Cancer Nanotechnology
·
2025
·Vol. 16
·期 1
·1-20
·
IF 4.8
Li Fangling,Liu Chengjing,Gu Wenyi,Xu Qianhe,Li Dongmei,Cao Dongdong,Liu Zhiyong
Kaposi's sarcoma-associated herpesvirus (KSHV) infection can cause a variety of tumors and is one of the leading causes of death in acquired immune deficiency syndrome (AIDS) patients. As a small molecule antiviral drug, ganciclovir (GCV) can be used for anti-KSHV treatment. However, GCV has non-specific action and toxic side effects in vivo, and how to make it safer and more effective against KSHV is still a great challenge. By encapsulating GCV into metal–organic skeleton material zeolitic imidazolate framework-8 (ZIF-8) and further modification of hyaluronic acid (HA), the nanomedical delivery system of GCV (HA/GCV@ZIF-8) has been developed for efficient GCV delivery and targeted anti-KSHV treatment. The modification of HA leads to the targeted binding of the nanocomplex with the overexpressed CD44 receptors in tumor cell membranes, resulting in the increased accumulation and cellular uptake of GCV. Exploiting the decomposition property of ZIF-8 under acidic conditions, the nanocomplex exhibits pH-responsive drug release in slightly acidic tumor environment. In addition, HA/GCV@ZIF-8 not only suppresses expression of KSHV pathogenic genes with less drug dose, but also inhibits the ability of cell proliferation and migration. In vivo anti-tumor results showed that HA/GCV@ZIF-8 accumulated in tumor cells and effectively inhibited tumor growth. The results open a gate for the targeted anti-KSHV treatment. Graphical
研究领域:
医学
·
药学
·
病毒学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2014
·Vol. 32
·期 10
·1329-1337
·
IF 1.42
Zhang Yan,Wang Xiao-ju,Guo Miao,Yan Hu-sheng,Wang Chen-hong,Liu Ke-liang
Multifunctional nanocarriers with multilayer core-shell architecture were prepared by coating superparamagnetic Fe 3 O 4 nanoparticles with diblock copolymer folate-poly(ethylene glycol)- b -poly(glycerol monomethacrylate) (FA-PEG- b -PGMA), and triblock copolymer methoxy poly(ethylene glycol)- b -poly(2-(dimethylamino) ethyl methacrylate)- b -poly(glycerol monomethacrylate) (MPEG- b -PDMA- b -PGMA). The PGMA segment was attached to the surfaces of Fe 3 O 4 nanoparticles, and the outer PEG shell imparted biocompatibility. In addition, folate was conjugated onto the surfaces of the nanocarriers. Cisplatin was then loaded into the nanocarrier by coordination between the Pt atom in cisplatin and the amine groups in the inner shell of the multilayer architecture. The loaded cisplatin showed pH-responsive release: slower release at pH 7.4 ( i.e. mimicking the blood environment) and faster release at more acidic pH ( i.e. mimicking endosome/lysosome conditions). All of the cisplatin-loaded nanoparticles showed concentration-dependent cytotoxicity in HeLa cells. However, the folate-conjugated cisplatin-loaded carriers exhibited higher cytotoxicity in HeLa cells than non-folate conjugated cisplatin-loaded carriers.
