ACS Applied Materials & Interfaces
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2024
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IF 8.3
Jia-Wei Cai,Jing-Ting Ye,Ya-Nan Zhong,Zhong-Da Zhang,Hao Zong,Li-Xing Li,Xue-Er Han,Jian-Long Xu,Xu Gao,Shuit-Tong Lee,Sui-Dong Wang
In the vanguard of neuromorphic engineering, we develop a paradigm of biocompatible polymer memcapacitors using a seamless solution process, unleashing comprehensive synaptic capabilities depending on both the stimulation form and history. Like the human brain to learn and adapt, the memcapacitors exhibit analogue-type and evolvable capacitance shifts that mirror the complex flexibility of synaptic strengthening and weakening. With increasing frequency and intensity of the stimulation, the memcapacitors demonstrate an evolution from short-term plasticity (STP) to long-term plasticity (LTP), and even to metaplasticity (MP) at a higher level. A physical picture, featuring the stimulus-controlled spatiotemporal ion redistribution in the polymer, elaborates the origin of the memcapacitive prowess and resultant versatile synaptic plasticity. The distinctive MP behavior endows the memcapacitors with a dynamic learning rate (LR), which is utilized in an artificial neural network. The superiority of implementing a dynamic LR compared with conventional practices of using constant LR shines light on the potential of the memcapacitors to exploit organic neuromorphic computing hardware.
研究领域:
神经形态工程
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材料科学
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生物医学工程
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 11
·1908901
·
IF 16.836
Fumin Ma,Yangbin Zhu,Zhongwei Xu,Yang Liu,Xiaojing Zheng,Songman Ju,Qianqian Li,Ziquan Ni,Hailong Hu,Yang Chai,Chaoxing Wu,Tae Whan Kim,Fushan Li
Simulating the human brain for neuromorphic computing has attractive prospects in the field of artificial intelligence. Optoelectronic synapses have been considered to be important cornerstones of neuromorphic computing due to their ability to process optoelectronic input signals intelligently. In this work, optoelectronic synapses based on all-inorganic perovskite nanoplates are fabricated, and the electronic and photonic synaptic plasticity is investigated. Versatile synaptic functions of the nervous system, including paired-pulse facilitation, short-term plasticity, long-term plasticity, transition from short- to long-term memory, and learning-experience behavior, are successfully emulated. Furthermore, the synapses exhibit a unique memory backtracking function that can extract historical optoelectronic information. This work could be conducive to the development of artificial intelligence and inspire more research on optoelectronic synapses.
研究领域:
神经形态计算
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光电子学
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材料科学
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人工智能
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纳米技术
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DOI
高影响因子
Nature Communications
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2023
·Vol. 14
·期 1
·1-11
·
IF 16.6
Zhang Yuchun,Liu Lin,Tu Bin,Cui Bin,Guo Jiahui,Zhao Xing,Wang Jingyu,Yan Yong
Shrinking the size of the electronic synapse to molecular length-scale, for example, an artificial synapse directly fabricated by using individual or monolayer molecules, is important for maximizing the integration density, reducing the energy consumption, and enabling functionalities not easily achieved by other synaptic materials. Here, we show that the conductance of the self-assembled peptide molecule monolayer could be dynamically modulated by placing electrical biases, enabling us to implement basic synaptic functions. Both short-term plasticity (e.g., paired-pulse facilitation) and long-term plasticity (e.g., spike-timing-dependent plasticity) are demonstrated in a single molecular synapse. The dynamic current response is due to a combination of both chemical gating and coordination effects between Ag + and hosting groups within peptides which adjusts the electron hopping rate through the molecular junction. In the end, based on the nonlinearity and short-term synaptic characteristics, the molecular synapses are utilized as reservoirs for waveform recognition with 100% accuracy at a small mask length.
研究领域:
神经科学
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材料科学
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纳米技术
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电子学
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产品关联
DOI
PubMed
高影响因子
Device
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2025
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IF 8
Chengpeng Jiang,Honghuan Xu,Wenbo Wang,Lu Yang,Jiaqi Liu,Yao Ni,Xinyu Ye,Yu Zhang,Taoyu Zou,Kuniharu Takei,Wentao Xu
The majority of existing neuromorphic platforms focus on sensory fusion or recognition and lack the ability to identify relationships between multimodal inputs. Here, we developed an artificial synaptic cluster to realize an artificial neuromorphic multisensory inference system. This system comprises two laterally integrated synaptic transistors with shared electrolyte gates. The polycrystalline InZnO channel facilitates ionic modulation for short-term plasticity (STP), while the Au nanocrystal-based channel introduces discrete charge-trapping sites for long-term plasticity (LTP), enabling simultaneous multi-timescale synaptic processing. This mixed-plasticity architecture emulates the transient and persistent memory behaviors of biological synapses and evaluates the spatiotemporal alignment of infrared and ultrasonic sensory signals for hardware-level causal inference. Without external training or neural networks, the system achieves 95.3% and 94.2% accuracy in multisensory object classification and causal inference, respectively.
