POLYMER
·
2012
·
IF 3.438
Aifang Luo,Xuesong Jiang,Jie Yin
Soybean oil containing thioxanthone (TX) moieties and/or coinitiator DBA (ESO-ATX-DBA, ESO-ATX/ESO-DBA) were synthesized by grafting 2-acitic thioxanthone (ATX) and 4-(dimetheylamino) benzoic acid (DBA) to the backbone of epoxidized soybean oil (ESO). The obtained ESO-ATX-DBA, ESO-ATX and ESO-DBA were characterized by FT–IR, 1 H NMR and UV–vis spectra, and investigated as photoinitiators by photo-DSC. Photoinitiator systems ESO-ATX-DBA and ESO-ATX/ESO-DBA were more efficient than their low-molecular weight analogues (chemical mixture of ETX-DBA and physical mixture of ETX/EDB) especially in the photopolymeriztion of acrylate monomers containing pigment. Moreover, ESO-ATX-DBA exhibited much lower migration in comparison with their low-molecular weight analogues. These characteristics gave the obtained TX containing soybean oil potential in the application of ink, and these studies also provide alternative approach to prepare polymeric photoinitiators from the renewable source.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Huijun Guo,Jie Chen,Siqi Li,Yifei Qi,Guoxin Wang,Yue Zhang
In this work, a ratiometric double signals electrochemical sensing platform was constructed for creatinine (Cre) analysis employing silver nanoparticles (AgNPs)@ MXenes/thionine acetate (THAT) composites. The synthesis of MXenes/THAT composites was utilized to modify on the surface of a screen-printed electrode (SPE) via dripping coating, followed by the electro-deposition of AgNPs. While the anodic current of the AgNPs decreased in the presence of Cre due to the competive reaction for forming metal complexes, the current of THAT remained invariant, which attained a ratiometric response. Under optimized conditions, the response current ratio ( I Ag /I THAT ) decreases while the concentration of Cre increased linearly between 0 ∼ 1.2 mM, with 0.01 μM as a adaptive detection limit. It provided a new sensing platforming for employing double-signals nanostructures with remarkable stability and sensitivity to design ratiometic sensors for analysis of Cre in human urine samples with real-time.
研究领域:
分析化学
·
生物医学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 66
·53342-53348
·
IF 3.84
Xiaoqing Dong,Peng Hu,Guigang Zhu,Zhiquan Li,Ren Liu,Xiaoya Liu
A series of photobase generators (PBGs), which contain thioxanthone as the chromophore and different quaternary ammonium salts as latent active species, were straightforwardly synthesized in two steps and their structures were characterized. Investigation on the photophysical properties of the PBGs indicated that the PBGs were photosensitive to long wavelengths due to the characteristic absorption of thioxanthone at 380 nm. A study on photolysis confirmed the photoinduced decarboxylation mechanism, through which the PBGs released active basic species efficiently. All the novel PBGs showed high activity in catalysing thiol–epoxy polymerization without postexposure baking. This is especially true for the PBG containing 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), which exhibited a faster polymerization rate and higher epoxy conversion than the previously described highly active PBG system.
