Scientific Reports
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2021
·Vol. 11
·期 1
·1-11
·
IF 4.38
Yang Zuoyi,Mao Xingchen,Cui Jiahao,Wang Yujie,Zhang Yaping
This study examines the specific effect of Tween 80 on the conversion of anthracene (ANT) in laccase medium system regarding surfactant chemical changes and mechanism. The conversion rate and degradation products of ANT were investigated in different concentrations of Tween 80 solution. Between Tween 80 concentration 0–40 critical micelle concentrations (CMC), the kinetic parameter-k (h −1 ) and corresponding half-life T 1/2 decreased with increasing concentration. When Tween 80 was above 20 CMC the laccase-medium system converted > 95% of ANT to anthraquinone within 12 h. During the entire enzymatic reaction, the laccase activity in the system increased with increasing Tween 80 concentration. Combined with GC/MS analysis of the product, it was speculated that hydrogens belonging to the ether-oxygen bond and carbon–carbon double bond α-CH of Tween 80, were removed by the laccase-media system, promoting its degradation. Additionally, enhanced activity caused by oxygen free radicals (ROS) such as RO• and ROO•, continuously oxidized Tween 80, which in turn produced free radicals while converting ANT. This study provides new theoretical support toward the application of surfactants in the elimination of polycyclic aromatic hydrocarbons.
研究领域:
环境科学
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生物化学
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产品关联
DOI
PubMed
高影响因子
Waste and Biomass Valorization
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2018
·Vol. 10
·期 11
·3343-3350
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IF 1.874
Chen Cheng,Jiang Linfeng,Ma Guanfeng,Jin Dongxue,Zhao Lisha,Ouyang Xinping
Abstract Lignin removal from lignocellulosic materials plays a great role in the utilization cellulose with high efficiency. In order to improve the quality of reconstituted tobacco sheet, lignin existed in tobacco stem was removed by enzymatic hydrolysis with laccase enhanced by weak alkali treatment together with the addition of Tween 80 into laccase treatment system. It is found that lignin was partially removed by laccase. The treatment of tobacco stem with NaHCO 3 resulted in the dissolution of lignin, and hence increased the porosity and specific surface area of the pretreated tobacco stem. Consequently, laccase could access to the tobacco stem more completely. The surface activity and dispersion of Tween 80 improved laccase activity, solubilization of degraded products of lignin, and contact interface between laccase and tobacco stem. The synergistic action of laccase, weak alkali and Tween 80 improved the ratio of lignin removal significantly, reaching as high as 40.3%. Graphical Abstract
研究领域:
生物化学
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植物学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Xiaoxia Zhang,Ru Song,Xinyan Liu,Yan Xu,Rongbian Wei
Poor water solubility is one of the main adverse factors for vitamin D 3 to be used as a fortifier in water-soluble food system. In this study, a phase transformation based nanoemulsion fabrication process was developed to encapsulate vitamin D 3 with Tween 80 and Span 80 as a composite surface-active surfactant (named as Vit D 3 NEs). The encapsulation efficiency of vitamin D 3 in resultant oil in water nanoemulsions reached 99.9%. The prepared Vit D 3 NEs was spherical with average particle size of 391.47 ± 12.89 nm, polydispersity index of 0.23–0.31, and endothermic temperature of 127.1 ℃. Results of FTIR indicated that hydrophobic, electrostatic and hydrogen bond interactions were involved in Vit D 3 NEs fabrication. Compared to un-encapsulated Vit D 3 (bare Vit D 3 ), Vit D 3 NEs displayed higher stability under gastric digestion, and sustained release under intestinal digestion. The cumulative release of Vit D 3 reached 69% after 5 h of intestinal digestion. Further, Vit D 3 NEs demonstrated stronger thermal stability than the bare Vit D 3 at 40–60 °C, and the first-order kinetics was well fit to describe its thermal degradation . Our work suggests a new insight into the application of Vit D 3 NEs stabilized by Tween 80 and Span 80 in food industry.
