ADVANCED FUNCTIONAL MATERIALS
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2021
·Vol. 31
·期 34
·2103559
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IF 18.808
Xiao Peng,Kai Dong,Chuan Ning,Renwei Cheng,Jia Yi,Yihan Zhang,Feifan Sheng,Zhiyi Wu,Zhong Lin Wang
Human respiration is an indispensable physiological behavior of the body, which is an important indicator to evaluate health status, especially for sleep-related diseases. A real-time respiratory monitoring and sleep breathing detecting system with convenience, high sensitivity, simple fabrication, and wearing comfort still remains a challenge and urgently desirable. Here, a breathable, highly sensitive, and self-powered electronic skin (e-skin) based on a triboelectric nanogenerator (TENG) is reported for real-time respiratory monitoring and obstructive sleep apnea-hypopnea syndrome (OSAHS) diagnosis. By using multilayer polyacrylonitrile and “polyamide 66” nanofibers as the contact pairs, and deposited gold as the electrodes, a contact-separation type of TENG-based all-nanofiber e-skin is developed. The e-skin has a peak power density of 330 mW m −2 , high pressure sensitivity of 0.217 kPa −1 , excellent working stability, and good air permeability. Therefore, the e-skin is simultaneously capable of energy autonomy and accurate real-time subtle respiration monitoring. Meanwhile, a self-powered diagnostic system for real-time detection and severity evaluation of obstructive sleep apnea-hypopnea syndrome are further developed to prevent the occurrence of OSAHS, delay its development, and improve sleep quality. This study hopes to pave a new and practical pathway for real-time respiration monitoring and sleep breathing diseases clinical detection.
研究领域:
生物医学工程
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材料科学
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医学诊断
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2023
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IF 12.6
Jize Liu,Wei Zhao,Jiakai Li,Chaofan Li,Shuting Xu,Yang Sun,Zhichao Ma,Hongwei Zhao,Luquan Ren
The accurate monitoring of respiratory events and human motion states holds paramount importance in the realm of health surveillance and disease prognostication. An exquisitely precise, multifaceted, portable, and environmentally resilient sensor designed for health monitoring would undeniably be of utmost desirability , despite its persisting as a formidable challenge. Here, we propose a breath monitoring and posture recognition system that utilizes hydrogel electrolytes based on polyvinyl alcohol, sodium alginate , and starch , suitable for supercapacitors and multimodal wearable sensors . The multimodal smart sensors can independently detect mechanical and thermal changes through the output signals of capacitance and resistance, respectively. Moreover, we have cultivated an artificial neural network to achieve a finger-pressing posture recognition accuracy of up to 99.259%. Our hydrogel sensors have also been successfully employed in the diagnosis of obstructive sleep apnea syndrome. The flexible electronic device derived from this study exhibit a plethora of functionalities, thereby affording a novel perspective for the design and fabrication of advanced flexible electronic contrivances that find applications across diverse domains such as medicine and virtual reality.
研究领域:
生物医学工程
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材料科学
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健康监测技术
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DOI
PubMed
高影响因子
Nano-Micro Letters
·
2022
·Vol. 14
·期 1
·1-19
·
IF 23.655
Liang Yuning,Ding Qiongling,Wang Hao,Wu Zixuan,Li Jianye,Li Zhenyi,Tao Kai,Gui Xuchun,Wu Jin
A general strategy of fabricating thickness-controllable hydrogel films with diverse polymer networks for humidity sensing is proposed. The hydrogel film humidity sensor displays an unprecedented sensitivity up to 13,462.1%/%RH.
The stretchable humidity sensor can work normally under large tensile strains with even enhanced sensitivity, which makes the humidity responding property of hydrogel mechanically programmable.
A wireless respiratory interruption detection mask with Bluetooth transmission function is developed based on the sensor, enabling the real-time, wireless and accurate acquisition of user's breathing state, such as the interval and breathing frequency and apnea.
