ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Ximin Yuan,Weicheng Kong,Pengcheng Xia,Zhenjia Wang,Qing Gao,Jie Xu,Debin Shan,Qingqiang Yao,Zhiyong Ma,Bin Guo,Yong He
Implantable flexible electronic has attracted significant research interest in various fields. However, it still faces the challenge of simultaneously achieving tight adhesion to tissues in a mildly wet environment and possessing excellent biocompatibility to reduce immune rejection reactions after implantation. Here, a degradable wet-adhesive flexible electronic device based on liquid metal and ultrathin gelatin film is developed. The ultrathin gelatin film forms numerous hydrogen bonds with tissue in a slightly humid environment, rapidly constructing a wet-adhesive interface without damaging tissue structure. Inkjet printing is utilized to pattern the mixture of liquid metal and PVP on the surface of the ultrathin gelatin to create flexible patch. With the excellent conductivity of liquid metal, low toxicity, and similarity to natural tissue components of gelatin, flexible patch exhibits outstanding biocompatibility and fatigue resistance. It can be implanted in the body for up to 6 weeks, retaining monitoring capabilities and resisting 1 000 000 cycles of bending fatigue. This study provides a novel strategy for the future development of implantable flexible electronics.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 21
·2111406
·
IF 19.924
Junjie Zhou,Runhao Zhang,Ran Xu,Yong Li,Wei Tian,Meng Gao,Meng Wang,Dongwei Li,Xiu Liang,Lei Xie,Kang Liang,Pu Chen,Biao Kong
Transient devices represent an emerging type of electronics whose main characteristic is the constituent materials that could fully or partially dissolute or disintegrate by chemical or physical processes after completing the mission, and are considered as new research directions for implantable devices. However, research on transient devices is still in its infancy and there are many challenges to overcome, especially the development of transient energy devices is relatively slow. Here, an implantable, biodegradable transient zinc ion battery (TZIB) that assembles a carefully designed cellulose aerogel-gelatin (CAG) solid electrolyte. The new fully degradable CAG solid electrolyte allows TZIB to achieve controlled degradation and stable electrochemical performance, at the same time maintaining excellent mechanical properties. The entire battery device can be completely degraded within 30 days in the buffered proteinase K solution. More importantly, TZIB has excellent electrochemical performance while meeting controlled degradation, providing a specific capacity of 211.5 mAh g −1 at a current of 61.6 mA g −1 and a wide voltage range (0.85–1.9 V). These results demonstrate the potential of TZIB in future clinical applications and provide a new platform for transient electronic technology.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
Electronics
·
2023
·Vol. 12
·期 11
·2466
·
IF 2.9
Wanjing Li,Andeng Liu,Yimeng Wang,Kui Qu,Hao Wen,Jizhong Zhao,Yating Shi,Hao Wang,Meidan Ye,Wenxi Guo
Implantable sensors normally require devices with excellent biocompatibility and flexibility as well as wireless communication. Silk fibroin (SF) is an ideal material for implantable electronic devices due to its natural biodegradability and biocompatibility. In this work, we prepared SF protein materials with different force/chemical properties through mesoscopic regulation, and realized full protein replacement from substrate to dielectric elastomer for implantable sensors, so as to achieve controlled complete degradation. In wireless tests simulating intracranial pressure, the SF-based all-protein sensor achieved a sensitivity up to 4.44 MHz/mmHg in the pressure range of 0–20 mmHg. In addition, the sensor is insensitive to temperature changes and tissue environments, and can work stably in simulated body fluids for a long time. This work provides a wireless passive, all-protein material solution for implantable pressure sensors.Keywords:silk fibroin;implantable;degradable;biocompatibility;wireless passive;pressure sensor
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2017
·Vol. 106
·期 5
·1827-1841
·
IF 3.189
Yikun Yang,Chunyi Tong,Juchang Zhong,Ruiying Huang,Weihong Tan,Zhikai Tan
Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe 3 O 4 mats capable of high-performance hyperthermia using E-jet 3D printing technology. Our 3D printed mats not only maintained the heating efficiency of traditional techniques for magnetic hyperthermia but also prolonged the effective therapy in vivo . When Fe 3 O 4 nanoparticles (NPs) were used in mats at a concentration of 6 mmol/L, 0.07 g PCL/Fe 3 O 4 mats were able to increase the temperature peripherally to 45°C under an alternating magnetic field (AMF) within 45 min. Moreover, the reproducibility experiment indicated that the maximum temperature was achieved following repeated heating and cooling cycles. Cell toxicity tests showed a high cell death rate during one treatment cycle. In vivo experiments indicated clear signs of tumor growth inhibitory and prolonged survival time of tumor-bearing mice after 4 weeks of treatment. The present magnetic mats may be a potential candidate for a novel heat-generating substrate for localized hyperthermia cancer therapy. Furthermore, the main advantage of such implantable magnetic mats is the local and precise delivery of Fe 3 O 4 NPs, ideal for the hyperthermia treatment of easily accessible tumors. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1827–1841, 2018.
