Materials Today Bio
·
2025
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IF 10.2
Li Chen,Mengyi Zhan,Li Zhang,Zhuohang Xiong,Chi Zhang,Xuanxuan Zhang,Zhengyang Yang,Lixin Ma,Yibin Cheng,Huanhuan Chen
Diabetic foot ulcers (DFU) are a refractory form of chronic wound characterized by persistent infection and impaired healing. Distinct from other hard-to-treat infections, DFU are aggravated by neuropathy, vasculopathy, and immune dysfunction, which hinder microbial clearance and tissue repair. Their management is further challenged by antibiotic overuse, rising resistance, and the limited efficacy of current therapies. To address these issues, we developed the dual-layer microneedles (IGR MNs) platform that integrated a nitroreductase (NTR)-responsive fluorescent probe for real-time infection monitoring with near-infrared (NIR)-triggered photothermal therapy. The microneedle tips were loaded with liposome-encapsulated antibacterial and immunomodulatory agents for controlled, on-demand release, while the base layer incorporated the infection-responsive probe for spatially precise detection. The IGR MNs overcame the limitations of conventional single-layer microneedles by simultaneously enabling diagnosis and therapy. In vivo evaluations in diabetic wound models demonstrated efficient infection detection, reduced local inflammation, enhanced collagen deposition and neovascularization, and significantly accelerated wound closure. This antibiotic-free strategy enables targeted biofilm disruption and immunomodulation, providing a clinically translatable approach for managing refractory, infected diabetic wounds.
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JOURNAL OF NANOBIOTECHNOLOGY
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2025
·Vol. 23
·期 1
·1-15
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IF 12.6
He Jianan,Cai Jianxun,Zhang Jingjing,Li Yang,Wei Kunpeng,Liu Chenshu,Yan Leye,Hu Xinyan,Huang Lin,Gan Hairun,Wang Dashuai,Li Bing,Zhang Huitao,Pang Pengfei
Intraluminal drug coated devices, such as paclitaxel (PTX)-coated balloons, are commonly used to treat arterial occlusive diseases caused by atherosclerosis. However, their efficacy is limited by drug loss, poor drug retention, insufficient penetration and high costs. Nanoparticles with molecular targeting capabilities offer a promising solution to these challenges. Collagen hybridizing peptide (CHP) specifically binds to degraded collagen in atherosclerotic plaques, enabling precise molecular imaging and targeted therapy. In this study, we demonstrated that collagen degradation was significantly elevated in atherosclerotic plaques and could be effectively identified by CHP in both atherosclerosis patients and mice models. Using the emerging copper-free click chemistry reaction, we functionalized the widely used albumin-based indocyanine green nanoparticles and albumin-bound paclitaxel nanoparticles with CHP, developing a targeted nanoplatform for molecular imaging and therapy. In vivo photoacoustic (PA) imaging and ex vivo fluorescence (FL) imaging revealed significantly enhanced PA and FL signals in carotid artery and aorta plaques with CHP functionalized nanoparticles engaging. Furthermore, therapeutic evaluations showed that CHP significantly improved the plaque-targeting capability of albumin-bound paclitaxel nanoparticles, thereby enhancing their therapeutic efficacy against atherosclerotic plaques. These findings highlighted CHP-functionalized albumin nanoparticles as a promising strategy for precise and effective atherosclerosis molecular imaging and treatment. Graphical Albumin nanoparticles functionalized with CHP by copper-free click chemistry reaction, enhancing the imaging ability and therapeutic efficacy for atherosclerosis by elevated plaque targeting capability.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
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IF 15
Wenhui Dong,Yingying Wei,Chenyue Cao,Hongkai Mu,Shizhao Zhou,Yueyong Xiao,Yongzhen Yang,Lin Chen,Shiping Yu
Hepatocellular carcinoma (HCC), a predominant subtype of liver cancer, is witnessing a rising global incidence and urgently demands the development of innovative nanoplatforms that integrate precise therapeutic and immune regulatory functions. To address the limitations of conventional monotherapies, which often suffer from inadequate tumor targeting, insufficient efficacy, and limited immune activation, this study employs a "biomimetic targeting-synergy therapy" approach. We have engineered a composite system consisting of gadolinium-doped carbon dots (Gd-CDs) enveloped with hepatocellular carcinoma cell membranes (HCM), thereby imparting homologous targeting capabilities and immune activation properties. This Gd-CDs@HCM system facilitates photothermal immunotherapy, guided by bimodal fluorescence (FL) and magnetic resonance (MR) imaging. Upon laser irradiation, Gd-CDs@HCM can induce immunogenic cell death (ICD) in tumor cells. The tumor-associated antigens (TAAs) and damage-associated molecular patterns (DAMPs) released during ICD collaboratively enhance systemic anti-tumor immunity in conjunction with HCM, achieving a primary tumor ablation rate of 84.9% and inhibiting tumor progression. Consequently, this research offers an innovative strategy for real-time monitoring and precise synergistic treatment of HCC by utilizing FL/MR bimodal imaging and integrating bionic targeting, localized thermal ablation, and immune activation functions.
