POLYMER DEGRADATION AND STABILITY
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2025
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IF 7.4
Lei Zhang,Yi Wang,Yan Guo,Xi-Yuan Feng,Xiu-Li Wang,Lin Chen,Yu-Zhong Wang
The increasing fire risk in modern society urgently requires high-performance flame-retardant protective polymer materials. Polyester is a versatile thermoplastic polymer widely used in fiber textiles, films, and plastics. However, it remains a huge challenge to simultaneously achieve green preparation, heat resistance, flame retardancy, smoke suppression and non-dripping for polyester materials. Herein, we propose a halogen-free and phosphorus-free green strategy for synthesizing flame-retardant, smoke-suppressed and non-dripping polyesters with enhanced heat resistance. By chemically copolymerizing an aromatic-imine containing monomer CID, the corresponding polyester PET-CID exhibits an increased glass transition temperature of 84.0°C, a limiting oxygen index of 31.5%, a 42% reduction in peak heat release rate, a 45% reduction in peak release smoke rate, and passes the UL-94 V-0 rating without melt dripping. The key is that the smart crosslinkable aromatic-imine remains stable at the synthesis and processing temperatures of the polyester. At higher temperature during combustion, aromatic-imine rapidly crosslinks to increase the melt viscosity of the polyester and promote the formation of a dense char layer. This work simultaneously integrates the high heat resistance, flame retardancy, smoke suppression and non-dripping of polyester through a single aromatic-imine group, paving the way for the green development of high-performance flame-retardant polymer materials with low fire hazards.
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CELL DEATH AND DIFFERENTIATION
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2026
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IF 15.4
Yang Shuai,Song Jiawei,Wang Zhenzhen,Peng Guang,Tong Linglin,Li Xin,Yang Kexin,Chen Yang,Zhang He,Zhang Qing,Chen Renjin
eIF6 is overexpressed in multiple cancers. Previous work has showed that deficiency alters the gut microbiota. This study investigated the mechanism linking eIF6 deficiency, microbial dysbiosis, and colorectal cancer (CRC). eIF6 expression was assessed in human and mouse CRC samples. Functional assays were conducted in mice with AOM/DSS-induced CRC. Antibiotic treatment and faecal microbiota transplantation (FMT) were applied to evaluate microbiota-mediated effects. 16S rDNA sequencing and Dubosiella newyorkensis ( D. newyorkensis ) supplementation were used to identify key bacteria. Metabolites from the bacterial supernatant were analysed via targeted mass spectrometry. The effect of indole-3-carboxaldehyde (3-ICA) was tested in murine models. eIF6 expression was upregulated in CRC. Its deficiency reduced the tumour incidence and proliferation of tumours in mice and increased the abundance of beneficial bacteria such as Akkermansia and Dubosiella . FMT from e IF6 deficient mice and D. newyorkensis administration attenuated tumorigenesis and enhanced barrier function. 3-ICA, a metabolite of D. newyorkensis , also suppressed CRC progression. eIF6 deficiency exerts protective effects against CRC through the enrichment of D. newyorkensis and its metabolite 3-ICA, revealing a novel mechanism and potential therapeutic strategy for CRC.
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ACS Sustainable Chemistry & Engineering
·
2022
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IF 9.224
Lingling Ma,Lv Li,Minghao Yuan,Lei Bai,Anran Zhang,Xiaoming Yan,Gaohong He,Fengxiang Zhang
The hydroxide conductivity and alkaline stability play a significant role in the application of an anion exchange membranes (AEMs) fuel cell. These high performances are closely related to the structure of the polymer. Side-chain structure is commonly used to construct microphase separation. On this basis, a new strategy is to incorporate a rigid bulky structure into an AEM to break chain packing and reduce resistance against hydroxide ion transport. In this work, rigid bulky hydrophilic–hydrophobic side-chain grafted, ether-free poly(biphenyl indole) (PBN) AEMs are designed and prepared by chemical incorporation of hydrophilic bulky cyclodextrin and hydrophobic bulky adamantane onto the PBN backbone. The enhanced driving force of microphase separation and the enlarged free volume can make for high hydroxide conductivity. The fabricated AEM with an ion exchange capacity (IEC) of 1.81 mmol g–1 shows a conductivity of 122.0 mS cm–1 at 80 °C, which can be retained by 90% after treatment of the AEM in a 1 M NaOH solution at 80 °C for 1008 h. Its single H2/O2 fuel cell yields a peak power density of 603 mW cm–2 at 60 °C; the fuel cell can maintain 70.2% of its initial voltage after operating for 30 h. This strategy provides a new and effective route for the preparation of AEMs with superior performance.
