DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2015
·
IF 2.101
Jianmin Chen,Yuqin Qiu,Suohui Zhang,Guozhong Yang,Yunhua Gao
Coated microneedles have been paid much attention recently, and several coating strategies have been developed to address the problems during coating process. However, there are still some unresolved issues, such as, precise control requirements, microneedle substrate contamination and high processing temperature. The purpose of this study was to develop a simple and controllable method to make uniform coatings on microneedles at room temperature. This novel method avoids the contamination of microneedle substrate by providing both the adsorption force of thickener and micro-scale coating film produced by a newly design device. Thickeners were screened to enhance the mass of coatings. The parameters that influence the coatings were tested systematically, which made coating process controllable. Finally, three model drugs were coated onto microneedles to prove the method is applicable more broadly. In addition, insertion experiments were carried out to test the drug delivery feasibility of the coated microneedles. In conclusion, this study presents a simple and controllable method to coat microneedles with small molecular chemical drugs or large proteins for rapid skin drug delivery.
研究领域:
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Liyang Jing,Yiheng Song,Shuyan He,Xinming Fu,Zhengliang Du,Xianze Yin
The investigation of Marangoni effect-driven actuators holds significant importance due to their wide-ranging applications in smart devices and biomedical fields. However, traditional Marangoni hydrogel actuators often lack spontaneity and are difficult to control. In this study, we designed and prepared a dual-mode driven Marangoni hydrogel actuator (DDMA) which combines the spontaneity of solvent exchange-based hydrogel actuators with the controllability of photothermal-based ones. DDMA not only exhibits excellent ethanol loading capacity but also demonstrates both sustained motion for approximately 21 minutes and rapid motion. Furthermore, controlled motion can be achieved under infrared light, by adjusting the illumination point, the hydrogel can navigate through complex N-shaped mazes and achieve turning angles exceeding 180°. This spontaneously controllable potential of hydrogel motion holds great promise in the field of intelligent transportation and soft robotics technology.
研究领域:
智能材料
·
生物医学工程
·
软体机器人技术
✓ 已验证
产品关联
DOI
高影响因子
PHYSICS OF FLUIDS
·
2023
·Vol. 35
·期 8
·
IF 4.6
Yang Hongbin,Lv Zhiqi,Li Zhe,Guo Bumin,Zhao Jian,Xu Yantao,Xu Wenjiang,Kang Wanli
In order to solve the uncontrollable swelling ratio and degradation time and insufficient strength of conventional self-degradable temporary plugging agent (CSD-TPA), a controllable self-degradable temporary plugging agent (SD-TPA) was proposed. A series of SD-TPA were prepared with free radical polymerization, and the SD-TPA was synthesized by different mass ratios of acrylamide, acrylic acid, hydrophobic monomer, and modified nanoparticles. The effects of modified nanoparticles content, hydrophobic monomers content, temperature, and salinity on its swelling performance, self-degradable performance, and rheological properties were researched systematically. The plugging and unblocking performance of SD-TPA were studied by a core displacement test. The experimental results showed that SD-TPA can be gelatinization after 4 h at 40 °C. Under the formation condition, SD-TPA had better viscoelasticity, shear resistance, and higher yield stress than CSD-TPA. The core plugging rate increased from 86.44% to 91.41%, and the formation damage rate decreased to 14.11%. This work provides a new temporary plugging material during hydraulic fracturing process and the swelling ratio, degradation time, and insufficient strength of SD-TPA can be adjusted according to the requirement of fracturing.
