CEMENT & CONCRETE COMPOSITES
·
2022
·
IF 9.93
Linan Gu,Tiejun Liu,Kai Wu,Zhenghong Yang,Zhaoyin Wen,Zhenlei Zhang,Haoxin Li
It is still uncertain whether temperature exerts some influence on the water retention (WR) and bleeding of cement-based materials with viscosity-enhancing admixtures (VEAs). Thus, WR and bleeding of cement-based materials with selected VEAs, such as sodium polyacrylate (PANA), hydroxyethoxy methoxy cellulose (HEMC) and hydroxypropoxy methoxy cellulose (HPMC), were evaluated at 20, 30, 40, 50, and 60 °C, and experiments on the apparent viscosity , total organic carbon (TOC) content, hydrodynamic radius and thermogravimetry were carried out to explore the responsible mechanisms. The results show that VEAs enhance WR and reduce bleeding at room temperature to varying degrees. However, this improvement at higher temperature does not occur as at room temperature (20 °C). The decreased improvements in WR and bleeding at higher temperature are associated with the lowered apparent viscosity , TOC content, hydrodynamic radius and the increased cement hydration . Below 40 °C, the apparent viscosity, adsorption and hydrodynamic radius dominate the bleeding behaviour of mortars with HPMC and HEMC. However, accelerated cement hydration is mainly responsible for the behaviour when the temperature exceeds 40 °C.
研究领域:
土木工程
·
材料科学
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DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2021
·
IF 4.384
Ding Zhang,Boqi Chen,Qingke Mu,Wei Wang,Kaili Liang,Liyan Wang,Qing Wang
Anti-cutaneous melanoma activity of the skin-delivered gambogic acid (GA) has been reported in our previous study. However, it is difficult for GA to diffuse passively through intact skin without any enhancement means. In this study, a combination of chemical enhancers (EN: azone and propylene glycol) and physical ultrasound (US) was used to improve the percutaneous permeation of GA and enhance the anti-melanoma activity. The enhancement effect of the combination of EN and US (EN-US) on GA in vitro and in vivo was studied, and the enhancement mechanism and skin irritation were also evaluated. We showed that the parameters of US application at a constant frequency (30 kHz) with a duty cycle of 100% and intensity of 1.75 W/cm 2 for 20 min were optimal. In vitro , EN-US showed a considerable enhancement of the permeation of GA, and the enhancement effect was stronger than that with the use of EN or US alone. In vivo antitumor study showed that the tumor growth was significantly inhibited after percutaneous administration of GA by EN-US, more than in the intravenous injection group. The penetration enhancement mechanism revealed that EN-US not only altered the structure of lipid bilayers and keratins to reduce the barrier effect of the stratum corneum but also produced diffusion channels in the skin under the cavitation effect of US, thereby promoting the skin penetration of GA. In addition, there was no observable skin irritation in mice after treatment with EN-US. Our study demonstrated that the combination of EN and US improved the skin permeation and retention of GA to enhance the anti-melanoma activity. This method also provides technical guidance for the future development of topical and transdermal therapeutic system of GA.
研究领域:
药理学
·
肿瘤学
·
皮肤病学
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产品关联
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2024
·
IF 12.7
Baowei Qiu,Youquan Ling,Xiwen Gu,Lei Wang,Shengtai Zhou,Huawei Zou,Mei Liang
Interfacial properties were crucial in determining the mechanical properties of carbon fiber reinforced polymer composites (CFRPs). Applying appropriate sizing agents could effectively improve the interfacial properties of CFRPs. However, the influence of the pH of the sizing agents on the interfacial properties of CFRPs was still unclear. In this work, the above issues were elucidated by adjusting the pH of the diethanolamine-modified E51 (E51@DEA) sizing agent to investigate its impact on the interfacial properties of CFRPs. The molecular weight and emulsion particle diameter of E51@DEA increased with increasing pH of the sizing agent, despite the presence of identical chemical functional groups. E51@DEA-pH 7 showed the best interfacial enhancement. It exhibited ILSS and IFSS values of 102.24 and 113.45 MPa, respectively. This showed an increase of 76 % and 37 % when compared with T700. Additionally, the compressive and tensile strength of T700/E51@DEA-pH 7 also improved by approximately 13 % and 30 %, respectively. The suitable molecular chain length of the sizing agent and the high roughness of the surface of CFs were regarded as the contributing factors. This work further provided an effective and simple strategy for adjusting sizing agents to better improve the interfacial properties of CFRPs.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2020
