COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2020
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IF 3.99
Yonggan Yan,Shulei Xu,Huanxi Liu,Xin Cui,Jinlong Shao,Peng Yao,Jun Huang,Xiaoyong Qiu,Chuanzhen Huang
Designing and fabricating self-healing hydrogel adhesive is essential in many physical and biological applications such as wound closure and cartilage repair. In this work, a new type of hydrogel adhesive has been developed through ultraviolet (UV) curing acrylamide (AM) monomer and hyper-branched polyethylenimine (PEI) polymer. The synthesized PAM-PEI hydrogel (weight ratio for PEI: PAM = 1: 9) shows high stretchability (1D extension ratio > 5500 %) and good plasticity (it can be extended into 2D hydrogel film), quick self-healing property (within 30 s) at ambient enviornment and good adhesiveness to both inorganic (23 kPa ∼ 90 kPa for metal and glass) and organic substrates (∼ 8 kPa for polytetrafluoroethylene , 1 ∼ 7 kPa for skin and liver). More importantly, the adhesion-strip-cycle test suggested that the adhesion measured was reversible and did not attenuate for at least 5 cycles on various surfaces. Rheology tests have demonstrated the repeatability of self-healing behavior of the hydrogel between small (1%) and large (1000 %) strain. In addition, the self-healed hydrogel fragments show good injectability, which can be potentially used for 3D-printing. This work provides a facile way of preparing multifunctional hydrogel adhesive with potential engineering applications.
研究领域:
生物材料学
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组织工程
·
再生医学
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 220
·期 3
·1800484
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IF 2.492
Xiaoya Ding,Gao Li,Chunsheng Xiao,Xuesi Chen
Schiff base bonds formed by primary amines and aldehydes are attractive for the construction of self-healing and injectable hydrogels. However, biomedical applications of the Schiff base–based (SB) hydrogels are usually limited by their inherent low stability due to the rapid exchange dynamic of the Schiff base bond under physiological condition. Herein, a general method to improve the stability of SB hydrogels by simply doubling the Schiff base linkages at the cross-linking points is proposed. The hydrogels formed by single Schiff base linkage ( hydrogel I ) disorganize into nano-aggregates due to the rapid exchange dynamic of Schiff base bond, while the hydrogels formed by double Schiff base linkage ( hydrogel II ) maintain the gel network for longer times due to the improved stability of the double Schiff base linkage at cross-linking points. Moreover, the hydrogel II displays excellent self-healing and injectable properties due to the rapid dynamic nature of Schiff base bonds.
研究领域:
生物材料学
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医学工程
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高分子化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Chao Xie,Qili Sun,Jingle Chen,Bingsheng Yang,Huiwen Lu,Zhanpeng Liu,Yucong Li,Kai Li,Bin Tang,Lijun Lin
Cuproptosis affects osteosarcoma locally, and the exploitation of cuproptosis-related biomaterials for osteosarcoma treatment is still in its infancy. We designed and synthesized a novel injectable gel of Cu ion–coordinated Tremella fuciformis polysaccharide (TFP–Cu) for antiosteosarcoma therapy. This material has antitumor effects, the ability to stimulate immunity and promote bone formation, and a controlled Cu 2+ release profile in smart response to tumor microenvironment stimulation. TFP–Cu can selectively inhibit the proliferation of K7M2 tumor cells by arresting the cell cycle and promoting cell apoptosis and cuproptosis. TFP–Cu also promoted the M1 polarization of RAW264.7 cells and regulated the immune microenvironment. These effects increased osteogenic gene and protein expression in MC3T3-E1 cells. TFP–Cu could significantly limit tumor growth in tumor-bearing mice by inducing tumor cell apoptosis and improving the activation of anti-CD8 T cell-mediated immune responses. Therefore, TFP–Cu could be a potential candidate for treating osteosarcoma and bioactive drug carrier for further cancer-related applications.
