MICROCHEMICAL JOURNAL
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2026
·
IF 5.2
Yu Gan,Wenwen Lai,Mengbo Fan,Zhengchao Duan,Lianzhi Wang
A novel core–shell structured NH 2 -MIL-88(Fe)@TFPT-Tt-COF composite was successfully constructed via an in situ growth strategy, enabling intimate interfacial bonding and synergistic effects between the MOF core and the COF shell. • The composite exhibits dramatically enhanced fluorescence compared to the individual MOF or COF, and acts as a “turn-off” sensor for nitrofurantoin (NFT) with an ultralow detection limit of 0.18 μg·mL −1 based on the inner filter effect. • The sensing platform features rapid response (equilibrium within 1 min), excellent selectivity against common metal ions and antibiotics, and good applicability in real samples with recoveries of 84.3%–107.6% in soil and lake water. • Offers a new strategy for applying MOF@COF heterostructures to the on-site, rapid, and sensitive detection of trace antibiotic residues in complex environmental matrices. A core-shell structured NH 2 -MIL-88(Fe)@TFPT-Tt-COF composite was successfully constructed via an in situ growth strategy, using NH 2 -MIL-88(Fe) as the core and TFPT-Tt-COF as the shell. The structure, morphology, and thermal stability of the composite were systematically characterized by Fourier transform infrared spectroscopy, powder X-ray diffraction, scanning/transmission electron microscopy, thermogravimetric analysis, and nitrogen adsorption–desorption measurements. The results confirmed the intimate interfacial bonding between the MOF core and the COF shell. Compared with the individual components, the composite displayed significantly enhanced fluorescence intensity. A fluorescent sensing platform based on this composite was developed, which enabled highly sensitive and selective detection of nitrofurantoin (NFT). Preliminary mechanistic studies revealed that the quenching effect mainly originated from a photoinduced electron transfer (PET) mechanism. The proposed method was applied to the spike recovery analysis of NFT in real samples such as soil and lake water, yielding recoveries ranging from 84.3% to 107.6%, with a limit of detection as low as 0.18 μg·mL −1 , demonstrating that the sensor possesses satisfactory accuracy and practicality in complex environmental matrices. This work provides a new strategy for the application of MOF/COF composites in the rapid detection of antibiotic residues in the environment. Download: Download high-res image (167KB) Download: Download full-size image
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Xinmei Qian,Chunxiang Li,Mingyu Zheng,Keqin Deng
A flower-like S, N-codoped carbon nanosheets loaded with hybrid magnetic nanoparticles (HMNPs/S,N-CNSs) by using MOF as precursor was prepared. The morphology, composition, microstructure, and property were evaluated by SEM, HRTEM, EDS, XRD, XPS, magnetic analysis, and cyclic voltammetry. The hybrid nanoparticles were composed of most Fe 3 O 4 , some CoFe alloy, and a few Fe 2 S. The magnetic material showed high magnetism and brilliant electrocatalysis towards the electrochemical reduction of antibiotic nitrofurazone (NFZ). By utilizing screen-printed electrode (SPE) and HMNPs/S,N-CNSs, a disposable electrochemical NFZ sensor (HMNPs/S,N-CNSs/SPE) was fabricated by magnetic control. The current signal of NFZ at HMNPs/S,N-CNSs was 6.38 times higher than that of bare SPE. It displayed a wide detection range of 0.01–50 μM with a detection limit of 4.2 nM (S/N = 3). The practical applicability of the sensor in real samples presented satisfactory results. The disposability, low cost, high sensitivity, low consumption volume in analyses, and good selectivity make the proposed sensor a promising tool for NFZ detection.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 2
