Inorganics
·
2026
·Vol. 14
·期 7
·183
·
IF 3.4
Xianguang Bai,Huiping Wang,Zebao Lu,Bin Li
A novel carbohydrazide-based ligand (L) and its binuclear Cu(II) complex were successfully synthesized and characterized. Structural analysis confirmed that the Cu(II) complex adopted a monoclinic crystal system with a distorted coordination configuration, in which the multidentate Schiff base ligand chelated and bridged two Cu(II) centers. The in vitro anti-tumor results revealed that the Cu(II) complex exhibited prominent cytotoxicity against five human cancer cell lines with much lower IC50values than the free ligand, copper chloride and cisplatin. Mechanistic studies demonstrated that the Cu(II) complex significantly increased intracellular ROS and MDA levels, decreased the GSH/GSSG ratio, and reduced ATP content, thereby disrupting cellular redox balance and bioenergetic metabolism. In addition, flow cytometry analysis verified that the complex effectively triggered tumor cell apoptosis. In contrast, free CuCl2showed almost no anticancer activity, indicating that the synergistic effect between the Schiff base ligand and copper ions contributed to the excellent anti-tumor performance. This work suggests that the prepared binuclear Cu(II) complex can serve as a promising candidate for developing metal-based anticancer agents.
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Polymers
·
2023
·Vol. 15
·期 5
·1231
·
IF 5
Zhenyu Han,Yongqiang Zhang,Liang Wang,Guangqian Zhu,Jia Kuang,Guangyu Zhu,Guangqiang Xu,Qinggang Wang
3,4-Enhanced polymerization of isoprene catalyzed by late transition metal with high activity remains one of the great challenges in synthetic rubber chemistry. Herein, a library of [N, N, X] tridentate iminopyridine iron chloride pre-catalysts (Fe 1–4) with the side arm were synthesized and confirmed by the element analysis and HRMS. All the iron compounds served as highly efficient pre-catalysts for 3,4-enhanced (up to 62%) isoprene polymerization when 500 equivalent MAOs were utilized as co-catalysts, delivering the corresponding high-performance polyisoprenes. Furthermore, optimization via single factor and response surface method, it was observed that the highest activity was obtained by complexFe 2with 4.0889 × 107g·mol(Fe)−1·h−1under the following conditions: Al/Fe = 683; IP/Fe = 7095; t = 0.52 min.Keywords:tridentate iminopyridine iron complex;high activity;isoprene polymerization;response surface methodology
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高影响因子
MOLECULES
·
2023
·Vol. 28
·期 19
·6777
·
IF 4.6
Zhaoyu Zhang,Yurong Zhao,Zhang Hu,Zhenyu Si,Ziming Yang
The widespread prevalence of infectious bacteria is one of the greatest threats to public health, and consequently, there is an urgent need for efficient and broad-spectrum antibacterial materials that are antibiotic-free. In this study, 2-pyridinecarboxaldehyde (PCA) was grafted onto chitosan (CS) and the modified CS coordinated with silver ions to prepare PCA-CS-Ag complexes with antibacterial activity. To obtain complexes with a high silver content, the preparation process was optimized using single-factor experiments and response surface methodology. Under the optimal preparation conditions (an additional amount of silver nitrate (58 mg), a solution pH of 3.9, and a reaction temperature of 69 °C), the silver content of the PCA-CS-Ag complex reached 13.27 mg/g. The structure of the PCA-CS-Ag complex was subsequently verified using ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy, and thermogravimetric analysis. Furthermore, three possible complexation modes of the PCA-CS-Ag complex were proposed using molecular mechanics calculations. The results of the antibacterial assay in vitro showed that the PCA-CS-Ag complex exhibited strong antibacterial activity against both Gram-positive and Gram-negative bacteria, exerting the synergistic antibacterial effect of modified chitosan and silver ions. Therefore, the PCA-CS-Ag complex is expected to be developed as an effective antibacterial material with promising applications in food films, packaging, medical dressings, and other fields.Keywords:modified chitosan;silver;complex;response surface methodology;antibacterial
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xuyi Li,Chen Huang,Yu Fan,Zhiang Bai,Bao-Li An,Jiaqiang Xu,Weiwei Zheng,Yue-Ling Bai
A new strategy is developed herein to improve the solid fluorescence of thiazolothiazole viologen by using the ZnCl42– cluster as a scaffold to hinder π-stacking. Importantly, the Cl···H bonds are formed in the solid state to sustain the framework and can be automatically dissociated when dissolved in H2O, thus having no impact on the strong emission in aqueous solution. As such, the first case of organic–inorganic viologen–zinc halide named 4PV·ZnCl4 was designed and synthesized, and a significant increase in photoluminescence quantum yield (ΦF) is realized from 4PV·2Br (ΦF = 0%) to 4PV·ZnCl4 (ΦF = 27.0%) in solid and from 97% to 98% in H2O. 4PV·ZnCl4 also displays pH stimuli-responsive naked-eye chromic behavior and photoluminescence with different coloring states and intensities. The multifunctional performance of 4PV·ZnCl4 provides a prerequisite for carrying different information, expanding their promising application in multilevel information encryption.
