DRUG METABOLISM AND DISPOSITION
·
2025
·
IF 4
Yue Gao,Chenghui Cai,Wanyu Zheng,Shicheng Fan,Yifei Zhang,Yanying Zhou,Huilin Li,Jie Yang,Shaoxing Guan,Huichang Bi
Constitutive androstane receptor (CAR, NR1I3), a nuclear receptor superfamily member, plays a pivotal role in liver size regulation. Murine CAR agonist TCPOBOP was reported to induce hepatomegaly in mice, accompanied by hepatocyte hypertrophy and proliferation. However, whether CAR activation-induced hepatomegaly is reversible and the histological changes during reversal process remain elusive. In the current study, C57BL/6 mice were administered TCPOBOP for 5 days and sacrificed at different time points after drug withdrawal. The results showed that TCPOBOP-induced hepatomegaly required a long time to reverse, as evidenced by the liver-to-body weight ratio in the TCPOBOP group remained significantly higher than that in the Vehicle group even 120 days after withdrawal. CTNNB1 and CCND1 staining indicated a reduction in hepatocyte size and proliferating cells. To investigate the involved mechanisms, we measured proteins associated with hepatomegaly and liver regeneration termination. The results suggested that YAP, C-MYC, CTNNB1, FOXM1 and HNF4α changed significantly after TCPOBOP withdrawal and functioned at different stages during reversal. Furthermore, we established a UPLC-MS/MS method to quantify TCPOBOP concentration. The results indicated a long-term hepatic retention of TCPOBOP, which constantly activated CAR and led to sustained hepatomegaly after TCPOBOP withdrawal. Overall, these findings revealed the reversibility of CAR activation-induced hepatomegaly and provided new insights into the safety of CAR as a drug target. Additionally, the results highlighted the importance of considering long-term TCPOBOP accumulation in the liver to avoid potential adverse effects and experimental biases.
研究领域:
药理学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2011
·
IF 4.524
Pei Pei Yuan,Bin Hong Liu,Bang Jie Zhang,Zhou Peng Li
In this work, we report a new reversible hydrogen storage composite based on 6LiBH4+CaF2. It has a theoretical hydrogen capacity of 9.6 wt % (0.09 g·ml−1) and a slightly reduced thermodynamic stability compared with pure LiBH4. The dehydrogenation of 6LiBH4 + CaF2 yielded CaB6 and a solid solution of LiH and LiF that can be rehydrogenated to form LiBH4 and CaF2. The composite revealed good reversibility of hydrogen storage regardless of the hydrogen back pressure applied during the dehydrogenation. Catalysts like TiF3, CeF3, and NbCl5 were found to enhance its dehydriding kinetics. XRD and FT-IR analyses revealed that hydrogen uptake of the composite proceeded through a reaction path involving CaH2 as the main intermediate.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2013
·Vol. 1
·期 12
·3983-3991
·
IF 0
Lina Chong,Jianxin Zou,Xiaoqin Zeng,Wenjiang Ding
