REACTIVE & FUNCTIONAL POLYMERS
·
2022
·
IF 4.966
Ruyue Wang,Xingxing Chen,Yuxuan Yang,Yongliang Xu,Qiang Zhang,Yanfeng Zhang,Yilong Cheng
Hydrogels with outstanding mechanical characteristics , remoldability, and self-healability possess vast potentials in biomedical applications and flexible sensors. However, it is still difficult to prepare hydrogels with integrated mechanical characteristics straightforwardly. Herein, we proposed to introduce a hydrogen bonding reinforced factor, imidazolidinyl urea (IU), to the polymerization of acrylamide for the construction of multi-functional hydrogels in one pot. There are multiple hydrogen bonding donors and receptors in IU, which can interact with polyacrylamide through multiple hydrogen bonds to form the hydrogel networks. The break strength, fracture elongation, and compressive strength of the IU-included hydrogels could be adjusted in the range of 18.8–23.8 kPa, 305%–560%, and 2.0–3.9 MPa, respectively. The hydrogels featured outstanding fatigue resistance , and the obvious loss of compressive strength was not observed even after 50 cycles of loading-unloading under 85% strain. Moreover, the IU-based hydrogels not only showed promising self-healing and remodeling abilities but also exhibited nonconventional emission behaviors. Our work offers a facile strategy for the construction of multi‑hydrogen bond crosslinked hydrogels and may inspire researchers to explore new supramolecular systems using the hydrogen bonding reinforced factor (IU).
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2024
·
IF 6.2
Cuiyuan Jin,Caiyun Wang,Chen Zhang,Qi Ye,Yuanxiang Jin,Liyun Shi
As a fungicide with the characteristics of high effectiveness, internal absorption and broad spectrum, imazalil is widely used to prevent and treat in fruits and vegetables. Here, pregnant C57BL/6 mice were exposed to imazalil at dietary levels of 0, 0.025‰, and 0.25‰ through drinking water during pregnancy and lactation. We then analyzed the phenotype, metabolome, and expression of related genes and proteins in the livers of mice. There was a marked decrease in the body and liver weights of male offspring mice after maternal imazalil exposure, while this effect on the dam and female offspring was slight. Metabolomics analyses revealed that imazalil significantly altered the metabolite composition of liver samples from both dams and offspring. The preliminary results of the analysis indicated that glucolipid metabolism was the pathway most significantly affected by imazalil. We performed a coabundance association analysis of metabolites with significant changes in the pathway of glycolipid metabolism, and IMZ altered the networks of both dams and offspring compared with the network in control mice, especially in male offspring. The hepatic triglyceride, non-esterified fatty acid and glucose levels were increased significantly in the dams but decreased significantly in male offspring after maternal imazalil exposure. Furthermore, the expression levels of genes associated with glycolipid metabolism and m 6 A RNA methylation were significantly affected by maternal intake of imazalil. Imazalil-induced glucolipid metabolism disturbance was highly correlated with m 6 A RNA methylation. In conclusion, maternal imazalil exposure resulted in glucolipid metabolism disturbance and abnormal m 6 A RNA methylation in the livers of dams and offspring mice. We expected that the information acquired in this study will provide novel evidence for understanding the effect of maternal imazalil exposure on potential health risks.
研究领域:
毒理学
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代谢组学
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分子生物学
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发育生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Zhendong Dai,Runchen Lai,Qingqing Zhang,Youqi Li,Zhaohua Li,Yu Huang,Facai Wei,Feng Shao
The introduction of additives is a widely recognized and easily implementable strategy to regulate interfacial polymerization for preparing polyamide (PA) membranes in desalination applications. There is growing interest in minimizing potential health and environmental risks associated with conventional additives. In this study, we employed an environmentally friendly polar aprotic solvent, 1,3-dimethyl-2-imidazolidinone (DMI), as an aqueous-phase additive, to fabricate PA membranes with enhanced permeability and selectivity. Structural characterization and spectroscopic analysis consistently show that the resulting membranes are thin and dense, with ridge-and-valley features exhibiting a 37 % increase in surface roughness compared to the pristine membrane prepared without DMI. Solubility parameter calculations, physicochemical measurements, and molecular dynamics simulations reveal that DMI reduces the interfacial tension between the aqueous and organic phases, enlarges the miscible region, and facilitates amine monomer diffusion. With the addition of 3 wt% DMI, the resulting membranes achieved a water permeability of 3.73 L m −2 h −1 ·bar −1 , which is over 50 % higher than that of the control membrane, while maintaining a NaCl rejection of 98.36 % and excellent long-term operational stability. This study demonstrates the potential of DMI as a sustainable additive to enhance both performance and environmental compatibility in the fabrication of reverse osmosis membranes.