·81
·
IF 5.3
Zhang Haili,Peng Man,Lu Anjiang,Peng Xishun,Wang Cunwei,Zu Caizhen,Bai Zhongchen
A surface-enhanced Raman scattering (SERS) sensor of Au/Ag nanoparticles (NPs) grown on ZnO/polypyrrole@Poly(3,4-ethylene dioxythiophene)-poly(styrene sulfonate) (PPy@PEDOT:PSS) film for detecting norfloxacin (NFX) residues in milk is presented. The ZnO/PPy@PEDOT:PSS film was prepared by the electrochemical deposition method. Subsequently, Ag NPs and Au NPs were deposited on the surface of ZnO/PPy@PEDOT:PSS film to form a Au/Ag/ZnO/PPy@PEDOT:PSS film by an electrochemical deposition process and the magnetron sputtering process, respectively. Owing to the charge transfer between the SERS substrate and the NFX molecules, this SERS sensor could effectively identify low-concentration NFX molecules with a limit of detection (LOD) of 0.84 nM. Moreover, it could also recognize NFX residues in milk with recoveries of 91.2% to 108.4%. The SERS sensor of Au/Ag/ZnO/PPy@PEDOT:PSS film had a high sensitivity, excellent long-term stability, and significant potential in food safety monitoring applications. Graphical abstract
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2026
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IF 4.8
Xiaojing Mao,Huachang Li,Jiemin Liu,Jijun Liu,Pengcheng Han,Haijiao Xie
Fe 3+ and nitrofurazone (NFZ) can raise a risk for environment and human health due to accumulation in water. Hence, a post-synthetic modification strategy was employed to develop a visualization sensor for detecting Fe 3+ and NFZ. In this study, we selected a Zinc-based metal organic framework in combination with fluorescein to develop a fluorescent dyes-encapsulated sensor (Flu@Zn-MOF). The sensing experimental indicated that the Flu@Zn-MOF demonstrated excellent recognition performance for Fe 3+ and NFZ. The detection limits (LODs) of Fe 3+ and NFZ are 1.27 and 0.89 μM, respectively. Furthermore, the color of Flu@Zn-MOF turn from yellow-green to blue in the presence of NFZ. The proposed sensor can accurately identify Fe 3+ and three nitrofuran analogs (NFZ, NFT and FTD) by principal component analysis (PCA). In addition, satisfactory recovery rates and low standard deviation for detection of Fe 3+ and NFZ in real water samples confirms the practicability of Flu@Zn-MOF. Then, a sensing system was created that leverages smartphone technology for the quantitative and real-time monitoring of NFZ. Therefore, this work presents a new strategy for designing a novel sensing method for on-site recognition of nitrofurans pollutants in water.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Mingyan Li,Taotao Zhe,Ruixia Li,Feier Bai,Pei Jia,Zhihao Xu,Xin Wang,Tong Bu,Haiyu Wu,Li Wang
Designing efficient and sensitive methods for the detection of nitrofurantoin (NFT) residues is of great importance for food safety and environmental protection. Herein, a composite with cobalt nanoparticles encapsulated in nitrogen-doped carbon nanotube (N/ [email protected] @CC-II) was synthesized by in-situ growth and sublimation-gas phase transformation strategy and used to establish an ultrasensitive electrochemical sensor for NFT determination. The N/ [email protected] @CC-II sensor exhibits uniform N doping, fine hollow structure, and abundant active metal sites, which lays a solid foundation for the ultra-sensitive detection of NFT. Benefiting from these advantages, the N/ [email protected] @CC-II exhibits excellent sensitivity (8.19 μA μM −1 cm −2 ) and low detection limit (18.41 nM) for NFT detection. The practical feasibility of N/ [email protected] @CC-II was also demonstrated by the determination of NFT in milk and tap water samples. This study may open up new opportunities for the application of N -doped carbon nanotube materials encapsulating transition metals.