In this work, a reversible hydrogen storage composite, 3NaBH4/NdF3, has been prepared using a mechanical milling method. The de-/rehydrogenation properties as well as the mechanisms of reversible hydrogen sorption in the composite were carefully investigated. Based on the pressure–temperature–composition measurements, the de-/rehydrogenation enthalpies of the 3NaBH4/NdF3 composite are determined to be 86.4 kJ mol−1 H2 and −13.2 kJ mol−1 H2, respectively. The onset dehydriding temperature of the composite is determined to be 413 °C in 0.1 MPa Ar atmosphere and can be as low as 80 °C under vacuum conditions. Analyses revealed that NdB6, Nd2H5 and NaF were formed after the decomposition of the composite, which can be hydrogenated to produce NaBH4 and NaNdF4. The formation of NaNdF4 instead of NdF3 in the hydrogenated products is believed to be responsible for the reduced hydrogen storage capacity, while the intermediate formation of B, Nd and NdB4 during dehydrogenation accounts for the asymmetric hydriding/dehydriding behaviors in the 3NaBH4/NdF3 composite.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
Nanomaterials
·
2019
·Vol. 9
·期 10
·1370
·
IF 4.034
Liuting Zhang,Xiong Lu,Liang Ji,Nianhua Yan,Ze Sun,Xinqiao Zhu
Catalytic doping plays an important role in enhancing the hydrogen storage performance of MgH2, while finding an efficient and reversible catalyst remains to be a great challenge in enhancing the de/rehydrogenation properties of MgH2. Herein, a bidirectional nano-TiH1.971catalyst was prepared by a wet chemical ball milling method and its effect on hydrogen storage properties of MgH2was studied. The results showed that all the TiH1.971nanoparticles were effective in improving the de/rehydrogenation kinetics of MgH2. The MgH2composites doped with TiH1.971could desorb 6.5 wt % H2in 8 min at 300 °C, while the pure MgH2only released 0.3 wt % H2in 8 min and 1.5 wt % H2even in 50 min. It was found that the smaller the size of the TiH1.971particles, the better was the catalytic effect in promoting the performance of MgH2. Besides, the catalyst concentration also played an important role and the 5 wt %-c-TiH1.971modified system was found to have the best hydrogen storage performance. Interestingly, a significant hydrogen absorption amount of 4.60 wt % H2was evidenced for the 5 wt %-c-TiH1.971doped MgH2within 10 min at 125 °C, while MgH2absorbed only 4.11 wt% hydrogen within the same time at 250 °C. The XRD results demonstrated that the TiH1.971remained stable in cycling and could serve as an active site for hydrogen transportation, which contributed to the significant improvement of the hydrogen storage properties of MgH2.Keywords:hydrogen storage;MgH2;TiH1.971;catalytic effect;reversibility
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2020
·
IF 3.693
Zhang Xin,Zhang Xuelian,Ren Zhuanghe,Hu Jianjiang,Gao Mingxia,Pan Hongge,Liu Yongfeng
In this paper, we report amorphous-carbon-supported TiB2 nanoparticles having sizes of 2–4 nm (nano-TiB2@C) as highly active catalysts for hydrogen storage in NaAlH4. Nano-TiB2@C was synthesized by a simple calcination at 550°C with Cp2TiCl2 and MgB2 (molar ratio of 1:1) as precursors. The addition of 7 wt% nano-TiB2@C reduced the onset dehydrogenation temperature of NaAlH4 by 100 to 75°C. A practically available hydrogen capacity of 5.04 wt% could be desorbed at 140°C within 60 min, and completely hydrogenated at 100°C within 25 min under a hydrogen pressure of 100 bar. Notably, the hydrogen capacity was almost unchanged after 20 cycles, which shows the stable cyclability, considerably higher than those of structures catalyzed by Ti halides or TiO2. The stable catalytic function was closely related to the in-situ-formed Ti–Al alloy, which considerably facilitated the dissociation and recombination of H–H and Al–H bondings.