·
IF 7.094
Kaizheng Zhu,Yu Liu,Heliang Wang,Xiwei Guo,Shuangquan Liao,Zhifen Wang,Lin Fang
Reinforcing agents and accelerators are the most important auxiliaries for rubber industry. In this paper, ceric ammonium nitrate (CAN), for the first time, worked as a catalyst for hydroxyl groups in silica to prepare silica grafted sodium xanthate (SSX), which was used as an in-situ modified multifunctional rubber additive in this work. Compared with sodium isobutyl xanthate (SIBX), SSX has enhanced the initial and final degradation temperatures, achieving the improvement of 103 °C and 277 °C, respectively. Notably, owing to the powerful interaction between each component, SSX can be homogeneously dispersed in the natural rubber (NR) matrix in contrast to the seriously aggregated silica. Meanwhile, NR/SSX composites exhibited superior curing properties and showed an increase of 29.1% and 33.4% in the tensile strength and tear strength , respectively, compared to that of traditional 2-mercaptobenzothiazole (MBT) system. Since high-performance rubber composites can be obtained by introducing SSX, we believe that this work can provide a novel and facile approach to prepare natural silicate minerals-based vulcanization accelerators.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
Chemistry-An Asian Journal
·
2022
·Vol. 17
·期 17
·e202200561
·
IF 4.839
Zhanxiang Zhang,Haocheng Wang,Hua Yang,Wenping Song,Lizhou Dai,Shimin Yu,Xuejia Liu,Tianlong Li
Graphical In this article, a reconfigurable and mobile magnetic microswarm as MRI contrast enhancer was investigated experimentally and numerically. By changing motion mode, it could adaptively navigate multiple terrains. Furthermore, we demonstrated this microswarm performed great enhancement of MRI imaging. This microswarm held great promise for highly sensitive and accurate intestinal MRI in the clinic. Highly effective contrast enhancer that processes targeting ability and maneuverability is in great demand in clinics for accurate diagnosis. Here a new strategy using deformable and manipulatable magnetic microswarm as MRI contrast enhancer is developed. Magnetic microswarm aggregated from nanoparticles is inherently deformable and they can be controlled with multiple programmable deform abilities. It is demonstrated that spatiotemporal programming magnetic field enables the magnetic microswarm not only to exhibit both ribbon-like and round-like behaviours but also to adaptively navigate multiple terrains. Intestinal model is conducted to explore the effect of magnetic microswarm as MRI enhancer, indicating the obvious enhancement of T 2 -weighted MRI sequences. This magnetic microswarm holds great promise for highly sensitive and accurate intestinal MRI in the clinic.
研究领域:
医学影像学
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纳米医学
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生物工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 25
·5817-5829
·
IF 7
Shaohu Huo,Qianhui Xie,Min Zhang,Zitong Jiang,Ling Fu,Wenhong Li,Chenrong Bian,Kaile Wu,Yulin Zhu,Xuan Nie,Shenggang Ding
Antibiotic tolerance is implicated in difficult-to-treat infections and the development and spread of antibiotic resistance. The high storage capacities and excellent biocompatibilities of UiO-66-based metal–organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. In view of hydrogen sulfide (H2S) having been associated with the development of intrinsic resistance to antibacterial agents, we designed a strategy to potentiate existing antibiotics by eliminating bacterial endogenous H2S. We efficiently fabricated an antibiotic enhancer Gm@UiO-66-MA to remove bacterial H2S and sensitize an antibacterial by modifying UiO-66-NH2 with maleic anhydride (MA) and then loading it with gentamicin (Gm). UiO-66-MA achieved the removal of bacterial endogenous H2S and the destruction of bacterial biofilm by selectively undergoing Michael addition with H2S. Moreover, Gm@UiO-66-MA further enhanced the susceptibility of tolerant E. coli to Gm after reducing bacterial intracellular H2S levels. An in vivo skin wound healing experiment confirmed that Gm@UiO-66-MA could greatly reduce the risk of bacterial reinfection and accelerate wound healing. Overall, Gm@UiO-66-MA offers a promising antibiotic sensitizer for minimizing bacterial resistance and a therapeutic strategy for tolerant bacteria-related refractory infections.
