SENSORS AND ACTUATORS B-CHEMICAL
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2013
·
IF 3.535
Xin Tian,Zhengping Dong,Rou Wang,Jiantai Ma
A highly selective and sensitive method for recognition of Zn 2+ and hydrogen sulfide (H 2 S) in aqueous solution has been developed by using a quinoline fluorescent sensor functionalized magnetic silica nanoparticles ( R1 ). The chemosensor R1 shows excellent fluorescence sensitivity and selectivity toward Zn 2+ and H 2 S in aqueous media , and displays off–on–off type fluorescence change with alternately adding Zn 2+ and H 2 S to the media along with reversible association–dissociation of the complex. Furthermore, the magnetic nanocomposites can be easily separated from solutions by adding an external magnetic field . Finally, using Zn 2+ and H 2 S as inputs and the fluorescence intensity as output, an INHIBIT logic gate can be constructed at the nanoscale level.
研究领域:
分析化学
·
纳米技术
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2020
·
IF 1.943
Haibin Yuan,Hui Liu,Fen You,Xiaochao Shi
Palladium complexes bearing new tridentate quinolino-based [N − NN ox ] ligands were synthesized and tested for the polymerization of norbornene. Upon activation of MAO, all the palladium complexes showed high catalytic activities for the vinyl-addition polymerization of norbornene up to 11.5 × 10 6 g of PNB (mol of Pd) −1 h −1 . The structure–activity relationships in the polymerization of norbornene, namely steric and electric effects of the ligands, were carefully investigated.
研究领域:
有机化学
·
高分子化学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Miao Yu,Wei Wang,Ning Zhang
Quinoline based fluorescence sensor ( 1 ) was synthesized and characterized with mass spectra (MS), 1 H nuclear magnetic resonance ( 1 H NMR) spectrometer, elemental analyses, and infrared (IR) spectra. Following fluorescence experiments demonstrate 1 can coordinate with copper ions, and lead to fluorescence completely quenched. The 1 -copper complex was used as a “turn-on” fluorescence biosensor to convenient and highly effective detect nitric oxide (NO) over other radicals in solution and PCL-based thin film. The finding would enable the quinoline based fluorescence probe to be an “off–on” convenient NO fluorescence probe.
研究领域:
化学
·
生物学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Bibo Zhang,Haiyang Liu,Fengxu Wu,GeFei Hao,Yuzong Chen,Chunyan Tan,Ying Tan,Yuyang Jiang
A new and dual-response fluorescent probe (QLBM) based on quinoline and benzimidazole groups has been designed and developed for recognition of copper(II) ion (Cu 2+ ) and iron(III) ion (Fe 3+ ) simultaneously. This sensor displays a favorable selectivity for Cu 2+ and Fe 3+ ions over a range of other common metal cations in 100% aqueous medium (50 mM Tris buffer, pH 7.2), leading to prominent fluorescence on-off. The detection limits were 1.35 × 10 −7 M for Cu 2+ and 1.24 × 10 −7 M for Fe 3+ respectively. This dual-response fluorescent probe for Cu 2+ and Fe 3+ was distinguished by further reduction of the ascorbic acid. It is reported for the first time to use ascorbic acid to discriminate Cu 2+ and Fe 3+ by fluorescent probe technology. The recognizing mechanism of QLBM toward Cu 2+ and Fe 3+ has been investigated in detail by NMR, HR-MS and density functional theory (DFT) calculations. Moreover, further application of the sensor in fluorescence imaging was studied in HeLa cells due to the low cytotoxicity and good photophysical properties, suggesting that QLBM could be used as a fluorescent sensor for tracking Cu 2+ and Fe 3+ in cells.
研究领域:
分析化学
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生物医学工程
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细胞生物学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHIC SCIENCE
·
2020
·Vol. 58
·期 8
·687-694
·
IF 1.28
Ummiti Kumarswamy,Kumar J V Shanmukha
Ganirelix is a synthetic decapeptide linked with nine different amino acids. To understand the peptide amino acid sequence or primary structure, the first step is to determine the amino acid composition of the peptide which can be a determining factor for the peptide immunogenicity. Edman degradation is not a suitable analytical technique to identify amino acid sequence present in Ganirelix due to the absence of uncharged N-terminal amino group. To address this challenge, a pre-column derivatization method was developed with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate reagent. In the present work, the Ganirelix active pharmaceutical ingredient present in the injectable formulation was isolated by fraction collection and further purified by flash chromatography. The amino acid composition of Ganirelix is assayed by carrying out acid hydrolysis with 6 mol L−1 hydrochloric acid solution containing 1% phenol at 100°C for 24 h and derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate reagent solution, followed by determination of individual amino acids by reverse-phase chromatography using a C18 column. High resolution was achieved for the nine amino acid mixture. The amino acid composition results of temperature-stressed Ganirelix generic product and reference listed drug are in good agreement with the theoretical molar ratio of label information.
