PHYTOMEDICINE
·
2018
·
IF 3.61
Zhi-Shu Tang,Yan-Ru Liu,Yang Lv,Jin-Ao Duan,Shi-Zhong Chen,Jing Sun,Zhong-Xing Song,Xiao-Min Wu,Li Liu
Background Common farming environmental elements, such as longitude, latitude, and altitude, and physiological conditions, such as age and body weight, are thought to influence medicinal animal homeostasis and material quality by altering endocrine functions for primary and secondary metabolite formation. However, the currently available methods for evaluating complex components of traditional Chinese animal medicines have insufficient sensitivity and specificity. Purpose Characterizing the primary/secondary metabolomes of medicinal animals is essential for understanding their material basis, controlling product quality, and reflecting on distribution interactions. Therefore, this study aimed to screen ecological- and physiological-related metabolites in captive Moschus berezovskii throughout the collection period based on the quality marker (Q-marker) concept. Study design and methods Fifty-one musk deer samples from 12 different distribution farms ranging in age from 2 to 11 years were enrolled. Differentially expressed musk metabolites were assessed via chromatography-tandem mass spectrometry technologies. A metabolome that mapped connections among these factors was established using chemometric and topological calculations. Results Statistical analysis revealed that muscone , cis-9-hexadecenal, antioxidant 2264, prasterone-3-sulfate, androstan-17-one, and 1,2-benzenedicarboxylic acid showed significantly altered expression. Partial least squares (PLS) regression analysis of qualified data for these 6 secondary metabolites (active components) demonstrated that age is the most important factor underlying the varying levels of muscone, androstan-17-one and 1,2-benzenedicarboxylic acid. Furthermore, weight was the most important factor for cis-9-hexadecenal, longitude was important for antioxidant 2264, latitude was important for prasterone-3-sulfate, and altitude was important for antioxidant 2264, androstan-17-one and 1,2-benzenedicarboxylic. Metabolite analysis within the MetaboAnalyst (MetPA) suite showed that 18 candidate biomarker metabolites were screened, including allantoin , glycine, serine , creatine, alanine , taurine, lactate, 2-oxoglutarate (2-OG), fumarate , proline , xanthine , cytosine , carnitine , arginine, threonine , aspartate , and urea. Metabolic network analysis showed 4 important pathways that were involved: arginine and proline metabolism, the urea cycle , aspartate metabolism, and glycine, serine and threonine metabolism. Conclusion Using this combined metabolomic and chemometric approach, this study was successful in screening Q-markers for musk quality control and provided new insights into correlations among “ecological & physiological factors→Q-markers→metabolites”, which potentially provides crucial information for musk breeding and material quality control.
研究领域:
动物药学
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代谢组学
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中药学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 8
·1717
·
IF 4.6
Chenghong Ao,Mai Shan,Yue Zhang,Xiang Li,Ying Kong,Xinwei Dong,Yang Liu,Danping Wu
Biochar has attracted considerable interest owing to its high adsorption capacity; however, the mechanisms through which environmental factors influence the release of adsorbed pollutants remain unclear. This study investigates the adsorption and desorption dynamics of Rhodamine B (RhB) on biochars B2 and B6, which were pyrolyzed at temperatures of 200 °C and 600 °C, respectively, under varying conditions. The results indicated that there was no significant difference in removal efficiency at low RhB concentrations; however, at a concentration of 600 mg/L, biochar B2 had a higher removal efficiency than B6, likely attributable to more adsorption sites. Increased temperatures were found to enhance desorption from both B2 and B6, with B6 exhibiting a faster desorption rate. This phenomenon may be due to the stronger hydrogen bonding between B2 and RhB, which could inhibit desorption. In addition, elevated pH values facilitated desorption, presumably through electrostatic repulsion. Under alkaline conditions, B2 released a greater amount of dissolved organic matter (DOM), leading to increased RhB desorption relative to B6. This study offers a valuable reference for evaluating the environmental risk associated with the application of biochar in real-world settings.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2017
·Vol. 22
·期 12
·2250
·
IF 2.861
Umair Muhammad,Hedong Lu,Juan Wang,Jinzhi Han,Xiaoyu Zhu,Zhaoxin Lu,Sultana Tayyaba,Yousef I. Hassan