研究领域:
食品科学
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生物化学
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产品关联
DOI
高影响因子
Pharmaceutics
·
2024
·Vol. 16
·期 5
·639
·
IF 4.9
Junming Cui,Xinxi Cai,Rui Qian,Lin Wu,Xueyong Qi,Jin Cao,Song Shen
Artemisinin has an endoperoxide bridge structure, which can be cleaved by ferrous ions to generate various carbonyl radicals in an oxygen-independent manner, highlighting its potential for treating hypoxic tumors. In our study, we fabricated Tween 80 micelles loaded with Fe3O4nanoparticles and artemisinin for cancer therapy. The synthesized Fe3O4nanoparticles and drug-loaded micelles have particle sizes of about 5 nm and 80 nm, respectively, both exhibiting excellent dispersibility and stability. After uptake by MCF-7 cells, drug-loaded micelles release Fe2+and ART into the cytoplasm, effectively inducing the generation of reactive oxygen species (ROS) in hypoxic conditions, thereby enhancing toxicity against cancer cells. In vitro and in vivo studies have demonstrated that ART and Fe3O4nanoparticles are encapsulated in Tween 80 to form micelles, which effectively prevent premature release during circulation in the body. Although free ART and Fe3O4nanoparticles can inhibit tumor growth, TW80-Fe3O4-ART micelles demonstrate a more pronounced inhibitory effect, with a tumor suppression rate of up to 85%. A novel strategy based on artemisinin and ferroptosis is thus offered, holding a favorable prospect for hypoxic cancer therapy.
研究领域:
药学
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
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2024
·
IF 5.3
Rujing Xu,Ying Lu,Mengxiao Liu,Yanzhao Yin,Junsheng Zhao,Lin Wu,Song Shen
Oral delivery of insulin exhibits low bioavailability due to the hydrolysis in acidic gastric juice, biodegradation of enzymes, and inefficient penetration through the intestinal mucus and epithelial cell layer. Here, we report a micelle platform to enhance the oral delivery of insulin. Insulin was precipitated by zinc ions to form hydrophobic nanoparticles and subsequently coated with a surfactant polysorbate-80 (Tween-80) to form nanosized micelles (TW-Zn-rhINS). Tween-80 protects the insulin from the degradation of enzymes, meanwhile facilitating the diffusion within mucus and the epithelial cell layer by opening the tight junctions. The micelles were then lyophilized and encapsulated in enteric capsules to overcome acidic hydrolysis in gastric juice. The micelles significantly increased transcellular insulin transport and uptake. The in vivo experiments demonstrated that oral TW-Zn-rhINS micelle capsules (30 IU/kg) decreased the blood glucose of diabetic mice by 58.74% after administration for 6 h, while the postprandial blood glucose dropped by 51.1%. Pharmacokinetics data indicated that the relative oral bioavailability of TW-Zn-rhINS was 7.88%, which was 7.73 times higher than that of insulin. The micelles present a promising platform to enhance the oral bioavailability of insulin, also indicating a potential for oral delivery of protein.
研究领域:
药剂学
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生物医学工程
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药物代谢动力学
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产品关联
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2019
·Vol. 230
·期 6
·1-12
·
IF 1.774
Yang Min,Ke Junfeng,Zhang Qiwu,He Xiaoman
Surfactants are considered promising and practical substances for enhancing polycyclic aromatic hydrocarbon (PAHs) removal from contaminated soil. In order to explore the effects of single and mixed surfactants on the removal of high-concentration PAHs from soil, a series of experiments have been conducted. In this study, Tween80-saponin (a mixed surfactant), Tween80 (a nonionic surfactant), and saponin (a biosurfactant) were used to remove two typical and high concentration PAHs (anthracene and pyrene) from contaminated soil. Results showed that the mixed surfactant had better performance on the solubilization of anthracene and pyrene than Tween80, but its performance was worse than saponin. When the proportion and concentration of the mixed surfactant were 1:9 and 800 mg L −1 respectively, the elution rate of anthracene could reach 97.67%, it was better than that by Tween80 and saponin. In addition, the Tween80-saponin mixed surfactant had good performance on actual PAHs contaminated soil remediation. When the proportion and concentration of Tween80-saponin were 1:9 and 800 mg L −1 respectively, the PAHs elution rate of actual contaminated soil could reach 81.31%.