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Polymers
·
2021
·Vol. 13
·期 24
·4322
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IF 4.329
Xiang He,Ruyue Liu,Huiqing Liu,Ruixiao Wang,Zhenhao Xi,Yixiang Lin,Jie Wang
In order to replace traditional wound treatments such as sutures, tissue adhesives with strong wet tissue adhesion and biocompatibility have attracted more attention to the applications of non-invasive wound closure. Herein, inspired by tunicate adhesive protein, a series of 2,3,4-trihydroxybenzaldehyde (TBA)-modified chitosan hydrogels (CS-TBA-Fe) were prepared by easily mixing the solutions of chitosan-FeCl3and TBA via the Schiff-base reaction and the coordination between Fe3+and pyrogallol groups. The gelation time was greatly shortened to only several seconds after induced even trace Fe3+. The hydrogel (CS-TBA-Fe) exhibited ~12-fold enhanced wet tissue adhesion strength (60.3 kPa) over the commercial fibrin glue. Meanwhile, the hydrogel also showed robust adhesion to various substrates such as wood, PMMA, and aluminum. The swelling ratio and rheological property can be simply controlled by changing the concentrations of chitosan, TBA, and Fe3+. Moreover, the hydrogel displayed a rapid and highly efficient self-healing ability and an excellent antibacterial activity againstE. coli. The overall results show that the CS-TBA-Fe hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material.Keywords:facile preparation;tunicate-inspired;chitosan;hydrogel;tissue adhesive
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Microorganisms
·
2021
·Vol. 9
·期 7
·1511
·
IF 4.128
Jia Yin,Yujie Song,Yaozhong Hu,Yuanyifei Wang,Bowei Zhang,Jin Wang,Xuemeng Ji,Shuo Wang
Akkermansia muciniphila, a potential probiotic, has been proven to lessen the effects of several diseases. As established, the relative abundance ofAkkermansiais positively correlated with tryptophan metabolism. However, the reciprocal interaction between tryptophan andAkkemansiais still unclear. Herein, for the first time, the possible effects of tryptophan and its derived metabolites onA. muciniphilawere preliminarily investigated, including growth, physiological function, and metabolism. Obtained results suggested that 0.4 g/L of tryptophan treatment could significantly promote the growth ofA. muciniphila. Notably, when grown in BHI with 0.8 g/L of tryptophan, the hydrophobicity and adhesion ofA. muciniphilawere significantly improved, potentially due to the increase in the rate of cell division. Furthermore,A. muciniphilametabolized tryptophan to indole, indole-3-acetic acid, indole-3-carboxaldehyde, and indole-3-lactic acid. Indoles produced by gut microbiota could significantly promote the growth ofA. muciniphila. These results could provide a valuable reference for future research on the relationship between tryptophan metabolism andA. muciniphila.Keywords:Akkermansia;tryptophan metabolites;indole;indole derivates
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
·
IF 6.1
Haiyan Zhao,Hongfu He,Zhongjie Shen,Chunle Wei,Limin Yin,Yunying Zhu,Hongxia Lu,Runjiang Song,Deyu Hu
Potato virus Y (PVY) is a highly destructive pathogen that infects Solanum tuberosumvL., commonly known as potato, a crop that produces one of the most crucial food staples of the world. The PVY viral infection can considerably reduce the yield and quality of potatoes, thereby causing significant economic ramifications. Given the unsatisfactory performance of commercially available antiviral agents against PVY, we synthesized a series of novel indole-derived compounds followed by their bioevaluation and investigation of the mechanisms governing their anti-PVY activity. These indole-based derivatives contain dithioacetal as a key chemical moiety, and most of them exhibit promising anti-PVY activities. In particular, compound B2 displays remarkable in vivo protective and inactivating properties, with half-maximal effective concentration (EC50) values of 209.3 and 113.0 μg/mL, respectively, in stark contrast to commercial agents such as ningnanmycin (EC50 = 281.4 and 136.3 μg/mL, respectively) and ribavirin (EC50 = 744.8 and 655.4 μg/mL, respectively). The mechanism using which B2 enhances plant immune response to protect plants from PVY is elucidated using enzyme activity tests, real-time quantitative polymerase chain reaction (RT-qPCR), and proteomics techniques. This study aims to pave the way for developing candidate pesticides and related molecules using antiphytoviral activity.
