A highly selective and sensitive method for recognition of Zn 2+ and hydrogen sulfide (H 2 S) in aqueous solution has been developed by using a quinoline fluorescent sensor functionalized magnetic silica nanoparticles ( R1 ). The chemosensor R1 shows excellent fluorescence sensitivity and selectivity toward Zn 2+ and H 2 S in aqueous media , and displays off–on–off type fluorescence change with alternately adding Zn 2+ and H 2 S to the media along with reversible association–dissociation of the complex. Furthermore, the magnetic nanocomposites can be easily separated from solutions by adding an external magnetic field . Finally, using Zn 2+ and H 2 S as inputs and the fluorescence intensity as output, an INHIBIT logic gate can be constructed at the nanoscale level.
In this article, three series of dihydrotriazine derivatives bearing a quinoline moiety ( 5a , 5b , 8a – 8c , and 9a – 9m ) have been designed, synthesized, and evaluated as antibacterial agents. Compounds 8a – 8c were found to be the most potent of all of the compounds tested with an MIC value of 1 μg/mL against several Gram-positive ( S. aureus 4220 and MRSA CCARM 3506) and Gram-negative ( E. coli 1924) strains of bacteria. In addition, 3-[4-amino-6-(phenethylamino)-2,5-dihydro-1,3,5-triazin-2-yl)-6-[(3-chlorobenzyl)oxy]quinolin-2-ol ( 8a ) showed potent inhibitory activity (MIC=2 μg/mL) against Pseudomonas aeruginosa 2742, indicating that its antibacterial spectrum is similar to those of the positive controls gatifloxacin and moxifloxacin. Structure-activity relationships (SAR) analyses and docking studies implicated the dihydrotriazine group in increasing the antimicrobial potency of the quinoline compounds. In vitro enzyme study implied that compound 8a also displayed DHFR inhibition. Graphical
危险品化学品经营许可证（带存储）