研究领域:
材料科学
·
能源化学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Renhui Ling,Mingxing Li,Xin Li,Laihuan Pei,Xiaoyan Luo,Congmin Wang
MOFs have high adsorption performance of ammonia (NH 3 ) because of its porosity and abundant coordination sites, especially MOFs containing carboxylic acid ligands have emerged as effect NH 3 adsorbents. But, it’s troublous for reversible ammonia adsorption for the strong metal-NH 3 coordination or the collapse of adsorbents. [MEDTA] 2- is a very stable and classic carboxylic acid-containing complex, but there was no relevant report. Therefore, this work carried out the design and synthesis of PVIm-R8-MEDTA based on the use of the coordination structure of [MEDTA] 2- and the stability of PILs’ skeleton. The characterization indicated the [MEDTA] 2- could be introduced into PILs successfully for the hydrogen bonding interactions with the imidazolium cation, and the obtained PVIm-R8-MEDTA presented enhanced NH 3 capacity (10.4–14.7 mmol/g) than their precursor PVIm-R8-Br (7.8 mmol/g). The mechanism of NH 3 adsorption was proposed by DFT calculation, spectroscopic method, and the calorimetric test, it indicated the NH 3 was fixed by imdazolium cation through hydrogen bonding and inserted into two of the carboxylate and metal bonds of [MEDTA] 2- . Because of the multi-meshing coordination of [EDTA] 4- and metal ions, the disconnected carboxylate ions could easily coordinate with metal ions again and repair the chelating structure of [MEDTA] 2- , which caused the ammonia easily be desorbed. In the process of gas adsorption, there was no bonding breakage of the skeleton of PILs, which helped the PVIm-R8-MEDTA be recovered under moisture and NH 3 atmosphere. Thanks for the designability of PILs, such as the cationic structure, structure and size of cross-linking agent, the choice of complex anion and so on, it provides a new design idea and theoretical basis for efficient and reversible ammonia adsorption materials.
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 3
·期 8
·4493-4500
·
IF 0
Lina Chong,Jianxin Zou,Xiaoqin Zeng,Wenjiang Ding
In the present work, hydrogen sorption behaviors of some of the 3NaBH4–LnF3 (Ln = Ce, Sm, Gd and Yb) composites were investigated and the mechanisms associated with different effects of LnF3 (Ln = La, Ce, Pr, Nd, Sm, Gd, Ho, Er and Yb) on reversible hydrogen sorption in NaBH4 were proposed based on careful comparisons. The key factors controlling the properties of 3NaBH4–LnF3 can be summarized as follows: (i) electronegativity χp of Ln3+ determines the thermodynamic stability of 3NaBH4–LnF3 composites with their χp in the range of 1.23–1.54 being suitable for reversible hydrogen storage; (ii) the electronic configuration of Ln3+ influences rehydrogenation behaviors: more stable the oxidation state of the Ln3+ is, the better is the rehydrogenation performance of NaBH4; (iii) the unique crystal structure of the Ln–B phase formed during dehydrogenation, and geometrical configuration of B in Ln–B, provide dangling bonds for hydrogen atoms to embed in, consequently modifying the rehydrogenation kinetics. Because Gd3+ possesses a combination of suitable electronegativity, stable oxidation state and favorable geometric structure in GdB4, the 3NaBH4–GdF3 composite exhibits the best overall hydrogen storage properties among all the studied 3NaBH4–LnF3 composites, with high cycling stability up to 51 cycles along with fast kinetics. This understanding provides us with criterions to design new borohydride-based hydrogen storage systems and to optimize their hydrogen storage properties.
研究领域:
材料科学
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化学
✓ 已验证
DOI
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2018
·
IF 2.891
Qingming Wang,Shanshan Wu,Yingzi Tan,Yulin Yan,Lei Guo,Xinhui Tang
In present report, a new BDA for Cu 2+ has been disclosed for the first time. The presence of Cu 2+ caused an obvious fluorescence enhancement at 407 nm upon excitation at 360 nm, which could be distinguished by the naked eye under a UV lamp. It was found to have acceptable detection limits (0.12 μM), high selectivity and reversibility/reusability. The photoluminescence measurement indicates that BDA with Cu 2+ presence, showed very strong blue emission bands with CIE chromaticity coordinates (0.1652, 0.0723). Besides, the designed probe has shown potential applications in the area of sample monitoring, photo-printing.