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Laser & Photonics Reviews
·
2026
·
IF 9.7
Xuan You,Xiaolong Liu,Wei Liu,Peijin Zhang,Yuhuang Zhang,Yalun Wang,Jianguo Wang,Jun Qian
Temporal compressive imaging enables the reconstruction of multi-frame dynamic scenes from a single exposure by multiplexing spatially encoded temporal slices. This approach mitigates integration time loss and facilitates high-speed imaging via low-frame-rate cameras. Herein, a second near-infrared (NIR-II) temporal compressive wide-field microscope (TCWM) is established, utilizing the EfficientSCI algorithm for frame reconstruction. Simulations initially verify the transferability of EfficientSCI to biological microscopic imaging. Furthermore, mask acquisition with a spectrally matched NIR backlight proves effective for the high-fidelity reconstruction of fluorescent targets. Utilizing a conventional NIR camera of 25 frames per second (FPS), NIR-II TCWM achieves a maximum in vitro reconstruction rate of 333.3 FPS, surpassing the native frame rate by over 13-fold. Additionally, its robust anti-scattering capability for dynamic imaging at significant depths is substantiated using Intralipid. Finally, NIR-II TCWM is applied to in vivo cerebrovascular imaging at depths up to 300 µm. With a 100 FPS reconstruction frame rate, NIR-II TCWM successfully demonstrates simultaneous, high-speed tracking of multiple fluorescent particles across multiple vessels, highlighting the potential for comprehensive deep-tissue hemodynamic research in living organisms.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Yu Jiang,Yaowu Zhang,Jingqi Hou,Heng Liu,Xianyu Dai,Yuchuan Hou
Characterizing the tumor immune microenvironment (TIME) to explore potential therapeutic targets is fundamental to advancing precision tumor immunotherapy. However, the immunosuppressive nature of “cold” tumors, notably prostate cancer, poses a significant barrier to immunotherapy, demanding new approaches to simultaneously reinvigorate anti-tumor immunity and modulate the molecular drivers of immune evasion. Here, we identified VSIG4 as a key regulator of prostate tumor-resident macrophage fate through single-cell sequencing analysis. Meanwhile, a shikonin (Shik)-mediated downregulation of VSIG4 in macrophages is verified, potentially attenuating its immunosuppressive effects. Building on these findings, cytosine guanine dinucleotide (CpG) oligodeoxynucleotide (ODN)-modified manganese (Mn)-Shik metal-polyphenol network nanodrugs (Mn/Shik@CpG NDs) are designed to reverse the “cold” immune environment of prostate tumor. In this scenario, Mn/Shik@CpG NDs release monomeric components under the stimulation of acidic and glutathione-rich tumor microenvironment (TME), thus exerting their immunomodulatory effects synergistically. Since the released Shik can induce DNA damage by necroptosis promoting reactive oxygen species production, cGAS-STING signaling pathway is initiated, which further activates interferon production in the TME. In addition, the necroptosis of Shik initiates immunogenic cell death, further activating innate immunity and promoting adaptive immune responses. Mn 2+ is a cGAS-STING sensitizer, which amplifies the intratumoral interferon response. As an immune adjuvant, CpG ODN effectively promotes the maturation of dendritic cells, as well as the helper T cell differentiation and pro-inflammatory cytokine secretion, thus activating both innate and adaptive immunity. In vivo studies suggest that Shik-mediated VSIG4 downregulation, combined with innate and adaptive immune activation, remodels the TIME to evoke a significant anti-tumor response. Furthermore, transcriptomic analysis of rechallenged tumors indicated this durable protection was driven by a genuine immune memory response, revealing a gene signature of T cell activation and immune reprogramming. Collectively, beyond presenting a novel therapeutic candidate for converting immunologically “cold” tumors into “hot” ones, our work validates a data-guided design pipeline, offering a conceptual blueprint to inform the precise engineering of future nanodrugs.