研究领域:
材料科学
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生物医学工程
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传感器与执行器
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无线通信
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Shuhang Deng,Xiaoran Ming,Guilong Yan,Li Wang,Zhenyu Li,Jingyu Chen,Jingjuan Lai,Dong Li,Dong Xiang,Chunxia Zhao,Hui Li,Xuezhong Zhang,Han Li,Xungai Wang,Yu Xiao,Yuanpeng Wu
Severe disruptions in the respiratory system can lead to a range of health issues. Real-time monitoring of respiration is crucial for preventing and treating associated diseases. Herein, a simple and portable respiratory monitoring device was developed by simply integrating the conductive hydrogel on the medical mask. The core conductive hydrogel was successfully synthesized by interpenetrating carboxymethyl cellulose into a HA network through a ‘one-pot’ thermal-initiated polymerization process. This hydrogel exhibits superior comprehensive performance, including high tensile strain (1100 %), high gauge factor (2.45), a wide strain detection range (0.1–1000 %), and strong adhesion (40 kPa). When subjected to external force, the structure of the hydrogel changes, resulting in alterations to its internal conductive pathways, which subsequently affect the resistance. The integrated device shows high sensitivity, moisture resistance and cycle stability for monitoring significant human physical movements. Especially, he integrated device can effectively recognize the breathing behaviors associated with obstructive sleep apnea diseases including cough, apnea, and snoring, as well as achieving hour-level continuous service more than 1000 cycles. These exceptional characteristics indicate that these novel hydrogels hold great potential in applications such as smart wearable electronics, intelligent respiratory monitoring and diagnosis.
研究领域:
生物医学工程
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材料科学
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健康监测
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2024
·Vol. 35
·期 10
·1-13
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IF 2.8
Ge Rui,Shi Bin,Liu Xiaobo,Yin Bing
With the development of the internet of things technology, sensors have played an important role in aerospace, industry, agriculture, medical and other fields. Especially in the aspect of wearable respiratory monitoring, real-time monitoring of multiple respiratory physiological parameters through intelligent sensors enable people to achieve early prevention and timely diagnosis of respiratory diseases. However, most of the humidity sensors have the disadvantages of poor permeability, long response time and narrow detection range. Therefore, this paper introduced a flexible humidity sensor with a wide detection range and fast response time for respiratory monitoring. The sensor used PEDOT:PSS-GO composite material as humidity sensitive material. Due to the addition of GO, the sensor had a wide linear detection range of humidity (35–80%RH) and a short response/recovery time (0.53/0.8 s). Moreover, the sensor used the micromesh structure of PI as the substrate, which had better flexibility and permeability and the sensor was easy to attach to complex surfaces such as masks or human skin. Based on these excellent sensing characteristics, the humidity sensor was connected with a miniature wireless communication component for human respiratory detection. The humidity sensor can clearly show the difference between normal and abnormal respiratory signals and this provided a new idea for the intelligent healthcare technology.
研究领域:
传感器
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可穿戴技术
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医疗保健
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材料科学
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物联网
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
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2025
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IF 5.4
Xiaoyou Wang,Zhenzhen Zhang,Tao Wu,Lei Wang,Jungang Jiang,Yifan Zhang
Real-time monitoring of respiration plays a crucial role in assessing human health. However, traditional respiratory monitoring devices face several challenges, such as safety concerns, poor mechanical properties, and low portability, which limiting their use in everyday portable applications. In this study, a dual-protein network hydrogel, composed of bovine serum albumin (BSA) and silk fibroin (SF), was developed using thiol–ene click chemistry and enzymatic cross-linking. This hydrogel demonstrates excellent mechanical reversibility, frost resistance (−20 °C), and electrical conductivity. The hydrophilic amino acids and hydrogen bonding within the hydrogel network contribute to its high stability and broad humidity monitoring range (11%–85%), making it ideal for use in flexible humidity sensors. By integrating wireless transmission technology, a stable and fast signal transmission is achieved, enabling real-time monitoring of respiratory conditions. The present work offers new insights into the development of natural protein-based materials for advanced smart health detection systems.