This work provides an optimized extraction approach intended to maximize the recovery of dihydromyricetin (DHM) from Chinese vine tea (Ampelopsis grossedentata) leaves. The presented work adopts a Box-Behnken design as a response surface methodology to understand the role and influence of specific extraction parameters including: time, temperature, and solvent composition/ethanol (%) on DHM final yields. Initially, single factor experiments were used to delineate the role of above factors (temperature, time, and solvent composition) before proceeding with three factors-three levels Box-Behnken design with 17 separate runs to assess the effect of multifactorial treatments on DHM recovery rates. The collected data shows that independent variables (solvent composition, time, and temperature) can significantly affect DHM recovery rates with maximum yields resulting from a combined 60 °C, 60% aqueous ethanol, and 180 min treatment. From the empirical point of view, the above optimized extraction protocol can substantially enhance processing and profitability margins with a minimum need of interventions or associated costs.Keywords:dihydromyricetin;extraction;factors;temperature;solvent;time
研究领域:
药学
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化学工程
·
植物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Menglan Gao,Zhibin Jiang,Xiaobin Liao,Huan Qi,Lei Zhao,Chao Chen,Danielle Westerman
Aliphatic amines, common constituents that contribute to dissolved organic nitrogen (DON), can quickly react with ozone due to the lone electron pair on the nitrogen atom and this may produce carcinogen N -Nitrosodimethylamine (NDMA). 3-(Dimethylamino)-1-propylamine (DMAPA) was chosen as a representative to elucidate the NDMA formation characteristics, kinetic rates, reaction pathways, and influencing factors during ozonation in this study. The results demonstrated that NDMA generated directly from DMAPA during ozonation. Moreover, the NDMA yields increased with ozone dosages. The NDMA molar yield increased and then decreased when the pH raised from 5 to 9, achieving the maximum value at pH 8. Hydroxyl radical (∙OH) played a promotional role in NDMA formation, and its scavenger dramatically cut down its yields. Low levels of Br − facilitated NDMA formation, while the value significantly reduced when Br − was up to 1 mM. The NDMA amount was slightly raised by NO 2 − , but it was inhibited by NH 4 + and NO 3 − . Moreover, it was also depressed by co-existing components in actual lake water. Based on the result of the Gaussian calculation, the LC-MS/MS and GC–MS analysis, four possible transformation pathways were proposed. The radical recombination was verified to be the primary pathway for ozone promoting NDMA formation from DMAPA.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
·
2023
·
IF 13.1
Oluwadamilola Pikuda,Eva Roubeau Dumont,Qiqing Chen,Jun-Ray Macairan,Stacey A. Robinson,Dimitrios Berk,Nathalie Tufenkji
We conducted a systematic review of 124 published articles that investigated the toxicity of microplastics and nanoplastics to Daphnia magna . This review summarizes studies assessing acute, chronic, and multigenerational impacts, as well as the effects observed via leached chemicals from plastics and the role of plastics as contaminant vectors. Overall, observed toxicity varies across different polymer types, and shapes. One of the most visible findings is that targeted research synthesis of the acute toxicity tests found more toxicity in smaller-sized particles. Most studies use spherical plastics that are commercially available, especially polystyrene, while the use of irregular-shaped and/or secondary plastics is still emerging. Also, there are still various confounding factors that make the comparison of the observed results difficult. Future studies should focus on irregular-shaped particles, and other polymer types, besides polystyrene. More research efforts are needed to understand the impacts of environmental factors and complex matrices.
研究领域:
生态毒理学
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环境科学
✓ 已验证
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Jian-jun Lian,Shun Jiang,Hua-fei Si,Qiong-jie Wang,Hong-yan Wu,Xin-zhu Hong,Qiao-ping Kong,Bo Chen
Microplastics (MPs), as a common “vector” of pollutants in the aquatic environment, have a significant impact on the migration and transformation of heavy metals. In order to explore the mechanism and the influencing factors of the adsorption behavior of microplastics (MPs) on selenium (Se) in aqueous solution under the coexistence of nanoparticles, polystyrene microplastics (PS), nano-titanium dioxide particles (TiO 2 ) and their coexisting compounds (PS+TiO 2 ) were used as adsorbents to investigate the adsorption kinetics, isotherms and thermodynamic processes of Se. The effects of pH, humic acid concentration and coexisting ions on the adsorption behavior of Se(VI) were also analyzed. The results showed that the adsorption process of Se(VI) by PS and PS+TiO 2 could be well fitted by pseudo-second-order kinetic model and Freundlich isotherm model, and it was an endothermic reaction with increased entropy. The adsorption capacity of Se(VI) by PS, TiO 2 , and PS+TiO 2 were decreased with the increase of solution pH. Humic acid and Ca 2+ promoted the adsorption of Se(VI), while PO 4 3- significantly inhibited the adsorption of Se(VI) in the above three systems. The main adsorption mechanism of PS on Se(VI) was electrostatic adsorption and hydrogen bonding. The TiO 2 adsorbed on the surface of PS mainly affected the adsorption behavior of PS on Se(VI) through hydrogen bonding.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
