POLYMER
·
2025
·
IF 4.5
Chunhua Li,Yifu Ruan,GengXin Liu
Polymeric soft-nanoparticles (SNPs) synthesized via microemulsion polymerization, are widely used in both academia and industry. However, achieving a significantly smaller diameter still presents a challenge. Despite the use of excess surfactants, surface tension constraints prevent microemulsion droplets from decreasing in diameter below 20 nm. Still using conventional surfactants, we introduce a simple and efficient method for mass production of SNPs down to 10–15 nm in diameter. The microemulsion is prepared by incorporating solvents that are good for both monomers and polymers. This method effectively yields significantly smaller SNPs. In the melts of such small SNPs, the Rouse-like viscous-dominant behavior is observed and fully mapped with respect to the diameter and degree of cross-linking. This was previously not observed in microemulsion polymerized SNPs. We assess the cold flow conditions by determining the ability to form transparent sheets from the powder at room temperature when subjected to pressure. It is governed by the diameter and degree of crosslinking. The ultrasmall SNPs thus have the potential to be used as fillers in various industries.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2024
·
IF 18
Jinzhou Huang,Jianmin Xue,Jimin Huang,Xinxin Zhang,Hongjian Zhang,Lin Du,Dong Zhai,Zhiguang Huan,Yufang Zhu,Chengtie Wu
The significance of collagen and vascular in skin augmentation have been recognized in recent years. However, current skin tissue fillers, e.g. hyaluronic acid (HA) or HA-based hydrogel, fail to meet the perfect augmentation requirements due to their inadequate long-term support effect and the lack of tissue-inducing activity. Herein, an injectable skin filler containing hyaluronic acid (HA) hydrogel and lithium calcium silicate (LCS, Li 2 Ca 4 Si 4 O 13 ) bioceramic microspheres was developed for skin tissue fillers, owing to the excellent biological function of silicate bioceramics. The HA-LCS fillers could be easily injected through a tiny standard medical needle (27 G) with force of less than 36 N, and showed good biocompatibility both in vitro and in vivo . Furthermore, the bioactive ions released from HA-LCS fillers significantly enhanced the expression of vascularization-related genes and collagen-related genes. Importantly, the HA-LCS fillers not only stimulated the regeneration of mature blood vessels, but also promoted collagen secretion in dermal skin and filling area. This study not only presented an injectable filler with enhanced regeneration of blood vessels and collagen, but also provided a new strategy for developing tissue-induced fillers based on bioactive components of silicate bioceramics.
研究领域:
生物医学工程
·
皮肤科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Wenjie Chen,Han Wang,Qing Zhou,CuiCui Wu,Qianqian Zhu,Xi Luo,Wenran Liu,Lifang You,Shunqing Tang
Currently, injectable soft tissue fillers suffer from rapid degradation, unsatisfactory filling effects, and poor biocompatibility. To identify more suitable materials for dermal injections, this study successfully prepared agarose acetate microspheres (AGA microspheres) of different sizes using an electrostatic spraying method. Various parameters, including voltage, injection speed, stock solution concentration, and needle nozzle size, were optimized during the preparation process. AGA microspheres had sizes of about 20 μm with the most favorable parameter of electrostatic spraying, and were stable in the in vitro enzyme containing PBS media and the in vivo implantation. The results of the in vitro cellular assay showed that AGA microspheres had no cytotoxicity and immunostimulated RAW 264.7 expressing less inflammatory factors than Agarose did. The results of rat subcutaneous implantation disclosed that AGA microspheres were stable in 8 weeks, and caused less inflammatory reaction of surrounding tissues. Minimal inflammatory responses and consistent filler volume retention establish AGA microspheres as a promising candidate for long-lasting, biocompatible dermal fillers.