研究领域:
材料化学
·
光化学
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产品关联
DOI
高影响因子
Polymers
·
2017
·Vol. 9
·期 9
·400
·
IF 3.364
Xiaoqing Dong,Peng Hu,Weizhen Shen,Zhiquan Li,Ren Liu,Xiaoya Liu
Photobase generator (PBG)-mediated thiol–epoxy photopolymerization has received widedspread attention due to its versatility in various applications. Currently, nearly all reported PBGs release amines as active species. The formed amines induce odor, yellowing, and potential toxicity. In this study, a series of novel thioxanthone-based PBGs, which were able to generate carbanion via decarboxylation under LED light irradiation, were designed and straightforwardly prepared. The formed carbanion can be used as a superbase to catalyze thiol–epoxy polymerization efficiently. Investigation on1H NMR and FT-IR confirmed the generation of carbanion intermediates. The counteranion significantly affected the photodecarboxylation efficiency. The study of photopolymerization tests, based on real-time FT-IR and dielectric analysis measurements, indicated that the generated carbanion exhibited faster polymerization rate and higher epoxy conversion than traditional superbase 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). In differential scanning calorimeter, thermogravimetric, and nanoindentation tests, comparable thermal and mechanical properties of the photocured films catalyzed by novel PBGs were obtained. The high initiation ability combined with straightforward synthesis makes these PBGs promising candidates for commercialization.Keywords:photopolymerization;thiol–epoxy;carbanion;superbase;decarboxylation;thioxanthone
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 94
·52324-52331
·
IF 3.708
Qingqing Wu,Ying Xiong,Qiuhong Liang,Hongding Tang
Three new amino-thioxanthone photoinitiators (PIs) with different substituents on nitrogen, including 2-allyl(methyl)amino-9H-thioxanthen-9-one (PI-1), 2-benzyl(methyl)amino-9H-thioxanthen-9-one (PI-2) and 2-butyl(methyl)amino-9H-thioxanthen-9-one (PI-3) were synthesized and characterized. They showed high molar extinction coefficients and very broad absorption range in the visible region. Among them, PI-2 showed the best visible light photoinitiating properties evidenced by the fact that it successfully initiated polymerization of 1,6-hexanedioldiacrylate (HDDA) under xenon light exposure (28 mW cm−2) both in the presence and absence of N,N-dimethylaniline (DMA) for 0.5 h with 92% and 52% conversion, respectively. For TMPTA, the conversion of PI-2 and PI-2/N-methyldiethanolamine (MDEA) systems is 32% and 62% under xenon lamp exposure for 10 min. The photoinitiation mechanisms were analysed through EPR, fluorescence spectra and visible light photolysis experiments.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 9
·6932-6938
·
IF 3.289
Yueyun Li,Yihe Zhang,Liping Jiang,Paul K. Chu,Ynhui Dong,Ping Wang
An ultrasensitive electrochemical immunosensor is designed and constructed for the quantitative detection of squamous cell carcinoma antigens (SCCAs). Silver nanoparticles (AgNPs) hybridized and 3-aminopropyltriethoxysilane functionalized graphene sheets (Ag@APTES-GS) serve as the platform to immobilize primary antibodies (Ab1). The mesoporous AgNPs-decorated silica KIT-6 (Ag@KIT-6) with a large specific surface area is utilized to label the electron mediator thionin (TH) and secondary antibodies (Ab2) by physical adsorption and chemical bonding. Carboxymethyl chitosan (CMC) doped with ionic liquids (ILs) is used to facilitate electron transfer and prevent leaking of TH resulting in multiple signal amplification. In addition to the excellent detection limit (17 fg mL−1, S/N = 3) and wide linear range (5 × 10−5 ng mL−1 to 102 ng mL−1), the immunosensor shows good selectivity, reproducibility, and stability. Providing quantitative detection of SCCA in serum, the sensor has great potential in clinical and diagnostic applications.
研究领域:
生物医学工程
·
诊断学
·
纳米技术
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 18
·14796-14804
·
IF 3.201
Xiaohui Gao,Rijun Gui,Kendrick Qizhou Xu,Huijun Guo,Hui Jin,Zonghua Wang
A novel and facile ratiometric electrochemical sensor was developed for the sensitive determination of uric acid (UA). Using one-step co-reduction of HAuCl4 and AgNO3 (as precursors) under cyclic voltammetry scanning, gold–silver bimetallic nanoparticles (Au–Ag NPs) were electrodeposited on the surface of a glassy carbon electrode (GCE). Through electrostatic interactions, self-assembly of graphene oxide (GO) and thionine (TH) occurred to form a GO–TH complex. The complex was drop-coated on Au–Ag NPs to prepare the Au–Ag NPs/GO/TH@GCE sensing platform through interactions among different components. The electrochemical signal responses of the sensing platform were recorded by square wave voltammetry measurements. With the increase of UA concentration [UA], the redox current peak intensity of UA (IUA at 0.46 V) increased regularly and that of TH (ITH at −0.28 V) was almost unchanged. The relationship between IUA/ITH and [UA] (1–100 μM) was linearly plotted (R2 = 0.9929), with a low detection limit of 0.3 μM. A facile sensor was fabricated based on the sensing platform and enabled sensitive ratiometric electrochemical sensing of UA in real human serum and urine fluids, over potential interferents. The experimental results confirmed high detection stability and recoveries of this sensor, indicating its high feasibility for UA detection in biological fluids.
