WATER SCIENCE AND TECHNOLOGY
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2018
·Vol. 2017
·期 2
·340-350
·
IF 1.247
Ma Jie,Li Haiyan,Yang Yongqi,Li Xuening
The present study explored the influence of Cl − , Br − , CO 3 2− , HCO 3 − , PO 4 3− , HPO 4 2− , NO 3 − , SO 3 2− and natural organic matter (NOM) on the reaction kinetics and the formation of undesired degradation byproducts during phenol oxidation by heat-activated persulfate (PS). CO 3 2− and PO 4 3− promoted the phenol degradation, because the hydrolysis of CO 3 2− and PO 4 3− created basic pH conditions which were conducive to enhanced PS oxidation rate. Br − promoted the reaction by reacting with sulfate radicals (SO 4 •− ) to produce bromine radicals that can selectively react with electron-rich phenol. NOM scavenged reactive SO 4 •− , thus inhibiting the reaction. As a strong reducing agent, SO 3 2− rapidly reduced PS, thus completely suppressing the reaction. HCO 3 − , HPO 4 2− , Cl − , and NO 3 − had negligible impact on PS oxidation of phenol. Six intermediates were detected in the no anion control using gas chromatography–mass spectrometry (GC-MS). Various toxic halogenated phenols and halogenated hydroquinones were detected in the treatment containing Cl − and Br − . In contrast, in the treatment containing CO 3 2− , HCO 3 − , PO 4 3− , HPO 4 2− , and NO 3 − , no new intermediates were identified except for the intermediates already detected in the control treatment. Based on intermediates identified, reaction pathways for PS oxidation of phenol without anions and in the presence of halides were proposed respectively.
研究领域:
环境化学
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水处理技术
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高级氧化过程
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污染物降解
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反应机理
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环境毒理学
✓ 已验证
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Yijian Zhang,Weiling Yin,Yang Liu,Mingzhuang Hou,Qin Shi,Tao Liu,Miao Wang,Huilin Yang,Guoqing Pan,Fan He,Xuesong Zhu
Limited self-renewal potency of cartilage impedes the repair and regeneration at the site of damage. Investigating small-molecule compounds to boost chondrogenesis has yielded the dawn. However, the durability and targeting of current drug delivery and the adaptive integration for cartilage defects are not addressed. Herein, we fabricated a dynamic hydrogel based on the coordination between metal ions and collagen and then supramolecularly enveloped with a chondro-inductive factor kartogenin (KGN) via cyclodextrin (CD). The self-recovery and injectability of dynamic hydrogel enabled minimally invasive and precise treatment of cartilage injury assisted by continuous KGN administration. The hydrogel could significantly promote the expression of cartilage matrix components (type II collagen and aggrecan) in articular chondrocytes without affecting cell proliferation or migration in vitro . Mechanistically, the protective effects depended on enhancing chondrocyte mitochondrial function and intracellular antioxidant properties. In situ hydrogel injection strengthened cartilage regenerative potential and facilitated the reconstruction of subchondral bone following full-thickness defects in vivo . This study revealed that the dynamic chondrogenic hydrogel could benefit cartilage repair via mitochondrial reinforcement, acting as a novel therapeutic strategy for refractory cartilage damage.
研究领域:
生物医学工程
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组织工程
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再生医学
·
骨科
·
药学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Feng Fan,Lijun Jin,Lihua Yang
Pancreatic tumor is extremely lethal because its cancerous structures are sheltered by dense stromal barriers that hinder the infiltration of therapeutics. To facilitate the infiltration of therapeutics through the stromal barrier, remodeling the stroma with an adjuvant prior to or together with gemcitabine—the current chemotherapeutic standard for pancreatic cancer—is a widely studied strategy; nevertheless, the intrinsic nonuniformity in distribution (spatial and/or temporal) of the adjuvant and gemcitabine has raised the increased risk of tumor metastasis as a major concern. In this work, we propose long-circulating, pH-sensitive nanoparticles composed solely of cellular membrane-disruptive molecules as a new approach for treating pancreatic cancer. Using a micelle of a polymeric mimetic of host defense peptides as the model for such nanoparticles, we showed that this nanoparticle exhibited acid-activated cytotoxicity indiscriminately to both cancerous and fibroblast cells, and the underlying activity mode was acid-activatable disruption of cellular membrane integrity. As a result, our acid-activatable nanoparticle effectively permeabilized the stromal barrier and eradicated the otherwise sheltered pancreatic cancer cells, as demonstrated with a three-dimensional spheroid in which a shell of fibroblast NIH-3T3 cells was cultured over a core of pancreatic BxPC-3 cells. When administered intravenously into mouse models bearing xenograft pancreatic BxPC-3 tumors, our acid-activatable nanoparticle efficiently inhibited tumor growth without causing noticeable off-target adverse effects or promoting tumor metastasis. Notably, this nanoparticle permeabilized the otherwise dense pancreatic tumor tissue while significantly suppressing the expression of extracellular matrix components and activated cancer-associated fibroblasts. Although the feasibility of our approach was demonstrated with a micelle of a polymeric molecule, we trust that future research efforts in this pathway may eventually offer translational formulations for improving the therapeutic efficacy of pancreatic cancer.
研究领域:
纳米技术
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癌症研究
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药学科学
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生物医学工程
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xudong Yao,Miner Hu,Xinrang Zhai,Junxin Lin,Xiaojun Xia,Wei Wei,Shudong Xia
Elderly patients predispose to cardiovascular implantable electronic devices (CIEDs) pocket infections due to multiple comorbidities. Treating infections with the antibiotics further carry higher risks for complications, and surgical intervention can be costly when device removal and reimplantation are required, both emphasizing the importance of novel preventive strategies to minimize the incidence of pocket infections. To meet the unique needs for elderly, we constructed an CIED surface modified hydrogel which crosslinked polyethylene glycol diacrylate (PEGDA) with hyaluronic acid-nitrobenzene (HN) to form the polymeric structures that mimic the natural environment for promoting “Pocket” surrounding tissue integration and healing. Importantly, we synthesized the new peptidomimetics FK-13 derived by shortening amino acid sequence of LL-37 which is the only human cathelicidin-derived antimicrobial peptide. By incorporating FK-13 with initial PN hydrogel via Schiff base formation, the created PN-FK hydrogel exhibited broad-spectrum antimicrobial activity against bacteria with excellent biocompatibility and mechanical properties in a long-term release manner. In an in vitro setting, PN-FK hydrogel demonstrated the regeneration capacity by expression of Hmox1, Col5 and Col6 associated genes in fibroblasts as well as expression of Gpx1, Cdc20 and MMP9 genes in stem cells to accelerate self-renewal, collagen secretion and reconstitution of matrix components. In the following in vivo model of subcutaneous implantation, CIED-shape titanium mesh with surface modification by PN-FK hydrogel efficiently subsided over-inflammation compared to bare titanium implant, and expedited collagen deposition and angiogenesis in peri -pocket tissues within 2 weeks. These findings underscore the potential of the PN-FK hydrogel as a transformative approach to CIED postoperative management, offering a dual-action solution that combines infection resistance with tissue regeneration capabilities.
研究领域:
生物医学工程
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材料科学
·
生物材料
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组织工程
·
抗菌技术
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心脏病学
·
老年医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）