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DOI
PubMed
高影响因子
Advanced Sensor Research
·
2023
·
IF 0
Tianqing Liu,Danyao Qu,Lihao Guo,Gandong Zhou,Guangjian Zhang,Tao Du,Weiwei Wu
Human respiration reflects abundant physiological information and could enable non-invasive monitoring, providing information about various biological parameters such as respiration rate and depth. The rapidly growing field of humidity sensors bring forward the requirement for good performance. In this work, by virtue of good hydrophilicity and conductivity, a MXene/thermoplastic polyurethane (TPU) composite film is prepared by coating MXene nanosheets on chitosan-modified TPU electrospun nanofibers via electrostatic interactions, for fabricating a humidity sensor. Based on the principle that the tunnel resistance changing with water molecules influences the distance of MXene nanosheets, the MXene/TPU humidity sensor exhibits fast response (12 s), wide humidity response range (11–94% RH), low hysteresis (<7% RH), and excellent repeatability. The humidity sensor can be assembled with a face mask for distinguishing different human respiration patterns and accurately monitoring respiratory signals during different physical activities, suggesting its promising applications in the fields of respiratory monitoring.
研究领域:
材料科学
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生物医学工程
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DOI
JOURNAL OF CHEMICAL PHYSICS
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2024
·Vol. 160
·期 17
·
IF 3.1
Liu Yaqi,Liu Zhuo,Chen Yijing,He Jing,Niu Yuqing,He Yuwei,Wang Yanjie,Ju Yun,Jiang Jie,Zhang Hong,Qiao Lina
Fatty acids from cooking fumes and hypochlorous acid (HOCl) released from indoor cleaning adversely affect respiratory health, but the molecular-level mechanism remains unclear. Here, the effect of cooking oil fumes [palmitic acid (PA), oleic acid (OA), and linoleic acid (LA)] on lung model phospholipid (POPG) hydrochlorination mediated by HOCl at the air–water interface of the hanged droplets was investigated. Interfacial hydrochlorination of POPG was impeded by OA and LA, while that of POPG was facilitated by PA. The effect on POPG hydrochlorination increased with the decrease in oil fume concentration. A potential mechanism with respect to the chain length of these oil fumes, regardless of their saturation, was proposed. PA with a short carbon chain looses the POPG packing and leads to the exposure of the C=C double bonds of POPG, whereas OA and LA with a long carbon chain hinder HOCl from reaching the C=C bonds of POPG. These results for short chain and low concentration dependence suggest that the decay of oil fumes or the conversion of short-chain species by indoor interfacial chemistry might be adverse to lung health. These results provide insights into the relationship between indoor multicomponent pollutants and the respiratory system.
研究领域:
生物学
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医学
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环境科学
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DOI
PubMed
高影响因子
LUNG CANCER
·
2021
·
IF 5.705
Yingchang Zou,Yu Wang,Zaile Jiang,Yuan Zhou,Ying Chen,Yanjie Hu,Guobao Jiang,Duan Xie
Objectives Lung cancer is continuously the leading cause of cancer related death, resulting from the lack of specific symptoms at early stage. A large-scale screening method may be the key point to find asymptomatic patients, leading to the reduction of mortality. Methods An alternative method combining breath test and a machine learning algorithm is proposed. 236 breath samples were analyzed by TD-GCMS. Breath profile of each sample is composed of 308 features extracted from chromatogram. Gradient boost decision trees algorithm was employed to recognize lung cancer patients. Bootstrap is performed to simulate real diagnostic practice, with which we evaluated the confidence of our methods. Results An accuracy of 85 % is shown in 6-fold cross validations. In statistical bootstrap, 72 % samples are marked as “confident”, and the accuracy of confident samples is 93 % throughout the cross validations. Conclusion We have proposed such a non-invasive, accurate and confident method that might contribute to large-scale screening of lung cancer. As a consequence, more asymptomatic patients with early lung cancer may be detected.