研究领域:
环境科学
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污染治理
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化学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
·
IF 3.909
Cihui Tian,Sajid Asghar,Yurui Xu,Zhipeng Chen,Jingwei Zhang,Qineng Ping,Yanyu Xiao
Redox-sensitive micelles based onhydrophilic hyaluronic acid-ss-hydrophobic curcumin conjugate were designed as a novel delivery system for gliomas targeting. Furthermore, the obtained micelles were further functionalized with Tween 80 (CUR-THSC) for better brain penetration. Dynamic light scattering experiment and in vitro release study showed that the synthetic disulfide-linked conjugate possessed redox-sensitivity under high glutathione conditions. Spherical micelles with a mean particle size of 74.2 nm, negative zeta potential (−30.25 mV), high entrapment efficiency (94.12%) and drug loading (8.9%) were obtained. XRD analysis of micelles revealed amorphous form of the encapsulated drug. CUR-THSC micelles showed good plasma stability and did not induce any hemolysis in erythrocytes. In addition, highest cytotoxicity in G422 cells was observed compared to the free curcumin group and non-sensitive micelles group. These results indicate that the Tween 80-modified hyaluronic acid-ss-curcumin micelles could emerge as a promising platform for the delivery of curcumin in the treatment of gliomas.
研究领域:
药剂学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2018
·
IF 5.091
Zhenbao Zhu,Ying Wen,Jianhua Yi,Yungang Cao,Fuguo Liu,David Julian McClements
Hypothesis This study compared the interfacial and emulsification properties of tea saponins , quillaja saponins, and Tween 80. We hypothesized that tea saponins are an effective and sustainable source of plant-based emulsifiers that could replace synthetic or animal-based emulsifiers in many commercial applications. Experiments Interfacial tension measurements were used to characterize the behavior of the three surfactants at an oil-water interface. The emulsifying properties of the surfactants were determined by preparing oil-in-water emulsions containing 10 wt% medium chain triglycerides (MCT) and varying surfactant levels (0.1–2 wt%) using high-pressure homogenization (pH 7). The impact of surfactant type on emulsion formation and stability was determined by measuring particle size, zeta–potential, microstructure, and creaming stability. Findings The tea saponins were capable of producing nano-scale droplets ( d 32 < 200 nm) at low surfactant-to-oil ratios (SOR < 0.1). Emulsions containing tea saponins remained stable to droplet aggregation when exposed to various temperatures (30–90 °C), salt levels (0–200 mM NaCl), and pH values (3–9). However, droplet flocculation and/or coalescence occurred under highly acidic (pH 2) and high ionic strength (300–500 mM NaCl) conditions. Tea saponin-coated oil droplets appeared to be mainly stabilized by a combination of electrostatic and steric repulsion. The tea saponins behaved similarly or better than the other two emulsifiers under most conditions. These results suggest that tea saponins are effective plant-based surfactants that may have applications in commercial products.
研究领域:
食品科学
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表面化学
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植物化学
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DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2021
·
IF 6.789
Tong Zhang,Jujin Cheng,Hanyue Tan,Shuai Luo,Yuanyuan Liu
Surfactants are often used to elute the contaminants from soils in order to remediate the polluted soils. However, the heterogeneity of minerals and organic matters with soil particle size may result in adsorption and precipitation of surfactants and affect the distribution of petroleum hydrocarbons (PHCs). In this work, spiked soil samples and surfactant mixture consisting of Tween 80 (TW80) and sodium dodecyl sulfate were prepared. Results showed that the silt-clay-mixture held the high retention capacity of PHCs, and 30% total petroleum hydrocarbons (TPHs) was retained in the soil fraction of ‘<125 μm’ (high concentration), while 70% TPHs (low concentration) was retained in the soil fraction of ‘>125 μm’. TW80 was highly adsorbed on the montmorillonite and aluminosilicates of the soil, and the adsorption of TW80 in surfactant mixture could be relieved at mass ratio of 1:1. This study provides a novel strategy in the elution removal of PHCs from the contaminated soils, in which with the separation of soil particles by the size of 125 μm before elution, as high as 80% PHCs could be eluted from the soil by surfactant mixture.
