TALANTA
·
2022
·
IF 6.556
Qianqian Shang,Huajing Liu,Hang Mei,Chuixiu Huang,Xiantao Shen
Coextraction of different groups of analytes is vital for saving sample volumes and simplifying analytical procedures in bioanalysis . Conventionally, coextraction was achieved by using multi-extraction systems with different supported liquid membranes (SLMs). However, the different membrane solvents tended to diffuse into the aqueous solutions and the other SLM to reach distribution equilibrium during extraction process, causing the system instability. In this work, a stable multi-extraction system (integration of liquid-phase microextraction and electromembrane extraction, LPME/EME) based on the identical supported semi-liquid membrane (SsLM) was developed. Principally, the state of distribution equilibrium of the membrane solvent (polypropylene glycol with molecular weight 4000) in SsLM could be reached at the beginning of extraction, which enhanced the coextraction stability. With this multi-extraction system, acidic and basic analytes were simultaneously extracted from practical biological samples. The extraction recoveries of the six model drugs in undiluted urine samples were over 70%. Followed by LC-MS/MS, the limits of quantification (LOQs) were in the range of 5–10 ng mL −1 . The multi-extraction system using the identical SsLM in this study shows promising potential in construction of other stable multi-extraction systems (e.g., LPME/LPME and EME/EME) in the future, which will greatly benefit the group separation of analytes in complicated biological samples.
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ANALYTICA CHIMICA ACTA
·
2021
·
IF 6.558
Ruiqin Zhu,Hang Mei,Huajing Liu,Changbao Hong,Xiantao Shen,Chuixiu Huang
Practical biological and environmental samples always contain both acidic and basic substances, and the samples are always precious. Thus, separation of analytes with different nature from the same sample was of great significance. Successive liquid phase microextraction (sLPME) of acidic and basic analytes under optimal extraction conditions was therefore proposed for the first time. The concept of sLPME was proved by using three acidic analytes (naproxen, flurbiprofen and diclofenac) and three basic analytes (haloperidol, fluoxetine and sertraline) as model analytes, and using polypropylene glycol with an average molecular weight of 4000 (PPG4000) as SLM . The recoveries of all target analytes by sLPME were similar to that by individual LPME due to good affinity of PPG4000 to both acidic and basic analytes. Under optimal extraction conditions, the recoveries for all analytes by sLPME from urine samples were in the range of 62%–95%. Moreover, combined with LC-MS/MS, such sLPME approach was also evaluated with urine samples. The matrix effect of sLPME-LC-MS/MS at different levels for all analytes ranged from −14.1%–13.2%. The linear ranges with R 2 > 0.996 were 5–1000 ng mL −1 for basic analytes, and 20–1000 ng mL −1 for acidic analytes except diclofenac (1–1000 ng mL −1 ). The repeatability and accuracy at four levels were in the range of 3%–10% and 86%–120%, respectively. The limit of detection (LOD, S/N = 3) and limit of quantification (LOQ, S/N = 10) were found to be 0.07–0.49 ng mL −1 and 0.25–1.63 ng mL −1 , respectively. Finally, the strategy for constructing a sLPME system was further confirmed with urine, plasma and saliva using another two versatile SLM solvents possessing high affinity to both acidic and basic analytes. Successive LPME enabled separation of acidic and basic analytes from the same sample under optimum extraction conditions for all target analytes. Thus, we believe that the sLPME system will become a potent platform for forensic toxicology analysis, food science, environmental analysis and epidemiology study.
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GREEN CHEMISTRY
·
2021
·Vol. 23
·期 4
·1782-1793
·
IF 10.182
Hang Mei,Huajing Liu,Qianqian Shang,Ying Dong,Stig Pedersen-Bjergaard,Chuixiu Huang,Xiantao Shen
In this work, a green, stable and versatile organic-solvent-free electromembrane extraction (EME) system based on semi-interpenetrating polymer networks (semi-IPN) is proposed for the extraction and enrichment of both basic and acidic drugs from human urine. Because of its non-toxicity and high affinity in target separation, semi-solid polypropylene glycol (PPG) was selected as a component for the synthesis of semi-IPN networks via an ultrasonic-assisted blending (UAB) method. Using the homogeneous semi-IPN membrane as the supported liquid membrane (SLM), the organic-solvent-free EME system was obtained. Under the optimized conditions, the organic-solvent-free EME system showed high recovery efficiency for both basic analytes (70–97%) and acidic analytes (86–100%). Moreover, the organic-solvent-free EME set-up could be reused in eight successive extraction batches without an obvious decrease in extraction efficiency. In addition, the EME system could be conveniently stored at ambient temperature for a long time, which will greatly promote the commercialization of EME. We believe this study provides new insights and attempts in the development of green sample preparation approaches.