研究领域:
药学
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 6
·860
·
IF 4.034
Ji Chen,Guotao Li,Qihong Liu,Yan Liang,Miaochang Liu,Huayue Wu,Wenxia Gao
Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.Keywords:prodrug;photocleavable;stimuli-responsive release;methotrexate;chemotherapy
研究领域:
药学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Chaoping Fu,Hailiang Li,Nannan Li,Xiangwan Miao,Minqiang Xie,Wenjun Du,Li-Ming Zhang
A prodrug gelation strategy was developed for the sustained and dual stimuli-response release of doxorubicin hydrochloride (DOX·HCl), a commonly used anticancer drug. For this purpose, the chemical conjugation of DOX·HCl onto thiolated hyaluronic acid (HA) was carried out by an acid liable hydrazone linkage and verified by 1 H NMR analyses. When exposed to the air, such a polysaccharide conjugate showed unique self-gelation ability in aqueous solution. The gelation time and extent depended mainly on the content of thiol groups on thiolated HA. The resultant hydrogel exhibited a dominant elastic response and a thixotropic property. In particular, it could release sustainably conjugated DOX·HCl in dual pH- and reduction-responsive modes. The cumulative drug release was found to be significantly accelerated under the conditions mimicking the intracellular environments of cancer cells. The in vitro cytotoxicity assays for the human nasopharyngeal carcinoma CNE2 cells treated with various release media confirmed the effectiveness of this conjugate hydrogel for cancer cell inhibition.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 103
·101267-101276
·
IF 3.289
Hongshan Liang,Bin Zhou,Jing Li,Yun He,Yaqiong Pei,Bin Li
Pickering emulsions are widely used as delivery systems in food, cosmetics, and pharmaceutical industries for the encapsulation and sustained release of hydrophilic compounds. The solid colloidal particles stabilized in oil–water interface can prevent the oil droplets from undesired coalescence and endow additional functionality. In order to impact further protection and pH-responsive deliver of the encapsulated component, we used two kinds of mechanisms. For internal interaction, the excess Ca2+ on the surface of zein–tannic acid (TA)/Ca2+ nanoparticles (NPs) interacted with alginate added to form a second layer. In the case of external gelation, a cross-linking agent (Ca2+) was dissolved in the aqueous gelling bath outside. When added the mixture of the emulsions to Ca2+ solution, alginate–Ca beads were formed to encapsulate the emulsions and further impact the pH-responsive deliver of VD3 in stomach and rapid release of it in small intestine.
研究领域:
食品科学
·
药物递送系统
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 21
·15609
·
IF 5.6
Xiao Han,Yinjie Qian,Jiapeng Li,Zhongkai Zhang,Jinbo Guo,Ning Zhang,Longyu Liu,Zhiqiang Cheng,Xiaobin Yu
In order to reduce the use of fungicide and ensure food safety, it is necessary to develop fungicide with low toxicity and high efficiency to reduce residues. Azoxystrobin (AZOX), which is derived from mushrooms, is an excellent choice. However, conventional AZOX release is difficult to regulate. In this paper, a pH-responsive fungicide delivery system for the preparation of AZOX by impregnation method was reported. The Zinc metal–organic framework/Biomass charcoal (ZIF-8/BC) support was first prepared, and subsequently, the AZOX-ZIF-8/BC nano fungicide was prepared by adsorption of AZOX onto ZIF-8/BC by dipping. Gray mold, caused byBotrytis cinerea, is one of the most important crop diseases worldwide. AZOX-ZIF-8/BC could respond to oxalic acid produced byBotrytis cinereato release loaded AZOX. When pH = 4.8, it was 48.42% faster than when pH = 8.2. The loading of AZOX on ZIF-8/BC was 19.83%. In vitro and pot experiments showed that AZOX-ZIF-8/BC had significant fungicidal activity, and 300 mg/L concentration of AZOX-ZIF-8-BC could be considered as a safe and effective control ofBotrytis cinerea. The above results indicated that the prepared AZOX-ZIF-8/BC not only exhibited good drug efficacy but also demonstrated pH-responsive fungicide release.Keywords:AZOX-ZIF-8/BC;Botrytis cinerea;fungicide;nano fungicide;pH-responsive release
研究领域:
植物保护
·
农业科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Fei Teng,Zhaogui Wang,Mingyu Xue,Hui Li,Quanmin Wen,Peng Xu,Dejun Hao
Pine wilt disease is caused by Bursaphelenchus xylophilus invasion and has a great impact on global pine resources. Injection of emamectin benzoate (EB) into pine trunks is an effective way to control B. xylophilus. However, EB has limited aqueous solubility, easily photodissociates, and its long-term use causes resistance problems. In this study, the metal–organic framework material ZIF-8 was prepared, and EB was loaded onto ZIF-8 through physical adsorption, resulting in a pH-responsive EB@ZIF-8 nanopesticide with a high drug loading rate (36.04%). Simulated release experiments of EB@ZIF-8 under different pH conditions showed a cumulative release of 64.43% within 10 h at pH 5.0, which increased as the pH decreased, compared to conditions at pH 7.0 and 9.0. EB@ZIF-8 showed positive insecticidal activity in a laboratory biological test (LC50 = 52.503 mg/L). In addition, 7 days after trunk injection in Pinus massoniana, EB residuals were detected in all parts of the branches, with the lowest residue level being 73.39 mg/kg. The proportion of the EB residue in the lower, middle, and upper branches of P. massoniana gradually increased, reaching 43.92% at 28 days after trunk injection, indicating that EB was distributed evenly in the tree. Therefore, EB@ZIF-8 had good morphology, structure, and pH-responsive release performance. EB@ZIF-8 also exhibited a high nematocidal ability due to its smaller particle size and rapid transport in P. massoniana. This study provides a new approach for the development of highly effective EB preparations, improvement of pesticide utilization, and B. xylophilus control.
