ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Xue-lin Dong,Jun-han Liu,Zheng-xun Jia,Shao-zhan Tang,Shuo-yun Tong,Yu-xiang Xiong,Lei Ouyang
Background The quantification of rare earth elements (REEs) in barite-associated geological samples is complicated by persistent matrix effects from coexisting elements and overlapping mass spectral interferences. These analytical challenges are particularly pronounced in samples containing high concentrations of light REEs (LREEs), which induce spectral overlaps on heavy REEs (HREEs) during inductively coupled plasma mass spectrometry (ICP-MS) measurements. Results A two-stage precipitation protocol achieved separation efficiencies exceeding 93.0 % for nine matrix elements (Ba, Na, Sr, etc.), while subsequent 717-type anionic resin chromatography enabled group separation of REEs. Sequential elution with methanol-nitric acid (3.40 mol/L, 7:3 v/v) and 0.20 mol/L nitric acid solutions yielded distinct recovery profiles: HREEs (Eu–Lu) showed >90.0 % recovery in the first elution phase, followed by quantitative isolation of LREEs (La, Ce, Pr) in the second phase. The method was verified by using certified reference materials (GBW07892, GBW07893), and the determination results were consistent with the certified values. The application to three natural barite-associated REE ores was also realized. Significance This methodology resolves critical limitations in REE analysis through matrix element elimination and controlled LREE/HREE fractionation. The demonstrated 90.2–106.9 % recovery range across all REEs confirms operational robustness, while successful implementation in certified materials and field samples establishes reliability for geochemical characterization. The elution sequence optimization provides a template for analyzing REEs in barite-associated ores.
研究领域:
地球化学
·
分析化学
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DOI
PubMed
高影响因子
ENVIRONMENTAL RESEARCH
·
2021
·
IF 6.498
Li Changmei,Wei Gengrui,Wu Haizhen,Wang Yuxiao,Zhu Shuang,Wei Chaohai
Polycyclic aromatic hydrocarbons (PAHs) and phenol are persistent pollutants that coexist in coking wastewater (CWW). Fluoranthene (Flu) is the predominant PAH species in the CWW treatment system. Our work emphasized on distinguishing the effects of phenol on Flu biodegradation by co-culture of Stenotrophomonas sp. N5 and Advenella sp. B9 and illustrated the molecular mechanisms. Results showed Flu biodegradation by co-culture was enhanced by phenol. According to the first-order degradation kinetic analysis of Flu, phenol significantly increased the biodegradation rate constant and shortened the half-life of Flu. Transcriptome analysis pointed out the up-regulation of DNA repair activity and 3717 significantly differentially expressed genes (DEGs), were triggered by 800 mg/L phenol. GO enrichment analysis suggested these DEGs are mainly concentrated in biochemical processes such as metal ion binding and alpha-amino acid biosynthesis, which are closely associated with Flu biodegradation, indicating that phenol promotes DNA repair activity and reduces Flu genotoxicity. qRT-PCR was performed to detect the gene expression of aromatic ring-opening dioxygenase. Combined with transcriptome analysis, the qRT-PCR results suggested phenol did not induce the expression of related PAHs-degrading enzymes. RNA extraction and microbial growth curves of COC and COC + Ph provided further evidence that phenol serves as co-substrate which increases biomass and the concentration of degrading enzymes, therefore promoting the Flu degradation.
研究领域:
环境科学
·
微生物学
·
分子生物学
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Qiong Guo,Yaqiong Qin,Lining Pan,Fuwei Xie,Shaofeng Liu,Xuehui Sun,Xiaoyu Wang,Junlan Cai,Xiaodong Zhao,Huimin Liu
A bstract Tobacco alkaloids are important precursors of carcinogenic tobacco-specific nitrosamines . Therefore, accurate quantification of tobacco alkaloids is highly important. This study investigates the compensation effects of novel analyte protectants (APs) for matrix effects (MEs) to determine seven minor tobacco alkaloids (nornicotine, myosmine , anabasine , anatabine , nicotyrine , 2,3′-bipyridine, and cotinine) in mainstream cigarette smoke with high accuracy and robustness. By comparing the heights and shapes of the chromatographic peaks before and after the addition of APs to standard solutions prepared in dichloromethane and cigarette smoke solutions, the compensation effects of 12 APs and their combinations on the MEs of seven minor tobacco alkaloids were evaluated, and the best combination of 2-pyridylethylamine (2 mg/mL)+1,2-decanediol (1 mg/mL) was identified. This AP combination could effectively improve the shapes and increase the heights (by 7–371%) of chromatographic peaks for standard solutions prepared in dichloromethane and cigarette smoke solutions. Before the addition of this AP combination, the slope ratios of the calibration curves for two types of standard solutions of the seven target chemicals were 71.4–159.8%, while they were 87.4–105.6% after the addition, indicating that this AP combination reduced the matrix difference between pure solvent and cigarette smoke solution. After adding the AP combination, the standard curves of solutions prepared in dichloromethane showed good linearity ( r 2 ≥ 0.999), the spiked recoveries were between 80.9% and 119.6%, and the inter- and intraday precisions were between 1.5–9.5% and 3.1–8.5%, respectively. Three commercial cigarette samples and one mixed standard solution were also tested under four different instrument working conditions to verify the long-term accuracy and ruggedness of the approach in routine real-world analysis of the method. The results showed that the RSD values were higher (3.5–25.4%) without the AP combination than that (<6.7%) with the AP combination. Because of its high accuracy, precision, and robustness, this method has good practical prospects.