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
Toxicology Research
·
2021
·Vol. 10
·期 3
·467-475
·
IF 3.524
Gao Jiapan,Che Delu,Du Xueshan,Zheng Yi,Jing Huiling,Wang Nan
Imidazolidinyl urea (IU) is used as an antimicrobial preservative in cosmetic and pharmaceutical products. IU induces allergic contact dermatitis, however, the mechanism has not yet been elucidated. Mas-related G protein-coupled receptor-X2 (MRGPRX2) triggers drug-induced pseudo-allergic reactions. The aims of this study were to determine whether IU activated mast cells through MRGPRX2 to further trigger contact dermatitis. Wild-type (WT) and KitW-sh/HNihrJaeBsmJNju (MUT) mice were treated with IU to observe its effects on local inflammation and mast cells degranulation in vivo. Laboratory of allergic disease 2 cells were used to detect calcium mobilization and release of inflammatory mediators in vitro. WT mice showed a severe local inflammatory response and contact dermatitis, whereas only slight inflammatory infiltration was observed in MUT mice. Thus, MRGPRX2 mediated the IU-induced activation of mast cells. However, histamine, a typical allergen, was not involved in this process. Tryptase expressed by mast cells was the major non-histaminergic inflammatory mediator of contact dermatitis. IU induced anaphylactic reaction via MRGPRX2 and further triggering non-histaminergic contact dermatitis, which explained why antihistamines are clinically ineffective against some chronic dermatitis.
研究领域:
免疫学
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皮肤科
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药理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2016
·
IF 2.822
Feng Wu,Ting Huang,Yangjian Hu,Xin Yang,Qingji Xie
A composite film of glucose oxidase (GOx), imidazolium alkoxysilane (ImAS, a silane-ionic liquid (IL) bifunctional reagent) and chitosan (CS) was electrodeposited in a one-pot manner on a reduced graphene oxide (RGO)–Pt nanoparticle (PtNP) modified Au electrode for biosensing of glucose. Cyclic voltammetry electroreduction of coexisting p -benzoquinone was used to lift the electrode-surface pH for the GOx–ImAS–CS deposition, as a result of deprotonation of CS and hydrolyzation/condensation of ImAS at lifted pH. The RGO–PtNP composite was prepared through mild room-temperature chemical reduction of graphene oxide and H 2 PtCl 6 ·6H 2 O by formic acid , as characterized by UV–visible/FT-IR/Raman spectrophotometry , scanning electron microscopy and electrochemical techniques. The GOx–ImAS–CS/RGO–PtNP/Au electrode was used for glucose biosensing by anodically detecting the enzymatically generated H 2 O 2 at 0.55 V versus SCE. Under the optimal conditions, the GOx–ImAS–CS/RGO–PtNP/Au electrode showed a linear amperometric response to glucose concentration from 2.0 μM to 5.5 mM with a sensitivity of 84.4 μA mM − 1 cm − 2 and a limit of detection of 0.02 μM ( S / N = 3), which is superior to GOx–CS/RGO–PtNP/Au, GOx-(IL-NH 2 )–CS/RGO–PtNP/Au, GOx-(3-aminopropyltriethoxysilane)–CS/RGO–PtNP/Au and GOx–ImAS–CS/Au electrodes as well as many reported enzyme electrodes fabricated using similar materials.
研究领域:
生物化学
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材料科学
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分析化学
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产品关联
DOI
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 14
·5371-5381
·
IF 6.482
Qianyun Zhong,Xingxing Chen,Yuxuan Yang,Chenhui Cui,Li Ma,Zhen Li,Qiang Zhang,Xiaoming Chen,Yilong Cheng,Yanfeng Zhang
Transparent and degradable polyurethane elastomers with high strength and toughness are in demand for various applications, such as tissue engineering and flexible electronics. However, designing specific chemical structures is challenging, and thus fabricating novel elastomers is sometimes unattainable. An effective approach to develop elastomers is through the introduction of sacrificial bonds, e.g. hydrogen bonds, to enhance their mechanical properties and toughness, which provide hidden lengths and hierarchical structures for energy dissipation. This study introduced a facile and efficient strategy by employing imidazolidinyl urea (IU) as a multiple hydrogen-bonding motif to fabricate transparent and degradable polyurethane elastomers (PHI) with superior breaking strength and excellent toughness. The resultant breaking strength and toughness reached up to 24.9 MPa and 168.2 MJ m−3, respectively. Additionally, the breaking strength increased to 49.9 MPa after the sample was pre-stretched to 600% strain due to strain-induced crystallization (SIC). Moreover, the PHI film with degradability and good biocompatibility showed potential application in post-operative anti-adhesion.
