack of stretchable reflective electrodes. This study reports a facile procedure to deposit smooth and uniform liquid metal films over large-area elastomeric substrates as stretchable reflective electrodes. The as-prepared electrodes exhibit low sheet resistance (0.15 Ω sq–1), high optical reflectance (95% at 550 nm), and ultrahigh deformability (500% strain). The electrode shows sufficient durability to survive repetitive tensile deformations. Successful implementation of a liquid metal electrode in a stretchable light-emitting device achieves single-side emission with enhanced light extraction. The stretchable reflective electrode reported here represents a key building component to enable a broad range of applications such as deformable lighting, wearable displays, and soft robotics.
研究领域:
材料科学
·
光电子学
·
可穿戴技术
·
软体机器人
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）