研究领域:
化学
·
毒理学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Jun Wang,Hui-Ling Duan,Shi-Yao Ma,Jing Zhang,Zhi-Qi Zhang
n-Octadecylamine was adopted as a cleanup agent to develop a novel solidification of a switchable solvent-based QuEChERS method. At higher temperatures (such as 55 °C), n-octadecylamine can melt into a liquid, allowing effective extraction of matrix interferences in acetonitrile solution (i.e., in dispersive liquid–liquid microextraction). At lower temperatures, n-octadecylamine carrying matrix interferences can rapidly solidify and easily separate from the acetonitrile solution. The results demonstrated that n-octadecylamine possessed a better ability to remove matrix interferences and reduce matrix effects than those of traditional solid-phase dispersive extraction cleanup agents of primary secondary amine and octadecyl bonded silica gel. By coupling it with gas chromatography–mass spectrometry, the proposed method was applied to the detection of 16 pesticides in cucumber. The recoveries were from 80.9 to 112.6% with relative standard deviations less than 12.9%. Satisfactory results were also obtained for the detection of 16 pesticides in pear, orange, apple, pepper, lettuce, and tomato.
研究领域:
分析化学
·
食品安全
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Jingdong Yang,Yu Li,Zequn Yang,Kaimin Shih,Guang-Guo Ying,Yong Feng
The presence of 1,4-dioxane in various water streams poses a threat to the health of human beings. In this study, the oxidative combination of ozone with peroxymonosulfate (PMS) was for the first time used to remove 1,4-dioxane from water. Near complete abatement of 1,4-dioxane was achieved by ozone-PMS after reaction of only 15 min and the degradation kinetics was found to be positively correlated with doses of PMS and ozone. Ozone-PMS oxidation had the optimum performance at slight base pH values. Both sulfate radicals and hydroxyl radicals were generated in ozone-PMS oxidation and these radicals resulted in the degradation of 1,4-dioxane. The effects of common water constituents and real water matrices were investigated. It was found that bicarbonate ions with a concentration up to 10 mM had a slight promoting effect, while either chloride ions or natural organic matter inhibited only slightly the degradation. Meanwhile, no obvious difference in the degradation of 1,4-dioxane was found among the real water matrices and deionized water , which demonstrates that ozone-PMS oxidation has high tolerance and stability. The results from this study demonstrate that ozone-PMS may be a promising technology for the removal of 1,4-dioxane from various water matrices.
研究领域:
环境科学
·
水处理技术
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Ruihong Liu,Lining Pan,Yaqiong Qin,Fuwei Xie,Cong Nie,Xiaoyu Wang,Xiaobing Zhang,Mantang Chen,Bing Wang,Peijian Sun,Jizhao Guo,Huapeng Cui
Accurate quantitative analysis of flavor components is critical to eusuring product quality and safety. Matrix effects (MEs) in gas chromatography (GC) analysis frequently leads to a low sensitivity and inaccurate quantitation. This study first analyzed the MEs of 32 representative flavor components that cover the volatility range of GC-amenable analytes. The results revealed that flavor components with high boiling points, polar groups, or at low concentrations were particularly susceptible to MEs. The compensatory effects of 23 potential APs on MEs were evaluated, and the impacts of retention time ( t R ), hydrogen bonding capability, and concentration of APs on their compensatory effects were explored. The results indicated that a broader t R coverage rate and stronger hydrogen bonding capability led to better enhancement, while increasing AP concentration improved analyte peak intensity. However, similar t R , strong hydrogen bond capability or high AP concentration could also introduce negative effects, such as interference, insolubility, t R shift or peak distortion. Based on a comprehensive assessment of both positive and negative effects, a suitable AP combination of malic acid +1,2-tetradecanediol (both at 1 mg/mL) was developed to compensate the MEs across more analytes. After adding the combination, significant improvements were observed in the linearity, limit of quantitation (5.0–96.0 ng/mL), and recovery rate (89.3–120.5 %) of the method. This study comprehensively considered factors including the solubility, interference, protective effect of the agents, providing an efficient strategy for developing potential APs. This strategy holds broad application prospects in various fields, such as foods, beverages, cosmetics and more.