研究领域:
材料科学
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生物医学工程
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高分子化学
✓ 已验证
DOI
高影响因子
JOURNAL OF PLANT PATHOLOGY
·
2024
·
IF 2.2
Reymick Okwong Oketch,Duan Bin,Feng Zhao,Zhang Yong Hua,Ouyang Qiuli,Kaaya Archileo N.,Tao Nengguo
Management of Penicillium digitatum requires use of highly effective fungicides that are not prone to drug resistance and are safe to humans and the environment. This study examined the fungicidal potential of combinations of cuminaldehyde (CA) + trans-2-hexen-1-al (TH) and CA + Citral. Both CA + TH and CA + Citral exhibited enhanced fungitoxicity against P. digitatum than CA, citral or TH alone. The minimum inhibitory concentration (MIC) of CA + Citral consisted of 0.13 ml/L CA and 0.3 ml/L citral, representing a synergistic interaction. MIC of CA + TH consisted of 0.12 ml/L CA and 0.15 ml/L TH, representing an additive interaction. The minimum fungicidal concentration (MFC) of CA + Citral and of CA + TH consisted of 0.26 ml/L CA and 0.6 ml/L citral, and 0.18 ml/L CA and 0.24 ml/L TH, respectively. 10×MFC CA + Citral in Tween-80 (WCI) delayed onset of hyphal growth in fruits inoculated with P. digitatum to day 5 compared to day 4 in the 10×MFC CA + TH in Tween-80 (WCT) treatment, and day 3 for the control samples. Daily green mold disease incidence and disease severity were much lower in WCI and WCT treatments than in the 10×MFC CA in Tween-80 (WCA) treatment and in control samples. Our results show that WCI was much fungitoxic against P. digitatum than WCT and WCA, its effect being comparable to that of imazalil. Additionally, at 25 ± 2 °C and 85–90% relative humidity, both WCI and WCT markedly preserved fruit quality by day 6 of treatment. WCI and WCT are thus, safe, cheap and highly effective alternatives to chemical fungicides being used to control postharvest green mold in citrus fruits.
研究领域:
植物病理学
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食品科学
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微生物学
·
农业化学
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产品关联
DOI
高影响因子
IONICS
·
2020
·Vol. 26
·期 7
·3473-3482
·
IF 2.394
Wang Dan,Hu Guangxing,Yang Peixia,Pan Xiaona,Xu Hao,Liu Lilai,Zhang Jinqiu,An Maozhong
Due to the excellent intrinsic activity of platinum, developing a Pt-based oxygen reduction catalyst with both high performance and low loading is highly desirable but still challenging. How to improve the utilization of platinum-based materials has become one of the most critical issues. Herein, a synthesis strategy using the 5,5-dimethylhydantoin (DMH) as complexing agent is designed to synthesize the Pt catalyst via pulse electrodeposition. On the one hand, the platinum nanoparticles prepared by electrodeposition are exposed on the surface of support materials, which effectively avoids performance degradation caused by the coverage of binder and support. On the other hand, the strong coordination affinity between DMH and platinum ions significantly inhibits the electrodeposition process, resulting in a smaller size of platinum nanoparticles. The effect of plating composition and pulse plating parameters on the Pt/KB catalyst activity for oxygen reduction reaction (ORR) has been investigated. The deposited Pt nanoparticles show a face-centered cubic ( fcc ) crystal structure with a size ranging from 3 to 10 nm. The optimized Pt/KB catalyst exhibits an enhanced activity (i.e., a half-wave potential of 0.906 V) and stability in the acidic media, even with lower loading of platinum. Moreover, the vital role of the DMH in the pulse electrodeposition process is further verified by using linear sweep voltammetry and cyclic voltammetry.
研究领域:
材料科学
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电化学
·
催化
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Yifan Li,Xinmin Zhao,Ni Meng,Shuo Dong,Shan Yan,Man Yang,Changjiu Sun,Zhiqiang Li,Shaopeng Yang,Mingjian Yuan,Tingwei He
Mixed-halogen wide-bandgap (WBG) perovskite materials are employed in tandem solar cells (TSCs) due to their continuous tunability of bandgap. However, inhomogeneous halogen phases are often observed in bromine-rich perovskite films, which restricts the performance of WBG perovskite solar cells (PSCs) and TSCs. Here, homogeneous halogen-phase perovskite is proposed to form film by a synchronous halogen-phase transformation strategy. 1,3-Dimethyl-2-imidazolidinone (DMI) is introduced into the perovskite precursor solution, due to its stronger binding energy with lead halide (PbX 2 ). The homogeneous DMI-PbX 2 adducted intermediate phase is stable in precursor solution and at spin-coating stage. And it then synchronously transforms into a homogeneous halide-phase perovskite film at the annealing stage. Benefited from efficient carrier extraction and suppressed carrier recombination, the resulting 1.76 eV-bandgap PSC achieves a record power conversion efficiency (PCE) of 21.42% (certified 21.18%) among devices with a bandgap wider than 1.74 eV. Based on the high transmittance of semitransparent-WBG PSC, a 4-terminal all-perovskite TSC achieves a PCE of 29.66%.