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JOURNAL OF COORDINATION CHEMISTRY
·
2021
·
IF 1.751
Na Zhang,Yuying Li,Liduo Chen,Cuiqin Li,Guoliang Mao,Jun Wang
A series of star iminopyridine ligands, containing different groups (H, CH3, Br) in the pyridine ring, have been synthesized and characterized by FT-IR, 1H NMR, and UV-vis. The corresponding nickel(II) complexes have been prepared in good yields. The nature of the Ni complexes has been established by FT-IR, UV-vis, ESI-MS, and ICP. Upon activation with methylaluminoxane (MAO), the nickel complexes were able to oligomerize ethylene to produce C4–C18 fractions at activity of up to 105 g (mol Ni h)−1. The influence of substituent, catalyst structure, solvent, co-catalyst, and reaction conditions on the catalytic activity and product selectivity was investigated. The results showed that substitution on the pyridine ring had large influence on the catalytic activity and product selectivity. The catalytic activity increased at first and then decreased with the increase of reaction temperature and Al/Ni molar ratio. However, the catalytic activity continuously increased with increasing reaction pressure. When toluene was used as solvent and MAO was used as co-catalyst, catalytic activity of 4.39 × 105 g (mol Ni h)−1 and 31.93% selectivity of higher carbon olefins (C8–C18) were obtained at 10 °C, Al/Ni molar ratio 500, and the reaction pressure 1.0 MPa.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Jun-Shuai Zhang,Wen-Chen Zhou,Wei-De Zhang,Yu-Xiang Yu
Developing earth abundant, active and stable photocatalysts for water splitting is a critical but challenging procedure for efficient conversion and storage of sustainable energy. Here, a ternary photocatalyst was rationally prepared for efficient H 2 production by covalently anchoring a nickel molecule cocatalyst (NiL) onto graphitic carbon nitride nanosheets (CN) and introducing nickel oxides (NiO x ) as hole-transport materials. The lower H 2 overpotential by NiL and the faster separation of photoinduced carriers by NiO x nanoparticles account for the efficient H 2 generation of CN without the help of noble metals. Eventually, the prepared NiL/NiO x /CN catalyst exhibited excellent performance for H 2 evolution (289 μmol g −1 h −1 ) in TEOA solution under visible light irradiation , which is superior to 3NiL/CN (161 μmol g −1 h −1 ) and CN (Null). Furthermore, a possible mechanism of photocatalytic H 2 production for NiL/NiO x /CN is proposed based on a series of electrochemical measurements. The noble-metal-free photocatalyst developed in this work will pave a new way to synthesize low-cost multicomponent photocatalysts for solar conversion.