研究领域:
食品科学
·
分析化学
·
香料研究
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Congcong Yu,Dongyu Hao,Qiao Chu,Ting Wang,Songnan Liu,Tao Lan,Fenghe Wang,Canping Pan
Tea polyphenols, chlorophyll and lutein generally cause strong matrix effects and challenge analysis of trace substances in tea. Seven frequently used adsorbents were chosen to test removal ability for tea polyphenols, chlorophyll and lutein based on the adsorption isotherm fitting. Results showed that MWCNTs-NH 2 demonstrated the strongest removal ability, which may be ascribed to the π-π and electrostatic interaction. Then a method of MWCNTs-NH 2 modified QuEChERS coupled with HPLC-MS/MS detection of 10 organophosphorus pesticide residues in tea was developed and validated. Unlike traditional QuEChERS, only one adsorbent (MWCNTs-NH 2 ) was applied in this method to replace the combined effect of various adsorbents, which improved the easiness and generality of the method. The LOQs were 1.7–9.0 µg/kg. The average recovery rate ranged from 72% to 116% with RSDs less than 14%. This study provides a targeted strategy to develop analysis method for trace substances in a complicated matrix.
研究领域:
分析化学
·
食品科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2024
·
IF 2.8
Wen Liu,Fei Liu,Anyi Che,Yanjing Chen,Jiayi Cai,Wenjie Liu,Guoxing Jing,Wenshan Li,Jianna Yu
Ion mobility spectrometry (IMS) has a promising application prospect in food surveillance. However, due to the complexity of food matrix and trace levels of pesticide residues, the effective and rapid detection of pesticides by IMS has been a challenge, especially when using electrospray ionization (ESI) as an ion source. In this study, low-temperature partitioning with dispersive solid-phase extraction (LTP-dSPE) was explored and compared with conventional procedures. Both methods were validated for the quantification of eight pesticides in apples, obtaining a limit of detection (LOD) of 0.02–0.12 mg/kg for LTP-dSPE and 0.02–0.09 mg/kg for conventional solid-phase extraction (SPE), lower than those usually stipulated by government legislation in food matrices. For LTP-dSPE, the matrx effect (ME) ranged from −16.3 to −68.6 %, lower than that for the SPE method, ranging from −70.0 to −92.9 %. The results showed satisfactory efficiency and precision, with recovery values ranging from 67.9 to 115.4 % for LTP-dSPE and from 62.0 to 114.8 % for conventional SPE, with relative standard deviations below 13.0 %. Notably, the proposed LTP-dSPE/ESI-IMS has been shown to be more cost-effective, easier to use, more environment-friendly, more accessible, and, most importantly, less matrix effect than the conventional method, thereby being suitably applicable to a wide range of food safety applications.
研究领域:
食品安全检测
·
分析化学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2019
·
IF 5.399
Fei Xu,Feng Liu,Chaozhan Wang,Yinmao Wei
Magnetic solid-phase extraction (MSPE), using a new reversed-phase/weak anion exchange mix-mode mesoporous magnetic SiO 2 adsorbent, was assessed as an approach for reducing matrix effects in the analysis of six lipophilic marine biotoxins in shellfish using ultrahigh-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The adsorbent showed greater adsorption capacity and selectivity for the analytes and, thus, the MSPE microspheres reduced the matrix effects significantly in the subsequent analysis. In the UPLC-MS/MS analysis, precursor and product ions of the analytes were monitored quantitatively and qualitatively using multiple reaction monitoring and product ion confirmation modes. The proposed method exhibited a linear correlation of 0.9980–0.9991 in the working range for azaspiracids (2.0–200.0 ng/mL) and okadaic acid and its derivatives dinophysistoxins (4.0–200.0 ng/mL) with satisfactory recoveries (82.8–118.6%, RSD < 12%), lower LODs (0.4–1.0 μg/kg) and LOQs (1.0–4.0 μg/kg) than existing methods. In addition, consumption of the adsorbent was reduced, and the MSPE operation is simple and rapid relative to alternatives. These results suggest the proposed method has potential for use in the analysis of lipophilic marine biotoxins in shellfish samples.