研究领域:
石油工程
·
材料科学
✓ 已验证
DOI
高影响因子
Advanced Materials Technologies
·
2023
·Vol. 8
·期 15
·2300001
·
IF 6.8
Iek Man Lei,Duo Zhang,Wenxi Gu,Ji Liu,Yunlong Zi,Yan Yan Shery Huang
Embedded 3D printing is widely adapted for fabricating architected soft and non-self-supporting hydrogels for applications ranging from tissue engineering to soft robotics. Although the matching between hydrogels and supportive baths sets the foundation in embedded 3D printing, the rule-of-thumb for supportive bath selection and creation is not yet established. Herein, the “shapeability” of distinct classes of hydrogel inks (i.e., pH-responsive, photo-crosslinkable, thermal-sensitive, chemically crosslinkable monomeric, and cationic and anionic inks) in diverse representative support baths (i.e., gelatin slurry, agarose fluid gel, Carbopol and oil-based baths) is evaluated. The results show that the dominate mechanisms for interfacial instabilities, including diffusion-driven or charge-driven, can be predicted by evaluating the composition pairing of the pre-crosslinked hydrogel ink and supportive bath. Based on this, a general and simplistic guideline for supportive bath selection to attain hydrogel shapeability is proposed. The approach can widen the spectrum of hydrogel materials that can be structured on-demand for a plethora of functionalities.
研究领域:
生物材料学
·
组织工程
·
软体机器人技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Bin Wang,Fuhan Liu,Huimin Nai,Haoqi Guo,Jian Zhang,Debin Xia,Kaifeng Lin,Yulin Yang
The controllability of thrust is paramount for electronically controlled solid propellants (ECSPs), which rely on the rapid redox reaction of hydroxylamine nitrate (HAN) as their primary oxidant. This study proposes a mechanism for HAN-electrolysis and electrode-induced solid propellant interphases (SPIs). The electrocatalytic oxidation of hydroxylamine in HAN plays a crucial role in the formation of interphases with copper, stainless steel, and titanium electrodes. The resulting hydroxyl radical oxidizes these electrodes to produce SPIs and also oxidizes polyvinyl alcohol to accelerate the thermal decomposition. The current density on the combustion process is significantly influenced by SPIs, determining whether the combustion state is electrolytically-led rapid combustion or pyrolytically-led slow combustion. SPIs with different electrodes are identified as Cu 2 (NO 3 )(OH) 3 , Fe(OH) 3 , and a mixture of the thermal decomposition of the propellants, respectively. Cu 2 (NO 3 )(OH) 3 has the smallest energy gap and impedance, resulting in the highest current density and optimal performance. The gas production of the Cu electrode is about 3.8 times that of the stainless steel electrode and about 6.7 times that of the Ti electrode at the same conditions. The in-situ SPIs are substituted with Cu 2 (NO 3 )(OH) 3 as the interface layer, leading to increased gas production for the copper electrode (by 3 times), stainless steel electrode (by 5.7 times), and titanium electrode (by 4.2 times). This research introduces the effects of SPIs and the electrocatalytic oxidation of hydroxylamine, offering a direction for improving the thrust and controllability of ECSPs.
研究领域:
化学工程
·
材料科学
·
航空航天工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Zhouyu Miao,Mengya Mu,Hou-Yong Yu,Yanjuan Dong
This study presents a novel and environmentally friendly method for producing cellulose microspheres (CM) with controllable morphology and size using electrostatic droplets. The traditional droplet method for CM production requires complex equipment and harmful reagents. In contrast, the proposed method offers a simple electrostatic droplet approach to fabricate CM10 at 10 kV, which exhibited a smaller volume, linear microscopic morphology, and a larger specific surface area , with a 36.60 % improvement compared to CM0 (prepared at 0 kV). CM10 also demonstrated excellent underwater structural stability, recovering in just 0.5 s, and exhibited the highest adsorption capacity for Cr(VI) at 190.16 mg/g, a 72.15 % improvement over CM0. This enhanced adsorption capacity can be attributed to the unique structure of CM10 and the introduction of more amino groups. Moreover, CM10 displayed good cyclic adsorption capacity and high dynamic adsorption efficiency, making it highly suitable for practical applications. CM10 exhibited remarkable adsorption capacity, stability, and practical value in treating Cr(VI) wastewater. This work proposes a simple and eco-friendly method for producing CM with excellent structural controllability and stability, providing an effective route for wastewater treatment .