研究领域:
环境科学
·
土壤修复
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Xiaoxiao Sun,Chuqiao Pan,Zhuoyang Ying,Dongyan Yu,Xitai Duan,Fangfang Huang,Junhong Ling,Xiao-kun Ouyang
We aimed to develop a stable nanosystem with k -carrageenan (Kc), an anionic polysaccharide , combined with tween 80 to stabilize zein nanoparticles. The experimental results showed that the particle size, zeta-potential, and stability of the system depend on the Kc amount when the zein amount was unchanged. We found that the nanosystem with 5.0 and 10.0 mg Kc had a smaller particle size (250.1 ± 0.9 and 287.6 ± 1.4 nm, respectively), low polydispersity index (PDI, ≤ 0.20), and high stability when the external conditions changed. No obvious flocculation or deposition was observed at pH of 3–9, salt ion concentrations of 0–500 mmol/L, temperature of 30 °C and 50 °C–90 °C, and storage at 4 °C for 30 days. When the Kc-ZNP system was loaded with curcumin (Cur), there was a good encapsulation effect (5.0 mg Kc with 1.00 mg Cur (EE (%) = 34.69% ± 2.02%, size = 380.23 ± 5.80 nm, PDI = 0.252 ± 0.018) and 10.0 mg Kc with 2.00 mg Cur (EE (%) = 20.13% ± 1.05%, size = 431.27 ± 0.78 nm, PDI = 0.269 ± 0.020), ensuring that the particle size was not too large. Therefore, Kc–ZNPs could be a potential delivery system for fat-soluble drugs.
研究领域:
食品科学
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药物递送系统
·
生物材料
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2022
·
IF 10.53
Xianglei Han,Zhi Wang,Jixiao Wang
The development of highly selective polyamide (PA) membranes is critical for improving the quality and efficiency of the reverse osmosis (RO) process. However, the preparation of highly selective RO membranes exhibits some limitations, such as low efficiency and complex preparation process. Herein, RO membranes with high selectivity were prepared by adding Tween 80, a nonionic surfactant , to an organic phase. The state of Tween 80 in the organic phase and its function in the interfacial polymerization process were thoroughly discussed based on the detailed characterization of the organic phase solution and membrane. Furthermore, the optimization of the Tween 80 concentration, organic phase temperature, organic solvent type, and heat treatment temperature enabled the preparation of a membrane with high rejection (99.61%), high water flux (40.28 L m −2 h −1 ), and high stability. Compared with the virgin membrane, the selectivity of the optimized membrane increased by 136% and its permeability decreased by only 23%. In summary, the nonionic surfactant Tween 80 reacted with trimesoyl chloride (TMC) in the developed membrane preparation method to produce a new product TW-TMC, exhibiting a dual role of a surfactant and a co-monomer in the interfacial polymerization process, thereby regulating the formation and stacking of PA molecules.
研究领域:
材料科学
·
化学工程
·
环境科学
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DOI
高影响因子
Journal of Oleo Science
·
2024
·
IF 1.6
Aicha Mekkaoui,You Li,Zhaoming Ran,Ying Cai,Li Zhao,Baocai Xu,Ce Wang
In recent years, there has been a growing interest in regulating lipid digestion through the construction of various interfacial structures. In the present work, a series of complex interfacial structures were designed by combining Tween 80 in the aqueous phase and lecithin in the oil phase at different concentration ratios. The emulsification properties, the roles in regulating lipid digestion, and the interfacial dilatational rheological properties of the composite emulsifying systems were characterized. The results showed that the combination of Tween 80 and lecithin at different ratios could effectively modulate the rate of lipid digestion. The polyoxyethylene chains of Tween 80 formed a network, that provided a spatial obstacle for the adsorption of bile salts and lipases. Thus, Tween 80 significantly delayed the lipid digestion. The introduction of lecithin gradually replaced Tween 80 molecules at the interface, thus providing space for the adsorption of bile salts and lipases. In addition, as the ratio of lecithin concentration to Tween 80 increased, lecithin gradually became the dominant factor in the interfacial properties. As a result, the rate of lipid digestion was accelerated. Therefore, by compounding different ratios of lecithin and Tween 80, a series of emulsions with different lipid digestion rates were obtained. This research provides a basis for rationally designing food emulsions according to specific needs.
研究领域:
食品科学
·
化学工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）