研究领域:
生物医学工程
·
材料科学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Weiling Lu,Xianjin Wang,Changchang Kong,Shijunyin Chen,Chengtao Hu,Jianfa Zhang
Hydrogels composed of natural polysaccharides have been widely used as filling materials, with a growing interest in medical cosmetology and skin care. However, conventional commercial dermal fillers still have limitations, particularly in terms of mechanical performance and durability in vivo. In this study, a novel injectable and implantable hydrogel with adjustable characteristics was prepared from succinoglycan riclin by introducing PEG diglycidyl ether as a cross-linker. FTIR spectra confirmed the cross-linking reaction. The riclin hydrogels exhibited shear-thinning behavior, excellent mechanical properties, and cytocompatibility through in vitro experiments. Furthermore, when compared with subcutaneous injection of a commercial hyaluronic acid hydrogel, the riclin hydrogels showed enhanced persistence and biocompatibility in Balb/c mice after 16 weeks. These results demonstrate the great potential of the riclin-based hydrogel as an alternative to conventional commercial soft tissue fillers.
研究领域:
生物材料
·
组织工程
·
医学美容
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Silu Chen,Chengtao Hu,Weiling Lu,Jianfa Zhang
The structure of soft tissues is often destroyed by injury and aging. Injectable fillers eliminate the need for surgery and enhance repair. Hyaluronic acid-based hydrogels are commonly employed for their effectiveness and biocompatibility. However, hyaluronidase breaks them down quickly. Lubcan, a naturally sourced microbial extracellular polysaccharide, has demonstrated significant water absorption and retention capabilities, as well as lubricating properties comparable to those of hyaluronic acid. In this study, a novel injectable and implantable hydrogel was created from lubcan by adding polyethylene glycol diglycidyl ether as a cross-linking agent. Lubcan hydrogels exhibit exceptional thermal stability, favorable swelling behavior, in vitro degradation, compressive strength, injectability, and rheological properties, all while preserving the integrity of their three-dimensional porous structure. In vitro tests indicated that the lubcan hydrogel was non-cytotoxic, did not adhere to blood cells, and exhibited good hemocompatibility. Compared to the subcutaneous injection of commercially available hyaluronic acid hydrogels, lubcan hydrogels demonstrated superior integrity, persistence, and a softer texture in Balb/c mice after 16 weeks. At the same time, lubcan hydrogel is non-toxic to organs, does not affect blood biochemical test values, and is non-immunogenic in mice. These findings suggest that lubcan hydrogel may be a promising new superficial soft tissue filler.
研究领域:
生物材料学
·
医学工程
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2023
·
IF 4.9
Jiajing Zhao,Ziwei Chen,Xiaoshuo Li,Zheren Tong,Zijin Xu,Peishi Feng,Ping Wang
Injectable hyaluronic acid (HA) hydrogel plays an important role in dermal filling. However, conventional HA dermal fillers mostly lack bio-functional diversity and frequently cause adverse reactions because of the chemical stiffness of highly modified degree and crosslinker residues. In this study, polylactic acid (PLA) was embedded into HA hydrogel as a bioactive substance and 1,4-butanediol diglycidyl ether was used as a crosslinker to prepare the HA/PLA composite hydrogel with enhanced biocompatibility and biological performance. We aimed to investigate the properties of HA/PLA composite hydrogels as dermal fillers by assessing the rheological properties, surface microstructure, enzymolysis stability, swelling ratio, degradation rate, cytotoxicity, and anti-wrinkle effect on photo-aged skin. The results showed that the stability and stiffness of the composite hydrogel decreased with an increasing amount of PLA, while the in vivo safety of the HA/PLA hydrogel was enhanced, showing no adverse reactions such as edema, redness, or swelling. Moreover, the composite hydrogel with 2 wt% PLA exhibited excellent anti-wrinkle effects, showing the highest collagen production. Thus, the PLA-embedded HA composite hydrogel showed potential as a dermal filler with high safety, easy injectability, and excellent anti-wrinkle effects.