研究领域:
植物保护
·
材料科学
·
农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2025
·
IF 2.7
Naikuan Fu,Ao Li,Jing Zhang,Peng Zhang,Hong Zhang,Shicheng Yang,Jianhua Zhang
The therapeutic efficacy of Bortezomib (BTZ) is severely limited by its low solubility, poor stability in vivo and nonspecific toxicity. PEGylated nanocarriers can improve drug delivery efficiency, but their applications often suffer from low drug loading, premature leakage and accelerated blood clearance phenomenon. Herein a kind of catechol-functionalized and sulfobetaine-based zwitterionic block copolymer (PGMAD-PSBMA) is prepared by RAFT copolymerization and an epoxy-amino click reaction. And then PGMAD-PSBMA is readily used to conjugate with BTZ by the formation of dynamic boronate bonds to obtain zwitterionic BTZ prodrug (PGMAD@BTZ-PSBMA) and PGMAD@BTZ-PSBMA micelles. The structure and morphology, physicochemical characteristics, drug loading, pH-triggered drug release as well as in vitro cytotoxicity of PGMAD@BTZ-PSBMA micelles are investigated in detail. The results demonstrate that PGMAD@BTZ-PSBMA micelles can not only possess high drug loading (12.9%) and stable dispersion in physiological pH condition (pH 7.4), but also respond to the tumor acid microenvironment and achieve pH-responsive BTZ release. The nanocarriers designed here readily combine the desirable functions of polycatechols for stable conjugation and acid-triggered release and polysulfobetaines for long circulation in blood, which have great potential to enhance therapeutic efficacy and reduce toxic side effects of BTZ and other boronic acid-containing drugs, such as Ixazomib and Steboronine.
研究领域:
药学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2021
·
IF 8.198
Amir E. Kaziem,Liupeng Yang,Yigang Lin,Anas E. Kazem,Hanhong Xu,Zhi-xiang Zhang
Site-specific pesticide delivery is one of the potential strategies to enhance the use of fungicides and decrease undesirable environmental damages. Herein, a β-glucanase enzyme-responsive nanovehicle used for controlling chlorothalonil (CHT) release in the plant vascular system was synthesized (CHT@MSNs-β-glucans) by attaching β-glucans extracted from the yeast cell wall on MSNs pore rims for the management of rice blast (Magnaporthe grisea). CHT@MSNs-β-glucans characteristics were examined by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transfer infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), N2 isotherm, and Zetasizer. The obtained results showed that CHT@MSNs-β-glucans have excellent enzymatic release dependency, an outstanding loading efficacy of 24.99%, remarkable protection from acidic and alkaline conditions, and UV shielding ability up to 3 times greater than that of CHT commercial product (CHT-WP). CHT@MSNs-β-glucans showed excellent bioactivity against rice blast compared with CHT-WP. Moreover, CHT@MSNs-β-glucans showed better distribution in different tissues of rice plants. Additionally, CHT@MSNs-β-glucans showed 2.6 times lower toxicity to Daphnia magna and exhibited lower changes in soil microbial abundance than CHT-WP. This study provides significant sustainable management of plant pathogens for better farming.
