JOURNAL OF LUMINESCENCE
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2024
·
IF 3.3
Jianai Chen,Mingjiao Sun,Yujie Dong,Weijun Li,Fener Chen
Mechanical stimulus-responsive materials are generally considered to be closely related to molecular packing in the solid state, underscoring the significance of regulating molecular packing via precise molecular design. In this study, flexible alkyl substituents were employed to adjust the molecular packing. By modifying alkyl substituents, predictable changes in the molecular packing of their derivatives were observed, resulting in adjustable ML properties. The DPA-PYZ-TB with a tert-butyl-side chain exhibited strong ML and MC stimulus response signals. The enhanced ML and MC performance can be attributed to the effective suppression of non-radiation through the helical crystal arrangement and strong intermolecular interactions. The relationship between molecular arrangement and ML/MC properties was validated through analysis of the single crystal structure and corresponding experimental results. This study offers valuable insights into the enigmatic ML process and the development of efficient luminous materials that utilize both MC and ML.
研究领域:
材料科学
·
晶体学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
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2024
·
IF 4.1
Luheng Wang,Gaige He
The assessment of buried flaws in the interlayer structure of curved metal is crucial to system safety. To improve the flexibility of eddy current sensor, an intrinsically flexible flaw sensing probe made of coil-shaped conductive polymer composite is proposed. The experimental data show that the response signal of the coil-shaped composite changes at the flaw and increases with the increases of flaw height/length, with a maximum sensitivity of 0.435 mV/mm for differential amplitude and 4.904 °/mm for differential phase. The results show that the height of the characteristic signals in the response signals reflects the change in flaw height, and the length of the characteristic signals in the response signals reflects the change in flaw length. The relative change rate of the coil-shaped composite is higher than that of a metal coil of the same structure. The above results have laid a preliminary foundation for using the coil-shaped composite to detect flaws.
研究领域:
材料科学
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无损检测
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Jiaying Wang,Yu Tian,Kai Zhang,Jiantong Jiao,Yi Zhao
NF-κB p50 is a critical transcription factor that plays an essential role in regulating immune responses, inflammatory pathways, and tumor progression. Its aberrant expression is closely linked to various pathological conditions, making it a valuable biomarker for early disease diagnosis and therapeutic monitoring. In this work, we developed a highly sensitive and reusable electrochemical biosensor capable of detecting NF-κB p50 at ultralow concentrations. The biosensor integrates a pH-responsive regeneration mechanism and a multi-stage signal amplification cascade involving Exonuclease III (Exo III)-assisted recycling, CRISPR/Cas12a-mediated trans -cleavage, and DNA tetrahedron nanostructure-functionalized electrodes. This synergistic design significantly enhances detection sensitivity and stability. The platform offers a broad dynamic detection range from 5 aM to 100 fM with a remarkably low detection limit of 2.38 aM. More importantly, the biosensor demonstrates excellent reusability through efficient regeneration under alkaline conditions (pH 10.0), with minimal loss in signal output. Validation in tenfold-diluted human serum samples yielded high recovery rates (99.61 %–106.23 %) and low relative standard deviations, confirming its practical applicability. This study not only presents a robust approach for ultrasensitive protein detection but also introduces a generalizable strategy for the regenerative electrochemical analysis of protein-based biological macromolecules in clinical diagnostics.
研究领域:
生物医学工程
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分子诊断学
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纳米技术
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产品关联
DOI
高影响因子
Chemosensors
·
2022
·Vol. 10
·期 6
·226
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IF 4.229
Xue Shi,Hua Zhang,Hanyang Ji,Fanli Meng
Volatile organic compounds (VOC) harm human health seriously in the air. Therefore, it is essential to recognize VOC gases qualitatively and quantitatively. The dynamic measurement method can improve the selectivity of metal oxide semiconductor (MOS) gas sensors to VOC, but there is a problem of the insufficient number of characteristic peaks. From the experimental point of view, the primary judgment basis for the correct qualitative and quantitative recognition of VOC gases by the dynamic measurement method is the characteristic peak of the dynamic response signal. However, the traditional dynamic measurement method generally only has two characteristic peaks. In this experiment, the voltage was changed at the time of the second characteristic peak by controlling the constant dynamic response period. Taking ethyl alcohol as an example, the experimental results show that the characteristic peak of the dynamic response signal does not increase when the voltage is constant. However, a new characteristic peak will appear based on a continuously rising heating voltage. The characteristic peaks of the dynamic response of n-propyl alcohol, isopropyl alcohol, and n-butyl alcohol were also increased based on the rising heating voltage waveform. Based on the K-Nearest-Neighbors algorithm, the qualitative and quantitative recognition rate of the four alcohol homologue gases reached 100%.Keywords:dynamic response signal;characteristic peaks;ZnO gas sensor;periodic cycle heating waveform;alcohol homologue gases
研究领域:
传感器技术
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环境科学
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材料科学
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产品关联
DOI
高影响因子
Nature Chemical Biology
·
2024
·
IF 12.9
Yang Sihui,Wang Miao,Tian Dawei,Zhang Xiaoyu,Cui Kaiqing,Lü Shouqin,Wang Hong-hui,Long Mian,Nie Zhou
Synthetic signaling receptors enable programmable cellular responses coupling with customized inputs. However, engineering a designer force-sensing receptor to rewire mechanotransduction remains largely unexplored. Herein, we introduce nongenetically engineered artificial mechanoreceptors (AMRs) capable of reprogramming non-mechanoresponsive receptor tyrosine kinases (RTKs) to sense user-defined force cues, enabling de novo-designed mechanotransduction. AMR is a modular DNA–protein chimera comprising a mechanosensing-and-transmitting DNA nanodevice grafted on natural RTKs via aptameric anchors. AMR senses intercellular tensile force via an allosteric DNA mechano-switch with tunable piconewton-sensitive force tolerance, actuating a force-triggered dynamic DNA assembly to manipulate RTK dimerization and activate intracellular signaling. By swapping the force-reception ligands, we demonstrate the AMR-mediated activation of c-Met, a representative RTK, in response to the cellular tensile forces mediated by cell-adhesion proteins (integrin, E-cadherin) or membrane protein endocytosis (CI-M6PR). Moreover, AMR also allows the reprogramming of FGFR1, another RTK, to customize mechanobiological function, for example, adhesion-mediated neural stem cell maintenance.
研究领域:
生物技术
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细胞生物学
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分子生物学
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）