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Polymers
·
2020
·Vol. 12
·期 9
·1921
·
IF 3.426
Yanyan Lou,Fibor J. Tan,Rong Zeng,Mengen Wang,Pan Li,Shengji Xia
The unique two-dimensional structure and chemical properties of graphene oxide (GO) provide a convenient method for preparing novel membranes. In this study, GO membranes were prepared through filtration by a pressure-assisted self-assembly method involving the cross-linking of three diamine monomers on a polyethersulfone (PES) support. The different small molecular diamines, ethylenediamine, butanediamine, and p-phenylenediamine, were introduced as cross-linking agents to investigate the effect of diamine on the properties of GO membranes. The hydrophobic substances ibuprofen, gemfibrozil, and triclosan were selected as target pharmaceuticals and personal care products (PPCPs). The adsorption and molecular sieving activities of PPCPs by cross-linked GO membranes at a pH of 3 were investigated. The permeate water was analyzed for dissolved organic carbon, ultraviolet absorption at 254 nm, molecular weight distribution, and fluorescence excitation–emission matrices. The results showed that the removal of hydrophobic PPCPs by GO membranes was mainly due to their adsorption and molecular sieving activities. Adsorption was mainly determined by the hydrophilic and hydrophobic properties of the membranes and PPCPs. The interception effect was mainly determined by the interlayer spacing between the GO membranes and the molecular weight and steric hindrance of the PPCPs. A smaller spacing of the GO membrane layers resulted in greater steric hindrance and a higher removal rate.Keywords:graphene oxide;polyethersulfone;cross-linked;ultrafiltration membrane;PPCPs
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NANO
·
2020
·
IF 1.566
Shicheng Liu,Guanjing Qi,Cong Ding,Kun Tan,Meiling Yin,Tingting Zhang,Zhenzhen Xu
Adsorption of gemfibrozil (GF) from aqueous solution by highly/lowly graphitized carbon black (GCB-H/GCB-L) was investigated by batch and fixed-bed experiments. Results showed that the adsorption of GF onto GCB greatly depended on solution pH and graphitization of carbon. The pseudo-second-order kinetic model was found to be more appropriate in describing the adsorption processes of two GCBs. The adsorption equilibriums were well fitted with the Langmuir isotherm model, and GCB-H exhibited a higher adsorption capacity of 47.68 mg g −1 at 298 K, compared with GCB-L of 4.33 mg g −1 . GCB-H achieved 69.76% GF removals in simulated water after 6 h, indicating its potential practicability. The GCBs were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR), and the results indicated that the π - π interaction was strongly involved in the adsorption. Thermodynamic studies further suggested that the adsorption of GF on GCB-H was exothermic, which could happen spontaneously at any temperature mainly through π - π interaction for physical adsorption on the surface of the plane.