研究领域:
生物材料学
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肿瘤学
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免疫学
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骨再生医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Penghui Fan,Shangzhi Li,Junfeng Yang,Kaidan Yang,Ping Wu,Qi Dong,Yingshan Zhou
The cystic cavity that develops following spinal cord injury is a major obstacle for repairing spinal cord injury (SCI). The injectable self-healing biomaterials treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury. Herein, a natural extracellular matrix (ECM) biopolymer hyaluronic acid-based hydrogel was developed based on multiple dynamic covalent bonds. The hydrogels exhibited excellent injectable and self-healing properties, could be effectively injected into the injury site, and filled the lesion cavity to accelerate the tissue repair of traumatic SCI. Moreover, the hydrogels were compatible with cells and various tissues and possessed proper stiffness matched with nervous tissue. Additionally, when implanted into the injured spinal cord site, the hyaluronic acid-based hydrogel promoted axonal regeneration and functional recovery by accelerating remyelination, axon regeneration, and angiogenesis. Overall, the injectable self-healing hyaluronic acid-based hydrogels are ideal biomaterials for treating traumatic SCI.
研究领域:
生物材料学
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神经科学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2023
·
IF 4.6
Hanwen Jiang,Yan Xiao,Huanxuan Huang,Wang Yin,Meidong Lang
Antibacterial hydrogel has emerged as an excellent candidate for wound dressing with the ability to eliminate infection and promote wound healing. Herein, a dynamic hydrogel is developed by Schiff base reaction of mixed charged polypeptides and oxidized dextran (ODex). Specifically, biodegradable polypeptides of 1-(propylthio)acetic acid-3-butylimidazole-modified poly(L-lysine) (PLL-PBIM) and adipate dihydrazide-modified poly(L-glutamic acid) (PLG-ADH) are achieved with tunable substitution and charge. By mixing with ODex, charged polypeptides of PLL-PBIM and PLG-ADH led to an injectable and self-healing hydrogel in seconds. The injectable and self-healing performances of the hydrogels are ascribed to the reversible imine and hydrazone bonds formed between polypeptides and ODex. The positively charged hydrogels exhibited over 95% antibacterial activity against E. coli and S. aureus . An optimized balancing of PLG-ADH and PLL-PBIM significantly reduced the hemolysis rate and cytotoxicity of hydrogels. Therefore, the dynamic hydrogel with excellent biocompatibility and inherently antibacterial ability can have potential application for wound dressing.
研究领域:
生物材料学
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医学工程
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组织工程
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2024
·
IF 10
Qian Han,Jiahui He,Lang Bai,Ying Huang,Baojun Chen,Zhenlong Li,Meiguang Xu,Qiaonan Liu,Shuai Wang,Nuanyang Wen,Jing Zhang,Baolin Guo,Zhanhai Yin
Partial-thickness cartilage defect (PTCD) is a common and formidable clinical challenge without effective therapeutic approaches. The inherent anti-adhesive characteristics of the extracellular matrix within cartilage pose a significant impediment to the integration of cells or biomaterials with the native cartilage during cartilage repair. Here, an injectable photocrosslinked bioadhesive hydrogel, consisting of gelatin methacryloyl (GM), acryloyl-6-aminocaproic acid- g -N-hydroxysuccinimide (AN), and poly(lactic- co -glycolic acid) microspheres loaded with kartogenin (KGN) (abbreviated as GM/AN/KGN hydrogel), is designed to enhance interfacial integration and repair of PTCD. After injected in situ at the irregular defect, a stable and robust hydrogel network is rapidly formed by ultraviolet irradiation, and it can be quickly and tightly adhered to native cartilage through amide bonds. The hydrogel exhibits good adhesion strength up to 27.25 ± 1.22 kPa by lap shear strength experiments. The GM/AN/KGN hydrogel demonstrates good adhesion, low swelling, resistance to fatigue, biocompatibility, and chondrogenesis properties in vitro. A rat model with PTCD exhibits restoration of a smoother surface, stable seamless integration, and abundant aggrecan and type II collagen production. The injectable stable adhesive hydrogel with long-term chondrogenic differentiation capacity shows great potential to facilitate repair of PTCD.