研究领域:
材料科学
·
生物医学工程
·
化妆品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2025
·
IF 8.1
Zhao Miaoran,Chang Shuhua,Wang Yunpeng,Cao Jun,Pu Yuji,He Bin,Pan Shengsheng
Injectable facial fillers such as Sculptra® stimulate collagen regeneration to fill wrinkles; however, the collagen regeneration is not satisfactory due to the slow emergence of filling effect. In this study, we designed a regenerative dermal filler to provide both immediate and long-lasting filling effects. A hydrogel matrix composed of crosslinked hyaluronic acid (HA) and collagen was engineered to encapsulate porous poly(L-lactide) (PLLA) microspheres and tranexamic acid (TXA). The hydrogel matrix was administered via intradermal injection to achieve wrinkle filling. TXA is released to exert skin-whitening effects, while the porous PLLA microspheres and their degradation product, lactic acid, continuously stimulate collagen regeneration over an extended period. Facial volume increased immediately following hydrogel injection. Large amounts of new Type I and Type III collagens are generated. The porous structure of PLLA microspheres facilitated the “penetrating growth” of collagen fibers, which effectively filled facial depressions and smoothed wrinkles. Overall, the HA/collagen composite hydrogel filler exhibited excellent aesthetic effects.
研究领域:
生物材料学
·
医学美容
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomedical Materials
·
2024
·Vol. 19
·期 5
·055021
·
IF 3.9
Qi Wang,Huiyu Yan,Jingting Zhang,Xinyu Tian,Jianxi Xiao
Skin aging, characterized by reduced regeneration, chronic inflammation, and heightened skin cancer risk, poses a significant challenge. Collagen fillers have emerged as a potential solution for skin rejuvenation by stimulating collagen regeneration. However, their clinical efficacy is limited by inherent instability and vulnerability to in vivo degradation by collagenase. Chemical cross-linking presents a promising approach to enhance stability, but it carries risks such as cytotoxicity, calcification, and discoloration. Here, we introduce a highly durable 1,4-butanediol diglycidyl ether (BDDE) cross-linked collagen filler for skin rejuvenation. BDDE effectively cross-links collagen, resulting in fillers with exceptional mechanical strength and injectability. These fillers demonstrate favorable stability and durability, promoting proliferation, adhesion, and spreading of human foreskin fibroblast-1 cells in vitro. In vivo studies confirm enhanced collagen regeneration without inducing calcification. BDDE cross-linked collagen fillers offer promising prospects for medical cosmetology and tissue regeneration.
研究领域:
皮肤科
·
组织工程
·
化妆品科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
·
2025
·
IF 6
Chen Shen,Xingyu Zhou,Junhui Jiang,Junbo Dang,Tong Lin,Ruibo Hu,Tianhao Zhao,Dahui Sun,Mei Zhang
Soft tissue fillers have received much attention for the treatment of skin aging and the restoration of missing or excised soft volumes. However, the development of fillers with both safety and applicability remains a challenge. This study presented a synergistic composite filler comprising aldehyde-modified hyaluronic acid (OHA), hydrazide-modified hyaluronic acid (NHA), amino-modified poly-L-lactic acid microspheres (NPLLA), and antioxidant copper peptide. The hydrogel formed in situ via Schiff base reaction exhibited excellent mechanical properties and immediate filling effect. The amino-modified PLLA microspheres were less likely to agglomerate, avoiding the occurrence of adverse reactions and further enhancing the mechanical properties of the filler. The timed-release platform provided protection for copper peptide stability, scavenged reactive oxygen species during the fibrotic encapsulation phase, and synergistically promoted collagen deposition. In a nude mice skin aging model, hydrogels stimulated collagen production through the TGF-β/Smad signaling pathway with good long-term filler efficacy. Therefore, NPLLA microspheres/hyaluronic acid-based composite hydrogels exhibit great potential as injectable soft tissue fillers.
研究领域:
生物材料
·
组织工程
·
生物医学工程
·
皮肤科学
·
药物递送
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）