JOURNAL OF APPLIED POLYMER SCIENCE
·
2020
·Vol. 138
·期 6
·49813
·
IF 2.52
Yingtong Pan,Zhonglin Luo,Biaobing Wang
Amino trimethylene phosphonic acid piperazine (ATPIP) salt, as a novel charring agent, is prepared via a simple ionic reaction in distilled water using amino trimethylene phosphate (ATMP) and piperazine as raw materials. The synergistic flame retardant effect of ATPIP and ammonium polyphosphate (APP) as an intumescent flame retardant (IFR) is investigated by various characterization and testing methods. The results show that the polypropylene (PP)/modified APP with piperazine (MAPP)/ATPIP ternary blend passes UL-94 V-0 rating and achieve a limiting oxygen index (LOI) of 30% at a loading level of 25 wt% IFR (MAPP:ATPIP = 3:1). Meanwhile, the total smoke production (TSP) value of IFR-PP samples is 3.3 m 2 , which decreases by 93.2% compared with that of pure PP, exhibiting excellent smoke suppression performance. Besides, the analysis of gaseous pyrolysis products and char residue indicates that the IFR-PP samples show a synergistic flame-retardant mechanism including the gas phase and the condensed phase.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 44
·期 3
·852-860
·
IF 3.069
Juan Xu,Rongkai Du,Lvying Wu,Xianrui Zhang,Su Guan,Lei Zhang,Lifeng Ning,Shan Li
Two azilsartan–piperazine salt solvates with methanol (Az–Pz·MeOH) and ethanol (Az–Pz·EtOH) and a hydrate (Az–Pz·H2O) have been prepared and exhaustively characterized by physicochemical methods. The crystal structures suggest that one azilsartan transfers one proton from the carboxylic group to piperazine to form 2-D corrugation-like structures in Az–Pz·MeOH and Az–Pz·EtOH, and transfers two protons from carboxylic and oxadiazolyl groups to piperazine to form a 1-D chain structure in Az–Pz·H2O. The salt solvates and hydrate are very stable after 24 h slurry experiments in distilled water at 37 °C, and improve the azilsartan solubility with approximately a 322-fold increase for Az–Pz·H2O and a 140-fold increase for Az–Pz·MeOH and Az–Pz·EtOH over that of the free Az form. The pharmacokinetic experiments show that Az–Pz·EtOH and Az–Pz·H2O improve the plasma azilsartan concentration Cmax and AUC (P < 0.05) over the free Az form in Sprague-Dawley rats. The most incredible result is that Az–Pz·H2O features bioequivalence to an azilsartan tablet (Azilva®, P > 0.05). The research demonstrates that the pharmaceutical salt is a promising approach in increasing the solubility and enhancing the oral bioavailability of low-solubility azilsartan.
研究领域:
药学
·
晶体学
·
药物化学
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产品关联
DOI
高影响因子
POLYHEDRON
·
2022
·
IF 2.975
Jian-Hang Hu,Zhi-Chao Yu,Jia-Yi Zhang,Zhi-Nian Liu,Run-Xin Hou,Yu Xiong,Carl Redshaw,Zhu Tao,Xin Xiao
The interaction between symmetric tetramethyl cucurbit[6]uril (TMeQ[6]) and 2,3-dimethylphenylpiperazine hydrochloride (PMY) has been studied in the presence of [CdCl 4 ] 2− . Each port of the TMeQ[6] is connected to PMY through weak interactions such as ion dipole interactions and C H⋯O hydrogen bonding interactions, whilst the [CdCl 4 ] 2− is connected with the portal carbonyl oxygen, glycoside urea methylene and a bridging methylene of a TMeQ[6] molecule via ion–dipole interactions. These interactions were evident from a single crystal X-ray diffraction study of TMeQ[6]-PMY-[CdCl 4 ] 2− . In addition, the complex can form a one-dimensional supramolecular chain structure, and then assemble into a two-dimensional supramolecular framework, which can be described as a TMeQ[6]-PMY-[CdCl 4 ] 2− based supramolecular framework (QSF).
研究领域:
化学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2025
·
IF 4.7
Xian-Rui Zhang,Xiao-Han Zhang,Xian-Ying Xie,Jia-Yu Luo,Hui-Jun Chen,Lei Gao
To overcome the limitations of diflunisal (DIF) regarding its solubility and dissolution rate, two different ratios of DIF-piperazine (PIP) salts were synthesized using a salt formation strategy via proton transfer crystallization. The resulting DIF-PIP salts were characterized using various techniques, including crystal structure analysis, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier transform infrared (FT-IR) spectroscopy. The results demonstrated a significant enhancement in solubility for both the DIF-PIP (1:1) and DIF-PIP (2:1) salts when compared to the DIF active pharmaceutical ingredient (API), with increases of 56.5-fold and 3.7-fold, respectively. Notably, the DIF-PIP (1:1) salt exhibited exceptional dissolution performance across various media. Specifically, its dissolution rates in water, pH 6.86 buffer, and pH 9.18 buffer increased by 338.5-fold, 104.8-fold, and 1.5-fold, respectively. This superior dissolution performance suggests potential advantages for pharmaceutical applications, particularly its high dissolution rate in water, which could improve the disintegration and dissolution properties of oral tablets. Additionally, we investigated the polymorphic transformation conditions between DIF-PIP (1:1) and DIF-PIP (2:1) salts in detail, providing both theoretical and experimental insights into controlling the physicochemical stability of pharmaceutical formulations during preparation and storage.
研究领域:
药学
·
晶体工程
·
药物传递
·
固态化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 30
·16999-17010
·
IF 4.22
Xu Yue,Liu Lubin,Yan Chentao,Hong Yukai,Xu Miaojun,Qian Lijun,Li Bin
In the field of electronic and electrical applications, it has always been a challenge to synchronously improve the flame-retardant and smoke-suppression properties for epoxy resins. In this research, a novel flame-retardant phosphonic acid piperazine salt (PTPAP) was successfully synthesized in an environmentally friendly manner and used to fabricate flame-retardant EP thermosets. The fire safety and flame-retardant mechanisms of EP/PTPAP thermosets were detailedly studied. When merely 6 wt% PTPAP was introduced into EP substrate, the EP/PTPAP thermosets gained UL-94V-0 grade and their LOI value improved from 21.3% of pure EP to 28.3% with the increase of 32.9%. The introduction of PTPAP promoted the premature degradation and charring of EP matrix, and the intumescent, compact, and sealed char layer was produced on the surface of EP/PTPAP thermosets during combustion. Besides, PTPAP decomposed and produced the PO· and inert gases, which efficaciously exerted the free radical trapping and dilution effect in vapor phase. Therefore, the emission of smoke and heat was distinctly constrained and the EP/PTPAP thermosets was endowed with the superior fire safety. This flame-retardant EP/PTPAP thermosets showed broad application prospects under the environment of sustainable development because of the eco-friendly and simplicity of the synthesis of PTPAP. Graphical abstract
研究领域:
材料科学
·
化学工程
·
消防安全
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）