研究领域:
生物医学工程
·
分析化学
✓ 已验证
DOI
高影响因子
Pharmaceutics
·
2020
·Vol. 12
·期 2
·111
·
IF 4.421
Weinan Li,Jialin Sun,Xiaoyu Zhang,Li Jia,Mingxi Qiao,Xiuli Zhao,Haiyang Hu,Dawei Chen,Yanhong Wang
PEG-poly(β-amino ester) (PEG-PBAE), which is an effective pH-responsive copolymer, was mainly synthesized by Michael step polymerization. Thioridazine (Thz), which was reported to selectively eliminate cancer stem cells (CSCs), was loaded into PEG-PBAE micelles (PPM) prepared by self-assembly at low concentrations. The critical micelle concentrations (CMC) of PPM in water were 2.49 μg/mL. The pH-responsive PBAE segment was soluble due to protonated tertiary amine groups when the pH decreased below pH 6.8, but it was insoluble at pH 7.4. The Thz-loaded PEG-PBAE micelle (Thz/PPM) exhibited a spherical shape, and the drug loading was 15.5%. In vitro release of Thz/PPM showed that this pH-sensitivity triggered the rapid release of encapsulated Thz in a weakly acidic environment. The in vitro cytotoxicity and cellular uptake of various formulations at pH 7.4 and 5.5 were evaluated on the mammospheres (MS), which were sorted by MCF-7 human breast cancer cell lines and identified to be a CD44+/CD24−phenotype. The results of the cytotoxicity assay showed that blank micelles were nontoxic and Thz/PPM exhibited a similar anti-CSC effect on MS compared to Thz solution. Stronger fluorescence signal of Coumarin-6 (C6) was observed in MS treated by C6-loaded PPM (C6/PPM) at pH 5.5. The tumor inhibition rate and tumor weight of the free DOX and Thz/PPM groups were significantly different from those of the other groups, which free DOX and Thz/PPM effectively suppressed breast tumor growth in vivo. The above experimental results showed that Thz/PPM is an ideal and effective pH-responsive drug delivery carrier to a targeted therapy of CSCs.Keywords:poly(β-amino ester);polymeric micelles;pH-responsive;cancer stem cells;thioridazine
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2019
·Vol. 11
·期 4
·695
·
IF 3.164
Qingqing Wu,Wen Liao,Ying Xiong,Jianjing Yang,Zhen Li,Hongding Tang
A silicone-thioxanthone (STX) visible light photoinitiator was prepared by the nucleophilic substitution reaction of 2-[(4-hydroxybenzyl)-(methyl)-amino]-9H-thioxanthen-9-one (TX-HB) and γ-chloropropylmethylpolysiloxane-co-dimethyl-polysiloxane (PSO-Cl). Its structure was confirmed by1H NMR,13C NMR, FTIR, UV-vis and GPC. The photopolymerization kinetics of 1, 6-Hexanedioldiacrylate (HDDA) and trimethylolpropane triacrylate (TMPTA) initiated by STX confirmed that STX is an efficient photoinitiator. Its visible light photolysis experiment and the photopolymerization kinetics studies implied that a possible synergistic effect existed between two adjacent thioxanthone groups. Moreover, a higher migration stability was revealed in STX than 2-benzyl (methyl) amino-9H-thioxanthen-9-one (TX-B). STX could change the surface property of the cured film of polyurethane diacrylate prepolymer (PUA) from hydrophilic to hydrophobic, as well as change the thermal stability of the polymer network. Meanwhile, it could improve the resistance against water and acid. Thus, STX is an effective multifunctionalized photoinitiator.Keywords:photopolymerization;visible light photoinitiator;silicone;thioxanthone;modification;thermal stability;resistance against water/acid
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2012
·
IF 5.602
Limei Zhu,Liqiang Luo,Zhenxin Wang
A novel protocol for development of DNA electrochemical biosensor based on thionine-graphene nanocomposite modified gold electrode was presented. The thionine-graphene nanocomposite layer with highly conductive property was characterized by scanning electron microscopy, transmission electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy. An amino-substituted oligonucleotide probe was covalently grafted onto the surface of the thionine-graphene nanocomposite by the cross-linker glutaraldehyde. The hybridization reaction on the modified electrode was monitored by differential pulse voltammetry analysis using an electroactive intercalator daunomycin as the indicator. Under optimum conditions, the proposed biosensor exhibited high sensitivity and low detection limit for detecting complementary oligonucleotide. The complementary oligonucleotide could be quantified in a wide range of 1.0 × 10 −12 to 1.0 × 10 −7 M with a good linearity ( R 2 = 0.9976) and a low detection limit of 1.26 × 10 −13 M (S/N = 3). In addition, the biosensor was highly selective to discriminate one-base or two-base mismatched sequences.