研究领域:
神经形态工程
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人工智能
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神经网络
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材料科学
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电子工程
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感知处理
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认知计算
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DOI
高影响因子
Journal of Physical Chemistry Letters
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2024
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IF 4.8
Chuanyu Fu,Mengjiao Pei,Hangyuan Cui,Shuo Ke,Yixin Zhu,Changjin Wan,Qing Wan
Nanofiber neuromorphic transistors are regarded as promising candidates for mimicking brain-like learning and advancing high-performance computing. Composite nanofibers (CNFs) typically exhibit enhanced optoelectronic and mechanical properties. In this study, indium–gallium–zinc oxide (IGZO)/polyvinylpyrrolidone (PVP) CNFs were synthesized, and the neuromorphic transistor was integrated on both rigid and flexible substrates. The learning behavior, characterized by the transition from short-term plasticity (STP) to long-term plasticity, was achieved through photoelectric stimulation of the rigid neuromorphic transistor. The nonlinear STP was simulated by the flexible neuromorphic transistor through electrical pulses, matching effectively with a reservoir computing (RC) system. Hand gesture recognition with little energy consumption (49 pJ per reservoir state) and a maximum accuracy of 92.86% has been achieved by the RC system, proving the substantial potential of the IGZO/PVP CNF neuromorphic transistor for wearable intelligent processing tasks.
研究领域:
神经形态工程
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纳米技术
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光电子学
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人工智能
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柔性电子学
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储层计算
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DOI
高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 9
·3213-3226
·
IF 6.4
Zihong Shen,Zunxian Yang,Yuanqing Zhou,Yuliang Ye,Bingqing Ye,Qiaocan Huang,Wenbo Wu,Hongyi Hong,Zeqian Hong,Zongyi Meng,Zhiwei Zeng,Songwei Ye,Zhiming Cheng,Qianting Lan,Jiaxiang Wang,Ye Chen,Hui Zhang,Tailiang Guo,Yun Ye,Zhenzhen Weng,Yongyi Chen
Artificial photonic synapses, owing to their high sensitivity, low power consumption, and integration of sensing and memory, have aroused comprehensive discussion and have been developed into devices used as the new sensors for the Internet of Things (IoT) and artificial neural networks (ANNs). Colossal energy consumption may be one of the factors hindering the development of neuromorphic computing. Herein, ternary component organic array films of TIPS-pentacene, polystyrene, and CsPbBr3 perovskite quantum dots (QDs) are effectively developed to fabricate photonic synaptic transistors. The patterned organic thin films prepared by the solution processes can be distinctly controlled in the crystallographic orientation using a pre-patterned-guided crystallizing strategy and the corresponding transistor of TIPS-pentacene with mobility over 1 cm2 V−1 s−1 is successfully achieved. On this basis, the ternary composite film exhibits synaptic behaviours from short-term plasticity (STP) to long-term plasticity (LTP), including paired-pulse facilitation (PPF), spike-time-dependent plasticity (STDP), spike-number-dependent plasticity (SNDP), spike-frequency dependent plasticity (SFDP) and light-potentiation/electric-depression. Benefiting from the improved material compatibility and film-forming properties of small molecule semiconductors and perovskite QDs with polymer polystyrene, our synapses still exhibit prominent synaptic features at a low power consumption of 0.036 fJ. Utilizing time-dependent plasticity, the synaptic device stimulated by a series of light signals realizes wireless optical communication. In addition, the pattern recognition function by ANNs is verified. This work provides a feasible fabricating path to patterned array film-based photonic synapses for the next generation human–computer interaction sensors.
研究领域:
材料科学
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类脑计算
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光电技术
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人工智能
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2025
·
IF 8.2
Juan Gao,Qin Gao,Jiangshun Huang,Xueli Geng,Pengzhan Li,Yihang Liu,Qiaofeng Yang,Hao Zhang,Mei Wang,Zhisong Xiao,Paul K. Chu,Ruifeng Lu,Anping Huang
Low-power and color-sensitive neuromorphic vision systems are critical to the next generation of intelligent devices. Here, we report a coral-inspired, lead-free synaptic device based on Cs3Bi2Br9 perovskite nanocrystals prepared by centrifugal casting into a porous thin film. The device exhibits wavelength-dependent plasticity under 405, 520, and 635 nm illumination without an external bias. By modulating the light wavelength and intensity, short-term and long-term synaptic plasticity are achieved to mimic excitatory, inhibitory, and saturating biological responses. Structural and spectroscopic analyses reveal that bromine vacancies play a key role in the dynamic modulation of carrier transport and plasticity evolution. The efficient preprocessing of RGB visual information significantly enhances recognition accuracy in artificial neural network devices. This wavelength-specific modulation of synaptic plasticity, a novel approach for color image preprocessing and recognition, is very promising for the advancement of neuromorphic systems.
