COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2020
·
IF 3.99
Yonggan Yan,Shulei Xu,Huanxi Liu,Xin Cui,Jinlong Shao,Peng Yao,Jun Huang,Xiaoyong Qiu,Chuanzhen Huang
Designing and fabricating self-healing hydrogel adhesive is essential in many physical and biological applications such as wound closure and cartilage repair. In this work, a new type of hydrogel adhesive has been developed through ultraviolet (UV) curing acrylamide (AM) monomer and hyper-branched polyethylenimine (PEI) polymer. The synthesized PAM-PEI hydrogel (weight ratio for PEI: PAM = 1: 9) shows high stretchability (1D extension ratio > 5500 %) and good plasticity (it can be extended into 2D hydrogel film), quick self-healing property (within 30 s) at ambient enviornment and good adhesiveness to both inorganic (23 kPa ∼ 90 kPa for metal and glass) and organic substrates (∼ 8 kPa for polytetrafluoroethylene , 1 ∼ 7 kPa for skin and liver). More importantly, the adhesion-strip-cycle test suggested that the adhesion measured was reversible and did not attenuate for at least 5 cycles on various surfaces. Rheology tests have demonstrated the repeatability of self-healing behavior of the hydrogel between small (1%) and large (1000 %) strain. In addition, the self-healed hydrogel fragments show good injectability, which can be potentially used for 3D-printing. This work provides a facile way of preparing multifunctional hydrogel adhesive with potential engineering applications.
研究领域:
生物材料学
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组织工程
·
再生医学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 220
·期 3
·1800484
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IF 2.492
Xiaoya Ding,Gao Li,Chunsheng Xiao,Xuesi Chen
Schiff base bonds formed by primary amines and aldehydes are attractive for the construction of self-healing and injectable hydrogels. However, biomedical applications of the Schiff base–based (SB) hydrogels are usually limited by their inherent low stability due to the rapid exchange dynamic of the Schiff base bond under physiological condition. Herein, a general method to improve the stability of SB hydrogels by simply doubling the Schiff base linkages at the cross-linking points is proposed. The hydrogels formed by single Schiff base linkage ( hydrogel I ) disorganize into nano-aggregates due to the rapid exchange dynamic of Schiff base bond, while the hydrogels formed by double Schiff base linkage ( hydrogel II ) maintain the gel network for longer times due to the improved stability of the double Schiff base linkage at cross-linking points. Moreover, the hydrogel II displays excellent self-healing and injectable properties due to the rapid dynamic nature of Schiff base bonds.
研究领域:
生物材料学
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医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Penghui Fan,Shangzhi Li,Junfeng Yang,Kaidan Yang,Ping Wu,Qi Dong,Yingshan Zhou
The cystic cavity that develops following spinal cord injury is a major obstacle for repairing spinal cord injury (SCI). The injectable self-healing biomaterials treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury. Herein, a natural extracellular matrix (ECM) biopolymer hyaluronic acid-based hydrogel was developed based on multiple dynamic covalent bonds. The hydrogels exhibited excellent injectable and self-healing properties, could be effectively injected into the injury site, and filled the lesion cavity to accelerate the tissue repair of traumatic SCI. Moreover, the hydrogels were compatible with cells and various tissues and possessed proper stiffness matched with nervous tissue. Additionally, when implanted into the injured spinal cord site, the hyaluronic acid-based hydrogel promoted axonal regeneration and functional recovery by accelerating remyelination, axon regeneration, and angiogenesis. Overall, the injectable self-healing hyaluronic acid-based hydrogels are ideal biomaterials for treating traumatic SCI.
研究领域:
生物材料学
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神经科学
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组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2023
·
IF 4.6
Hanwen Jiang,Yan Xiao,Huanxuan Huang,Wang Yin,Meidong Lang
Antibacterial hydrogel has emerged as an excellent candidate for wound dressing with the ability to eliminate infection and promote wound healing. Herein, a dynamic hydrogel is developed by Schiff base reaction of mixed charged polypeptides and oxidized dextran (ODex). Specifically, biodegradable polypeptides of 1-(propylthio)acetic acid-3-butylimidazole-modified poly(L-lysine) (PLL-PBIM) and adipate dihydrazide-modified poly(L-glutamic acid) (PLG-ADH) are achieved with tunable substitution and charge. By mixing with ODex, charged polypeptides of PLL-PBIM and PLG-ADH led to an injectable and self-healing hydrogel in seconds. The injectable and self-healing performances of the hydrogels are ascribed to the reversible imine and hydrazone bonds formed between polypeptides and ODex. The positively charged hydrogels exhibited over 95% antibacterial activity against E. coli and S. aureus . An optimized balancing of PLG-ADH and PLL-PBIM significantly reduced the hemolysis rate and cytotoxicity of hydrogels. Therefore, the dynamic hydrogel with excellent biocompatibility and inherently antibacterial ability can have potential application for wound dressing.