研究领域:
分析化学
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生物化学
·
药物分析
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Siying Che,Linlin Yin,Ming Chen,Yao Fan,Anni Xu,Chunsong Zhou,Haiyan Fu,Yuanbin She
Herein, a novel ionic fluorescent probe for mercury(II) detection is presented consisting of a functional quinoline-based IL. Interestingly, the probe displayed high sensitivity (0.8 nM) and selectivity through the regulation function of electrostatic attraction, where its performance was significantly superior to that of quinoline probes without negative charge. Furthermore, the probe was found to exhibit two different fluorescent signals and colorimetric signals in the presence of different concentrations of mercury(II), which was consistent with the reaction mechanisms of the generation of large conjugated systems and the formation of anion-mercury(II) complexes. Moreover, this probe could be further loaded on a simple filter paper to serve as a visual paper sensor due to its adequate response time of less than 5 s. This regulation function strategy of electrostatic attraction has excellent potential for use in the precise detection of targeted analytes in real complex samples with improved accuracy and selectivity.
研究领域:
分析化学
·
环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY & BIODIVERSITY
·
2019
·Vol. 16
·期 6
·e1900056
·
IF 1.449
Xueqian Bai,Ying Chen,Zhe Liu,Linhao Zhang,Tianyi Zhang,Bo Feng
In this article, three series of dihydrotriazine derivatives bearing a quinoline moiety ( 5a , 5b , 8a – 8c , and 9a – 9m ) have been designed, synthesized, and evaluated as antibacterial agents. Compounds 8a – 8c were found to be the most potent of all of the compounds tested with an MIC value of 1 μg/mL against several Gram-positive ( S. aureus 4220 and MRSA CCARM 3506) and Gram-negative ( E. coli 1924) strains of bacteria. In addition, 3-[4-amino-6-(phenethylamino)-2,5-dihydro-1,3,5-triazin-2-yl)-6-[(3-chlorobenzyl)oxy]quinolin-2-ol ( 8a ) showed potent inhibitory activity (MIC=2 μg/mL) against Pseudomonas aeruginosa 2742, indicating that its antibacterial spectrum is similar to those of the positive controls gatifloxacin and moxifloxacin. Structure-activity relationships (SAR) analyses and docking studies implicated the dihydrotriazine group in increasing the antimicrobial potency of the quinoline compounds. In vitro enzyme study implied that compound 8a also displayed DHFR inhibition. Graphical
研究领域:
药物化学
·
药理学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Yong-Po Zhang,Qing He,Xin-Hui Zhou,Guang-Huan Liu,Ai-Qin Yue,Chun-Yan Gao,Jin-Zhong Zhao,Wei-Jun Du,Shi-Ping Yan
Two new Cu(І) complexes, [Cu 2 (L 1 ) 2 (μ-Br) 2 ] (1) and [Cu 2 (L 1 ) 2 (μ-Cl) 2 ] (2) were synthesized from Cu(II) halogen salts and the reduced Schiff base ligand. Stable Cu(І) complexes were obtained via in situ reduction of Cu(II) to Cu(I) and the C N was oxidize to C = N in the ligand. The structures of two complexes were characterized by X-ray single crystal diffraction analysis as well as IR and UV–Vis spectra. The two complexes have potential antioxidant capacity and exhibit efficiently self-activated DNA cleavage activity and hydroxyl radical ROS cleavage mechanism. MTT was used to assay cytotoxicity of the complexes toward a series of tumor cell and HUVEC cell lines. Both complexes exhibited higher selective cytotoxicity against tumor cells than normal cells, which is significantly superior to the positive control. The complexes could induce cell apoptosis via mitochondrial pathway by increase of ROS levels and decrease of mitochondrial membrane potential (Δψ m ). Furthermore, the complexes can obviously inhibit the migration and invasion of the quiz tumor cells, as well as inhibit the angiogenesis of HUVEC cells.
研究领域:
化学
·
生物化学
·
分子生物学
·
癌症研究
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药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）