研究领域:
植物病理学
·
农业科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2024
·
IF 4.3
Yuqi Cao,Yingpei Liu,Chenchen Ding,Tingting Ma,Huimin Ye,Weiwei Zhong,Wei He
In this study, four cobalt ferrite@carbon nitride (CoFe 2 O 4 @g-C 3 N 4 ) composites were prepared by co-precipitation method to achieve chemo-photodynamic synergistic cancer therapy. The effect of the morphology of g-C 3 N 4 on the chemotherapy and photodynamic therapy of CoFe 2 O 4 @g-C 3 N 4 (CFO@g-C 3 N 4 ) was investigated in detail. CFO@PMCN with porous structures and CFO@CNT with a reticulated structure displayed high loading efficiencies of doxorubicin (DOX), exhibiting a pH-responsive release property and facilitating the delivery of DOX into cancer cells for chemotherapy. CFO@CNT possessed a higher photothermal performance for photothermal agents in cancer treatment compared with other CoFe 2 O 4 @g-C 3 N 4 composites. In addition, more reactive oxygen species (ROS) was generated in the assistance of CFO@CNT under the irradiation condition for photodynamic therapy (PDT) treatment. Based on the synergistic effect of chemotherapy and photodynamic therapy, the obtained CFO@CNT-DOX exhibited an excellent therapeutic effect and significant pH-responsive release characteristics confirmed by dimethylthiazol diphenyltetrazolium bromide (MTT) assay and dual staining fluorescence imaging analysis.
研究领域:
纳米医学
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Environmental Science-Nano
·
2024
·
IF 5.8
Ao Liang,Yunzheng Zhang,Xiang Xu,Hao Wang,Changwei Gong,Jie Hu,Xiangsong Li,Jizhi Yang,Anchun Peng,Xuegui Wang
Chilo suppressalis is a major pest that severely impacts rice production in China. However, the widespread use of insecticides has resulted in the development of resistance in C. suppressalis. The advancement of nanotechnology offers promising prospects for enhancing insecticide formulations and improving their efficacy. This study designed a pH-responsive release system composed of γ-PGA and chitosan (CS) loaded with chlorantraniliprole (CLAP). The synthesized CLAP-loaded nanoparticles had an average particle size of approximately 39.67 nm and a loading efficiency of 38.87%. Under a pH of 8.5, 64.4% of the pesticide was released within 120 hours. The CLAP@CS/γ-PGA formulation, after loading, exhibited a significant synergistic insecticidal effect, with bioassay results showing an 82.2% mortality rate of C. suppressalis six days post-treatment. Tests of metabolic genes and enzyme activities showed that CLAP@CS/γ-PGA rendered C. suppressalis more sensitive to insecticides by inhibiting the activities of P450 and by decreasing the expression of CYP9A68. CLAP@CS/γ-PGA also demonstrated favorable transport properties within C. suppressalis and rice plants, and due to the encapsulation by the nanoparticle carrier, it reduced toxicity to zebrafish. In summary, the system we investigated not only meets the needs of pest management but also enhances the utilization of pesticides.
研究领域:
农业科学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Zhiyou Tan,Shan Wang,Zhuorong Hu,Weilong Chen,Zhencai Qu,Changan Xu,Qian Zhang,Kun Wu,Jun Shi,Mangeng Lu
In this work, we offered a facile strategy to produce lignin microspheres (LMS) with loading of benzotriazole (BTA) inhibitors, which were released as the pH changed. The morphological and compositional characterizations demonstrated that the BTA inhibitors were efficiently encapsulated in the LMS whose load was up to 15.5 wt %. Tests of crossed scratches of coatings indicated that the LMS@BTA/pure waterborne epoxy resin (WEP) had a good self-healing property. By the electrochemical impedance spectroscopy test, the long-term anticorrosion property of LMS@BTA/WEP composites was 1 order of magnitude higher than that of WEP, which indicated that LMS@BTA greatly improved the corrosion resistance. The highly effective anticorrosion should be attributed to the pH-responsive release behavior of BTA from LMS, which actively protected the steel substrate. The enhanced anticorrosion and the controlled release of BTA enlarged the high value-added applications of lignin.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）