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2023
·Vol. 98
·期 4
·1014-1024
·
IF 3.4
Diantong Li,Jiayu Li,Balijiang Yeerhazi,Yongtao Cheng
BACKGROUND With the rapid development of modern industry and agriculture, large amounts of sewage of various types are being discharged into water bodies every year, causing huge environmental pressure and posing a threat to organisms. Amongst different solutions to this problem, microalgae can remove pollutants including pesticides and antibiotics from water . In this work, an algal strain designated as Scenedesmus sp. TXH. was isolated from the Tangxun Lake Sewage Treatment Plant (Wuhan, China) and used to remove imidacloprid (IMI) from sewage. The removal efficiency, degradation products, removal of conventional contaminants [total dissolved nitrogen (TDN) ammonia nitrogen (NH 4 + -N), total dissolved phosphorus (TDP)], the biochemical response of the microalgae, and the effects of environmental factors such as light intensity and temperature were investigated. RESULTS The results showed that: (i) the highest IMI removal efficiency of ≈60% was achieved under 80 μmol m −2 s −1 at 25 °C; (ii) the removal of NH 4 + -N, TDP and TDN in the sewage reached 90%, 90% and 65%, respectively; (iii) there was a significant linear relationship between the concentration of total chlorophyll and the removal of IMI in the sewage; and (iv) finally, based on the analysis of degradation products by mass spectrometer, three potential IMI degradation pathways were proposed. CONCLUSION In summary, our results showed that Scenedesmus sp. TXH can remove IMI and conventional nutrients efficiently from sewage, implying a potential application in sewage treatment in the near future. © 2023 Society of Chemical Industry (SCI).
研究领域:
环境科学
·
微生物学
✓ 已验证
DOI
高影响因子
Agronomy-Basel
·
2024
·Vol. 14
·期 12
·2959
·
IF 3.3
Zhijia Cheng,Zhongbin Lu,Zhiwei Shao,Bowen Huang,Yang Xiong,Hongqiang Fei,Xian Wu,Yanwei Liu,Mei Li,Zhiguang Hou,Zongzhi Lu
The photolysis kinetics of propaquizafop in water under ultraviolet light was investigated in this study, and the effects of different influencing factors (pH,NO3−, metal ions) on the photolysis of propaquizafop were clarified. Propaquizafop residues in water were determined by a HPLC-UV detector. The results showed that the pH of the aqueous solution had no significant effect on the photolysis of propaquizafop (p< 0.05). The lowNO3−, concentration (0.5~2 mmol/L) had a weak inhibitory effect on the photolysis of the propaquizafop; when the concentration ofNO3−was 4 mmol/L, the degradation half-life of the propaquizafop was significantly higher than with other treatments (p< 0.05); Different concentrations of Fe3+had varying degrees of inhibitory effects on the photolysis of propaquizafop. The inhibitory effect was stronger at low concentrations (0.5 mmol/L and 1 mmol/L) and weaker at high concentrations (2 mmol/L and 4 mmol/L). As the concentrations of Cu2+, Cd2+, Mn2+, Zn2+, and Ni2+increased, their inhibitory effect on the photolysis of propaquizafop in an aqueous solution became stronger. In addition, LC–QTOF-MS was used to identify the photoproducts of propaquizafop in aqueous solution in this study. Five types of photoproducts were identified, and several propaquizafop degradation pathways and mechanisms were proposed, mainly including rearrangement, cracking reactions, dechlorination reactions, and light-induced redox reactions. The results of this study will help us to better understand the photodegradation law of propaquizafop in aqueous solution and provide data support for its safety evaluation in water.
研究领域:
环境科学
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分析化学
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农药学
✓ 已验证
产品关联
DOI
高影响因子
Food Chemistry-X
·
2022
·
IF 6.443
Tao Zheng,Jia-qian Sun,Xiao-jun Shi,Du-ling Liu,Bing-yin Sun,Yuanjie Deng,Ding-ling Zhang,Shu-ming Liu
Through field investigation, UPLC-MS/MS technology and MaxEnt model were performed to predict the suitable distribution area for red huajiao ( Zanthoxylum bungeanum maxim.) in China from 2021 s to 2060 s, and evaluate the effects of climate factors on the quality of red huajiao. The results demonstrated that mean temperature of the coldest quarter and min temperature of the coldest month were the most important environmental variables influencing red huajiao distribution. Suitable habitats for red huajiao were located mainly in dry and hot valley zone in the Qinba Mountains and the semi-humid and semi-arid areas of the Loess Plateau. The amides contents were higher in high suitability areas, while it was decreased in medium and low suitability areas, and temperature, wind speed and precipitation played a key role in their accumulation. This investigation was of great significance for the planting area optimization, quality control, benefit improvement and industrial development of red huajiao.