研究领域:
生物医学工程
·
材料科学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sensors
·
2019
·
IF 6.944
Jin Zhou,Zhen Ma,Xiao Hong,Hui-Min Wu,Shu-Yan Ma,Yang Li,Da-Jing Chen,Hai-Yin Yu,Xiao-Jun Huang
Fabrication of an outer membrane is crucial for an implantable biosensor to enhance the long-term stability and accuracy of sensors. Herein, an adaptable, controllable, porous outer membrane for an implantable biosensor was fabricated using a “top-down” method, allowing maximum retention of enzyme activity and fine control over membrane microstructure. Polysulfone hollow fibrous membranes with different pore sizes and porosities were used as a base membrane. Chitosan (CH) and sodium alginate (SA) were self-assembled on the inner surface of PSfHM to construct a biocompatible and conductive interface between PSfHM and the electrode. In vitro and in vivo experiments were used to evaluate the performance of implantable glucose biosensors with PSfHM and CH/SA modified PSfHM (PSfHM-CH/SA). The glucose biosensor with PSfHM-CH/SA exhibited a more stable output current than bare sensors and a quick response time (<50 s). The glucose biosensor with PSfHM-CH/SA linear sensing range was between 0 and 22 mM (R2 = 0.9905), and relative sensitivity remained at >87% within 7 days and >76% within 15 days. Furthermore, response currents recorded by implanted sensors closely followed the blood glucose trend from the tail vein blood during in vivo experiments.
研究领域:
生物医学工程
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Rui Liu,Suting Zhou,Meimei Yu,Yumeng Wang,Fen Ran
Flexible supercapacitors have become the top choice for wearable and implantable devices due to their stretchable mechanical adaptability and safety. However, in the current research situation, flexible supercapacitors still face many problems such as insufficient biocompatibility, lack of adhesiveness, or unstable interfaces. In this work, gelatin and polyacrylamide, which possess good biocompatibility, high water retention capacity, and good flexibility, are selected to construct a double-network hydrogel matrix. Tannic acid with abundant catechol groups is added to prepare the gel electrolyte membrane with good mechanical and adhesive properties. A conductive polymer PEDOT:PSS with good biocompatibility and conductivity is polymerized on the upper and lower surfaces of the hydrogel through simple in situ polymerization to form a symmetrically integrated supercapacitor. This device meets the basic requirements of high safety and good biocompatibility for implantable devices. At the same time, it has good adhesive properties, low interfacial impedance, and the characteristics of miniaturization and lightweightedness. This work provides a simple design concept and application potential for the development of wearable and implantable devices.