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Frontiers in Pharmacology
·
2024
·
IF 4.4
Zhang Junzhi,Lin Binyan,Zhang Ying,Hu Xiaochao,Liu Tongtong,Liu E-Hu,Liu Shijia
Background: Baitouweng decoction (BTW) is a classic botanical drugs formula that has been widely used clinically for the treatment of gut-related disorders in China. However, its role in ameliorating ulcerative colitis (UC) remains to be explored.Purpose: The study aimed to determine the therapeutic efficacy and potential mechanism of action of BTW on dextran sodium sulfate (DSS)-induced colitis mice.Methods: In vivo: 3.5% DSS-induced experimental colitis mice were treated with BTW (Pulsatilla chinensis (Bunge) Regel, Phellodendron chinense C. K. Schneid, Coptis chinensis Franch and Fraxinus chinensis Roxb), kynurenine or DOPA decarboxylase (DDC) inhibitor (carbidopa). In vitro: Caco-2 cells were stimulated with TNF-α to activate inflammation and later treated with various concentrations of BTW and carbidopa. Model evaluation included body weight, disease activity index (DAI) score, colon length and histopathology. Cytokine levels were measured by flow cytometry. Protein levels were analyzed by proteomics and functionally annotated. The levels of tryptophan metabolites in mouse serum and colon were detected by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Alcian Blue/Phosphate Acid Schiff (AB/PAS) staining, immunohistochemistry and western blot were used to assess the intestinal barrier function and detect the protein expression levels.Results: BTW significantly reduced the DAI, ameliorated colonic injury and regulated inflammatory cytokines in DSS-induced colitis mice. The botanical drugs formula also promoted intestinal epithelial barrier repair by enhancing the expression of the tight junction (TJ) proteins. Tryptophan metabolic signaling pathway was significantly enriched in DSS-induced UC mice, and BTW decreased the level of kynurenine, increased indole metabolites. The therapeutic effect of BTW was evidently reduced when kynurenine was given to mice. Also, BTW promoted DDC protein expression and activated the aryl hydrocarbon receptor (AHR)/IL-22 signaling pathway.Conclusion: BTW improves ulcerative colitis by promoting DDC expression, regulating the conversion of tryptophan metabolism from the kynurenine pathway to the indole metabolism pathway, thereby modulating tryptophan metabolism to increase indole metabolites, and activating AHR receptors to restore intestinal barrier function.