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ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Xu Wen,Xueling Yan,Xiaoling Zheng,Qiming Kou,Lulan Yang,Jiaming Tang,Xingyue Chen,Yong Xie,Tao Le
Nitrofurazone (NFZ) is an antibiotic banned in many countries, as its residue seriously harms the human body. Herein, anti-NFZ aptamers were selected and identified based on the magnetic bead SELEX technique using a ssDNA library with a full length of 90 nucleotides (nt). Five full sequence candidate aptamers (NFZ8, NFZ24, NFZ28, NFZ34, and NFZ70) were obtained by secondary structure analysis. We optimized the entire sequence to obtain a truncated aptamer, a 16 nt sequence (NFZ8-1:5′-GTTCTATTGAAAAAAC-3′) that showed the highest affinity for NFZ (K d = 76.11 nM). The binding site of NFZ and aptamer NFZ8-1 was found to be "GAA" by molecular docking . In addition, utilizing the most special truncated aptamer NFZ8-1 as the identification probe, a graphene oxide fluorescent aptasensor is an innovative for the detection of NFZ residue that showed a wide linear reach from 1.25 to 160 ng/mL and a low limit of detection of 1.13 ng/mL. In the actual water environment sample detection, the recovery rate ranged from 95.21 to 113.66%, and the coefficient of variation ranged from 3.53 to 11.24%. These results demonstrate that the NFZ-truncated aptamer applied to the aptasensor provides a novel methodology for recognizing NFZ residues.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Yan Wu,Yue Zhou,Hongchen Long,Xiangyu Chen,Yuanyuan Jiang,Lei Zhang,Tao Le
The study investigates a bimetallic organic framework (Zn/Eu-MOF) based fluorescent probe for visual detection of ofloxacin (OFL) in pork, beef and fish. The developed sensing probe recognizes OFL through internal filtration and cation-π interaction between OFL and Zn/Eu-MOF, resulting in a distinct color change from orange-red to light green. The content of OFL can be determined through RGB analysis by a mobile-phone. The developed sensing probe offers several advantages such as broad linear range (0.1 ∼ 80 μM), rapid response time (30 s), low detection line (0.44 μM). The effectiveness of the sensing probe can last for five rounds with good recovery. Moreover, the application of the sensing probe on pork, beef and fish samples are reliable, with recoveries ranging from 93.4 to 112.1%, and the relative standard deviations (RSD) within 1.17% to 2.06%. These results suggest that the developed sensing probe could have significant potential for practical on-site test in food.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
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IF 4.831
Yuanjie Teng,Zhenni Wang,Shaohua Zuo,Xin Li,Yinxin Chen
Universal and fast antibiotic residues detection technology is imperative for the control of food safety in aquatic products. However, accurate surface-enhanced Raman scattering (SERS) quantitative detection of complicated samples is still a challenge. A recognition method powered by deep learning and took advantage of the unique fingerprint information merits of SERS was proposed. Herein, the spectra were collected by Ag nanofilm SERS substrate prepared by self-assembly of Ag nanoparticles on water/oil interface. A SERS-based database of commonly used antibiotics in aquatic products was set up, which is suitable for employed as input data for learning and training. The results show that the five types of antibiotics are successfully distinguished through principal component analysis (PCA) and each antibiotic in every type was successfully distinguished. Furthermore, one-dimensional convolutional neural networks (1-D CNN) was used to distinguish the antibiotics, and the results show that all the test samples were correctly predicted by 1-D CNN model. The results of this research suggest the great potential of the combination of SERS spectra with deep learning as a method for rapid and highly accurate identification of antibiotic residues in aquatic products.
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JOURNAL OF FOOD SCIENCE
·
2022
·Vol. 87
·期 7
·3318-3328
·
IF 3.693
Shuai Yan,Yongyu Li,Yankun Peng,Shaojin Ma,Donghai Han
Residues of veterinary antibiotics in honey may be damaging to human health. Surface-enhanced Raman scattering spectroscopy (SERS) is an emerging technology widely applied in food safety. SERS has advantages of enabling fingerprint identification and fast detection, as well as does not require complex pretreatment. Considering the overuse of nitrofurans in honeybee breeding, SERS combined with spectral preprocessing was used to detect nitrofurantoin in honey. By using standardized experimental procedures and improved spectral correction methods, the lowest detection limit of nitrofurantoin was 0.1321 mg/kg. A good linear relationship in the partial least squares regression model was found among spiked samples, which allowed prediction of nitrofurantoin content in honey sample ( R C 2 $R_C^2$ = 0.9744; R P 2 $R_P^2$ = 0.976; RMSECV = 1.0353 mg/kg; RMSEP = 0.9987 mg/kg). Collectively, these results reliably demonstrated that quantification is more accurate when spectral preprocessing is better controlled. Therefore, this study indicates that SERS could be further implemented in fast and onsite detection of nitrofurantoin in honey for improved food safety. Practical Application This article presents a novel SERS-based method for the rapid detection of nitrofurantoin residues in honey. The original spectra were corrected by multiple linear regression based on the fitting baseline. This study aims to develop a rapid onsite detection method for toxic hazardous substance residues in food.
