Tenvermectin (TVM) is a novel 16-membered macrolide compound isolated and purified from the fermentation broth of genetically engineered Streptomyces avermitilis strain MHJ1011 . TVM and ivermectin were administered at the dose of 0.3 mg/kg body weight through a single subcutaneous injection route followed by plasma collectiom and analysis at different time intervals. Plasma concentrations of TVM and IVM were determined by high-performance liquid chromatography with fluorescence detector. Pharmacokinetic analysis was completed using the non-compartmental method with WinNonlin™ 6.4 software. TVM is rapidly absorbed after administration with peak plasma concentrations ( C max , 9.78 ± 2.34 ng/ml) obtained within 6–22 h. AUC 0-last was 586.86 h·ng/ml ± 121.24 h·ng/ml. The mean elimination half-life of TVM ( T 1/2λz ) was 97.99 h ± 46.41 h. The T 1/2λz of IVM was 146.59 h ± 22.26 h in the study. The present study showed that subcutaneous administration of TVM at 0.3 mg/kg body weight (BW) in swine is absorbed more rapidly than IVM in swine. Compared to the pharmacokinetic characteristics of IVM, there was little difference in the half-life of TVM among different individuals. The data will contribute to refining the formulation and dosage regime for TVM administration.
Yahui Cai,Jianfei Wu,Kaili Wang,Youming Dong,Jundie Hu,Jiafu Qu,Dan Tian,Jianzhang Li,Qiliang Fu
Designing highly porous materials is of great importance for liquid separation, water purification, and disinfection, such as spill oil cleaning and recycling, seawater desalting, and oil/water separation. However, a remaining challenge is to produce porous materials with the characteristics of fast absorption, continuous directional transport, and self-release of viscous liquid. Herein, a functional cellulosic composite is reported by the chemical treatment and functionalization of wood resulting in a smart wood that can thermally self-release and separate high viscosity oil. The smart wood has a high absorption speed of 1398 mL/(m 2 ·s) (ethylene glycol) and a maximum absorption capacity of 47.2 g/g (chloroform) due to its intrinsic vertical micro/nanoscale channel structure, low tortuosity, and high porosity. Moreover, the switchable wettability is achieved by the surface coating of poly(N-isopropylacrylamide) on the porous wood, which enables the collection and removal of oil from the oil/water mixture. The high viscosity oil can be automatically released due to the passive oil release at room temperature. The release capacity of the smart wood remains above 91% after 15 cyclic tests. We envision that this functional smart wood could be extended to a wide range of applications in smart hydrogels, microfluidics, artificial drug release, and environmental restoration.
危险品化学品经营许可证（带存储）