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Advances in Experimental Medicine and Biology · 2016 · IF 1.953

The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases

Yan Heping,Chen Yashun,Zhang Jucheng,Liu Wei,Chen Rui

The first derivatives of gelatin and type I collagen fluorescence spectra were characterized in order to describe the effect of free radicals on pyridinoline (PYD) cross-links. The different gas saturation conditions were used to investigate the effect of different free radicals. An analysis of first derivative fluorescence spectra suggests that PYD cross-link fluorescence emission is composed of three peaks in gelatin, but only two in type I collagen. The PYD cross-link was photo-degraded more than other gases in the presence of O 2 . This suggests that the singlet oxygen ( 1 O 2 ) plays a key role when using photodynamic therapy to treat skin fibrosis disease with Hypocrellin B (HB).

研究领域: 光生物学 · 皮肤科学 · 分子生物学 · 结缔组织病 · 自由基化学 · 光动力学 · 纤维化疾病

✓ 已验证 DOI 高影响因子

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ASIAN JOURNAL OF ANDROLOGY · 2019 · IF 2.862

Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea

Tao Li,Fu-Dong Fu,Chang-Jing Wu,Feng Qin,Run Wang,Jiu-Hong Yuan

This study aimed to explore whether and how anti-lysyl oxidase (anti-LOX) combined with a vacuum device (VD) could promote penile lengthening and to evaluate the effect on erectile function. This study was performed on four groups of adult rats: control, anti-LOX, VD (negative pressure value of −300 mmHg), and anti-LOX + VD. Penile length was measured by a modified VD method and verified on exposed length data. Intracavernous pressure (ICP) and maximum ICP/mean arterial pressure (MAP) ratio were recorded to assess erectile function. For corpus cavernosum, LOX activity and concentrations of pyridinoline, desmosine, hydroxyproline, and elastin were analyzed; transmission electron microscope and Hart's elastin staining were performed to monitor microstructural changes. Anti-LOX and VD significantly lengthened the penis by 10.8% (3.75 mm) and 8.2% (2.48 mm) compared with the control group, respectively, while anti-LOX + VD achieved the longest penile size (40.58 ± 0.40 mm) which was 17.4% longer than the control group (34.58 ± 0.54 mm). After 1-week washout, no penile retraction was observed. Meanwhile, exposed penile length data confirmed that the penis in the anti-LOX + VD group was also significantly longer. Anti-LOX inhibited LOX activity to reduce pyridinoline level, which led the penile tunica albuginea remodeling. However, it had no effect on hydroxyproline, desmosine, and elastin levels. Moreover, anti-LOX had no impact on erectile function, which was determined by ICP and ICP/MAP ratio. These results suggest that anti-LOX elongates the penis by reducing pyridinoline, which induces tunica albuginea remodeling. This lengthening effect was more obvious when combined with a VD. All procedures had no impact on erectile function.

研究领域: 泌尿学 · 药理学 · 生物医学工程

✓ 已验证 DOI PubMed 高影响因子

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Food Frontiers · 2024 · IF 7.4

Textural dynamic crisping mechanism of crisp grass carp: Oxidative stress, apoptosis, collagen filling, and cross-linking

Mi Tang,Ting Shao,Liang Ma,Hongjie Dai,Yu Yong,Xin Feng,Yuhao Zhang

Feeding faba beans to freshwater fish could crisp its muscle texture to avoid softening. However, the dynamic crisping mechanism was unclear. Herein, a 120-day feeding trial was conducted to systemically investigate the textural crisping mechanism of crisp grass carp (CGC) via molecular-level, gene/protein expression analysis. In the early crisping stage (0–30 days), the total antioxidant capacity significantly decreased (by 16.79%), TUNEL staining and qRT-PCR results revealed that apoptosis occurred, which was induced by oxidative stress validating by proteomics. Meanwhile, the content of dityrosine and hydroxylysyl pyridinoline rose, thereby substantially increasing the hardness and chewiness of CGC by 37.51% and 40.84%, respectively. With further crisping (30–90 days), Masson staining exhibited collagen gradually filling the gap between myofibrils, the content and cross-linking degree of collagen further increased, finally elevating the hardness and chewiness of CGC. This study laid a theoretical foundation for producing and supplying aquatic raw materials with different texture characteristics.

研究领域: 水产养殖 · 食品科学 · 分子生物学 · 蛋白质组学

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The Role of Free Radicals in the Photodynamic Treatment of Fibrotic Skin Diseases

Anti-lysyl oxidase combined with a vacuum device induces penile lengthening by remodeling the tunica albuginea

Textural dynamic crisping mechanism of crisp grass carp: Oxidative stress, apoptosis, collagen filling, and cross-linking