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Science China-Life Sciences
·
2025
·
IF 9.5
Han Ziyi,Fu Jian,Gong Aiyan,Ren Wenkai
The gut microbiota plays key roles in host health by shaping the host immune responses through their metabolites, like indole derivatives from tryptophan. However, the direct role of these indole derivatives in macrophage fate decision and the underlying mechanism remains unknown. Here, we found that bacterial indole-3-propionic acid (IPA) downregulates interleukin-1beta (IL-1β) production in M1 macrophages through inhibition of nuclear factor-kappa B (NF-κB) signaling. Mechanistically, IPA binds specifically with methionine adenosyl-transferase 2A (MAT2A) to promote S-adenosylmethionine (SAM) synthesis, which facilitates the DNA methylation of ubiquitin-specific peptidase 16 (USP16, a deubiquitinase), and in turn promotes Toll-like receptor 4 (TLR4) ubiquitination and NF-κB inhibition. Furthermore, IPA administration attenuates sepsis in mouse models induced by lipopolysaccharides (LPS), showcasing its potential as a microbial-derived adjunct in alleviating inflammation. Collectively, our findings reveal a newly found microbial metabolite-immune system regulatory pathway mediated by IPA.
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TETRAHEDRON
·
2013
·
IF 2.803
Xiaona Zhang,Liang Sun,Wei Zheng,Xichang Bao,Ning Wang,Ting Wang,Renqiang Yang
Two indole-containing fullerene derivatives, N -hydrogen-2-[3-( N -2-ethylhexylindolyl)][60]fulleropyrrolidine (EHIHC60P), and N -(2-ethylhexylindolyl))-2-[3-( N -2-ethylhexylindolyl)][60]fulleropyrrolidine (DEHIC60P) were synthesized by the typical Prato reaction. The absorption spectra, electrochemical properties of the two compounds were measured. Inverted solar cells were fabricated with the structure of ITO/ZnO/poly(3-hexylthiophene) (P3HT):fullerene derivatives/MoO 3 /Ag. The highest power conversion efficiencies (PCEs) of 3.32% and 3.23% were obtained for P3HT/EHIHC60P and P3HT/DEHIC60P based solar cells at the composite ratio of 1:1 after the active layers were annealed at 150 °C under inert atmosphere , with a open-circuit voltage ( V oc ) of 0.66 V and 0.74 V, respectively. For comparison, the device based on P3HT/PCBM at the same conditions showed the PCE of 3.28%, with a V oc of 0.61 V. The influence on the photovoltaic property of the fullerene derivatives, which was induced by some subtle changes in the chemical structure was compared and discussed.
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Food Bioscience
·
2024
·
IF 4.8
Mengshi Xiao,Jiayuan Bi,Xinmiao Ren,Xiaodan Fu,Dongyu Li,Rong Li,Haijin Mou
Fucose-containing oligosaccharides exhibit various biological activities, particularly for improving the intestinal health of infants. Bacterial exopolysaccharides are promising resource of fucose-containing oligosaccharides. A fucose-containing trisaccharide ( d - Glc p-β-(1 → 4)- l - Fuc p and d - Gal p-α-(1 → 3)- l - Fuc p, GuFGa) with same monosaccharide composition with 2′-fucosyllactose (2′-FL, the most abundant oligosaccharide in human milk), is obtained from bacterial exopolysaccharides. This study compared the in vitro prebiotic activities of GuFGa and 2′-FL using mono- and co-culture fermentation. Mono-culture shows GuFGa could be utilized by Bifidobacterium infantis and Lactobacillus plantarum , while 2′-FL only promote the proliferation of B . infantis . Co-culture fermentation involves cross-feeding between B . infantis and L . plantarum to utilize GuFGa. Further in vitro fecal microbiota fermentation of breastfed infants demonstrates that GuFGa exhibits better prebiotic activity than 2′-FL in increasing beneficial bacteria ( Bifidobacterium and Lactobacillus ) abundance and reducing harmful bacteria ( Clostridium _ sensu _ stricto and Escherichia - Shigella ) abundance. Moreover, GuFGa and 2′-FL fermentation shifted the gut microbiota composition of formula-fed infants to that of breastfed infants. Furthermore, herein, GuFGa and 2′-FL caused distinct metabolic profiles in both short-chain fatty acids and indole derivatives (e.g. indolelactic acid and indolepropionic acid). In summary, this study provides insights into the exploration of novel functional fucose-containing oligosaccharides as potential prebiotics.