研究领域:
材料科学
·
储能技术
·
生物医学工程
·
高分子科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-26
·
IF 15.7
Li Kai,Yu Xuan,Xu Yanteng,Wang Haixia,Liu Zheng,Wu Chong,Luo Xing,Xu Jiancheng,Fang Youqiang,Ju Enguo,Lv Shixian,Chan Hon Fai,Lao Yeh-Hsing,He Weiling,Tao Yu,Li Mingqiang
Non-nucleotide stimulators of interferon gene (STING) agonists hold promise as immunotherapeutic agents for postsurgical adjuvant treatment of tumors. However, their limited effect duration hampers therapeutic effectiveness, necessitating prolonged administration of multiple doses that heightens infection risk and impacts patient compliance. Here, we develop an implantable dual-drug depot in a sandwich-like configuration, with a non-nucleotide STING agonist (MSA-2) in the outer layers of 3D-printed scaffolds and an immunogenic apoptosis inducer (doxorubicin, DOX) in the inner layer of electrospun fibers. We discover that MSA-2 can elicit endoplasmic reticulum stress-mediated and general immunogenic apoptosis of cancer cells. The stimulations with tumor-associated antigens and damage-associated molecular patterns from cancer cells, along with proinflammatory factors secreted by matured dendritic cells and M1-polarized macrophages, can depolymerize intracellular microtubules guiding activated STING trafficking towards lysosomes for degradation. Collectively, the dual-drug depots can initiate a long-lasting cascaded immunotherapy and chemotherapy, suppressing postsurgical tumor recurrence and metastasis.
研究领域:
肿瘤学
·
免疫疗法
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yufei Chen,Wei Zheng,Youchen Xia,Lihao Zhang,Yue Cao,Sunlong Li,Weipeng Lu,Cihui Liu,Sengwang Fu
In the quest to develop advanced monitoring systems for intestinal peristaltic stress, this study introduces a groundbreaking approach inspired by nature’s sensory networks. By the integration of novel materials and innovative manufacturing techniques, a multifunctional Janus hydrogel patch has been engineered. This unique patch not only demonstrates superior stress-sensing capabilities in the intricate intestinal environment but also enables adhesion to wet tissue surfaces. This achievement opens new avenues for real-time physiological monitoring and potential therapeutic interventions in the realm of gastrointestinal health.
研究领域:
生物医学工程
·
材料科学
·
胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Gang Wang,Jiayu Gao,Yike Fu,Zhaohui Ren,Jie Huang,Xiang Li,Gaorong Han
The anticancer efficacy of chemodynamic therapy (CDT) is considerably restrained by the inadequate content of H 2 O 2 within tumor microenvironment (TME), unexpected oxidation of Fenton agents and low targeting efficiency of particulate therapeutic platforms. Herein for the first time, an implantable CDT platform was designed and synthesized by combining Fe 0 nanocrystal embedded mesoporous silica nanoparticles (FeMSN) and PCL-gelatin fibres (PG fibres), denoted as [email protected] fibres. FeMSN was fabricated via in situ reduction of ferrous ions within the mesopores of MSNs, and assembled at the surface of electrospun PG fibres by electrostatic interaction to form a fibrous mesh. The findings reflected that, in an acid condition, FeMSN nanoparticles can liberate from the composite fibres, and be effectively uptaken by 4T1 cancer cells. The FeMSN released may react with oxygen to generate H 2 O 2 in the acidic microenvironment, and subsequently transform H 2 O 2 to intracellular hydroxyl radicals, inducing enhanced cell-killing effect. By implanting the composite fibres locally at the tumor site of mice, promoted anticancer efficacy was observed with comparison of the intratumoral-injected FeMSN nanoparticles. This study suggests that [email protected] composite fibres can serve as a potential localized PDT platform for effective antitumor purposes, which may spark a series of follow-on investigations for localized cancer therapeutic technology.
研究领域:
癌症治疗
·
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Shaoguang Li,Jun Dai,Man Zhu,Netzahualcóyotl Arroyo-Currás,Hongxing Li,Yuanyuan Wang,Quan Wang,Xiaoding Lou,Tod E. Kippin,Shixuan Wang,Kevin W. Plaxco,Hui Li,Fan Xia
The ability to track the levels of specific molecules, such as drugs, metabolites, and biomarkers, in the living body, in real time and for long durations, would improve our understanding of health and our ability to diagnose, treat, and monitor disease. To this end, we are developing electrochemical aptamer-based (EAB) biosensors, a general platform supporting high-frequency, real-time molecular measurements in the living body. Here we report that the use of an agarose hydrogel protective layer for EAB sensors significantly improves their signaling stability when deployed in the complex, highly time-varying environments found in vivo. The improved stability is sufficient that these hydrogel-protected sensors achieved good baseline stability and precision when deployed in situ in the veins, muscles, bladder, or tumors of living rats without the use of the drift correction approaches traditionally required in such placements. Finally, our implantable gel-protective EAB sensors achieved good biocompatibility when deployed in vivo in the living rats without causing any severe inflammation.