研究领域:
生物医学工程
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组织工程
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再生医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Ruquan Zhang,Yongzhen Tao,Qianru Xu,Nian Liu,Pu Chen,Yingshan Zhou,Zikui Bai
The hydrogels with injectable and self-healing properties were prepared from xanthan gum (XG) and silk fibroin (SF) by using sodium trimetaphosphate (STMP) as crosslinker. A three-stage model of oscillation-shear-oscillation experiment was designed to mimic injection process and to observe destruction and regeneration of the hydrogels after shear. The XG3-SF-STMP hydrogels immediately recovered to original storage modulus of 80.6%–93.8% on removing shear. The hydrogels were 3D printed into the self-supporting constructions of hydrogel fibers with connected porous structures, and the XG3-SF-STMP hydrogel fibers exhibited smaller width than XG3-STMP. Oscillation rheological behavior indicated that XG3-SF-STMP hydrogels formed rapidly and exhibited more solid-like gel behavior than XG3-STMP. The hydrogel structures were destroyed under a strain (100%) larger than critical strain, but were rebuilt under a small strain (1%) with recovery ratio of 91.36–93.96% within 120 s, suggesting a self-healing property. Introduction of SF particles into XG3-STMP crosslinked networks improved stiffness and retained recoverability. Carboxyl and phosphate groups in the hydrogel networks are beneficial for XG3-SF-STMP hydrogels to absorb enough liquid electrolytes, leading to effective ionic conductivity . The ion-conductive hydrogel with injectable, self-healing, controlled release and non-cytotoxic properties possesses a promising prospect for tissue engineering and drug release application.
研究领域:
材料科学
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生物医学工程
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组织工程
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产品关联
DOI
PubMed
高影响因子
ACS Omega
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2018
·
IF 0
Yueyuan Zheng,Yuqing Liang,Depan Zhang,Xiaoyi Sun,Li Liang,Juan Li,You-Nian Liu
Injectable scaffolds are of great interests for skin regeneration because they can fill irregularly shaped defects through minimally invasive surgical treatments. In this study, an injectable hydrogel from biopolymers is developed and its application as wound dressings is examined. Gelatin-based hydrogels were successfully prepared at body temperature upon blending with low content of gellan, and the synergetic effect on the gel formation was carefully characterized through rheological methods. The electrostatic complexation between gelatin and gellan was confirmed to contribute a continuous hydrogel network. The obtained blend hydrogel demonstrates remarkable shear-thinning and self-recovering properties. For antibacterial purpose, tannic acid was incorporated into the blend hydrogel. In addition, tannic acid-loaded blend hydrogel was verified to accelerate the wound healing on the mice model, significantly than the control groups. Thus, this paper presents a facile approach without chemical modification to construct injectable gelatin-based hydrogels, which have great potential as a wound dressing or tissue scaffold at body temperature.
研究领域:
生物材料学
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组织工程学
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产品关联
DOI
PubMed
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 7
·1746-1752
·
IF 5.976
Qiang Zhang,Libin Liu,Chenguang Pan,Dong Li,Guangjie Gai
Self-healable conductivity is an important feature of electronic skin, which is highly desirable for next-generation wearable devices. However, the preparation of conductors with good mechanical properties combining thermal sensitivity, adhesion, and injectability as well as self-healing capability remains a great challenge. Herein, a series of self-healing conductors were fabricated through random copolymerization of butyl methacrylate (BMA), lauryl methacrylate (LMA) and undecylenyl alcohol modified multi-walled carbon nanotubes (mMWCNTs). The covalent binding between mMWCNTs and polymers avoids the aggregation and uneven dispersion of MWCNTs in the polymer matrix. The resulting conductors possess electrical conductivity (about 11 S m−1) and high mechanical performance (Young's modulus: ∼10 MPa and tensile strength: ∼0.89 MPa) as well as high mechanical and electrical self-healing efficiency (>94% of mechanical strength and >98% of conductivity). More importantly, the composites also exhibit other unique features, including adhesive, injectable, and sensing capability. This work provides new routes to design and fabricate self-healing conductive materials for applications in next-generation wearable devices.
