Oxidative Medicine and Cellular Longevity
·
2023
·
IF 7.31
Hongwei Shi,Liang Duan,Ying Lan,Quan He,Peng Pu,Heng Tang
Pirarubicin (THP) is one of the classic chemotherapy drugs for cancer treatment. It is often clinically limited because of its cardiotoxicity. The occurrence and development of THP-mediated chemotherapy-related cardiotoxicity (CRC) may be reversed by RING finger protein 10 (RNF10). This study was performed with the aim of evaluating the inhibitory effect of RNF10 on THP-mediated CRC and its molecular mechanism. In vivo, we found that the expression of RNF10 decreased in THP-induced CRC rats, accompanied by Meox2 inhibition and AP-1 activation, resulting in increased cardiomyocyte apoptosis. After small interfering RNA (siRNA) and lentivirus transfection (Lv) of RNF10 in vitro, the expression of RNF10, Meox2, and AP-1 proteins and the degree of cardiomyocyte apoptosis were detected. We found that overexpression of RNF10 in H9C2 cardiomyocytes significantly promoted Meox2 and inhibited AP-1, alleviated apoptosis, and showed further inhibitory activity on THP-induced cardiomyocyte toxicity. Silencing RNF10 showed the opposite result. Our study showed that RNF10 inhibited THP-induced CRC through the activity of Meox2 and AP-1 proteins. RNF10 may be the next drug target for the treatment of CRC and other related cardiovascular diseases.
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PubMed
高影响因子
Biomaterials Science
·
2023
·Vol. 11
·期 14
·4948-4959
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IF 6.6
Lulu Wang,Fan Qi,Luopeng Bi,Jiao Yan,Xiaoqing Han,Yanjing Wang,Panpan Song,Yanbo Wang,Haiyuan Zhang
Bladder cancer (BC), such as non-muscle invasive bladder cancer (NMIBC), has a significantly high recurrence rate even after intravesical therapy because traditional intravesical chemotherapeutic drugs have short retention time in the bladder and lack efficient uptake in BC cells. Pollen structure usually shows potent adhesion ability to tissue surfaces, different from traditional electronic interaction or covalent binding. 4-Carboxyphenylboric acid (CPBA) has high affinity to sialic acid residues that are overexpressed on BC cells. In the present study, hollow pollen silica (HPS) nanoparticles (NPs) were prepared and modified with CPBA to form CHPS NPs, which could be further loaded with pirarubicin (THP) to form THP@CHPS NPs. THP@CHPS NPs showed high adhesion to skin tissues and could be more efficiently internalized by a mouse bladder cancer cell line (MB49) than THP, inducing more significant apoptotic cells. After intravesical instillation into a BC mouse model through an indwelling catheter, THP@CHPS NPs could more significantly accumulate at the bladder than THP at 24 h post-instillation, and after 8 days of intravesical treatments, magnetic resonance imaging (MRI) revealed that the bladders treated with THP@CHPS NPs showed more smooth bladder lining and more reduction in size and weights than those with THP. Moreover, THP@CHPS NPs exhibited excellent biocompatibility. THP@CHPS NPs hold great potential for intravesical treatment of bladder cancer.
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PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2023
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IF 3.8
Hongji Liu,H. C. Stephen Chan,Xinyi Yu,Jianting Li,Jiaquan Li,Zhengzheng Zhou
In this study, the crystal structures of 1:1 theophylline–ferulic acid cocrystal polymorphs are reported for the first time. Interestingly, both forms crystallize in the same space group but with a different number of molecules in the asymmetric unit (form I = 2; form II = 4). The two polymorphs show distinct crystal morphology, demonstrating prism and rod single crystals, respectively. Theoretical calculations are performed to predict their morphology and thermodynamic stability (form I > form II). The prediction result agrees well with the measured pharmaceutical properties. Form I presents better hygroscopic stability (RH < 95%), slower dissolution, and lower solubility (1.06 ± 0.03, 1.63 ± 0.01, 1.30 ± 0.08 and 4.09 ± 0.05 mg/mL in water, pH = 1.2, pH = 4.5 and pH = 6.8 buffered solutions) over form II (8.45 ± 0.33, 2.41 ± 0.17, 3.46 ± 0.26 and 28.71 ± 0.87 mg/mL in water, pH = 1.2, pH = 4.5 and pH = 6.8 buffered solutions). In summary, this work elucidates the experimental findings with relevant predictions systematically and enriches our understanding of the structure–property relationship of the theophylline cocrystal system.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 15
·6856-6864
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IF 3.591
Hao Li,Xiaomei Song,Pengfei Li,Wen Li,Ting Wang,Liting Qin,Juying Zhou,Fuhou Lei