研究领域:
神经形态工程
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光电子学
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材料科学
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人工智能硬件
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光子学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
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2025
·
IF 7.7
Xiang Zuo,Huijuan Bai,Jinyu Qiu,Ruimin Li,Xiaochen Kuang,Yudi Zhao,Jingyi Tuo,Qili Zhao,Xin Zhao,Xizeng Feng
Anxiety Disorder is a common neurological disorder for which ubiquitous environmental endocrine disruptors may be risk factors. 17β-trenbolone (17-TB) has been recognized as a potential environmental endocrine disruptor and its neurotoxic effects have attracted attention. Tachykinin receptor 3 (TACR3), a G protein-coupled receptor involved in pubertal anxiety, and its underlying neural mechanisms remain enigmatic. Therefore, this study investigated the possible relationship between 17-TB and TACR3, testosterone (T), and synaptic plasticity. Our results showed that adolescent male Balb/c mice developed significant anxiety-like behavior after four weeks of exposure to environmentally relevant concentrations of 17-TB (100 μg/kg/day). Transcriptomic RNA-Seq results showed that 17-TB affected abnormal synaptic transmission signals in the hippocampus. Electrophysiological results showed that 17-TB reduced the activity of hippocampal dentate gyrus (DG) neurons and led to the downregulation of hippocampal TACR3 and T levels. In addition, Western blot, immunohistochemistry, ELISA, and qRT-PCR showed that 17-TB exposure led to the downregulation of key hippocampal synaptic proteins PSD95, Gephyrin, and Syn, and induced a metabolic imbalance in glutamate (Glu)/GABA signaling, affecting dopamine signaling. Interestingly, testosterone supplementation (10 mg/kg/day) was effective in ameliorating the above phenomena and alleviating anxiety-like behaviors. These results suggest that 17-TB modulates anxiety-related synaptic plasticity by regulating hippocampal TACR3 and T interactions in vivo. In conclusion, our study contributes to understanding the neurobehavioral and potential mechanistic effects of environmental 17-TB exposure in mammals. It alerts the public to the health risks of chemicals to mammals and suggests new research directions and potential therapeutic targets.
研究领域:
神经科学
·
毒理学
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内分泌学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
·
IF 4.9
Shengdu Yang,Keyu Lian,Pan Tian,Dianheng Lu,Junhua Zhang
Although numerous strategies refer to dynamic covalent bond exchanges of small molecules for self-repairing thermosets, it remains a critical challenge to be able to jointly tune the malleability and dynamic properties of photocurable materials via extending dynamical small molecule bridging chains with tunable kinetic features. Herein, we successfully synthesized two typical diboronic ester molecules (diboronic ester dithiol/diacid) with variable dioxaborolane metathesis kinetics, which acted as dynamical interlinking segments constructing simple hydrogenated bisphenol A (HBA) epoxy backbone to achieve dynamically cross-linking feature. Subsequently, the acrylate- and anhydride-modified HBA vitrimers bearing diboronic ester-extending segment variants and photocuring traits are successfully synthesized by a one-pot reaction. Consequently, it is demonstrated that the embedded amounts of dynamic diboronic ester bonds in the backbone play a key role in the photopolymerization rate of photocurable vitrimers. The photopolymerization rate decreases significantly as more diboronic ester segments. Moreover, the diboronic ester dithiol-mediated photocurable vitrimer (HBA-S) exhibits enhanced malleability (strain at break of 26.6 %), desirable photo-crosslinked network, and accelerated thermal-triggered self-healing ability (scratch self-healing efficiency of closing to 100 % at 150 °C), compared to those of the diboronic ester diacid-mediated vitrimer (HBA-O) under identical conditions. This work validates the probability of transferring the dioxaborolane metathesis of small molecules to dynamic properties of bulk UV-curing materials, which provides valuable guidance for the rational design and fabrication of tunable dynamic photocurable materials.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Shiyan Yue,Xiaoming Ye,Tiegui Nan,Chen Li,Luqi Huang,Yuan Yuan
Root plasticity is essential for optimizing crop yields and ensuring survival under stress. However, the regulatory roles of root-enriched secondary metabolites in developmental processes have remained largely unexplored. Pueraria thomsonii , a leguminous species distinguished by its rare tuberous roots, exhibits remarkable isoflavonoid accumulation. Chemical quantification and in vitro functional analyses have identified daidzin as a key regulator of root architectural plasticity in this species. Using an integrated approach combining Arabidopsis thaliana (L.) root phenotyping system, cellular thermal shift assays (CETSA) and thermal proteome profiling (TPP), daidzin was demonstrated to modulate root development via stem cell-related processes and auxin signaling pathways. Specifically, daidzin led to the reduced auxin levels, silenced DR5::GFP expression in the stele, and suppressed PIN protein expression accompanied by a lateral shift in PIN2 polarity. Furthermore, daidzin decreased SHR, SCR, PLT1, and PLT2 protein levels while increasing WOX5 and CYCD6;1 accumulation. In the wox5 mutant, daidzin inhibited root elongation, whereas in the p35S:WOX5-GR transgenic line, it enhanced root elongation and attenuated starch granule degradation. These findings reveal that WOX5 functionally counteracts daidzin-mediated root growth inhibition. Furthermore, daidzin stimulated cell proliferation in Pueraria thomsonii (Benth.) and induced root thickening in Panax quinquefolius (L.). Collectively, these results suggest that daidzin's coordinates root architectural plasticity by modulating auxin transport, polarity, and stem cell niche maintenance, highlighting its potential as a valuable tool for enhancing root development in economically important crops.