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JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Tiemei Li,Yuefei Song,Zhaoqi Dong,Yueyue Shi,Jing Fan
ABSTRACT As a new kind of green solvents for potential replacement of traditional volatile organic compounds, deep eutectic solvents (DESs) have been attracting more and more attention in various applications. In this work, three types of hydrophobic DESs were synthesized by simple mixing of trioctylmethyl ammonium chloride (used as hydrogen bond acceptor) with decanoic acid, ketoprofen and gemfibrozil (hydrogen bond donors), respectively, at different molar ratios. In order to evaluate the solvent characteristics of these DESs, some of the physical properties such as melting point, density, viscosity, and water contact angle were determined. Then, these hydrophobic DESs were used for the vortex-assisted liquid-liquid microextraction of bisphenol-type contaminants in water, followed by quantitative determination of bisphenols contents with high performance liquid chromatography (HPLC-FLD) coupled with fluorescence detection. For this purpose, four bisphenols, namely, 2, 2-bis(4-hydroxydiphenyl)propane (BPA), 2, 2-bis (4-hydroxyphenyl)butane (BPB), 4, 4′-(1-phenylethylidene)bisphenol (BPAP) and 4, 4′-cyclohexylidenebisphenol (BPZ) were selected as model contaminants. It was found that the enrichment factors of the proposed method were in the range from 97 to 112, depending on the structure of the analytes. Under optimal experimental conditions, the linearity ranges of the method varied from 0.3 to 700 µg L −1 with linear correlation coefficients (R 2 ) higher than 0.996. The limit of detections (LODs) and limit of quantifications (LOQs) were in the range of 0.3-0.5 µg L −1 and 0.06-0.08 µg L −1 , respectively. Furthermore, the developed method was successfully used in the extraction and determination of four bisphenols from food-contacted plastic samples.
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JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Yang Guo,Erzhuo Zhao,Jun Wang,Xiaoyuan Zhang,Haiou Huang,Gang Yu,Yujue Wang
The abatement of several emerging contaminants (ECs) in groundwater by conventional ozonation and three ozone-based advanced oxidation processes (AOPs) - catalytic ozonation with manganese dioxide (MnO 2 ), conventional peroxone (O 3 /H 2 O 2 ), and electro-peroxone (EP) - was compared in this study. The addition of MnO 2 , H 2 O 2 , or electro-generation of H 2 O 2 during ozonation enhanced ozone transformation to hydroxyl radicals to different extent. These changes did not considerably influence the abatement of ECs with moderate to high ozone reactivities ( k O 3 ≥500 M -1 s -1 ), whose abatements were similar with >90 % during all four processes. In comparison, the abatements of ozone-refractory ECs ( k O3 < 15 M -1 s -1 ) were lower during conventional ozonation (∼40–85 % abatement), but could be enhanced by ∼10–40 % during the three ozone-based AOPs. Besides enhancing ozone-refractory EC abatement, the three AOPs, especially the O 3 /H 2 O 2 and EP processes, reduced considerably bromate formation compared to conventional ozonation. These results demonstrate that the EP process performs similarly as catalytic ozonation and O 3 /H 2 O 2 processes in terms of EC abatement and bromate control. Considering its more convenient, flexible, and safer way of operation, the EP process may provide an attractive alternative to the two more traditional AOPs for water treatment.
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FITOTERAPIA
·
2015
·
IF 2.345
Lili Wu,Wanping Zhong,Junjin Liu,Weichao Han,Shilong Zhong,Qiang Wei,Shuwen Liu,Lan Tang
Oxysophocarpine (OSC), an active and toxic quinolizidine alkaloid, is highly valued in Sophora flavescens Ait. and Subprostrate sophora Root. OSC is used to treat inflammation and hepatitis for thousands of years in China. This study aims to investigate the CYP450-mediated reduction responsible for metabolizing OSC and to evaluate the absorption and metabolism of OSC in rat in situ. Four metabolites were identified, with sophocarpine (SC) as the major metabolite. SC formation was rapid in human and rat liver microsomes (HLMs and RLMs, respectively). The reduction rates in the liver are two fold higher than in the intestine, both in humans and rats. In HLMs, inhibitors of CYP2C9 , 3A4/5, 2D6, and 2B6 had strong inhibitory effects on SC formation. Meanwhile, inhibitors of CYP3A and CYP2D6 had significant inhibition on SC formation in RLMs. Human recombinant CYP3A4/5, 2B6, 2D6, and 2C9 contributed significantly to SC production. The permeability in rat intestine and the excretion rates of metabolites were highest in the duodenum (p < 0.05), and the absorbed amount of OSC in duodenum and jejunum was concentration-dependent. The metabolism could be significantly decreased by CYP3A inhibitor ketoconazole. In conclusion, the liver was the main organ responsible for OSC metabolism. First-pass metabolism via CYP3A4/5, 2B6, 2D6, and 2C9 may be the main reason for the poor OSC bioavailability.
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