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Polymers
·
2019
·Vol. 11
·期 9
·1417
·
IF 3.164
Wei Wang,Zufeng Xiao,Chaofan Huang,Kewang Zheng,Yin Luo,Yumin Dong,Zitong Shen,Wei Li,Caiqin Qin
Chitosan microspheres modified by 2-pyridinecarboxaldehyde were prepared and used in the construction of a heterogeneous catalyst loaded with nano-Cu prepared by a reduction reaction. The chemical structure of the catalyst was investigated by Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and X-ray Photoelectron Spectroscopy (XPS). Under mild conditions, such as no ligand at room temperature, the catalyst was successfully applied to catalyze the borylation of α,β-unsaturated receptors in a water-methanol medium, yielding 17%–100% of the corresponding β-hydroxy product. Even after repeated use five times, the catalyst still exhibited excellent catalytic activity.Keywords:chitosan microspheres;copper;organoboron compounds
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Journal of Materials Chemistry C
·
2014
·Vol. 2
·期 15
·2684-2691
·
IF 0
Gang Liu,Mingdi Yang,Lianke Wang,Jun Zheng,Hongping Zhou,Jieying Wu,Yupeng Tian
Three new Schiff base derivatives possessing vagarious blue aggregation-induced emission (AIE) characteristics in tetrahydrofuran (THF)–water were synthesized. Their photophysical properties in solution, aqueous suspension, film and crystalline states, along with their relationships, were comparatively investigated. The crystallographic data for dye 1 and dye 3 indicated that the existence of multiple intermolecular hydrogen bonding interactions restricted intramolecular vibration and rotation. Moreover, the sizes and growth processes of particles with different water fractions were studied using a scanning electron microscope (SEM) and dynamic light scattering (DLS). The results showed that the small homogeneous particles, assembled in an ordered fashion with appropriate water contents, exhibited distinct AIE behavior. Moreover, in a THF–H2O (4 : 1, v/v) solution of HEPES (20 mM) buffer, dye 2 showed fluorescence turn-on sensing towards Cr3+ and Al3+via chelation enhanced fluorescence (CHEF). The 2 : 1 stoichiometries of the sensor complexes (dye 2–Cr3+ and dye 2–Al3+) were calculated from Job plots based on fluorescence titrations.
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INORGANICA CHIMICA ACTA
·
2017
·
IF 2.002
Na Zhang,Jiaming Wang,Hongliang Huo,Liduo Chen,Weiguang Shi,Cuiqin Li,Jun Wang
A series of hyperbranched iminopyridyl ligands [ethylenediamine as terminal groups (L1), 1,4-butanediamine as terminal groups (L2), 1,6-hexamethylenediamine as terminal groups (L3)] were prepared. Ligands L1-L3 were reacted with MCl 2 ·nH 2 O (M = Fe, Co, Ni) to form three types of complexes (C1-C5). Both L1-L3 and C1-C5 were fully characterized by FT-IR, 1 H NMR, UV and ESI-MS. The nickel complexes exhibited better catalytic properties than iron and cobalt complexes for ethylene oligomerization. On activation with methylaluminoxane (MAO), the nickel complex C1 exhibited moderate catalytic activities up to 1.56 × 10 6 g mol −1 h −1 for ethylene oligomerization and the oligomers showed Schulz-Flory distribution. However, on activation with EtAlCl 2 , the nickel complex C1 exhibited higher catalytic activity up to 8.94 × 10 6 g mol −1 h −1 for ethylene oligomerization, but the products were mainly alkylated-toluenes. The influence of the solvent and reaction parameters such as reaction temperature, ethylene pressure and Al/Ni molar ratio on the catalytic behavior of the nickel complex C1 was also investigated. Moreover, in comparison with the catalytic activity and the distribution of oligomers obtained with related hyperbranched salicylaldimine nickel complex and other non-hyperbranched iminopyridyl nickel complexes, the catalytic activity and the content of low carbon number olefins (C 4 and C 6 ) obtained in this work possessed relatively higher.