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Nature Communications
·
2026
·
IF 18.1
Chen Bin,Ding Miaomiao,Feng Ye,Gao Chao,Rong Jinghui,Tan Haixin,Tian Hao,Wilson Daniela A.,Zhou Yecheng,Tu Yingfeng,Peng Fei
Anxiety and mood disorders, notably major depressive disorder characterized by suppressed neuronal excitability, involve disruption of endogenous molecular polarity homeostasis. Conventional monoamine antidepressants, constrained by delayed therapeutic onset and high risk of drug resistance, neglect and fail to address this pathological feature. Here, we report IC@His-ICG, a near-infrared-responsive photochemical nanomotor that enables polarity switching. Leveraging photochemically driven polarity change, the wireless nanomotors achieved ion-tolerant propulsion in physiological media and phototactic migration to predefined hippocampal targets. Spatiotemporal polarity tuning induced instantaneous calcium oscillations and hippocampal excitation transmission, restoring monoamine homeostasis and combating anxiety and depression in rodents. This polarity-based neuromodulation operates independently of ligand-receptor mechanisms, linking nanoscale polarity dynamics to neurochemical homeostasis and behavioral outcomes in a depressive mouse model. The noninvasive, precision nanomachine strategy differs from traditional intervention frameworks, offering a precise modulation approach for neural disorders.
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Journal of Materials Chemistry B
·
2026
·
IF 6.2
Jiaxing Li,Chenyang Chu,Lijun Zhu,Zhong Du,Yaqi Cui,Jiabao Xiong,Chi Zhang,Yuxiang Gao,Biao Dong,Nuernisha Alifu
The clinical translation of photodynamic therapy (PDT) for cervical cancer is constrained by limited visible-light penetration and tumor hypoxia. These limitations are further aggravated by the oxygen-consuming nature of PDT itself. Although near-infrared (700–1700 nm, NIR) light activation can alleviate the penetration issue, overcoming hypoxia remains a paramount challenge. Herein, an oxygen self-sufficient theranostic nanoplatform, designated IFHFC nanoparticles (IFHFC NPs), is developed to synergistically enhance NIR-PDT by implementing a novel dual oxygen-supply strategy that integrates catalytic oxygen generation with physical oxygen delivery. The NPs deliver oxygen through two complementary routes. They catalyze the decomposition of endogenous hydrogen peroxide into oxygen and, under NIR irradiation, release stored oxygen to sustain local oxygen availability. This coordinated oxygenation alleviates hypoxia and increases cytotoxic reactive oxygen species generation. Both in vitro and in vivo studies confirm improved inhibition of cervical tumor growth. Overall, combining deep-tissue-penetrating NIR activation with dual-mode oxygenation offers a promising strategy for overcoming key barriers of PDT in solid tumor treatment.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2026
·
IF 2.2
Yunhan Wang,Xinming Zhang,Fang Fang,Yunyan Chen,Yu Sun