研究领域:
分析化学
·
海洋生物学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2016
·Vol. 42
·期 9
·6959-6973
·
IF 1.833
Danish Muhammad,Gu Xiaogang,Lu Shuguang,Xu Minhui,Zhang Xiang,Fu Xiaori,Xue Yunfei,Miao Zhouwei,Naqvi Muhammad,Nasir Muhammad
The role of reactive oxygen species (ROSs) and effect of solution matrix have been investigated for the degradation of trichloroethylene (TCE). Zeolite-supported nano iron (Z-nZVI) was synthesized as an activator to catalyze sodium percarbonate (SPC) with or without hydroxylamine, i.e. as reducing agent (RA). The probe tests confirmed the generation of OH · and O
−· 2
in the Z-nZVI activated SPC system in absence of the RA, while the presence of RA significantly increased the generation of OH · and O
−· 2
radicals. Scavenger tests demonstrated that OH · was the main ROS responsible for TCE degradation, whereas O
−· 2
also participated in TCE degradation. From the solution matrix perspective, the experimental results confirmed significant scavenging effects of Cl − (1.0, 10.0, and 100 mmol L −1 ) and HCO 3
− (1.0 and 10.0 mmol L −1 ), whereas the scavenging effects were fairly impeded at 100 mmol L −1 concentration of HCO 3
− . On the other hand, a considerable decline in scavenging effect was observed in the presence of RA in tested Cl − and HCO 3
− concentration ranges. In addition, negligible scavenging effects of NO 3
− and SO 4
2− anions were found in all tested concentrations. The effect of initial solution pH on catalytic activity indicated a significant increase in the TCE degradation in the presence of RA even at higher pH value of 9. The results indicated that the Z-nZVI activated SPC system in presence of RA can effectively degrade chlorinated organic solvents, but it is important to consider the intensive existence of anions in groundwater.
研究领域:
环境科学
·
化学工程
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Qingyue Li,Mengtian Chen,Jieling Ren,Sichang Li,Tong Bu,Yang Wang,Xianqing Huang,Lianjun Song,Liang Liu,Ruifeng Luo,Yexuan Mao,Xiya Zhang
The food samples with high-fat content could induce matrix effects and interfere with the accuracy of lateral flow immunoassays (LFA), while deep eutectic solvents (DESs) as the innovative extraction solution had great potential to decrease this effect by rational design. First, 24 samples were evaluated for the detection performance of LFA using zearalenone (ZEN) as the target, and we found that black sesame, pecan, cashew, and pistachio with high-fat content could seriously affect recoveries and limit of detection (LOD), generating high matrix effects. To address this issue, six DESs with different polarities were designed by arrangement of two hydrogen bond donors and three hydrogen bond acceptors. DES-4, composed of betaine and ethylene glycol with a molar ratio of 1:4, displayed a lower molecular polarity index, which was similar to ZEN and possessed significant differences with fatty acids. Subsequently, DES-4 was applied to LFA for ZEN detection in these four high-fat matrices. After centrifugation, 70.5 %-92.3 % of fat in food matrices was transferred to the upper layer, and the fat content of the detection phase and food matrices phase by DESs extraction was 77.0–290.2 mg, obviously lower than that by acetonitrile/water extraction. Moreover, the recoveries ranged from 82.01 % to 114.26 % after diluting 50–70 times, and the LODs were 1.72–4.06 ng/mL, which were 1.4–4.6 times lower than that of acetonitrile/water extraction. Hence, DESs were considered as promising extraction reagents to reduce the high fat-induced matrix effects, which may be broadened to other target detection.
研究领域:
食品安全
·
分析化学
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2020
·
IF 3.004
Qiuyao Du,Yunfeng Zhang,Jifen Wang,Bingjie Liu
An ultra-performance liquid chromatography tandem triple quadrupole compound linear ion trap mass spectrometry (UPLC-Q-TRAP/MS) method was developed and validated for the detection of hypolipidemic drugs in fingerprints. 13 hypolipidemic drugs were well separated by the gradient elution of 0.01% formic acid in water and methanol at a flow rate of 0.4 mL/min within 11 min. The analytes were detected in positive (ESI + ) and negative (ESI - ) modes and scanned using scheduled multiple reaction monitoring-information dependent acquisition-enhanced product ion (SMRM-IDA-EPI) for best selectivity and sensitivity. The calibration curves showed good linearity in the range of 0.050–50.000 ng/patch with coefficients ( r 2 ) higher than 0.9904 for all analytes. Meantime, the LODs and LLOQs were in ranges of 0.001–0.034 and 0.003–0.050 ng/patch. The accuracies, intra-day and inter-day precision ranged from −13.3 to 0.3%, 1.1–10.4% and 3.7–14.5%, respectively. The recoveries ranged from 79.9 to 114.8%, while the absolute and relative matrix effects were in the range of 83.0–107.2% and 2.2–9.7%. By comparing the non-spiked fingerprints from healthy volunteers with the fingerprints obtained from patients, demonstrated that the method was competent for determination and quantitation of hypolipidemic drugs in fingerprints.
研究领域:
分析化学
·
药物分析
·
质谱分析
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）