Food Science & Nutrition
·
2020
·Vol. 8
·期 7
·3099-3109
·
IF 1.797
Xin Li,Zong-Cai Tu,Xiao-Mei Sha,Yun-Hua Ye,Zhong-Ying Li
Different surfactants (lecithin, Tween-20, and Tween-80) were added in composite film during the preparation. Flavor, antimicrobial activity, and physical properties of ginger essential oil -gelatin film were investigated, in order to study the effect of surfactants on the properties of film. The flavor of GEO was not detected in the film prepared with Tween-20 and film prepared with Tween-80, and these two films exhibited stronger antimicrobial activity; film prepared with lecithin possessed higher value in thickness, elongation at break, water solubility, Δ E and opacity, lower value in water vapor property, and tensile strength; attenuated total reflectance-Fourier transform infrared spectrum results suggested, Tween-20 and Tween-80 enhanced the strength of covalent bond, and lecithin weakened the strength of hydrogen bond; and the result of scanning electron microscope showed that Tween-20 and Tween-80 improved the dispersion of oil droplets in film. Therefore, this study suggested that surfactants had an influence on the physical properties and molecular structure of a resulting film; in addition, Tween-20 and Tween-80 could reduce the flavor of GEO in film, improving the antimicrobial activity of film.
研究领域:
材料科学
·
食品科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2021
·Vol. 11
·期 1
·1-11
·
IF 4.38
Yang Zuoyi,Mao Xingchen,Cui Jiahao,Wang Yujie,Zhang Yaping
This study examines the specific effect of Tween 80 on the conversion of anthracene (ANT) in laccase medium system regarding surfactant chemical changes and mechanism. The conversion rate and degradation products of ANT were investigated in different concentrations of Tween 80 solution. Between Tween 80 concentration 0–40 critical micelle concentrations (CMC), the kinetic parameter-k (h −1 ) and corresponding half-life T 1/2 decreased with increasing concentration. When Tween 80 was above 20 CMC the laccase-medium system converted > 95% of ANT to anthraquinone within 12 h. During the entire enzymatic reaction, the laccase activity in the system increased with increasing Tween 80 concentration. Combined with GC/MS analysis of the product, it was speculated that hydrogens belonging to the ether-oxygen bond and carbon–carbon double bond α-CH of Tween 80, were removed by the laccase-media system, promoting its degradation. Additionally, enhanced activity caused by oxygen free radicals (ROS) such as RO• and ROO•, continuously oxidized Tween 80, which in turn produced free radicals while converting ANT. This study provides new theoretical support toward the application of surfactants in the elimination of polycyclic aromatic hydrocarbons.
研究领域:
环境科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Waste and Biomass Valorization
·
2018
·Vol. 10
·期 11
·3343-3350
·
IF 1.874
Chen Cheng,Jiang Linfeng,Ma Guanfeng,Jin Dongxue,Zhao Lisha,Ouyang Xinping
Abstract Lignin removal from lignocellulosic materials plays a great role in the utilization cellulose with high efficiency. In order to improve the quality of reconstituted tobacco sheet, lignin existed in tobacco stem was removed by enzymatic hydrolysis with laccase enhanced by weak alkali treatment together with the addition of Tween 80 into laccase treatment system. It is found that lignin was partially removed by laccase. The treatment of tobacco stem with NaHCO 3 resulted in the dissolution of lignin, and hence increased the porosity and specific surface area of the pretreated tobacco stem. Consequently, laccase could access to the tobacco stem more completely. The surface activity and dispersion of Tween 80 improved laccase activity, solubilization of degraded products of lignin, and contact interface between laccase and tobacco stem. The synergistic action of laccase, weak alkali and Tween 80 improved the ratio of lignin removal significantly, reaching as high as 40.3%. Graphical Abstract
研究领域:
生物化学
·
植物学
✓ 已验证
DOI
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Pengkai Xie,Limin Cui,Mingdi Yu,Yulong Shao,Abdelaziz Elbarbary,Qingzhe Jin,Xingguo Wang,Jun Jin
