INSTRUMENTATION SCIENCE & TECHNOLOGY
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2017
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IF 0.874
Shuyan Niu,Yajie Fang,Kun Zhang,Juan Sun,Jun Wan
A facile and sensitive fluorescent strategy for the determination of dopamine is reported using 2, 3-diaminophenazine. Dopamine caused autooxidation in the presence of oxygen with catalysis by Mn2+ and formed 2, 3-dihydro-1H-indole-5,6-dione. 2, 3-Diaminophenazine provided relatively strong fluorescence. 2, 3-Diaminophenazine in aqueous solution caused fluorescence quenching when the aminochrome condensed with 2, 3-diaminophenazine to allow the determination of dopamine. Under the optimized conditions, the linear dynamic range for dopamine was from 2.0 × 10−6 mol · L−1 to 6.1 × 10−5 mol · L−1 with a detection limit of 1.76 × 10−6 mol · L−1.
研究领域:
分析化学
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生物医学
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Yiling Ran,Man Yang,Jian Li,Jinlei Song,Yi Wang,Zhanguo Li,Liyong Yuan
Developing versatile sorption materials for radionuclide capture (e.g. iodine) is critical for nuclear energy and environmental science. Covalent organic frameworks (COFs) have recently become a new platform for developing sorption materials because of their high surface area and functionalised skeleton structure. Herein, two types of COF materials containing thiophene were designed as iodine sorbents and synthesised via a Schiff base reaction of benzo[1,2-b:3,4-b’:5,6-b’’]trithiophene-2,5,8-tricarbaldehyde, benzidine (DADP) and p-phenylenediamine (DAB): DADP-COF and DAB-COF. DAB-COF exhibits a unique granular-rod-like morphology and has a higher surface area (1775 m 2 /g) than DADP-COF (1140 m 2 /g), which is clearly beneficial for the physical adsorption of iodine. Meanwhile, the COF backbone is rich in N and S sites, which are advantageous for the chemical adsorption of iodine. These two features make the two prepared COFs ideal iodine sorption materials. DAB-COF demonstrates an excellent gaseous iodine adsorption capacity of 4.2 g/g, ranking it as one of the most effective iodine sorption materials, while DADP-COF exhibits a good adsorption capacity of over 235 mg/g for iodine in cyclohexane solutions. Density functional theory calculations prove that imine N and thiophene S serve as active sites during the iodine adsorption. DAB-COF exposes more active sites because of its higher surface area, leading to a higher iodine adsorption capacity than DADP-COF. The results of this study indicate that introducing thiophene to COFs improves sorption efficacy for sorption applications in general and particularly paves the way for developing stable and effective COF sorbents for iodine capture from various environments.
研究领域:
核能科学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
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IF 6
Hao-Tian Zhu,Mi Chen,Ai-Jun Wang,Pei-Xin Yuan,Jiu-Ju Feng
Nowadays, organic molecules with excellent fluorescence often lack electrochemiluminescence (ECL), which seriously restricts their analytical and biomedical applications. In this work, we functionalized phenazine (PZ) derivatives by with the charged moieties and activated their ECL properties using K 2 S 2 O 8 as a coreactant, achieving a significant “off-to-on” ECL emission transition. For that, 7,8-dihydroxyphenazine-2-carboxylic acid (DHPZ) was synthetized, showing the largest ECL efficiency of 56.4% (versus Ru(bpy) 3 2+ as a standard). Its subsequent self-assembly with ethylene glycol (termed as DHPZ-EG) as emitter further boosted the 4.0-fold ECL efficiency. In the presence of riboflavin (RF), the DHPZ-EG assemblies underwent the light-induced photocatalytic oxidation (PR), enabling efficient ECL signal transduction via the structure-property correlation. The as-established ECL sensor exhibited a wide linear section from 10 nM to 1.0 mM and a limit of detection (LOD, 1.5 nM), and the ability to monitor the broad bean growth metabolism. This work opens a novel avenue for designing organic luminophores and developing sensors for dynamic botanical tracking.