研究领域:
植物学
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分子生物学
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药用植物学
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产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Dengkang Guo,Wenting Ren,Sisi Yao,Jingpeng Li,Yan Yu,Fuxiang Chu
Reckoning with the global environmental challenge of plastic pollution, particularly in terms of recycling and biodegradation of thermosetting plastics, sustainable alternatives are imperative. The rapidly growing and eco-friendly material bamboo has great potential as a sustainable resource; however, it lacks the inherent self-bonding and plasticity characteristics found in plastics. This study presents a feasible approach to enhance the plasticity of bamboo by selectively removing part of its lignin and disrupting the crystalline structure of cellulose. Concurrently, this process selectively transforms hydroxyl groups into highly reactive dialdehyde groups to increase the reactivity of bamboo. The resulting activated bamboo units undergo a hot-pressing process to transform them into a type of thermosetting plastic (ABTP). The ABTP is highly moldable, and its color can be precisely regulated by adjusting the lignin content. Additionally, it exhibits exceptional solvent and water resistance, along with notable mechanical properties, including a tensile strength of 50 MPa, flexural strength of 80 MPa, flexural modulus of 5 GPa, and Shore D hardness approaching 90. Furthermore, the bamboo-derived plastic exhibits exceptional reusability and biodegradability, presenting feasible and environmentally friendly alternatives to conventional plastics while harnessing the sustainable development potential of bamboo.
研究领域:
材料科学
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环境科学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
BMC Complementary Medicine and Therapies
·
2025
·
IF 3.4
Xuedi Kang,Ting Wang,Haiping Wan,Wenjun Fu,Songjun Lin
Background Corticosterone stimulation has profound physiological and neurological effects on individuals, necessitating effective interventions to mitigate its impact. Current therapeutic approaches for corticosterone stimulation injury have limitations, including addiction and tolerance issues. In contrast, historical formulations such as Xiao Yao San, a traditional Chinese medicine formula, have shown promise in addressing changes in corticosterone stimulation-related neuroplasticity. This study aimed to explore the potential of Xiao Yao San in modulating the glucocorticoid receptor (GR) signaling pathway and its downstream effects on hippocampal neuroplasticity under corticosterone stimulation conditions. Methods Primary hippocampal neurons were cultured and exposed to corticosterone to establish a corticosterone stimulation model. Cellular viability, apoptosis, and protein expression were assessed via CCK-8 assays, flow cytometry, and immunoblotting, respectively. Interactions between FK506 binding protein 51 (FKBP51), GR, and p-GR were analyzed via coimmunoprecipitation and GST pull-down assays. The influence of FKBP4 on the competitive binding of GR was explored via similar techniques. The functional consequences of gene knockdown and overexpression were evaluated through cellular assays. Results Xiao Yao San attenuated corticosterone-induced reductions in cell viability and apoptosis, counteracting the detrimental effects of corticosterone stimulation. It downregulated FKBP51 expression and suppressed GR phosphorylation and nuclear translocation. Additionally, it hindered the interaction between FKBP51 and GR/p-GR. FKBP4 overexpression rescued hippocampal neuron viability and protected against the GR phosphorylation and nuclear translocation induced by corticosterone. Conclusion Xiao Yao San exhibited promising effects in ameliorating changes in corticosterone stimulation-induced neuroplasticity through the modulation of the GR signaling pathway. By inhibiting FKBP51-mediated GR phosphorylation and nuclear translocation, Xiao Yao San has potential as an alternative therapeutic strategy for corticosterone stimulation-related conditions. Further clinical investigations and mechanistic studies are warranted to validate its therapeutic efficacy and elucidate its mechanisms of action.
研究领域:
神经生物学
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药理学
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传统中医
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）