Aerated emulsions find wide applications in the food industry, with partial coalescence playing a crucial role as the core of such products in whipping capabilities. Although tweens are the most traditional emulsifiers used in aerated emulsions, the microscopic mechanisms of how they work are still not fully understood. This study focused on elucidating the mechanisms of Tweens in fat crystallization, oil-water interface rheology, and fat globule interface membrane properties, clarifying their roles in partial coalescence and whipping capabilities. The fat crystals induced by Tween 20 (T20) faced difficulty in puncturing the interface membrane with a high elastic modulus (5.58 mN/m), which may constrain occurrence and progression of partial coalescence. Tween 60 (T60) and Tween 40 (T40) exhibited strong interactions with proteins, with the interface film formed by T60 having a high elasticity of up to 7.79 mN/m. However, the highest elasticity interface film formed by orogenic behavior from T60 was not conducive to the interaction between fat crystals and the interfacial proteins during the whipping process. T40 not only helps to stimulate fat crystallization and create interface films with appropriate elastic strength but also plays a role in enhancing foam quality as its concentration rises. This is supported by its rheological properties and microscopic structures. The interface membrane formed by Tween 80 (T80) was viscous, leading to a significant partial coalescence but poor foam quality. This study reveals the interaction mechanisms between fat crystallization, interface membrane, partial coalescence, and the structure of aerated emulsions regulated by Tweens.
研究领域:
食品科学
·
胶体化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Xiaoxia Zhang,Ru Song,Xinyan Liu,Yan Xu,Rongbian Wei
Poor water solubility is one of the main adverse factors for vitamin D 3 to be used as a fortifier in water-soluble food system. In this study, a phase transformation based nanoemulsion fabrication process was developed to encapsulate vitamin D 3 with Tween 80 and Span 80 as a composite surface-active surfactant (named as Vit D 3 NEs). The encapsulation efficiency of vitamin D 3 in resultant oil in water nanoemulsions reached 99.9%. The prepared Vit D 3 NEs was spherical with average particle size of 391.47 ± 12.89 nm, polydispersity index of 0.23–0.31, and endothermic temperature of 127.1 ℃. Results of FTIR indicated that hydrophobic, electrostatic and hydrogen bond interactions were involved in Vit D 3 NEs fabrication. Compared to un-encapsulated Vit D 3 (bare Vit D 3 ), Vit D 3 NEs displayed higher stability under gastric digestion, and sustained release under intestinal digestion. The cumulative release of Vit D 3 reached 69% after 5 h of intestinal digestion. Further, Vit D 3 NEs demonstrated stronger thermal stability than the bare Vit D 3 at 40–60 °C, and the first-order kinetics was well fit to describe its thermal degradation . Our work suggests a new insight into the application of Vit D 3 NEs stabilized by Tween 80 and Span 80 in food industry.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Pharmaceutics
·
2024
·Vol. 16
·期 5
·639
·
IF 4.9
Junming Cui,Xinxi Cai,Rui Qian,Lin Wu,Xueyong Qi,Jin Cao,Song Shen
Artemisinin has an endoperoxide bridge structure, which can be cleaved by ferrous ions to generate various carbonyl radicals in an oxygen-independent manner, highlighting its potential for treating hypoxic tumors. In our study, we fabricated Tween 80 micelles loaded with Fe3O4nanoparticles and artemisinin for cancer therapy. The synthesized Fe3O4nanoparticles and drug-loaded micelles have particle sizes of about 5 nm and 80 nm, respectively, both exhibiting excellent dispersibility and stability. After uptake by MCF-7 cells, drug-loaded micelles release Fe2+and ART into the cytoplasm, effectively inducing the generation of reactive oxygen species (ROS) in hypoxic conditions, thereby enhancing toxicity against cancer cells. In vitro and in vivo studies have demonstrated that ART and Fe3O4nanoparticles are encapsulated in Tween 80 to form micelles, which effectively prevent premature release during circulation in the body. Although free ART and Fe3O4nanoparticles can inhibit tumor growth, TW80-Fe3O4-ART micelles demonstrate a more pronounced inhibitory effect, with a tumor suppression rate of up to 85%. A novel strategy based on artemisinin and ferroptosis is thus offered, holding a favorable prospect for hypoxic cancer therapy.