研究领域:
生物材料学
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医学工程
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
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2018
·Vol. 6
·期 7
·1746-1752
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IF 5.976
Qiang Zhang,Libin Liu,Chenguang Pan,Dong Li,Guangjie Gai
Self-healable conductivity is an important feature of electronic skin, which is highly desirable for next-generation wearable devices. However, the preparation of conductors with good mechanical properties combining thermal sensitivity, adhesion, and injectability as well as self-healing capability remains a great challenge. Herein, a series of self-healing conductors were fabricated through random copolymerization of butyl methacrylate (BMA), lauryl methacrylate (LMA) and undecylenyl alcohol modified multi-walled carbon nanotubes (mMWCNTs). The covalent binding between mMWCNTs and polymers avoids the aggregation and uneven dispersion of MWCNTs in the polymer matrix. The resulting conductors possess electrical conductivity (about 11 S m−1) and high mechanical performance (Young's modulus: ∼10 MPa and tensile strength: ∼0.89 MPa) as well as high mechanical and electrical self-healing efficiency (>94% of mechanical strength and >98% of conductivity). More importantly, the composites also exhibit other unique features, including adhesive, injectable, and sensing capability. This work provides new routes to design and fabricate self-healing conductive materials for applications in next-generation wearable devices.
研究领域:
材料科学
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电子皮肤
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高分子化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Ruquan Zhang,Yongzhen Tao,Qianru Xu,Nian Liu,Pu Chen,Yingshan Zhou,Zikui Bai
The hydrogels with injectable and self-healing properties were prepared from xanthan gum (XG) and silk fibroin (SF) by using sodium trimetaphosphate (STMP) as crosslinker. A three-stage model of oscillation-shear-oscillation experiment was designed to mimic injection process and to observe destruction and regeneration of the hydrogels after shear. The XG3-SF-STMP hydrogels immediately recovered to original storage modulus of 80.6%–93.8% on removing shear. The hydrogels were 3D printed into the self-supporting constructions of hydrogel fibers with connected porous structures, and the XG3-SF-STMP hydrogel fibers exhibited smaller width than XG3-STMP. Oscillation rheological behavior indicated that XG3-SF-STMP hydrogels formed rapidly and exhibited more solid-like gel behavior than XG3-STMP. The hydrogel structures were destroyed under a strain (100%) larger than critical strain, but were rebuilt under a small strain (1%) with recovery ratio of 91.36–93.96% within 120 s, suggesting a self-healing property. Introduction of SF particles into XG3-STMP crosslinked networks improved stiffness and retained recoverability. Carboxyl and phosphate groups in the hydrogel networks are beneficial for XG3-SF-STMP hydrogels to absorb enough liquid electrolytes, leading to effective ionic conductivity . The ion-conductive hydrogel with injectable, self-healing, controlled release and non-cytotoxic properties possesses a promising prospect for tissue engineering and drug release application.
研究领域:
材料科学
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生物医学工程
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组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2017
·Vol. 218
·期 11
·1700002
·
IF 2.5
Yongqi Yang,Guanghui Gao
A great extent of past work has focused on the development of stimuli-responsive hydrogels that can primarily achieve a two-state transition, such as sol-gel translation. In the current work, a reversible hydrogel with three-state transition is designed. The three transformations between original, oxidized, and reduced states are achieved via controlling the external stimuli conditions. Hydrogels in their original state possess a weak self-healing property and negligible fluidity. The oxidized state hydrogel can keep molding, however, losing the self-healing property. In contrast, the reduced state hydrogels exhibit strong self-healing property. Moreover, the hydrogel becomes injectable subsequent to dithiothreitol addition. Thereafter, under UV-light irradiation or NaClO immersion, the hydrogels can be remolded to any desired shapes. These properties provide novel designing strategies and potential applications for smart and reusable materials.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Pengfei Xia,Kunxi Zhang,Yan Gong,Guifei Li,Shifeng Yan,Jingbo Yin
Microgels, with large surface area per volume, show great advantages in adipose tissue engineering due to their injectability and similarity with natural extracellular matrix. However, to date, no studies have tried applying microgels to adipose tissue regeneration. Herein, based on double-bonded poly(l-glutamic acid)-g-2-hydroxyethyl methacrylate (PLGA-g-HEMA) and maleic anhydride-modified chitosan (MCS), an open porous microgel with high hydrophilicity and great injectability is successfully prepared (microgels diameters of 200–300 μm, pore diameter of 38 μm, and porosity of 88.3%). The storage modulus of 30 mg/mL of the microgel dispersions is 2000 Pa, which is similar to that of the native adipose tissue. The spheroidal stem cell shape and extensive cell–cell connections can be formed in the present microgels to promote adipogenic differentiation and realize adipose tissue regeneration. After injection in vitro, the microgels can maintain high stem cell viability up to 14 days. The extensive Oil red O staining is observed after adipogenic induction for 14 days. After 12 weeks postimplantation, adipose tissues can be regenerated well. Blood vessels are formed in the neogenerated tissues. The degradation rate of microgels roughly matches with the adipose tissue formation rate. The study offers an applicable microgel system to boost the adipose tissue regeneration.