研究领域:
医学
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肿瘤学
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生物信息学
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DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2024
·
IF 5.3
Zhiwen Shi,Lijuan Qiao,Zhi Jia,Peng Zhang,Bingxin Liu,Li Gao
It is of great significance to detect methanol in human exhaled breath since it may cause neurological disorders. In this study, N-doped Ti 3 C 2 T x MXene was synthesized by annealing and nitrogen doping in clay-like Ti 3 C 2 T x MXene. Then, TiO 2 nanospheres was generated in situ on the surface of N-doped Ti 3 C 2 T x MXene to provide adsorption and reaction sites for methanol. Based on the synergistic effects of electronic properties and gas adsorption, the N-Ti 3 C 2 T x MXene/TiO 2 exhibits high responsiveness and excellent selectivity to methanol at room temperature. Moreover, the detection limit is 0.1194 ppm. In addition, the adsorption and oxidation process of methanol on the N-Ti 3 C 2 T x MXene/TiO 2 was explored by in situ infrared spectra testing to reveal that the oxygen vacancy on the surface of N-Ti 3 C 2 T x MXene/TiO 2 plays an important role in the selective detection of methanol. This experiment provides a feasible solution for the detection of methanol gas in exhaled breath at room temperature.
研究领域:
材料科学
·
医学诊断
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产品关联
DOI
高影响因子
Cell Reports Medicine
·
2025
·
IF 10.6
Zhi Yang,Yizheng Yao,Xi Chen,Victoria Madigan,Shanrui Pu,Xianqun Fan,Jun Pu,Fengfeng Bei
Efficient gene delivery vectors are crucial for respiratory and lung disease therapies. We report that AAV.CPP.16, an engineered adeno-associated virus (AAV) variant derived from AAV9, efficiently transduces airway and lung cells in mice and non-human primates via intranasal administration. AAV.CPP.16 outperforms AAV6 and AAV9, two wild-type AAVs with demonstrated tropism for respiratory tissues, and efficiently targets key respiratory cell types. It supports gene supplementation and editing therapies in two clinically relevant mouse models of respiratory and lung diseases. A single intranasal dose of AAV.CPP.16 expressing a dual-target, vascular endothelial growth factor (VEGF)/transforming growth factor (TGF)-β1-neutralizing protein protected lungs from idiopathic pulmonary fibrosis, while a similar application of AAV.CPP.16 carrying an “all-in-one” CRISPR-Cas13d system inhibited transcription of the SARS-CoV-2-derived RNA-dependent RNA polymerase (Rdrp) gene. Our findings highlight AAV.CPP.16 as a promising vector for respiratory and lung gene therapy.
研究领域:
医学
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基因治疗
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病毒学
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DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 7
·1815-1829
·
IF 6.183
Ji Tan,Zixiao Liu,Donghui Wang,Xianming Zhang,Shi Qian,Xuanyong Liu
Multifarious strategies have been proposed to enhance the antibacterial ability of implant surfaces for preventing bacterial infection, however, developing facile and universal modification methods still remains extremely elusive. Herein, inspired by the fact that the electron transfer respiratory chain of bacteria is embedded in the membrane, we proposed a novel strategy of local alkalinity disturbing bacterial respiration to endow implant materials with antibacterial ability. As a demonstration, MgO was deposited on biomedical titanium via magnetron sputtering to regulate surface alkalinity. With the thickness of MgO films increasing, they exhibited an excellent antibacterial rate against both Gram-negative and positive bacteria. The antibacterial mechanism confirmed that the alkaline surface can disturb the bacterial respiration action via weakening the transmembrane proton concentration gradient, resulting in the blockage of energy metabolism and the increase of oxidative stress of bacteria. Cell experiments indicated that MgO films not only have no obvious cytotoxicity to osteoblast cells, but can also selectively kill bacteria and promote cell proliferation in the presence of both bacteria and cells. More importantly, the by-product of MgO was only the biocompatible Mg2+, reducing any concerns about potential toxic effects. Furthermore, sputtering alkaline MgO films was confirmed to work well on polyetheretherketone polymer and zirconia ceramic implants, which indicates that this strategy has broad prospects of clinical application for preventing implant-associated bacterial infection.
研究领域:
生物医学工程
·
微生物学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）