The combination of photothermal therapy and chemotherapy based on nanocarriers is regarded as a promising strategy for enhancing therapeutic efficacy in cancer treatment. Despite the huge progress achieved in the past years, nanocarriers without further specific surface modification can be easily cleared by the immune system thus affecting the therapeutic outcomes. Thus, developing a nanoplatform for active-targeted drug delivery against cancer is of great necessity. Herein, multifunctional lipid-polymer hybrid nanoparticles (abbr. Cet-CINPs) with enhanced long circulation and active targeting ability were constructed by coating the PEGlyated phospholipids and PLGA hybrid core with cetuximab for efficient chemo-photothermal synergistic therapy. Cet-CINPs were prepared through an ultrasonic emulsification method for co-loading irinotecan and indocyanine green. It is demonstrated that Cet-CINPs have spherical morphology with particle size of 119.97 ± 0.93 nm and exhibited excellent dispersion stability in ultrapure water at 4 °C. In vivo experiments showed that compared with conventional drug-loaded nanoparticles without cetuximab modification (CINPs), Cet-CINPs effectively targeted irinotecan transport to Lovo tumor sites. Moreover, upon near-infrared laser irradiation, Cet-CINPs finally accomplished up to 96.71 ± 1.60% tumor inhibition with negligible damage to normal tissues and organs because of the chemo-photothermal combined effect. Therefore, the NIR-activatable and active-targeted lipid-polymer hybrid nanoparticles could provide a precise, efficient, and synergistic method that might have contributed to treatment in colorectal cancer therapy.
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Small
·
2026
·
IF 12.1
Yueguang Fang,Chenxi Li,Xinqi Li,Lanling Xiu,Dingwen Xiao,Miao Wang,Lin Sun,Junwei Ye
Titanium-based materials hold great biomedical potential owing to excellent biocompatibility. But titanium diboride (TiB 2 ), an emerging metal boride, is rarely explored for antitumor use, and developing multifunctional TiB 2 -based nanoplatforms with enhanced catalytic activity is urgently needed. Herein, we constructed a nanoplatform (TiB 2 -PEG-DOX) by modifying TiB 2 nanosheets (TiB 2 NSs) with amino polyethylene glycol (NH 2 -PEG-NH 2 ) and loading doxorubicin (DOX) via electrostatic interaction. We first clarified the boron (B)-mediated Ti valence cycle: B regulates Ti electron transfer, promotes Ti 4+ reduction to Ti 2+ , enhancing H 2 O 2 -rich tumor microenvironment Fenton-like reaction to generate cytotoxic •OH for chemodynamic therapy (CDT). Meanwhile, TiB 2 -PEG-DOX shows 53.53% photothermal conversion efficiency under 808 nm near-infrared (NIR) irradiation for efficient photothermal therapy (PTT), and NIR further triggers on-demand DOX release. DOX accumulates at tumor sites via the enhanced permeability and retention (EPR) effect to exert chemotherapy (CT). In vitro, it eliminates 86.32% of HCT-116 colorectal cancer cells via CDT/PTT/CT synergy; in vivo, it achieves nearly complete tumor ablation in mice with excellent biocompatibility. This work provides a high-performance synergistic antitumor platform and establishes a B-modulated metal valence cycling paradigm, paving the way for titanium-based nanomedicines.