研究领域:
分析化学
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生物传感
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分子生物学
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植物生理学
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转化医学
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光化学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
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2020
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IF 0
Pengjuan Ni,Siyuan Liu,Yuanyuan Jiang,Chuanxia Chen,Bo Wang,Chenghui Zhang,Jianbin Chen,Yizhong Lu
We report a fluorescence assay for alkaline phosphatase (ALP) detection using in situ generation of 2,3-diaminophenazine (OPDox) through an inner filter effect (IFE). AgNO3 can oxidize o-phenylenediamine in a short time to obtain fluorescent OPDox. p-nitrophenol is obtained from ALP-catalyzed hydrolysis of p-nitrophenylphosphate, which can result in the fluorescence quenching of OPDox via the IFE. Consequently, in situ generation of OPDox can be utilized for evaluating the activity of ALP. The fluorescence of OPDox decreases linearly with increasing concentration of ALP in the range from 0.1 to 8.0 mU mL–1, and the detection limit is calculated to be 0.05 mU mL–1. More importantly, this assay has been used to construct a logic gate. The IFE-based fluorescence assay exhibits several distinctive advantages, including high sensitivity, good selectivity, and simple operation. Consequently, it may pave the way for the detection of ALP by utilization of the in situ generation of fluorophores.
研究领域:
生物化学
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医学诊断
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产品关联
DOI
PubMed
DALTON TRANSACTIONS
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2024
·Vol. 53
·期 24
·10235-10243
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IF 3.5
Yibo Cui,Jindong Cao,Jiawei Lin,Chunxiao Li,Jiyong Yao,Kunjie Liu,An Hou,Zhongnan Guo,Jing Zhao,Quanlin Liu
Organic–inorganic metal halides (OIMHs) have drawn considerable attention due to their remarkable optoelectronic properties and substantial promise for nonlinear optical applications. In this research, phenazine has been selected as the organic cation because of its π-conjugated feature. Three compounds, (C12H9N2)PbCl3, (C12H9N2)SbCl4, and (C12H9N2)2InBr4·Br, were synthesized. Initial space group assignments were centrosymmetric for (C12H9N2)PbCl3 and (C12H9N2)SbCl4. However, under 1550 nm laser excitation, (C12H9N2)PbCl3 and (C12H9N2)SbCl4 exhibited second harmonic generation intensities ∼1.7 times greater than that of the benchmark KH2PO4. Structural reevaluation ultimately confirmed non-centrosymmetric P1 and P21 space groups for (C12H9N2)PbCl3 and (C12H9N2)SbCl4, respectively. Upon excitation at 335 nm and 470 nm, (C12H9N2)PbCl3, (C12H9N2)SbCl4, and (C12H9N2)2InBr4·Br emit fluorescence at room temperature. (C12H9N2)2InBr4·Br exhibits reversible phase transitions, showing potential for phase change energy storage. Our research underscores the critical role of comprehensive experimental validation in determining the precise crystallographic space groups and reveals the extensive potential of OIMHs as versatile candidates for advanced optoelectronic applications.
研究领域:
材料科学
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光电
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晶体学
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产品关联
DOI
PubMed
高影响因子
Materials Today Energy
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2024
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IF 9
Xin Zhang,Haiguang Gao,Wei Jin,Yucheng Huang,Juan Xu,Jianyu Cao
Phenazine derivatives are attractive anolyte redox-active species in aqueous redox flow batteries (ARFBs). Unfortunately, they typically suffer from sluggish reaction kinetics, resulting in poor rate capability and inferior energy efficiency, especially under high current densities . Herein, we report a composite of MgO and Ketjen black carbon (MgO/KB) that can serve as a low-cost ARFB electrocatalyst to significantly improve the redox reaction kinetics of phenazine derivatives. The MgO/KB composite catalyst exhibits excellent catalytic performance, with an area-specific resistance (ASR) of 1.54 and 1.11 Ω/cm 2 for the charge and discharge processes, respectively, as well as improved energy efficiency, capacity utilization, and durability in practical ARFB applications. Detailed research confirms that the oxygen vacancies within the MgO promote electron transfer and enhance catalytic activity for the electrochemical reaction of phenazine derivatives. Using density functional theory (DFT) calculations, we unveil that the underlying catalytic enhancement mechanism stems from a low free energy barrier of the rate-determining step (RDS) on oxygen-vacancy-enriched MgO for the oxidation reaction of dihydro-phenazine derivative. These findings will guide the design of highly active electrocatalysts for organic ARFBs.