研究领域:
植物学
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生态学
·
药用植物研究
✓ 已验证
DOI
高影响因子
MOLECULAR CARCINOGENESIS
·
2018
·Vol. 57
·期 10
·1371-1382
·
IF 3.851
Jie Gao,Zhao Wang,Gao-Ju Wang,Na Gao,Jing Li,Yun-Fei Zhang,Jun Zhou,Hong-Xin Zhang,Qiang Wen,Han Jin,Hai-Ling Qiao
Hepatofibrosis is an important susceptibility factor for hepatocarcinogenesis. However, only a handful of cases of hepatofibrosis will develop into hepatocellular carcinoma (HCC). As cytochrome P450 2E1 (CYP2E1) is involved in the metabolism and activation of many known environmental toxicants and procarcinogens, this enzyme may play a role in the development of hepatocarcinogenesis subsequent to hepatofibrosis. Herein, we evaluated whether higher CYP2E1 activity is a risk factor for the development of hepatocarcinogenesis from hepatofibrosis. CYP2E1 activity in fibrotic tissues from 72 HCC patients and in normal liver tissues from 59 control subjects was determined along with the severity of hepatofibrosis in hepatocarcinogenesis patients. Similarly, using a rat diethylnitrosamine-induced hepatocarcinogenesis model, CYP2E1 activity at the hepatofibrosis and hepatocarcinogenesis stages was determined, the correlation between CYP2E1 activity at the hepatofibrosis stage and hepatocarcinogenesis was explored, and the impact of inhibition of CYP2E1 activity on hepatocarcinogenesis was studied. The results showed that while CYP2E1 activity in HCC patients with underlying hepatofibrosis was increased, the severity of hepatofibrosis did not correlate with CYP2E1 activity. In the rat hepatocarcinogenesis model, unexpectedly, CYP2E1 activity was found to decrease from hepatofibrosis to hepatocarcinogenesis. Importantly, however, hepatofibrotic rats with higher CYP2E1 activity developed a more severe form of HCC. Moreover, inhibition of CYP2E1 activity could decrease the occurrence and development of HCC in rats. In conclusion, higher CYP2E1 activity may be a risk factor for hepatocarcinogenesis from hepatofibrosis, which raises the possibility of screening patients with hepatofibrosis for CYP2E1 activity to better estimate their risk for hepatocarcinogenesis.
研究领域:
医学
·
药理学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMBUSTION SCIENCE AND TECHNOLOGY
·
2021
·
IF 2.174
Jian Su,Yang Cheng,Shi Song,Hong Ma,Wen Wang,Yu Wang,Shi Zhang
In the paper, explosion characteristics of coal dust in the presence of strong oxidant were studied using a 20-L spherical vessel, and the influential factors, including air relative humidity, ambient temperature and combustible gas of hybrid explosion were investigated. Results showed that sodium chlorate dust could increase the explosion severity of coal dust to some extent, while the power of hybrid explosion was weakened for the increasing content of its decomposition product. The explosibility of blend samples both presented a trend of increasing at low air relative humidity and then deceasing at high air relative humidity. The explosion severities of blend samples were strengthened for the increasing ambient temperature in a certain range. CH4 had a promotion effect on the explosion performance of Blend A, and Pmax and (dP/dt)max values of Blend A dust explosion, respectively, increased by 56.1% and 200% with the addition of CH4. While the explosion severity of Blend B was promoted for adding a small amount of CH4, but suppressed for a high CH4 content. The experimental results have guiding significance for the risk assessment of coexistence of coal dust and hazardous chemicals, especially in confined space.
研究领域:
安全科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2021
·Vol. 10
·期 7
·1518
·
IF 4.35
Sankuan Xie,Jia Song,Bingqian Fan,Xuan Li,Yingqi Li,Fangming Mou,Yu Zheng,Min Wang
Polyphenols (PPs) are the main contributors to the health functions of Shanxi aged vinegar (SAV) and are mainly produced during the smoking process. This study aimed to explore the feasibility of regulating the accumulation of total water-soluble PPs (TWSP) by changing environmental factors based on the distribution of PPs. A total of eleven PPs, such as vanillin, vanillic acid, and (e)-ferulic acid, were detected during the smoking process. During the smoking process, the content of TWSP gradually increased and was accompanied by changes in environmental factors. Spearman correlation analysis and verification experiments showed that temperature, amino acids, and reducing sugars, as the main influencing factors, promoted the accumulation of TWSP. The in situ regulation strategy of changing environmental factors significantly increased the accumulation of TWSP by 12.24%.Keywords:Shanxi aged vinegar;polyphenols;smoking;influencing factors;in situ regulation
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）