Rosin-based polymer microspheres (RPMs) as stationary phases in HPLC were prepared using methyl acrylic acid as the functional monomer, ethylene glycol maleic rosinate acrylate as the cross-linker, and a carboxylic group as the major functional group. The obtained RPMs were characterized by different analytical techniques. The results indicated that the RPMs have a regular spherical shape with porous surfaces, an average particle size of 5.5 μm, a surface area of 96.73 m2 g−1, and an average pore size of 11.68 nm. Moreover, the RPMs displayed good thermal stability. Theophylline, caffeine, tetrahydropalmatine, and berberine hydrochloride were used as probes to study the separation properties of alkaloids and their analogs on an RPM chromatographic column. Theophylline/caffeine and tetrahydropalmatine/berberine hydrochloride were separated by a rosin-based chromatographic column under optimum chromatographic conditions, and their resolution factors were 5.29 and 3.72, respectively. Furthermore, the chromatographic thermodynamics and separation mechanism were also studied. Thermodynamic data obtained by van’t Hoff plots showed that their separation on the RPM chromatographic column was an enthalpy-driven exothermic process. Microcalorimetry and zeta potential were employed to investigate the separation mechanism of the binding of alkaloids to the rosin-based polymer surface. The RPM and theophylline (or caffeine) interact through hydrogen bonding interactions, whereas the interactions between the RPM and tetrahydropalmatine (or berberine hydrochloride) arose from hydrogen bonding and electrostatic attraction.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 75
·71351-71359
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IF 3.289
Haihang Wang,Haiyun Zhai,Zuanguang Chen,Zhixian Liang,Shumei Wang,Qing Zhou,Yufang Pan
A novel electrochemical sensor was designed to determine tetrahydropalmatine (THP) by using a nickel nanoparticles deposited on sulfonated graphene sheets-modified glassy carbon electrode (NiNPs/SGS/GCE). The components and morphological properties of the NiNPs/SGS nanocomposites were investigated by scanning electron microscopy. The anodic peak current (Ipa) of THP at the GCE modified with NiNPs/SGS was much higher than those at the bare GCE and SGS/GCE due to the enhanced effect of the modified nanomaterials. Differential pulse voltammetry (DPV) disclosed a good linear relationship between Ipa and concentrations of THP (0.50–20.0 μM), with a limit of detection of 0.17 μM. Finally, the modified electrode was successfully applied for the determination of THP in Yuanhu Zhitong capsules.
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Advanced Energy Materials
·
2024
·
IF 24.4
Shiwei Xu,Yue Liu,Yejing Li,Mengyan Cao,QingLi Wu,Bingyun Ma,Jiayi Zhang,Qiu Fang,Liquan Chen,Zhaoxiang Wang,Tao Cheng,Xuefeng Wang
Organolithium solutions, especially Li-arene solutions (LASs) with high reactivity and controllable redox potentials, have gained significant attention because of their wide applications in chemical lithiation, liquid anodes, and battery recycling. However, the sudden loss of reactivity when stored or applied at room temperature is still puzzling and inhibits the application of LASs. In this work, the degradation mechanism of LASs is fully investigated and revealed by combining various experimental characterization and computational simulations. A hierarchical reaction mechanism for lithium biphenyl/2-methyl tetrahydrofuran (Li-Bp-2MT), a lithiation solution used for most anodes, explains degradation and side product formation. Specifically, the dimerization of the active component Li 1 Bp[2MT] 1 forms an inactive dimer that is irreversibly reduced in the presence of locally accumulated highly reductive Li 0 . This reaction mechanism reveals the atomic origins of lithiation solution deactivation and accounts for all solid and gaseous byproducts. LiH is identified as the dominating solid byproduct, indicating irreversible destruction of the active components and facilitating side reactions producing H 2 and CH 4. Based on reaction mechanism insights, modifying molecular interactions and reaction kinetics are experimentally shown to inhibit Li 0 aggregation kinetics, enhancing long-term prelithiation performance. This research provides comprehensive guidelines for practical applications of LASs.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xinrong Li,Shuliang Chen,Zihui Dai,Xianzhi Hu,Futing Zi
The selective recovery of gold ions from gold leaching solutions limits the industrial application of the copper-ammonia (Cu 2+ –NH 3 )-thiosulfate system. Here, the influence of the carbon chain length of organic phosphines on the selective recovery of gold ions was studied, and an extractant (trihexylphosphine, THP) that is suitable for the selective recovery of gold ions from a Cu 2+ –NH 3 -thiosulfate leaching solution was screened. The selectivity of organic phosphines with different carbon chain lengths for gold ions was C 8 = C 6 > C 4 > C 3 > C 2 , and when the number of carbon atoms in a single carbon chain was at least six, the selective recovery of gold ions from the Cu 2+ –NH 3 -thiosulfate solution was realized. THP completely recovered low concentration gold ions (6.73 mg/L) in the Cu 2+ –NH 3 -thiosulfate gold leaching solution regardless of the pH. The mechanism of gold ion extraction into the organic phase mainly involved ligand exchange between THP and [Au(S 2 O 3 ) 2 ] 3− . Job’s method and density functional theory calculations confirmed that the composition ratio of the complex formed by THP and Au was 2:1 at the practical and theoretical levels, respectively. Finally, Multiwfn and VMD were used to visually predict the possible reaction sites in THP. This study provides an exact method for the selective recovery of gold ions from thiosulfate-based gold leaching solutions, which will promote the development of thiosulfate-based gold leaching systems.
