JOURNAL OF APPLIED POLYMER SCIENCE
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2023
·Vol. 140
·期 40
·1-12
·
IF 3
Yongxu Li,Fang Guo,Hairui Wang,Yongyin Cui,Cancai Wang,Qingfu Wang,Lan Cao
Tooth extraction will leave a wound that may cause blood leakage, and the application of liquid-absorbing hemostatic cotton pressed on the wound can play the effect of pressure to halt bleeding. Unfortunately, the loose structure of the dental absorbent hemostatic cotton causes local slag to fall. Cotton fiber will impede wound heading and possibly drop into the throat and esophagus, thus impacting the life and health of the patient. Therefore, it is of great significance to prepare a material with toughness and high liquid absorption. The polyurethane foams (PUFs) with different chain extension coefficients synthesized from polyether polyol and diphenylmethane diisocyanate (MDI) with water as the blowing agent have excellent toughness and liquid-absorbing properties with potential applications. The hydrophilic polyethylene glycol (PEG) is introduced into the polyurethane chain segment to form a synergistic effect with the three-dimensional foam network structure to absorb more wound exudate. The hydrophobic PUFs can be applied to wounds with less exudate and the hydrophilic PUFs can be applied to chronic wounds with more exudate. The porous structure gives the PUF a strong loading capacity and promotes the wound-healing effect. The PUFs exhibit good liquid absorption/retention performance in both 0.9 wt% NaCl solution and DI water, especially PUF-1.10 has an ultimate DI water absorbency of nearly 840%. According to the performance, comparison of the current market commonly used dental absorbent hemostatic cotton; PUF-1.10 is considered a promising candidate for replacing traditional dental commercial absorbent hemostatic slag-fall cotton in liquid absorption/retention and mechanical properties.
研究领域:
材料科学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
Cell Host & Microbe
·
2021
·
IF 21.023
Zhengwei Zhong,Ting Zhong,Yeqing Peng,Xiaofeng Zhou,Zhiqian Wang,Huiru Tang,Jingwen Wang
Summary Ticks are obligate hematophagous arthropods. Blood feeding ensures that ticks obtain nutrients essential for their survival, development, and reproduction while providing routes for pathogen transmission. However, the effectors that determine tick feeding activities remain poorly understood. Here, we demonstrate that reduced abundance of the symbiont Coxiella (CHI) in Haemaphysalis longicornis decreases blood intake. Providing tetracycline-treated ticks with the CHI-derived tryptophan precursor chorismate, tryptophan, or 5-hydroxytryptamine (5-HT; serotonin) restores the feeding defect. Mechanistically, CHI-derived chorismate increases tick 5-HT biosynthesis by stimulating the expression of aromatic amino acid decarboxylase (AAAD), which catalyzes the decarboxylation of 5-hydroxytryptophan (5-HTP) to 5-HT. The increased level of 5-HT in the synganglion and midgut promotes tick feeding. Inhibition of CHI chorismate biosynthesis by treating the colonized tick with the herbicide glyphosate suppresses blood-feeding behavior. Taken together, our results demonstrate an important function of the endosymbiont Coxiella in the regulation of tick 5-HT biosynthesis and feeding.
研究领域:
寄生虫学
·
分子生物学
·
传染病学
✓ 已验证
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Fuyu Song,Yue Kong,Changyou Shao,Yi Cheng,Jie Lu,Yehan Tao,Jian Du,Haisong Wang
Realizing the potential application of chitosan as an effective biomedical hemostatic agent has become an emerging research hotspot. However, fabricating a flexible chitosan-based hemostatic bio-hydrogel with self-adhesion feature in humid conditions and rapid hemostasis capability remains a challenge. Herein, we reported the development of chitosan-based hydrogels (DCS-PEGSH gels) with typical multilevel pore structures , which were cross-linked by 3-(3,4-dihydroxyphenyl) propionic acid-modified chitosan (DCS) and sebacic acid-terminated polyethylene glycol modified by p-hydroxybenzaldehyde (PEGSH). By precisely regulating the proportion of PEGSH, the fabricated bio-hydrogels displayed favorable cytocompatibility, suitable stretchability (∼780%), and blood absorbability (1300% ± 50%). Moreover, the strong adhesion (∼68.5 kPa) of the assembled bio-hydrogel ensured its firm adherence on pigskin and on bleeding wound in both static and dynamic humid environments without shedding, thus providing a long service life. The fabricated hydrogels exhibited shorter blood clotting time (50 s) and lower blood clotting index (BCI, 41) than the commercial chitosan sponge (288 s, BCI 65). Notably, the amount of blood loss from the liver in mice was reduced by almost 90% as compared to that for the control group. This study paves a solid way for developing a chitosan-based hydrogel with self-adhesive, self-healing, stretchability, biocompatibility, and antibacterial and antioxidant properties through molecular design and structural regulation, which will enable the biomedical application of chitosan in emergency hemostasis, particularly in joints and extremities. Statement of significance The design and preparation of multifunctional integrated green adhesive bio-hydrogels while avoiding the use of organic solvents and toxic chemical reagents has been an emerging challenge. Herein, a flexible chitosan-based hemostatic bio-hydrogel that integrates multifunctional properties was successfully synthesized. The bio-hydrogel displayed suitable stretchability (780%) and blood absorbability (1300% ± 50%). Moreover, the strong adhesion (68.5 kPa) ensured firm adherence of the assembled hydrogel on pigskin and on the bleeding wound site in both static and dynamic humid environments without shedding, thus providing a long service life. In addition, the designed hydrogel showed good compatibility and antibacterial performance. The dynamic Schiff base endowed the bio-hydrogel with excellent self-healing performance without any external stimuli.
研究领域:
生物医学工程
·
材料科学
·
组织工程
·
止血
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2023
·Vol. 10
·期 16
·2207347
·
IF 15.1
Ganghua Yang,Zhenzhen Huang,Alec McCarthy,Yueyue Huang,Jingye Pan,Shixuan Chen,Wenbing Wan
Uncontrolled hemorrhage is still the most common cause of potentially preventable death after trauma in prehospital settings. However, there rarely are hemostatic materials that can achieve safely and efficiently rapid hemostasis simultaneously. Here, new carbonized cellulose-based aerogel hemostatic material is developed for the management of noncompressible torso hemorrhage, the most intractable issue of uncontrolled hemorrhage. The carbonized cellulose aerogel is derived from the Agaricus bisporus after a series of processing, including cutting, carbonization, purification, and freeze-drying. In vitro, the carbonized cellulose aerogels with porous structure show improved hydrophilicity, good blood absorption, and coagulation ability, rapid shape recoverable ability under wet conditions. And in vivo, the carbonized aerogels show effective hemostatic ability in both small and big animal serious hemorrhage models. The amount of blood loss and the hemostatic time of carbonized aerogels are all better than the positive control group. Moreover, the mechanism studies reveal that the good hemostatic ability of the carbonized cellulose aerogel is associated with high hemoglobin binding efficiency, red blood cell absorption, and platelets absorption and activation. Together, the carbonized aerogel developed in this study could be promising for the management of uncontrolled hemorrhage.
研究领域:
材料科学
·
生物材料
·
止血学
·
创伤医学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）