研究领域:
药学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Rujing Xu,Ying Lu,Mengxiao Liu,Yanzhao Yin,Junsheng Zhao,Lin Wu,Song Shen
Oral delivery of insulin exhibits low bioavailability due to the hydrolysis in acidic gastric juice, biodegradation of enzymes, and inefficient penetration through the intestinal mucus and epithelial cell layer. Here, we report a micelle platform to enhance the oral delivery of insulin. Insulin was precipitated by zinc ions to form hydrophobic nanoparticles and subsequently coated with a surfactant polysorbate-80 (Tween-80) to form nanosized micelles (TW-Zn-rhINS). Tween-80 protects the insulin from the degradation of enzymes, meanwhile facilitating the diffusion within mucus and the epithelial cell layer by opening the tight junctions. The micelles were then lyophilized and encapsulated in enteric capsules to overcome acidic hydrolysis in gastric juice. The micelles significantly increased transcellular insulin transport and uptake. The in vivo experiments demonstrated that oral TW-Zn-rhINS micelle capsules (30 IU/kg) decreased the blood glucose of diabetic mice by 58.74% after administration for 6 h, while the postprandial blood glucose dropped by 51.1%. Pharmacokinetics data indicated that the relative oral bioavailability of TW-Zn-rhINS was 7.88%, which was 7.73 times higher than that of insulin. The micelles present a promising platform to enhance the oral bioavailability of insulin, also indicating a potential for oral delivery of protein.
研究领域:
药剂学
·
生物医学工程
·
药物代谢动力学
✓ 已验证
产品关联
DOI
高影响因子
SURFACE ENGINEERING
·
2025
·
IF 2.6
Chong Ke,Chenhua Zhang,Yongdong Jiang
In this study, durable antifogging coatings were fabricated on glass substrates by simply applying a mixture of silica sol and TweenⓇ40. The effects of TweenⓇ40 loading on the properties of the coatings were scrutinized. The coatings demonstrate good antifogging behavior, as no fog or haze was observed on the coated specimen when exposed to hot water steam at 85°C. The optimal coating retains its antifogging property for a notable 12 weeks. The antifogging behavior is mainly provided by TweenⓇ40 within the coating. Meanwhile, the silica sol in the coating serves as a matrix or host for TweenⓇ40, thereby enhancing the coating's robustness.
研究领域:
材料科学
·
表面工程
·
应用化学
✓ 已验证
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2019
·Vol. 230
·期 6
·1-12
·
IF 1.774
Yang Min,Ke Junfeng,Zhang Qiwu,He Xiaoman
Surfactants are considered promising and practical substances for enhancing polycyclic aromatic hydrocarbon (PAHs) removal from contaminated soil. In order to explore the effects of single and mixed surfactants on the removal of high-concentration PAHs from soil, a series of experiments have been conducted. In this study, Tween80-saponin (a mixed surfactant), Tween80 (a nonionic surfactant), and saponin (a biosurfactant) were used to remove two typical and high concentration PAHs (anthracene and pyrene) from contaminated soil. Results showed that the mixed surfactant had better performance on the solubilization of anthracene and pyrene than Tween80, but its performance was worse than saponin. When the proportion and concentration of the mixed surfactant were 1:9 and 800 mg L −1 respectively, the elution rate of anthracene could reach 97.67%, it was better than that by Tween80 and saponin. In addition, the Tween80-saponin mixed surfactant had good performance on actual PAHs contaminated soil remediation. When the proportion and concentration of Tween80-saponin were 1:9 and 800 mg L −1 respectively, the PAHs elution rate of actual contaminated soil could reach 81.31%.
