JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Jiaxing Yang,Shouchun Xiao,Pengxi Li,Bingxue Li,Bingying He,Xueke Liu,Donghui Liu,Zhiqiang Zhou,Peng Wang
Penthiopyrad, a chiral fungicide with a riskier S-enantiomer, exhibited poorly understood stereoselective behaviors in mammals. This study investigated the enantioselective accumulation and metabolism of penthiopyrad enantiomers in mammals using in vivo, in vitro, and in silico approaches. Penthiopyrad accumulated in the liver and kidneys at concentrations over 10-fold higher than those in the blood. S-penthiopyrad showed preferential absorption with 1.6-fold higher bioavailability than the R-enantiomer. Twenty-three metabolites (12 novel) were identified, with CYP-mediated N-demethylation as the dominant pathway. S-penthiopyrad was preferentially metabolized in mouse liver microsomes with a 1.5-fold shorter half-life, while human liver microsomes favored the R-enantiomer. CYP2E1, CYP2C (mouse), and CYP3A4 (human) mediated stereoselective metabolism, with the preferential metabolism of the R-enantiomer by human CYP3A4 attributed to its low binding energy and favorable conformation. This study comprehensively clarified the stereoselective behavior and metabolic pathway of penthiopyrad in mammals, providing valuable metabolic insights for further toxicological evaluation of penthiopyrad.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2026
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IF 19
Lihao Guo,Shuxiang Xu,Xiaolin Tai,Li Wang,Gandong Zhou,Jie Yang,Taorui Yang,Yue Lin,Jianzhi Gao,Minghu Pan,Weiwei Wu,Miaomiao Yuan
Sonodynamic therapy, as a deep penetrating therapy method with high therapy efficacy, is garnering attention in the field of tumor therapy. Nevertheless, the trade-off between high sonodynamic efficacy and stability is difficult to balance for conventional sonosensitizers, which impedes their clinical translation. Exploring the sonodynamic performance of novel materials is imperative to synchronously achieve these two aims. Two-dimensional (2D) metal borides (MBene) possess enormous application potential in biotechnology fields, but so far there are few studies on sonodynamic therapy research. In this work, two types of metal boride nanosheets, orthorhombic and hexagonal molybdenum boride (MoAlB-MoB and Mo 4/3 B 2-x T z ), are synthesized, and their properties are characterized to understand the structure-properties relationship. The MBene nanosheets demonstrate superior and stable sonodynamic efficacy compared with commercial sonosensitizers (TiO 2 and indocyanine green) and a nanosheet sonosensitizer (Mo 2 C MXene). By delivering via microneedle, the MBene nanosheets can significantly inhibit tumor growth with a high precision through sonodynamic reactions. Mechanistic investigations reveal that immunity is activated and long-term immunity memory is established to suppress tumor. The structure-function relationship of MBene nanosheets are further simulated. This work elucidates the therapeutic potential and mechanistic foundations of MBene-based sonodynamic therapy, establishing a promising platform for sonodynamic cancer therapy.
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高影响因子
ENVIRONMENTAL RESEARCH
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2023
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IF 8.3
Hui Liu,Mengqi Liu,Kuiyuan Chen,Mei Shan,Yongye Li
Penthiopyrad is a widely used chiral fungicide for controlling rust and Rhizoctonia diseases. Development of optically pure monomers is an important strategy to realize amount reduction and increment effects of penthiopyrad, wherein, fertilizers as the co-exiting nutrient supplement may alter the enantioselective residues of penthiopyrad in soil. In our study, influences of urea, phosphate, potash, NPK compound, organic granular, vermicompost and soya bean cake fertilizers on enantioselective persistence of penthiopyrad were fully evaluated. This study demonstrated that R -(−)-penthiopyrad dissipated faster than S -(+)-penthiopyrad during 120 days. High pH, available nitrogen, invertase activities and reduced available phosphorus, dehydrogenase , urease, catalase activities were situated to benefit removing the concentrations of penthiopyrad and weakening enantioselectivity in soil. With respect to the impact of different fertilizers on soil ecological indicators, vermicompost contributed to enhanced pH. Urea and compound fertilizer played an absolute advantage in promoting available nitrogen. All fertilizers didn't go against available phosphorus. Dehydrogenase responded negatively to phosphate, potash and organic fertilizers . Urea increased invertase, besides, it and compound fertilizer both diminished urease activity. The catalase activity was not activated by organic fertilizer. Based on all the findings, soil application of urea and phosphate fertilizers was recommended and considered as a better option to exhibit high efficiency for the dissipation of penthiopyrad. The combined environmental safety estimation can effectively guide the treatment of fertilization soils in line with the nutrition requirements and pollution regulation from penthiopyrad.