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MATERIALS & DESIGN
·
2026
·
IF 8.2
Jinhuan Li,Ling Cai,Zhen Fu,Xiaodong Zhu,Yanqiang Huang,Yuan Wu,Jin Chen
Due to the spatiotemporal specificity and high efficacy, tumor microenvironment (TME)-responsive nanozyme catalytic therapy has attracted considerable attentions. Nevertheless, it remained challenging to remodel TME for improving therapeutic benefits. Here, a TME-responsive nanozyme termed p-GOx-MnO 2 -ICG (p-GMI) was synthesized via biomimetic mineralization using ε-poly-L-lysine (EPL) as the template. The obtained p-GMI comprised glucose oxidase (GOx), MnO 2 nanoparticles, and photosensitizer indocyanine green (ICG), which exhibited prominent triple-enzyme activities (glucose oxidase, catalase-like, and peroxidase-like) enabling multimodal therapy. Specifically, starvation therapy (ST) was initiated through glutathione peroxidase-mediated glucose depletion. The released Mn 2+ in TME utilized the produced H 2 O 2 and gluconic acid to initiate Fenton-like reaction, enhancing chemodynamic therapy (CDT) efficacy. Meanwhile, the generated O 2 by catalase-like nanozyme can not only activate GOx but serve as the photodynamic therapy (PDT) substrate, leading to synergistically improved ST and PDT outcomes. Both in vitro and in vivo experiments indicated p-GMI nanozyme enabled fluorescence imaging/magnetic resonance imaging-guided ST/CDT/PDT combinational therapy, while also exhibiting favorable biosafety in the CAL-27 xenograft mouse model. Therefore, the built TME-responsive and dual-modal imaging guided p-GMI nanozymes as integrated cascade nanosystem held potentials in dealing with oral cancer.
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Advanced Healthcare Materials
·
2026
·
IF 9.6
Jingjing Yang,Jiawei Yang,Kunguo Liu,Shijie Wang,Ye Hu,Juanjuan Li,Hao Wang,Dan Jiang,Xin Han
Pyroptosis triggered by pore-forming Gasdermin proteins in cancer cells facilitates anti-tumor immune activation by releasing pro-inflammatory cytokines and immunogenic contents following cellular rupture. However, selectively triggering pyroptosis in tumors still remain limited in clinical applications. Here, it is reported a microfluidic-assisted bacterial delivery system using attenuated Salmonella typhimurium VNP20009 encapsulated with metal-phenolic networks composed of ferric ions (Fe 3 + ) and tannic acid (TA) to enhance intracellular gasdermin D (GSDMD) expression through targeted CRISPR/dCas9 delivery, thereby inducing robust tumor pyroptosis. Mechanistically, this system achieves cascade amplification of pyroptotic cell death through coordinated multi-modal mechanisms. Following systemic administration, VNP20009 specifically accumulates in hypoxic tumor regions while the coated Fe 3 + –TA nanofilm undergoes pH-responsive dissolution in the acidic tumor microenvironment (TME), simultaneously generating ROS through Fenton reaction and releasing CRISPR/dCas9 system to upregulate GSDMD expression. Concurrently, the abundant flagella of VNP activate caspase-1, which in turn cleaves the overexpressed GSDMD proteins into its active form, thereby triggering robust pyroptosis in tumor cells. Taken together, by coupling bacterial adjuvanticity with ROS-mediated stress and CRISPR-driven GSDMD upregulation, this strategy achieves efficient amplification of pyroptosis and promotes antitumor immune activation.
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BIOMACROMOLECULES
·
2026
·
IF 5.4
Jiao Sun,Yiqing Wang,Rongjing Zhou,Xian Zou,Qiqi Ge,Zheng Xing,Cheng Wang,Jianhao Wang
Conventional tumor starvation via embolization or glucose oxidase (GOx) is often hampered by poor specificity and enzyme instability. Herein, we developed a pH-responsive, amphiphilic GOx-conjugated polymer (LPHF-GOx) for synergistic cascade starvation therapy. Triggered by the acidic tumor microenvironment, LPHF-GOx undergoes rapid aggregation, achieving dual metabolic disruption through localized vascular embolization and GOx-mediated glucose depletion. LPHF-GOx demonstrated robust pH-dependent self-assembly while maintaining high catalytic activity. In vitro and in vivo evaluations confirmed that this dual-action system induces profound nutrient deprivation and oxidative stress, leading to significant tumor growth inhibition with negligible systemic toxicity. By integrating vessel occlusion with biochemical enzymatic interference, this study provides a potent and targeted platform for sustainable starvation therapy against malignant tumors.
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