研究领域:
分析化学
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材料科学
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环境科学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 29
·11636-11642
·
IF 3.069
Dongshun Deng,Xiuzhi Duan,Bao Gao,Chao Zhang,Xiaoxia Deng,Lei Gong
The hydrogen bond donor (HBD) glycerol (Gly) and hydrogen bond acceptors (HBA) selected among 1,2,4-triazole (Tri), imidazole (Im), tetrazole (Tz), 1-methyl-triazole (Tri-Me), 3-mercapto-1,2,4-triazole (Tri-SH), 3-amino-1,2,4-triazole (Tri-NH2), 3-cyano-1,2,4-triazole (Tri-CN), and 4-formalimidazole (Im-CHO) were paired to construct functional deep eutectic solvents (DESs) that were then utilized as ammonia (NH3) absorbents. The influences of the HBA in DESs, temperature, and partial pressure of NH3 on the NH3 absorption performance were systematically investigated. The results illustrated that all the DESs exhibited efficient and reversible absorption for NH3, and Tri–Gly possessed higher absorption capacity than Im–Gly, with the maximum absorption capacity of 0.115 gram NH3 per gram DES of Tri–Gly (1 : 3) at 313.15 K and 1.0 bar. The NH3-saturated DES could be easily recycled five times with a persistent absorption performance. The absorption mechanism was further deduced by the NMR and FTIR spectroscopy. These DESs acted as potential absorbents for NH3 due to their good absorption performance and reversibility.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2016
·
IF 2.101
Feng-Fei Pang,Sen Li,Wen-Quan Sun,Guo-Zhi Han
We report the reversible conductivity and morphology modulation of PEDOT:PSS composites based on pH. Through studying effects of pH on the morphology and conductivity of PEDOT:PSS composites, it was found that different pH of PEDOT:PSS composites solution will result in different morphology of PEDOT:PSS composites film . At the same time, conductivity of the film also changed accordingly. With the increase of pH from 3 to 11, the microstructure of PEDOT:PSS film reversibly changed from a continuous network to non-continuous clusters, and the corresponding conductivity decreased from 0.62 S/cm to 0.42 S/cm. Furthermore, the mechanism was innovatively investigated by Raman spectra , along with UV–Vis spectra and SEM .
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2015
·
IF 3.313
Qian Wen Bao,Wei Yuan Pan,Hao Liu,Bin Hong Liu,Zhou Peng Li
In this study, hydrogen release and uptake properties for composites of LiBH 4 with the conjugated polymer poly( p -phenylene) (PPP) were investigated. The incorporation of LiBH 4 with PPP led to a significant destabilization effect, decreasing the dehydrogenation temperature of LiBH 4 by 100 °C. Moreover, LiBH 4 could be regenerated at 450 °C under 9.0 MPa H 2 . By thorough analyses using XRD , HRTEM , FTIR , Raman, XPS as well as 11 B MAS NMR, the dehydrogenation product of LiBH 4 +PPP and the regeneration mechanism of LiBH 4 are elucidated. Also the reason of capacity degradation is discussed based on the analysis results. The formation condition of LiBH 4 was significantly moderated due to the presence of a simultaneously formed amorphous mixture of boron and carbon, which sheds light on the improvement of LiBH 4 reversibility .
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Tianping Huang,Jianxin Zou,Huabing Liu,Wenjiang Ding
Three kinds of transition metal fluorides TMF x (TM = Nb, Co, Ti) were introduced into the 3NaBH 4 -GdF 3 hydrogen storage system via mechanical milling. Their effects on the hydrogen storage behaviors of 3NaBH 4 -GdF 3 were systematically investigated by means of DSC and volumetric methods. All TMF x exhibited promoting effect on hydrogen desorption properties of 3NaBH 4 -GdF 3 to different degrees, especially when NbF 5 or TiF 3 was added. For example, the hydrogen desorption peak temperature was decreased by 17 °C with doping 3 mol% of NbF 5 . Besides, TiF 3 improved also the hydrogen absorption capacity and reversibility of 3NaBH 4 -GdF 3 . Based on XRD analyses, the role of TMF x on the dehydrogenation and the promoting effect of TiF 3 on the reversibility of 3NaBH 4 -GdF 3 were clarified. This work helped to understand the combination effect of rare earth metal fluoride (GdF 3 ) and transition metal fluorides on the reversible hydrogen storage properties of NaBH 4 .
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）