研究领域:
生物传感
·
电化学
·
生物医学工程
·
药理学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biofabrication
·
2020
·Vol. 12
·期 3
·035015
·
IF 8.213
Zhaoxuan Feng,Di Wang,Yudong Zheng,Liang Zhao,Tao Xu,Zhimeng Guo,M Irfan Hussain,Jinshi Zeng,Lingyun Lou,Yi Sun,Haiyue Jiang
Three-dimensional (3D) printing provides a new approach of fabricating implantable products because it permits a flexible manner to extrude complex and customized shapes of the tissue scaffolds. Compared with other printable biomaterials, the polyurethane elastomer has several merits, including excellent mechanical properties and good biocompatibility. However, some intrinsic behavior, especially its high melting point and slow rate of degradation, hampered its application in 3D printed tissue engineering. Herein, we developed a 3D printable amino acid modified biodegradable waterborne polyurethane (WBPU) using a water-based green chemistry process. The flexibility of this material endows better compliance with tissue during implantation and prevents high modulus transplants from scratching surrounding tissues. The histocompatibility experiments show that the WBPU induces no apparent acute rejection or inflammation in vivo. We successfully fabricated a highly flexible WBPU scaffold by deposition 3D printing technology at a low temperature (50°C ~ 70 °C), and the printed products could support the adhesion and proliferation of chondrocytes and fibroblasts. The printed blocks possessed controllable degradability due to the different amounts of hydrophilic chain extender and did not cause accumulation of acidic products. In addition, we demonstrated that our WBPU is highly applicable for implantable tissue engineering because there is no cytotoxicity during its degradation. Taken together, we envision that this printable WBPU can be used as an alternative biomaterial for tissue engineering with low temperature printing, biodegradability, and compatibility.
研究领域:
材料科学
·
生物医学工程
·
组织工程
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Hang Guan,Xiao Sun,Sijia Yu,Chengqiang Tang,Yiqing Yang,Wei He,Liyuan Wang,Lingsen You,Songlin Zhang,Huisheng Peng,Xuemei Sun
Arrhythmia is one of the most common complications during open-heart surgery and poses a serious threat to patient safety if not promptly treated. However, most recently developed implantable electrocardiogram sensors for arrhythmia monitoring and treatment adopt 2D thin-film structures, which are non-breathable and hinder metabolic exchange processes at the cardiac surface. Here, a highly breathable and mechanically adaptive knitted fabric structured cardiac electrode for real-time arrhythmia monitoring and radiofrequency ablation therapy is reported. The electrode is fabricated from nylon fibers coated with gold-shelled silver nanowires via computer-controlled flat knitting techniques. This knitted structure has an ultralow Young's modulus (9.31 kPa), significantly minimizing mechanical interference with cardiac motion. Moreover, the electrode passively stretches during diastole and actively retightens during systole, dynamically conforming to the beating heart, allowing for stable monitoring of the heart's surface for 12 h. The use of nanowires imparts excellent electrical properties, with the electrode impedance being only ≈1/3 that of dense silver wires at 1000 Hz, enabling high-fidelity signal recording and low-voltage ablation. Moreover, the electrode retains stable electrical performance after 500 000 cycles of dynamic strain. In vivo biocompatibility tests validate the safety of the device. In a mouse model, the electrode successfully localizes the origin of abnormal electrical signals during atrial fibrillation and guides effective radiofrequency ablation to restore sinus rhythm, demonstrating strong potential for clinical translation.
研究领域:
生物医学工程
·
心脏电生理学
·
可穿戴与可植入传感器
·
纳米医学
·
柔性电子学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）