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 41
·6688-6700
·
IF 5.342
Na Li,Xiaosai Qu,Lifeng Wang,Qingquan Tian,Yu Chen,Xianping Yao,Shusen Chen,Shaohua Jin
Aiming at solving the uncontrollability in the properties of chitosan caused by its uncontrollable structure, we synthesized two chitosan-mimetic polymers, the homopolymer mimic PHNI and the copolymer mimic PHNI-PHNIA, by ring-opening metathesis polymerization (ROMP) and characterized their structures and performances by FTIR, 1H-NMR, 13C-NMR, XRD and DTG. The reaction feature of ROMP demonstrated by size exclusion chromatography (SEC) signifies that the structure and number average molecular weight of ROMP products can be controlled by tuning the ratio of the monomer to the catalyst, and thus the mimics exhibit structure-controllable and mimicking properties. The relationship between the chemical structure and performance of the mimics is more explicit. The application exploration suggests that the Cu2+ adsorption performance of the PHNI-PHNIA hydrogel prepared with glutaraldehyde as the crosslinking agent is superior to that of the chitosan hydrogel. The catalytic activity of the PHNI-PHNIA-Cu2+ complex for the decomposition of H2O2 is much higher than that of the chitosan-Cu2+ complex. Our work has provided a new strategy for the synthesis of controllable chitosan mimics that can function as a substitute of basic polysaccharides for preparing the derivatives with controllable properties and expand the application scope of chitosan.
研究领域:
材料科学
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环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2021
·
IF 8.528
Shuai Yang,Yang He,Jinsong Leng
Multi-stimuli selective actuation of shape memory polymers (SMPs) with multi memory capabilities have attracted great attention in recent years, due to diverse active deformation application scenarios. Current multi-SMPs with low T t , however, are faced with inherent barriers, such as low fixation and inaccurate control, because the shape retainability, controllability, and responsiveness of SMPs are highly determined by transition temperature (T t ). Herein, quadruple-shape memory poly(aryl ether ketone) (PAEK) with tunable high T t and selective response characteristics were successfully fabricated for the first time, which especially harnessed ultra-high programmability and controllability. More significantly, the quadruple shape memory PAEK-based smart architectures such as “fingers” and “flower” were demonstrated to exhibit the controllable multi-stages actions. Utilizing a “man” as an example, we put forward different programming routes up to ten to make it perform complex pre-set deformation actions. The quadruple shape memory PAEK of high T t possessed great utilizing potential in fields of soft robots , actuators, and deformable devices.
研究领域:
材料科学
·
智能材料
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Meixiao Cheng,Hui He,Hongxiang Zhu,Wei Guo,Wenbo Chen,Fei Xue,Shile Zhou,Xingjuan Chen,Shuangfei Wang
Two novel pH-responsive reversible-wettability biomass cellulose-based materials of cellulose -g- PAA and cellulose -g- PAM were conveniently prepared by grafting acrylic acid (AA) and acrylamide (AM), respectively, onto eucalyptus pulp cellulose. The hydrophobic–oleophilic of cellulose -g- PAA and the oleophobic–hydrophilic of cellulose -g- PAM were converted to oleophobic–hydrophilic and hydrophobic–oleophilic, respectively, as the pH converted from 1 to 9. The pH-responsive mechanism of these cellulose-based materials was investigated by 13 C nuclear magnetic resonance, X-ray photoelectron spectroscopy, and atomic force microscopy analyses. The resulting cellulose -g- PAA and cellulose -g- PAM papers were applied in the switchable separation of oil/water mixtures. Water passed through the cellulose -g- PAA paper at pH = 9 and cellulose -g- PAM paper at pH = 1, while oil was retained. After changing the pH value, oil permeated these papers, but water did not. The papers exhibited excellent regeneration performances; the oil adsorbed on the papers was completely desorbed via pH control.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2015