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TRANSITION METAL CHEMISTRY
·
2016
·Vol. 41
·期 8
·897-907
·
IF 1.465
Wang Yi-Lin,Zhang Xia,Meng Xiang-Min,Li Xin,Bi Cai-Feng,Fan Yu-Hua
Three ternary copper(II) complexes [Cu(L 1 )(phen)] ( 1 ), [Cu(L 2 )(phen)] ( 2 ), and [Cu(L 3 )(phen)] · 2H 2 O ( 3 ) (L 1 = 4-fluoro-2-(picolinamido)benzoic acid, L 2 = 4,5-difluoro-2-(picolinamido)benzoic acid, L 3 = 4,5-difluoro-2-((2-hydroxybenzylidene)amino)benzoic acid, phen = 1,10-phenanthroline) have been synthesized and characterized by physicochemical and spectroscopic methods. In addition, X-ray crystallography showed that the Cu atoms in each of the complexes are five-coordinate, adopting distorted square pyramidal or trigonal bipyramidal geometries. The interactions of the complexes with calf-thymus DNA were investigated by UV absorption, fluorescence spectroscopy and viscosity measurements. In addition, the complexes were screened for in vitro cytotoxicity against A549 (human pulmonary carcinoma cells), Jurkat (human T lymphocyte cell line) and HepG-2 (human liver hepatocellular carcinoma cells); these experiments showed that complex 3 exhibited the most effective cytotoxicities (IC 50 = 1.224–7.099 µM). Antibacterial studies revealed that complex 3 also exhibited highest activity, consistent with the DNA binding affinities.
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ACS Catalysis
·
2025
·
IF 13.1
Yangguang Hu,Song Wang,Zifan Jiang,Wanbing Gong,Aobo Chen,Qiaoxi Liu,Guangyu Liu,Zhiqiang Shen,Jingxiang Low,Jun Ma,Jun Jiang,Chao Gao,Yujie Xiong
Selective semihydrogenation of acetylene to ethylene in ethylene-rich gas streams is a significant industrial process for obtaining high-quality polyethylene products. The conventional thermal hydrogenation route requires high temperature (>100 °C), excess H2, and noble metal Pd to achieve satisfactory conversion efficiency. Therefore, the development of a more efficient and economical low-energy method for acetylene semihydrogenation is greatly desired yet challenging. Here, we report a noble-metal-free molecular system consisting of a bioinspired [CoII(N4S2)](ClO4)2 catalyst and a copper photosensitizer, which achieves photocatalytic semihydrogenation of acetylene to ethylene with over 96% selectivity and 96–99.9% conversion under ambient conditions for both pure acetylene and industrially relevant ethylene cofeed (containing 1% acetylene) conditions using water as a proton source. In addition, our catalytic system in deuterium oxide exhibits ability for deuterated ethylene production, which is an important building block for various deuterated polyolefins and chemicals.
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CRYSTAL GROWTH & DESIGN
·
2024
·
IF 3.2
Xuyi Li,Chen Huang,Rui Xue,Jia-Ping Tong,Yuehan Cheng,Bao-Li An,Jiaqiang Xu,Yue-Ling Bai
Viologen has attracted much attention due to its sensitive chromic properties in response to external stimuli, especially its photochromic behavior. Herein, a viologen derivative, 4PV·2Br, was prepared based on our previous studies, which exhibited strong photoluminescence due to the introduction of the thiazolothiazole group but was silent to light, even under 300 W UV light irradiation. By anion exchange with tetraphenylborate, a new viologen derivative, 4PV·2B(Ph)4, was obtained, which not only exhibits strong fluorescence with a quantum yield of 69% and a lifetime of 1.93 ns in solution but also exhibits sensitive photochromism to UV light, even under sunlight within 5 s. It is very sensitive to light and may become a potential excellent solar chromic material. It should be emphasized that the colored 4PV·2B(Ph)4 radical is particularly stable and can maintain its coloring state in air for a long time, while vinegar vapor can cause it to fade in 2 s, giving it good color reversibility. The single-crystal structure before and after UV light excitation shows that UV light shortens the π···π distances between B(Ph)4 anions and 4PV cations, which is beneficial to faster electron transfer between them and the formation of stable viologen radicals. Sensitive photochromism accompanied by strong photoluminescence may endow 4PV·2B(Ph)4 with potential application in information security and provide a good strategy to regulate the functionality of materials by regulating the counteranions of new viologen derivatives.
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