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高影响因子
Small
·
2025
·
IF 12.1
Hongyu Lv,Qian Yao,Cheng Zheng,Yanan Sun,Zhao Qian,Zhikai Wei,Fang Xie,Rajeev Ahuja,Jian Yang
Sodium-ion batteries (SIBs) are attractive for large-scale energy storage and have to work at a wide temperature range. Compared to the performance at room temperature, the low-temperature performance of SIBs is always poor. Herein, tetrahydrofuran (THF) and 2-methyltetrahydrofuran (MTHF) are mixed as a model of weak solvating effect to improve the low-temperature performance. In the mixed electrolyte, the anion-dipole expulsion and steric hindrance in the solvation sheath increase, which weakens the cation-dipole attraction and reduces the desolvation energy. Meanwhile, the weak dipole-dipole interaction between THF and MTHF lowers the electrolyte viscosity and improves the ionic conductivity. The change in the solvation structure also results in an entropy increase, facilitates the cleavage of P-F in PF 6 ‾ , and the formation of NaF-rich solid electrolyte interphase (SEI). Using commercial Sn microparticles as a model, the mixed electrolyte enables them to deliver a capacity of 328 mAh g −1 after 1000 cycles at −40 °C, much better than the cases only using THF or MTHF alone. The electrolyte can be also successfully adapted to Bi and hard carbon, confirming its good compatibility with different anode materials. These results provide an in-depth understanding of low-temperature electrolytes for advanced sodium-ion batteries.
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PubMed
高影响因子
Energy & Environmental Materials
·
2025
·
IF 14.1
Yinlin Shen,Kangjie Xu,Zhirong Zhao-Karger,Xiangyu Zhao
Magnesium batteries are attracting growing interest as next-generation energy storage technology due to their high safety, cost-effectiveness, and resource abundance. However, their development remains limited by sluggish Mg 2+ transport kinetics at the electrode/electrolyte interface. Herein, we propose an electrolyte design strategy that modulates the Mg 2+ solvation structure by introducing tetrahydrofuran (THF) as a co-solvent into a borate-based electrolyte, Mg[B(hfip) 4 ] (MBF) in dimethoxyethane (DME). THF, selected from a series of linear and cyclic ethers, has a comparable dielectric constant and donor number to DME, but its cyclic structure introduces steric hindrance that induces competitive coordination with Mg 2+ . This competition weakens Mg 2+ − solvent interactions, yielding a more labile solvation structure and enhanced desolvation kinetics. As a result, Mg||Mg cells employing the optimized MBF/1D1T electrolyte (DME: THF = 1:1, v:v) exhibit a significantly reduced Mg plating/stripping overpotential of 120 mV at 10 mA cm −2 , compared with 316 mV at 8 mA cm −2 with MBF/DME, along with exceptional cycling stability exceeding 1200 h. Furthermore, representative sulfide cathodes such as CuS and VS 4 demonstrate faster activation and improved high-rate performance in the presence of MBF/1D1T.
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Molecular Catalysis
·
2024
·
IF 3.9
Ming Li,Ruixia Liu,Qi Liu,Ying Liu,Yifan Liu,Qian Su,Yunong Li,Zifeng Yang
Heterogeneous ionic liquid (IL) catalysts with multiple active sites can be considered as the highly efficient catalyst for CO 2 conversion to cyclic carbonates. It is extremely challenging to achieve the strategic design and precise control of multi-site polymeric ILs’ morphology and properties. In this work, we developed a novel and facile polymerization-ionization method employing flexible brominated monomers as raw materials ( e.g. 4‑bromo-1-butene) to successfully synthesize porous hyper-cross-linked phosphonium bromide-microspheres (PBr-microspheres), in order to break through the drawbacks of multi-step preparation and difficulty in microsphere forming. Compared with conventional bromine spheres of the same size, the specific surface area of the new synthetic bromine sphere is 16 times, and the average pore size is one-eighth, with 3-times CO 2 adsorption capacity, with rich microporous structure and exposed active sites, excellent CO 2 adsorption capacity and thermal stability. PBr-microspheres can achieve synergistic effect of physical adsorption and chemical interaction for CO 2 , thus enhancing the catalytic performance in CO 2 conversion process, affording propylene oxide conversion of 99.7 % and propylene carbonate selectivity of 99.9 %, while the catalytic activity did not decrease significantly after reusing 8 runs. This facile controllable synthesis of PBr-microspheres with excellent catalytic performance provides a new idea for heterogeneous ILs-catalyzed CO 2 utilization.
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高影响因子
危险品化学品经营许可证（带存储）