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MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Liyin Bu,Xiaohui Chen,Qingyuan Song,Ding Jiang,Xueling Shan,Wenchang Wang,Zhidong Chen
In this study, a supersensitive electrochemical impedance spectroscopy (EIS) analysis method combined the molecularly imprinted polypyrrole (MIP) which electropolymerized on the composites of zirconium-based metal organic framework (Uio-66) and carbon dots (CDs) modified glassy carbon electrode (GCE) was developed for chloramphenicol (CAP) determination. The integration of Uio-66 and CDs effectively promoted the sensitivity of the proposed MIP senor by improving the surface area and the charge transfer of electrode. By extraction of CAP template, the specific sites were formed on the MIP surface which can rewrap the CAP target molecules. The CAP determination was based on the charge transfer difference (△Rct) before and after the MIP/ [email protected] /GCE rebinding the CAP. The results showed that △Rct responded good linearity to the logarithm of CAP concetration in the range of 0.1 – 100 pmol/L, with a low detection limit of 0.061 pmol/L (S/N = 3), exhibiting high sensitivity and specificity for the determination of CAP.
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LUMINESCENCE
·
2023
·Vol. 38
·期 6
·796-802
·
IF 2.9
Yuyu Guo,Yiqing Chu,Xiaojuan Sun,Songhao Cao,Xin Li,Xinyue Li
In view of the significance of nitrofurantoin, there is an urgent need for efficient analytical methods for accurate detection of nitrofurantoin. Considering their superior fluorescence performance and rarity of reports regarding nitrofurantoin detection by fluorescent silver nanoclusters (Ag NCs), Ag NCs with good stability and uniform size were synthesized through a simple method by protection of histidine (His) and reduction of ascorbic acid (AA). Based on the quenching by nitrofurantoin, Ag NCs were applied successfully in the detection of nitrofurantoin with high sensitivity. In the range of 0.5–150 μM, a linear relationship was found between ln( F 0 / F ) and nitrofurantoin amounts. Static quenching and inner filter effect were proved to be the main quenching mechanisms. Significantly superior selectivity and satisfactory recovery results in bovine serum indicate that Ag NCs provide a better choice for nitrofurantoin detection.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Bao Siqi,Yu Xiaotong,Li Xiaolin
Antibiotic contamination has a significant negative impact on China, one of the largest producers and consumers of antibiotics worldwide. In this study, a three-dimensional flower-like structure of CoFe-LDHs was used to efficiently degrade tetracycline (TC) in a system triggered by peroxymonosulfate (PMS) and exposed to visible light. After exploring the effects of different metal ratios, catalyst dosage, initial TC concentrations, and pH, the optimal reaction conditions were determined. In comparison to pure CoFe-LDHs, the TC elimination rate was dramatically increased by the addition of the PMS. The strong environmental resistance, excellent stability and reusability, and universal flexibility were shown. The quenching experiments and electron spin resonance detection showed that the creation of reactive oxygen species was facilitated by the synergistic transmission of electrons between the active bimetallic components. Further, photogenerated holes was the dominant oxidizing species, which contributed more to the degradation of TC. The potential degradation pathways and intermediate toxicity of TC were suggested. This work offers a new method dominated by photogenerated holes for efficiently removing TC effluent.
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