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高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
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IF 6.1
Jingyuan Wang,Ronggang Zhai,Yifan Ma,Haoyu Chen,Danyang Jing,Huaiyu Yang,Yi Wang
Owing to their small size, morphology and release modification properties, nanopesticides are considered promising alternative strategies for enhancing biological activity and minimizing pesticide losses. In this study, we used a colloidal self-assembly method to develop a morphology-stable, regularly rod-shaped nanoselenium pesticide carrier (NSer), which was further modified with chitosan. After loading penthiopyrad (PEN), the biological activity of NSer@PEN and its impact on the physiological and biochemical processes of plants were further compared with those of spherical nanoselenium pesticides (NSes@PEN) and commercial materials (20 % PEN SC). The biological activities were quantified through the EC 50 values, which revealed that NSer@PEN (0.71 mg/L) and NSes@PEN (1.09 mg/L) exhibited significantly greater activity against Colletotrichum orbiculare Arx compared to 20 % PEN SC (2.70 mg/L). Moreover, through further investigation into the impact of nanopesticides on plant root exudates, Fourier transform infrared spectroscopy (FTIR) and two-dimensional correlation spectroscopy (2D-COS) analysis revealed that the ketone C O bond exhibited the strongest binding affinity, and the C O bond of phenols contributed significantly to the binding of cucumber root exudates induced by NSer@PEN, resulting in a mild response of the plant. The morphology-dependent nanoselenium carriers developed in this work are expected to enhance biological activity and reduce plant stress caused by pesticides, tackling one of the application challenges of pesticides.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2024
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IF 18.5
Jiahui Yan,Haoyu Chen,Carlos F. Guimarães,Rui L. Reis,Zhihua Zhu,Tianyi Wang,Fenglan Zhang,Yaqian Lv,Qihui Zhou,Xiaoying Kong,Jinsheng Shi
Ion interference including copper (Cu + )/calcium (Ca 2+ ) overload activate cell-specific death channels, damage mitochondria and disrupt cellular homeostasis, showing great potential in anti-tumor therapy. However, the complex metabolic environment and the powerful self-protection of tumors cause clinical failure of ion interference. Thus, metabolic disruption is expected an innovative strategy for the enhancement of ion interference. Herein, CuS-α-CHCA&penthiopyrad@CaCO 3 -RGD nanoparticles (CCPCR NPs) are prepared to provide a Cu + /Ca 2+ dual-overload anti-tumor therapy assisted by metabolic-symbiosis-destruction strategy, realizing the collapse of tumor self-protection. Specifically, precise CuS and CaCO 3 delivery triggered irreversible Cu + /Ca 2+ dual-overload and reactive oxygen species (ROS) attack toward 4T1 cells. Meanwhile, α-CHCA and penthiopyrad disturbed the metabolic symbiotic environment by disrupting the TCA cycle and preventing lactate efflux to aggravate intracellular acidosis and promote Fenton-like reaction of Cu + , enhancing the sensitivity of tumor cells to copper death and Ca 2+ overload. Further, aided by the metabolism of symbiosis, the destroyed tumor cells further activate the polarization of M1 macrophages and the maturation and antigen cross-presentation of dendritic cells (DCs), which further eliminate tumor cells. In summary, an amplified anti-tumor dual-ion interference strategy assisted by metabolic symbiotic destruction is established, which is of great significance in improving the clinical effect of ion therapy for tumors.
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