研究领域:
材料科学
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电化学
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能源存储与转换
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
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IF 5.256
Feng Zhang,Mengke Wang,Lili Zhang,Xingguang Su
Herein, we developed a novel and sensitive ratiometric fluorescence strategy for pH sensing and urea detection based on MoS 2 quantum dots (MQDs) and 2, 3-diaminophenazine (DAP). The DAP was pH-sensitive and can be used as pH indicator while MQDs was pH-insensitive and acted as a reference fluorescent signal. The fluorescence intensity of DAP at 568 nm exhibited increases gradually while the fluorescence intensity of MQDs at 420 nm kept unchanged as the pH changed from 3.0 to 9.0. So the ratio of the two fluorescence intensities at 568 nm and 420 nm can be used to monitor the change of pH. The pH-sensing system showed a linear and reversible respond to pH in the range of 3.8–6.0 with an interval of 0.2 pH unit. Furthermore, the enzymatic reaction of urea in the presence of urease can lead to the pH increase of the solution, which can be used to detect urea by using the above-mentioned pH-sensing system. There exhibited a good linear relationship between the ratiometric fluorescence intensity of I 568 /I 420 and urea concentrations ranging from 5 to 700 μM. And a low detection limit of 1.8 μM was obtained. The proposed strategy exhibited excellent selectivity and sensitivity. Additionally, the developed ratiometric fluorescence strategy was successfully applied to detect urea in water samples.
研究领域:
生物化学
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分析化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Jiandong Liang,Mengyao Tang,Liwei Cheng,Qiaonan Zhu,Runa Ji,Xiao Liu,Qi Zhang,Hua Wang,Zhitian Liu
Organic materials are attracting extensive attention as promising cathodes for rechargeable aqueous zinc-ion batteries (ZIBs). However, most of them fail to implement the requirement of batteries with combined high-rate and long-cycle performance. Herein, we report a flexible organic molecule 2,3-diaminophenazine (DAP) which exhibits ultrahigh rate performance up to 500C and high capacity retention of 80% after 10,000 cycles at 100C (25.5 A g −1 ). Moreover, the Zn 2+ storage mechanism in the DAP electrode is revealed by ex-situ characterization technologies and theoretical calculation, and the redox active centers C N participate in the reversible electrochemical reaction process. Furthermore, electrochemical analyses show that surface-controlled electrochemical behavior contributes to the high-rate performance of DAP cathodes. Besides, its excellent long-cycle performance can be ascribed to the suppressed DAP dissolubility by using a modified glass fiber separator with carbon nanotubes (CNT) film. Our work provides useful insight into the design of high-rate and long-life ZIBs .
研究领域:
材料科学
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电化学
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储能技术
✓ 已验证
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2024
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IF 2.6
Xu Lihuan,Yao Lin,Yang Naikun,Su Chang
Compared with traditional inorganic materials, the organic materials as electrodes are considered as candidates for the next-generation aqueous zinc-ion batteries (ZIBs) due to their high safety, low cost, design flexibility, high theoretical specific capacity, adjustable structure, controllable synthesis methods, and large-scale energy storage. Recently, the dihydrophenazine-based compounds with the multi-electron active center and high discharge voltage have attracted much attention. Herein, we prepared a dihydrophenazine-based polymer of poly-(N-phenyl-5,10-dihydrophenazine) (p-DPPZ) through Buchwald-Hartwig C-N coupling reaction. With the double tertiary amine active centers in each dihydrophenazine unit, the p-DPPZ as the cathode of ZIBs exhibited a discharge specific capacity of 136 mAh g −1 at 0.05A g −1 , companying with the multi-electron redox characteristics with two-step discharge platforms at the operating voltage of 0.65 and 1.18 V (vs. Zn 2+ /Zn), respectively. Also, the extended π-conjugated structure and the stable N redox-active centers by aromatic benzene linker in p-DPPZ polymer endowed the electrode material with the excellent rate performance and the cycling stability. It demonstrated a discharge specific capacity of 92 mAh g −1 even at high current rate of 1 A g −1 . Furthermore, it exhibited an ultralong cycle life of 5000 cycles at 5 A g −1 with 95.1% of the capacity retention as compared to its stable discharge specific capacity. Density functional theory (DFT) and molecular electrostatic potential (MESP) simulations indicated that during two-step redox processes of DPPZ–e – → DPPZ + and DPPZ + –e – → DPPZ 2+ , the SO 4 2− ions in the electrolyte were adsorbed at the active sites of the tertiary amine N in the organic cathode, the molecular orbital levels improved, and the corresponding energy gap became small, suggesting the favor charge transfer ability during the redox process. Furthermore, the electrochemical studies indicated that the energy storage mechanism for the p-DPPZ polymer was mainly controlled by the surface capacitance-diffusion hybrid kinetics process. This work demonstrates that the developed dihydrophenazine-based polymer was an efficient alternative to developing polymer-based cathodes with high performances for aqueous ZIBs.
