FOOD CHEMISTRY
·
2020
·
IF 6.306
Guohuan Huang,Yuping Yan,Danxia Xu,Jia Wu,Chuanhui Xu,Lihua Fu,Baofeng Lin
Food spoilage is one of the biggest concerns for food safety worldwide. Here, we describe the construction of a carrier for biological agents by chemical combination of porous nanoMOFs and carboxymethylated filter paper (CMFP). When curcumin was encapsulated in nanoMOFs@CMFP, they showed the ability to act as super-long-acting food preserving agents with controllable release of curcumin. Although only 22.3% of curcumin was released into water in 600 h, 65.8% was released into PBS in the same time, and the release into PBS could be tuned by adding citric acid at the time of greatest requirement. Furthermore, the chemical stability of curcumin in nanoMOFs@CMFP was >4.9 times greater than for free curcumin. The outstanding antioxidant and antimicrobial activity of curcumin-loaded nanoMOFs@CMFP paste was demonstrated by prolonging the shelf life of pitayas, which illustrates its potential for development as long-acting and stable preserving paste for use in food preservation.
研究领域:
食品科学
·
材料科学
·
生物学
✓ 已验证
DOI
高影响因子
PHOTOCHEMISTRY AND PHOTOBIOLOGY
·
2011
·Vol. 87
·期 3
·646-652
·
IF 2.679
LiLi Yu,Cong Lv,LiZhu Wu,ChenHo Tung,WanLiang Lv,ZhongJin Li,XinJing Tang
We intend to form photosensitive block copolymer micelles for controllable release of encapsulated substances. Here, we designed and synthesized a new photocleavable cross-linker (2-nitrophenyl ethylene glycol dimethacrylate) for methyl methacrylate (MMA) atom transfer radical polymerization. Four different ratios (0:1, 1:26, 1:16, 1:8.8) of the photocleavable cross-linker to MMA monomer were used and four block copolymers (P0, P1, P2, P3) were synthesized with PEO-Br as the macroinitiator. Gel permeation chromatography and 1 H NMR studies showed that linear polymer molecules could be cross-linked by the photocleavable linker. The fluorescence studies of the encapsulated Nile Red (NR) showed that there were lower critical micelle concentrations for the polymer P1, P2 and P3 than polymer P0. And dynamic light scattering and SEM confirmed the formation of polymer micelles. Photolysis experiments demonstrated that NR encapsulated in the polymer micelles could be released upon UV irradiation (365 nm, 11 mW cm −2 ) due to the breakage of the photocleavable linker and the generation of more hydrophilic acid moieties, which destabilized polymer micelles. Our study shows a new strategy for the possibility of photocontrollable drug release for hydrophobic drugs.
研究领域:
材料科学
·
药物递送
·
高分子化学
✓ 已验证
DOI
高影响因子
Current Drug Delivery
·
2024
·
IF 2.8
Yang Jinxin,Mou Jie,Ding Kexin,Zhu Shaoyue,Sun Zhe,Cui Yawen,Meng Sihan,Qiang Guowei,Zhong Weisen,Liu Zongxiang
Introduction: Mesoporous silica nanoparticles (MSN) are widely used as ideal nanovehicles
for the delivery of chemotherapeutic drugs. However, the balance between high anti-periodontitis
activity and low biotoxicity has been challenging to maintain in most relevant studies owing
to the slow degradation of silica in living organisms.
Method: In this study, -responsive hydroxyapatite (HAP) was doped into the MSN skeleton, and
the chemotherapeutic drug minocycline hydrochloride (MH) was loaded into the pores of MSN,
forming a negatively charged drug delivery system. Cationic chitosan (COS) is a biodegradable
material with high antibacterial performance and good biosafety. In this study, COS was immobilized
on the surface of the drug-loaded particles through stable charge interaction to construct a
composite drug delivery system (MH@MSNion@COS).
Results: In vitro and cellular experiments demonstrated effective degradation of the nanocarrier
system and synchronized controlled release of the drug. Notably, compared with single MH administration,
this system, in which MH and COS jointly regulated the expression levels of periodontitis-
associated inflammatory factors (TNF-α, IL-6, IL-1β, and iNOS), better inhibited the progress
of periodontitis and induced tissue regeneration without showing significant toxic side effects in
cells.
Conclusion: This system provides a promising strategy for the design of intelligent, efficient, and
safe anti-periodontitis drug delivery systems.