研究领域:
材料科学
·
光伏技术
·
纳米技术
·
能量转换
·
薄膜技术
·
太阳能
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2020
·
IF 7.864
Chenkai Jiang,Han Chen,Junliang Wang,Yao Shen,Jiexu Ye,Shihan Zhang,Lidong Wang,Jianmeng Chen
A biphasic solvent features high absorption capacity and low heat duty for CO2 capture. Phase separation behavior is essential to cut down energy penalty. Four phase splitting agents with different hydrophobicities, such as 1,3-dimethyl-2-imidazolidinone (DMI), 1-methyl-2-pyrrolidinone (NMP), N,N-dimethylformamide, and sulfolane, were dosed to biphasic solvents, triethylenetetramine and 2-(diethylamino)ethanol. Experimental results revealed that they can tune the phase separation behavior during CO2 absorption. Generally, under the same CO2 loading, the volume ratio of the rich phase increased with their hydrophobicity (log P), which accounts for over 50%. Moreover, their influences on absorption capacity, kinetics, and thermodynamics were also investigated. After dosing NMP, the heat duty was decreased by 22%. Furthermore, a phase splitting agent with a positive log P was more conducive to reducing the heat duty, and one with a negative log P enhanced the absorption rate. With DMI, the absorption rate was 114% higher than that of MEA at rich loading. The 13C NMR analysis showed that the agents were not involved in CO2 absorption and did not affect the reaction mechanism. Furthermore, quantum calculation was used to verify the reaction mechanism, confirming that the phase splitting agent increases the reaction equilibrium constant and makes it proceed more thoroughly.
研究领域:
化学工程
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2021
·Vol. 12
·期 44
·6417-6425
·
IF 5.582
Yi-Cong Wang,Pei-Yi Cheng,Zhi-Qian Zhang,Ke-Xin Fan,Rui-Qi Lu,Shu Zhang,Yi-Xian Wu
Highly efficient terpolymerizations of ethylene, propylene and 5-ethylidene-2-norbornene (ENB) using a half-titanocene containing iminoimidazolidine (T5) catalyst with a methylaluminoxane (MAO) cocatalyst could be achieved in the presence of small amounts of triisobutylaluminium (TIBA) and 2,6-ditertbutyl-4-methyl-phenol (BHT) at TIBA : BHT : Ti = 20 : 20 : 1 (molar ratio). The catalytic activity reached 2.20 × 107 g polymer per mol of Ti per h for the copolymerization of ethylene and propylene and the ethylene–propylene copolymer with a high incorporation ratio of propylene (39.1 mol%) was afforded by using the T5/TIBA/BHT/MAO catalytic system. Interestingly, the catalytic activity, the incorporation ratio of propylene into the copolymer chains and the percentage of randomly distributed sequences could be improved by an increase in the BHT/Ti molar ratio from 0 to 20. Very importantly, the ENB conversion could reach more than 95%, indicating that this T5/TIBA/BHT/MAO catalytic system exhibits excellent copolymerization ability for ENB with ethylene and propylene. The content of ENB units in the resulting ethylene–propylene–diene rubbers (EPDMs) could be increased up to 6.8 mol% (20.8 wt%) by increasing the ENB concentration in the monomer feed without sacrificing the catalytic activity and ENB conversion. The extremely high ENB conversion was significant for the highly efficient production of EPDMs with relatively low cost and short processes. The EPDM with a high content of ENB units is critical for rapid vulcanization during the processing and for the preparation of a functionalized EPDM. The CC double bonds in the ENB units in the above EPDM can be cleanly converted into carboxylic functional groups via light-mediated thiol–ene reaction, leading to the production of the functionalized EPDM with various contents of carboxylic side groups. The functionalized EPDMs exhibit enhanced hydrophilicity, which may result in good compatibility with inorganic fillers and strong interaction between inorganic fillers and organic terpolymers.
研究领域:
高分子化学
·
材料科学
·
催化
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）