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MOLECULAR MEDICINE
·
2025
·
IF 6.4
Yufei Deng,Xiaoying Hou,Qian Fang,Haiping Wang,Xiaoxuan Li,Zhiyong Hu,Zhaolu Liu,Limei Fan,Yunyi Liu,Zhengqi Fu,Xiji Shu,Binlian Sun,Lijun Huang,Yuchen Liu
Background FOLFOX is the recommended chemotherapy regimen for colorectal cancer (CRC), but its response rate remains low. Our previous studies have established a close relationship between gut microbiota and the anti-CRC effect of FOLFOX, though the underlying mechanisms remain unclear. Diet has been confirmed as a key factor influencing gut microbiota, and high-salt diets, representative of western dietary habits, has been shown to affect gut microbiota, immune function, and the risk of developing CRC. However, the impact of high-salt diets on the anti-CRC efficacy of FOLFOX remains unstudied. Therefore, we aimed to investigate the effect and mechanism of high-salt diets on the anti-CRC effect of FOLFOX. Methods We performed 16 S rRNA sequencing and T500 targeted metabolomics analysis on fecal samples from CRC patients and healthy adults. A CRC orthotopic xenograft mouse model was used to study the effect of a high-salt diet on FOLFOX’s anti-CRC efficacy. 16 S rRNA sequencing and non-targeted metabolomics were conducted on mouse fecal samples. Flow cytometry was used to assess immune cell infiltration in tumor and paracancerous tissues. A mouse macrophage conditioned medium system, with tryptophan metabolites, was employed to annotate the functional metabolites, followed by in vivo verification using the orthotopic xenograft mouse model. Results The structure and metabolic profiles of gut microbiota are significantly different between 9 healthy adults and 6 CRC patients. A high-salt diet significantly reduced the efficacy of FOLFOX in mice, with notable changes in gut microbiota and related metabolites. Correlation analysis revealed a significant relationship between gut microbiota, tryptophan metabolites and FOLFOX efficacy. Flow cytometry indicated that a high-salt diet altered macrophage infiltration (CD45 + F4/80 + ) in both the tumor and paracancerous tissues. In vitro experiments confirmed that the tryptophan metabolite SK reduced FOLFOX efficacy, while IPA enhanced it through macrophage-conditioned medium. In vivo, we verified that under a high-salt diet, SK inhibited the efficacy of FOLFOX, while IPA promoted it. Conclusion A high-salt diet reduces the anti-CRC efficacy of FOLFOX through gut bacterial tryptophan metabolism mediated macrophage immunomodulation. Supplementary Information The online version contains supplementary material available at 10.1186/s10020-025-01122-8.
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Food Chemistry-X
·
2024
·
IF 6.5
Jia Cheng Qian,Heng Peng Zhang,Yi Wang,Dan Liu
Cruciferous vegetables (CVs) are globally consumed with some health benefits believed to arise from indole-3-carbinol (I3C), a labile phytochemical liberated from indole glucosinolates, but few reports describe the effect of cooking on I3C reactions. Here, we present heat-promoted direct conversions of I3C in broccoli florets into indole derivatives, which are unique in the N -indolylmethylation and -hydroxymethylation of indole nuclei by 3-methyleneindole and formaldehyde formed in situ from the I3C dehydration and the dimerization of I3C to 3,3′-diindolylmethane (DIM), respectively. Such N -substituted indoles were found in a range of 0.4–4.6 μg per gram of steamed broccoli florets, with a novel compound N -(indol-3-ylmethyl)-3,3′-diindolylmethane (DIM-1) bio-evaluated to inhibit A375 cells with an IC 50 value of 1.87 μM. In aggregation, the investigation discloses the promoting effect of heating on the I3C transformation in CVs and identifies DIM-1 as an anti-cancer drug candidate, and thus updates the knowledge of I3C and bioactive derivatives thereof.
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