·
IF 4.457
Ming Zhang,Lingyan Liu,Weixing Chang,Jing Li
A novel dimethyl acrylate 18-membered macrocycle (DMECE), acting as both bifunctional monomer and cross-linker, was designed and synthesized, and thus employed to construct a series of macrocycle-containing amphiphilic hyperbranched polymers (HBPs). The macrocyclic recognition effect between the HBPs and alkali metal ions showed that Na+ was introduced in 1:1 interactive mode, whereas K+ and Rb+ were in 2:1 ratio. Through the formation of the DMECE/K+ = 2:1 rigid “sandwich” complex of amphiphilic hyperbranched polymers, dimple-shaped aggregates were observed by TEM, SEM and AFM. Moreover, the initial concentration, the nature of solvent, the mode and affinity of the macrocyclic recognition effect as well as the amount of K+, were essential control factors for the formation of dimple-shaped aggregates. Most importantly, the macrocyclic recognition effect endows the reversibility of the dimple-shaped aggregates and the size controllability of its circular opening, which provides a new strategy for design novel macrocycle-containing HBPs and great potential application in the field of capture and release.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Intelligent Systems
·
2024
·
IF 6.8
Yang Liu,Ying Feng,Linlin Liu,Miao An,Huaming Yang
Micro/nanorobots (MNRs) are promising for biomedical applications due to their unconstrained nature and small enough size to pass through many tiny environments. However, the efficient movement of MNRs in liquid environments is still a challenge due to the low Reynolds number environment and the Brownian motion of particles. Herein, emerging MNRs with hydrogel-loaded magnetic particles are designed. The proposed hydrogel MNRs (HMNRs) exhibit biocompatible and controllable characteristics. The motion controllability of HMNRs is realized by applying oscillating magnetic field and customized magnetic field. Experimentally, it is demonstrated that the HMNR swarms driven by the oscillating magnetic field exhibit a faster motion speed than the MNR swarms composed of magnetic particles. The HMNRs show precise controllability of the movement in the complex pipeline under the control of customized magnetic field. This method can offer a more benign approach to the general production of HMNRs for biological applications.
研究领域:
生物医学工程
·
纳米技术
·
机器人学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Fundamental Research
·
2022
·
IF 0
Junyu Ma,Chen Ma,Xiaoyu Huang,Pedro Henrique Hermes de Araujo,Amit Kumal Goyal,Guolin Lu,Chun Feng
Fragmentation/disassembly of fiber-like micelles generated by living crystalline-driven self-assembly (CDSA) is usually encountered in aqueous media, which hinders the applications of micelles. Herein, we report the generation of uniform fiber-like micelles consisting of a π-conjugated oligo( p -phenylenevinylene) core and a cross-linking silica shell with grafted poly(ethylene glycol) (PEG) chains by the combination of living CDSA, silica chemistry and surface grafting-onto strategy. Owing to the presence of crosslinking silica shell and the outmost PEG chains, the resulting micelles exhibit excellent dispersity and colloidal stability in PBS buffer, BSA aqueous solution and upon heating at 80 °C for 2 h without micellar fragmentation/disassembly. The micelles also show negligible cytotoxicity toward both HeLa cervical cancer and HEK239T human embryonic kidney cell lines. Interestingly, micelles with L n of 156 nm show the “stealth” property with no significant uptake by HeLa cells, whereas some certain amounts of micelles with L n of 535 nm can penetrate into HeLa cells, showing length-dependent cellular uptake behaviors. These results provide a route to prepare uniform, colloidally stable fiber-like nanostructures with tunable length and functions derived for biomedical applications.
研究领域:
生物材料学
·
纳米医学
·
药物递送系统
✓ 已验证
产品关联
DOI
危险品化学品经营许可证（带存储）