研究领域:
材料科学
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电化学
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能源存储
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产品关联
DOI
高影响因子
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
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2020
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IF 0
Xue-Wen Liu,Ning-Yi Liu,Yuan-Qing Deng,Shan Wang,Ting Liu,Yu-Cai Tang,Yuan-Dao Chen,Ji-Lin Lu
Ruthenium(II) complexes containing phenazine ring have attracted attention to design as ‘molecular light switches’. In this study, we synthesized two ruthenium complexes containing phenazine ring and studied their abilities to function as DNA intercalators, DNA ‘light switches’, DNA topo I inhibitors, DNA photocleavers and potential antitumor reagents. [Ru(bpy)2(mbipz)](PF6)2 (1) (bpy = 2,2′-bipyridine, mbipz = 2-(4′-methyl-bipyridine-4-yl)-1H-imidazo[4,5-b]phenazine) exhibited off–on type DNA ‘light swtich’ behavior. DNA binding modes of the two complexes were determined as intercalation by using UV–vis spectra, emission spectra, viscosity and molecular docking experiments. DNA photocleavage experimental results showed that the two ruthenium complexes effectively cleave plasmid DNA by producing singlet oxygen. Furthermore, they displayed good topo I inhibition activities. We further found that the two complexes displayed good antitumor activities against Eca-109 cells and A549 cells. The results demonstrated that introduction of phenazine ring will be helpful to design DNA ‘light switch’ based on ruthenium complex.Communicated by Ramaswamy H. Sarma
研究领域:
化学
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分子生物学
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癌症研究
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生物无机化学
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DOI
PubMed
ANALYST
·
2024
·
IF 3.6
Chengchen Tan,Xiaolong Yan,Xingchang Lu,Jianxiu Wang,Xinyao Yi
Breast cancer, as a malignant tumor with the highest incidence in the world, poses a great threat to human life and health. Early diagnosis of breast cancer may help enhancing the survival rate. In this work, a colorimetric and fluorescent dual-mode biosensor based on CRISPR-Cas12a system was constructed for the detection of breast cancer biomarker BRCA1. The intact G4 DNA could form DNAzyme in the assistance of K+ and hemin, catalyzed the oxidation of o-phenylenediamine (OPD) under the assistance of hydrogen peroxide (H2O2), and generate the oxidation product 2,3-diaminophenazine (DAP) with obvious absorption and fluorescence peaks. The presence of the target BRCA1 can activate the trans-cleavage activity of CRISPR-Cas12a, cleaving the G4 DNA and inhibiting the catalytic oxidation of OPD. The target BRCA1 was quantitatively determined by detecting both the absorbance and fluorescence intensity of DAP. Compared with single signal analysis, dual-signal output mode provided more reliable detection results. The detection limits were calculated to be 0.615 nM for colorimetric method and 0.289 nM for fluorescence method. The dual-mode biosensor showed good selectivity for BRCA1 and can resist the interference of complex substrates, which has great potential in biomedical detection.
研究领域:
生物医学工程
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分子生物学
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癌症研究
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生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Xiaoyan Sun,Yuxin Guo,Ruizhi Wen,Hongchang Li
Cu 2+ is a major environmental pollutant. An efficient measurement for Cu 2+ is urgently needed. In this report, we have developed a new sensitive and selective ratiometric sensing platform using 7-amino-4-methylcoumarin (AMC) for detecting Cu 2+ in real samples. In the presence of Cu 2+ , o-phenylenediamine (OPD) could be catalytically oxidized to 2,3-diaminophenazine (DAP), which could react with AMC, leading to quench the fluorescence intensity of AMC at 438 nm. Meanwhile, DAP provided a new emission peak at 557 nm. Based on the efficient overlapped spectrum of AMC and DAP, a ratiometric sensing platform through fluorescence resonance energy transfer (FRET) was carried out. Furthermore, the as-proposed strategy displayed the linear relationship in the wide range from 6 to 250 μM with a low detection limit of 0.059 μM, and the recoveries of the spiked samples in real samples ranged from 86.5% to 110.1%. Moreover, comparing the visual fluorescence colors of the real samples with the standard colorimetric card, we used the as-proposed strategy as a solid-based platform for realizing an efficient semi-quantitative detection of Cu 2+ via naked-eye visual fluorescence mode without any complicated instrument and operation. The above results implied that the as-proposed strategy could be used in the practice determination of Cu 2+ .
研究领域:
环境科学
·
分析化学
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光谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）