研究领域:
生物化学
·
纳米技术
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2013
·Vol. 160
·期 8
·B102
·
IF 2.588
Qian Han,Yonghua Wang,Yihan Huang,Liju Guo,Yingzi Fu
In the present study, a novel approach was designed to construct a reagentless chiral biosensor for highly selective recognition of N-isobutyryl-cysteine enantiomers. The reduced-graphene oxide sheets (rGO) and thionine (TH) were firstly stepwisely synthesized onto modified glassy carbon electrode using glutaraldehyde as a bifunctional reagent, and γ-globulin was adsorbed on the electrode surface as a chiral selector. TH-rGO with excellent redox electrochemical activities brought in more redox probes for chiral recogniton, which could improve the sensitivity of the biosensor. Good reproducibility and sufficient stability were obtained with the advantages of TH-rGO and glutaraldehyde reagent. Moreover, the proposed biosensor showed an obviously decreased current peak after adsorption of N-isobutyryl-L-cysteine isomer. As compared with penicillamine or cysteine enantiomers, the current biosensor showed good enantioselectivity for sensing N-isobutyryl-cysteine enantiomers.
研究领域:
分析化学
·
生物传感技术
·
电化学
✓ 已验证
DOI
高影响因子
Frontiers in Bioscience-Landmark
·
2024
·Vol. 29
·期 4
·132
·
IF 3.3
Wentao Lin,Yong Xia,Anqi He,Shuang Chen,Jie Zhang
Background: The incidence of melanoma brain metastasis (MBM) is high and significantly compromises patient survival and quality of life. Effective treatment of MBM is made difficult by the blood-brain barrier (BBB), since it restricts the entry of drugs into the brain. Certain anti-psychotic drugs able to cross the BBB have demonstrated efficacy in suppressing brain metastasis in preclinical studies. However, the activity of zuclopenthixol against MBM is not yet clear. Methods: Cell viability assays were employed to investigate the potential of zuclopenthixol in the treatment of MBM. Subsequently, the mechanism of action was investigated by RNA-sequencing (RNAseq), flow cytometry-based cell cycle and apoptosis assays, protein expression analysis, and autophagy flux detection. Additionally, the efficacy of zuclopenthixol against tumor growth was investigated in vivo, including MBM models. Results: Zuclopenthixol inhibited the proliferation of various melanoma cell lines at minimal doses by causing cell cycle arrest in the G0/G1 phase and mitochondrial-mediated intrinsic apoptosis. Zuclopenthixol also induced cytoprotective autophagy, and inhibition of autophagy enhanced the anti-melanoma effects of zuclopenthixol. Furthermore, zuclopenthixol inhibited the growth of human melanoma tumors in nude mice, as well as the growth of intracranial metastases in a mouse model of MBM. Conclusions: These results demonstrate that zuclopenthixol has significant potential as an effective therapeutic agent for MBM.
研究领域:
肿瘤学
·
药理学
·
神经科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）