研究领域:
药剂学
·
生物材料学
·
口腔医学
✓ 已验证
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2020
·Vol. 5
·期 2
·792-798
·
IF 6.788
Yiying Sun,Jiafu Shi,Ziyi Cai,Yizhou Wu,Weiran Li,Qian Huo,Zhongyi Jiang
Exploring systems with distinct stimuli-response properties is vital for controlled release. In our study, a reaction-triggered system based on enzyme-encased capsules is constructed through mussel-inspired chemistry for controlled release of insulin (INS, a kind of protein hormone for diabetes mellitus treatment). In detail, glucose oxidase (GOD) and INS were first entrapped in CaCO3 particles through a co-precipitation method. Tannic acid (TA, a natural polyphenol) was adhered on the particle surface and conjugated with polyethyleneimine (PEI) through a Schiff base reaction and electrostatic interactions, thus acquiring TA–PEI (TP) capsules encasing GOD and INS. The GOD inside the capsules catalysed the oxidation of glucose to form gluconic acid, which caused the enrichment of protons (H+) around the capsules. The decrease of the pH value further broke the CN bond in the capsule wall, which led to the disassembly of the capsules and the release of INS. The capsular system could continuously release 73.1% of the INS in 3 h, and exhibited a specific response to glucose. Combined with the facile and mild preparation of the enzyme-encased capsules, it was expected that the as-constructed capsular system could be applied for the delivery and controlled release of a broad range of cargoes.
研究领域:
生物医学工程
·
药物递送系统
·
酶催化反应
✓ 已验证
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2016
·Vol. 22
·期 25
·8508-8519
·
IF 5.771
Hao Yao,Miao Qi,Yuyang Liu,Wei Tian
Graphical Two binding sites better than one? The β-cyclodextrin/azobenzene (β-CD/Azo) host–guest binding sites of the two synthesized polymers have a pronounced effect on the morphology and size of the resulting Y-shaped supramolecular polymer self-assemblies with thermo and photo dual-responsiveness (see figure). Despite the remarkable progress made in controllable self-assembly of stimuli-responsive supramolecular polymers (SSPs), a basic issue that has not been consideration to date is the essential binding site. The noncovalent binding sites, which connect the building blocks and endow supramolecular polymers with their ability to respond to stimuli, are expected to strongly affect the self-assembly of SSPs. Herein, the design and synthesis of a dual-stimuli thermo- and photoresponsive Y-shaped supramolecular polymer (SSP2) with two adjacent β-cyclodextrin/azobenzene (β-CD/Azo) binding sites, and another SSP (SSP1) with similar building blocks, but only one β-CD/Azo binding site as a control, are described. Upon gradually increasing the polymer solution temperature or irradiating with UV light, SSP2 self-assemblies with a higher binding-site distribution density; exhibits a flower-like morphology, smaller size, and more stable dynamic aggregation process; and greater controllability for drug-release behavior than those observed with SSP1 self-assemblies. The host–guest binding-site-tunable self-assembly was attributed to the positive cooperativity generated among adjacent binding sites on the surfaces of SSP2 self-assemblies. This work is beneficial for precisely controlling the structural parameters and controlled release function of SSP self-assemblies.
研究领域:
材料科学
·
化学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2010
·Vol. 1
·期 10
·1638-1643
·
IF 0
Yin Wang,Guohua Jiang,Xinke Sun,Miaojun Ding,Hongyuan Hu,Wenxing Chen
Shell cross-linked polymeric nanoparticles were prepared through an interfacially confined copolymerization of styrene and disulfide cross-linker in a reversible addition-fragmentation chain transfer (RAFT) miniemulsion system using poly(2-(dimethylamino) ethyl methacrylate) (PDMAEMA) as stabilizer and macroinitiator. 1H NMR, FT-IR, and FE-SEM have been applied to investigate the structures and morphologies of the resultant nanoparticles. Fluorescent spectra results show that the as-prepared samples have fluorescent properties, which may be used as a fluorescent carrier for control release of guest molecules.
研究领域:
高分子化学
·
纳米医学
·
药物递送
·
生物材料
·
聚合物科学
✓ 已验证
DOI
Chemical Engineering Journal Advances
·
2023
·
IF 0
Yun-Da Yue,Yuan-Yuan Cui,Cheng-Xiong Yang
Rational design and fabrication of effective drug delivery systems (DDS) are crucial for improving the therapeutic effectiveness and overcoming the shortcomings of chemotherapy. Herein, we report the construction of a novel cyclodextrin microporous organic network (CD-MON)-based DDS via a convenient thiol‑yne click reaction and dehydration condensation modification for the controllable release and targeted delivery of doxorubicin (DOX), a typical chemotherapy drug. The constructed DDS afforded multiple hydrophobic, hydrogen-bonding, and host-guest interaction sites, allowing for the efficient loading of DOX. The obtained DDS also exhibited good sustained and long-term release of DOX. Additionally, the proposed DDS offers good biocompatibility and exhibits an obvious aggregation-induced emission. Furthermore, the introduction of folic acid (FA) into the CD-MON-based DDS provided excellent targeting capacity for FA receptor-positive NCI-H226 cells. This study proved the universality of the design, synthesis, and application of CD-MON-based DDS, revealing the great potential of CD-MONs in drug delivery.
研究领域:
药学
·
材料科学
·
纳米技术
·
化疗
·
药物递送
✓ 已验证
DOI
危险品化学品经营许可证（带存储）