研究领域:
材料科学
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电子皮肤
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高分子化学
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产品关联
DOI
高影响因子
Gels
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2022
·Vol. 8
·期 1
·52
·
IF 4.432
Che Zhao,Chengju Sheng,Chao Zhou
Traditional antibacterial hydrogels have a broad-spectrum bactericidal effect and are widely used as wound dressings. However, the biological toxicity and drug resistance of these antibacterial hydrogels cannot meet the requirements of long-term clinical application. Imidazolium poly(ionic liquids) (PILs) are polymeric antibacterial agents exhibiting strong antibacterial properties, as they contain a strong positive charge. In this study, two imidazolium PILs, namely poly(N-butylimidazolium propiolic acid sodium) (PBP) and poly(N-(3,6-dioxaoctane) imidazolium propiolic acid sodium) (PDP), as high efficiency antibacterial agents, were synthesized by polycondensation reaction. Then, the PILs were compounded with polyethylene glycol (PEG) by a thiol-yne click reaction to prepare injectable antibacterial hydrogels. An in vitro assay showed that the injectable antibacterial hydrogels could not only quickly killEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus), but also had low toxicity for human skin fibroblasts cells (HSFs) and human umbilical vein endothelial cells (HUVECs), respectively. Additionally, the lipopolysaccharide (LPS) inflammation model revealed that the injectable antibacterial hydrogels also had anti-inflammatory effects, which would be advantageous to accelerate wound healing.Keywords:antibacterial agents;imidazolium poly(ionic liquids);injectable hydrogels;anti-inflammatory
研究领域:
材料科学
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生物医学工程
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药剂学
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产品关联
DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 24
·5547
·
IF 4.967
Dashan Qi,Haowei Zhu,Yingjie Kong,Qingming Shen
Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomedicine (ICG—MTX) was fabricated by combining near-infrared (NIR) photothermal reagents (ICG) and chemotherapy drugs (MTX). The ICG—MTX was then mixed with the hydrogel precursor and radical initiator to obtain an injectable hydrogel precursor solution. Under the irradiation of NIR light, the precursor solution could release alkyl radicals, which promote the transition of the precursor solution from a liquid to a colloidal state. As a result, the nanomedicine could effectively remain at the site of the tumor and continue to be released from the hydrogel. Due to the targeted nature of MTX, the released ICG—MTX could target tumor cells and improve the accuracy of photothermal–chemo combination therapy. The results indicated that the injectable nanomedicine–hydrogel system has a favorable therapeutic effect on tumors.Keywords:injectable hydrogel;nanomedicine;near-infrared;photothermal therapy;chemotherapy
研究领域:
生物医学工程
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药学
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癌症研究
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Jiameng Wang,Hao Cheng,Weiyi Chen,Peide Han,Xiaohong Yao,Bin Tang,Wangping Duan,Pengcui Li,Xiaochun Wei,Paul K. Chu,Xiangyu Zhang
Antibacterial hydrogels with injectable and self-healing properties have attracted much attention in the field of wound dressings because they not only can prevent bacterial infections, but also meet the basic needs for wound healing. However, how to achieve high antibacterial efficacy and low drug resistance for hydrogels is still a challenge. Herein, an injectable, self-healing, near-infrared (NIR) photosensitive antibacterial hydrogel composed of CuS-grafted-curcumin ( [email protected] ) and carboxymethyl cellulose modified with aldehyde groups and hydroxypropyl trimethyl ammonium chloride chitosan is prepared for wound dressings. The p-n junction formed between curcumin and CuS promotes separation of electron-hole pairs, enhances the mobility of photogenerated charges, and destroys the conjugated structure of curcumin simultaneously consequently increasing the photocatalytic activity. [email protected] is immobilized and distributed uniformly in the hydrogel via the π-π conjugation ring. The hybrid hydrogel exhibits excellent antibacterial activity after irradiation with 808 NIR light for 10 min due to the enhanced photodynamic and photothermal antibacterial effects. In addition, the hybrid structure improves the biocompatibility of CuS and expedites infected-wound healing at a mild temperature of 45 ℃. This organic/inorganic hybrid is shown to be an excellent wound dressing for the treatment of bacterial-infected wounds.
研究领域:
生物材料学
·
医学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）