研究领域:
环境科学
·
污染治理
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Cihui Tian,Sajid Asghar,Yurui Xu,Zhipeng Chen,Jingwei Zhang,Qineng Ping,Yanyu Xiao
Redox-sensitive micelles based onhydrophilic hyaluronic acid-ss-hydrophobic curcumin conjugate were designed as a novel delivery system for gliomas targeting. Furthermore, the obtained micelles were further functionalized with Tween 80 (CUR-THSC) for better brain penetration. Dynamic light scattering experiment and in vitro release study showed that the synthetic disulfide-linked conjugate possessed redox-sensitivity under high glutathione conditions. Spherical micelles with a mean particle size of 74.2 nm, negative zeta potential (−30.25 mV), high entrapment efficiency (94.12%) and drug loading (8.9%) were obtained. XRD analysis of micelles revealed amorphous form of the encapsulated drug. CUR-THSC micelles showed good plasma stability and did not induce any hemolysis in erythrocytes. In addition, highest cytotoxicity in G422 cells was observed compared to the free curcumin group and non-sensitive micelles group. These results indicate that the Tween 80-modified hyaluronic acid-ss-curcumin micelles could emerge as a promising platform for the delivery of curcumin in the treatment of gliomas.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
XENOBIOTICA
·
2020
·
IF 1.902
Ruicong Ma,Gentao Li,Xue Wang,Yajuan Bi,Youcai Zhang
To date, relatively little is known about the interactions of pharmaceutical excipients with hepatic and renal drug uptake transporters. The present study was designed to systematically evaluate the effects of 16 commonly consumed excipients on human organic cation transporter 1 and 2 (hOCT1 and hOCT2), human organic anion transporter 1 and 3 (hOAT1 and hOAT3) and human organic anion transporting polypeptide 1B1 and 1B3 (hOATP1B1 and hOATP1B3).The inhibitory effects and mechanisms of excipients on transporters were investigated using in vitro uptake studies, cell viability assays, concentration-dependent studies, and the Lineweaver–Burk plot method.Triton X-100 is a non-competitive inhibitor for all six transporters. Tween 20 inhibits hOCT2, hOAT1, hOAT3, and hOATP1B3 in a mixed way, whereas it competitively inhibits hOATP1B1. The inhibition of Tween 80 is competitive for hOCT2, non-competitive for hOATP1B1 and hOATP1B3, and mixed for hOAT1 and hOAT3. Concentration-dependent studies identify Triton X-100 as a strong inhibitor of hOCT1 and hOCT2 with IC50 values of 20.1 and 4.54 μg/mL, respectively. Additionally, Triton X-100, Tween 20, and Tween 80 strongly inhibit hOAT3 with IC50 values ≤31.0 μg/mL.The present study is significant in understanding the excipient–drug interactions and provides valuable information for excipient selection in drug development.
研究领域:
药理学
·
药物开发
·
制药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2022
·
IF 3.269
Lu Wang,YingLin Liu,Tianxin Weng,Xinyu Li,Yushu Wu,Yanna Zhao,Jie Liu,Min Liu
Bisdemethoxycurcumin (BDMC), one of the main curcuminoids, has numerous biological activities. However, the low solubility and stability of BDMC limit its application. In this work, in order to improve the solubility and stability of BDMC, we encapsulated BDMC using cetyltrimethylammonium bromide (CTAB) + Tween 20/Tween 60 mixed surfactants. The molar ratio of CTAB to Tween 20/Tween 60 was optimized by response surface analysis. The thermodynamic parameters (binding constant, enthalpy change, entropy change and Gibbs free energy change) for the interaction of BDMC with CTAB + Tween 20/Tween 60 mixed micelles were obtained by fluorescence spectroscopy and UV–visible absorption spectroscopy. Positive enthalpy change and entropy change indicated that hydrophobic interaction was the main driving force. Moreover, due to the longer alkyl chains of Tween 60, the encapsulation of BDMC by CTAB + Tween 60 mixed micelles was stronger. The encapsulation of BDMC in the hydrophobic alkyl chains by the mixed micelles was determined by fluorescence polarization technology, time-resolved fluorescence assay, and 1 H nuclear magnetic resonance spectroscopy. Solubilization and stability experiments showed that the solubility of BDMC was improved and the alkaline hydrolysis of BDMC was inhibited due to the encapsulation of the mixed micelles. The improvement of the solubility and stability of BDMC was more obvious in CTAB + Tween 60 mixed micelles because of the stronger interaction between them. The above results indicated that CTAB + Tween 20/Tween 60 mixed micelles could be used to encapsulate BDMC to improve its solubility and stability.
研究领域:
药学
·
物理化学
·
材料科学
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）