研究领域:
生物材料学
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再生医学
·
组织工程学
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Wenwen Hou,Nannan Sheng,Xiaohui Zhang,Zhaohui Luan,Pengfei Qi,Min Lin,Yeqiang Tan,Yanzhi Xia,Yanhui Li,Kunyan Sui
High performance strain sensors have recently attracted immense interest because of their potential applications in wearable devices. However, it remains a challenge in achieving critical feature combinations (e.g., high sensitivity, high mechanical properties, and easy fabrication) for soft wearable sensors. Herein, we fabricated new ionic strain sensors based on agar/NaCl/polyacrylamide double network hydrogels. By taking the advantage of the electric neutrality of agar, we can easily combine the sensitivity and mechanical properties into same ionic hydrogel by tuning the chemical compositions of the hydrogels. Moreover, thanks to the thermoreversible sol-gel properties of agar, the pregel can be injected into various complex shapes. The ionic hydrogels exhibit high strain sensitivity and many superior mechanical properties. The ionic sensor can monitor human motions such as joint motions, slight wrist pulse and subtle muscle movements of throat. Thus, this study demonstrates that the ionic hydrogels have potential applications as high performance strain sensors.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
BIOMACROMOLECULES
·
2020
·
IF 6.092
Caicai Jiao,Lilong Gao,Hui Zhang,Bing Yu,Hailin Cong,Youqing Shen
Hydrogels have a wide range of applications in the fields of biomedicine, flexible electronics, and bionics. In this study, injectable and self-healable hydrogels were first prepared based on a dynamic covalent C═C bond formed via the Knoevenagel condensation reaction between poly(ethylene glycol) dicyanoacetate and water-soluble poly(vanillin acrylate). Three kinds of catalysts (phosphate buffer, zeolitic imidazolate framework-8, and tertiary amine) were used in Knoevenagel condensation for preparing hydrogels. All hydrogels in this study could be formed in situ, and their gelation time ranged from seconds to minutes. The properties and application of hydrogels could be customized according to the type of catalyst employed. 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) results indicated that all the components and hydrogels exhibited low toxicity, and the hydrogels could be used as 3D cell culture scaffolds. Because of the dynamic covalent C═C bond formed by Knoevenagel condensation, the resultant hydrogels were found to be dynamic and showed good self-healing properties. This work presents a new dynamic covalent chemistry for the preparation of self-healable materials.
研究领域:
生物医学工程
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材料科学
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Yi Fang Xi,Yong Mei Chen,Yasir Aziz,Meng Liang Bi,He Ming Song,Jian Hui Li,Hao Peng Li,Hong Xu Jin,Hideyuki Miyatake,Yoshihiro Ito,Miklós Zrínyi
Storage and transportation of dynamic hydrogel in ambient conditions is challenging. At present, cold-chain management is the most suitable option but it requires substantial infrastructure and energy. Moreover, the raw materials for preparing dynamic hydrogels often require chemical modification and purification, making the process cumbersome and time-consuming. This poses challenges for the practical applications of dynamic hydrogels. Here, we have developed a dynamic micron-sized (DMS) gel powder that can be packed, stored, and transported in a freeze-dried powdered form and rehydrated into a dynamic hydrogel before use. The dynamic hydrogel obtained by rehydrating the DMS gel powder stored under ambient conditions for 7 months can achieve properties similar to the original hydrogel, including stable protein delivery, mechanical properties, injectability, self-healing and remodeling. We propose a novel strategy for preparing a long-term storable DMS gel powder that can maintain properties similar to those of the original hydrogel after rehydration. Considering the advantages in terms of convenience and commercialization for practical applications in the biomedical fields, this unique ready-to-use DMS powder offers a practical, scalable, and simple solution to enable mass production, cold-chain free, and low cost off-the-shelf dynamic hydrogel.
研究领域:
生物材料学
·
药物递送系统
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Xueyu Jiang,Xuefeng Yang,Boguang Yang,Lina Zhang,Ang Lu
To meet the rising demand of injectable hydrogels with self-healing, robustness and biocompatibility for biomedical engineering, the reversible ketoester-type acylhydrazone linkages was used for the fabrication of novel cellulose-based hydrogel. The ketoester-type acylhydrazone bond exchanged rapidly, endowing the hydrogels with highly efficient self-healing performance without any external stimuli under physiological environment, which was hardly achieved with the widely used arylhydrozone bond. The dynamic hydrogels exhibited tunable mechanical property, pH responsiveness, injectability and biocompatibility, demonstrating immense applications prospect for various biomedicines , such as drug and cell delivery. The pH-responsive controlled release of model drug doxorubicin (DOX) loaded in the hydrogel was demonstrated. In addition, benefitting from the excellent biocompatibility and the reversible ketoester-type acylhydrazone bonds, cells were encapsulated in the hydrogels as 3D carrier. The covalent adaptable network intensified injectability of cell-laden hydrogels and improved the long-lasting viability for cell culture, showing great potential in the biomedical field.
研究领域:
生物材料学
·
生物医药工程
·
组织工程
✓ 已验证
DOI
PubMed
高影响因子
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