研究领域:
材料科学
·
微生物学
·
药物递送
·
感染与免疫
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DOI
PubMed
高影响因子
LUMINESCENCE
·
2013
·Vol. 29
·期 4
·301-306
·
IF 1.273
Xiaoqi Tao,Wenjun Wang,Zhanhui Wang,Xingyuan Cao,Jinghui Zhu,Lanlan Niu,Xiaoping Wu,Haiyang Jiang,Jianzhong Shen
In this study, a high sensitivity chemiluminescence enzyme immunoassay (CLEIA) based on novel enhancers was developed. Under optimal conditions, we developed an enhanced chemiluminescence reaction (ECR) catalyzed by horseradish peroxidase (HRP-C) in the presence of 3-(10'-phenothiazinyl) propane-1-sulfonate (SPTZ) and 4-morpholinopyridine (MORP) as enhancers. The limit of detection of the newly prepared chemiluminescent cocktail for HRP was 0.33 pg/well, which is lower than that of commercial Super Signal substrate. The results showed that this novel chemiluminescent cocktail can significantly increase the light output of HRP-catalyzed ECR, which can be translated into a corresponding improvement in sensitivity. Similar improvements were observed in CLEIA for the determination of chloramphenicol in milk. In addition, the ECR of N-azoles as secondary enhancer was also presented. Copyright © 2013 John Wiley & Sons, Ltd.
研究领域:
分析化学
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生物医学工程
·
免疫学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2012
·
IF 2.453
Ye Liu,Shoufeng Zhang,Fei Zhang,Rongliang Hu
Four botanical polysaccharide preparations (from Astragalus , Echinacea , wolfberry, and kelp) were evaluated as immunopotentiators/adjuvants of a veterinary rabies vaccine. Results showed that lymphocyte proliferation and some cytokines were significantly elevated, with cellular immune responses skewed towards Th1 and Tc1. All four polysaccharides produced accelerated and enhanced effects on rabies-neutralizing antibody responses in mice and dogs. The results also indicated that certain botanical polysaccharides could be used in rabies vaccine formulations for early and persistent prophylaxis.
研究领域:
免疫学
·
兽医学
·
植物化学
✓ 已验证
DOI
PubMed
高影响因子
CEMENT AND CONCRETE RESEARCH
·
2025
·
IF 13.1
Jing Qiao,Chunsheng Zhou,Jingjing Feng,Miao Miao,Yanliang Ji,Linan Gu
Limestone powder (LS) with large particle sizes is widely used, but its effect on water migration behavior remains unclear. This study investigates the influence of LS and viscosity-enhancing admixtures (VEAs) on the water migration behavior and water distribution in fresh cement paste using 1 H low-field nuclear magnetic resonance (LF-NMR). Results indicate that LS increases the size of water migration channels, accelerates the water migration rate, and raises the bleeding ratio, while VEAs substantially mitigate the effects of LS. Compared to polyacrylamide, cellulose ether significantly slows down the water migration rate before 40 min, thereby reducing the bleeding ratio. Additionally, relaxation times were found to decrease during bleeding and can reflect the sedimentation process. It is confirmed that the pore structure of fresh paste exhibits fractal characteristics, with the fractal dimension closely correlating with water migration rates. The underlying mechanisms and their implications on material behavior are thoroughly analyzed and discussed.
研究领域:
材料科学
·
土木工程
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Lei Cai,Xiyu Mou,Jieshee Hong,Chun Cui
With the improvement of people's living standards and health awareness, reducing salt, sugar, and fat is gradually becoming the mainstream trend. In this work, we delved into the development of an innovative taste enhancer, N-lauroyl theanine (NLT), and its taste presentation mechanism. NLT was synthesized in the aqueous phase by enzyme-catalyzed and direct-heating methods using food-grade enzymes in yields of up to 64.33 % and 49.11 %, respectively. Sensory evaluation and molecular docking techniques revealed the potential of NLT to enhance salty, umami, sweet, and kokumi taste sensations and its taste presentation mechanism. Results revealed significant taste enhancement of saltiness, umami, sweetness, and kokumi and prolonged their duration in the oral cavity by 0.25–1 mg/L NLT. Molecular docking analyses showed that NLT had a strong binding affinity for a variety of taste receptors. These findings highlight the potential of NLT as a potent taste enhancer for the development of healthier salt/sugar-reduced foods.
研究领域:
食品科学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
·
2025
·
IF 4.5
Jiahao Sun,Shihang Lu,Ming Cheng,Nianting Xue,Shiqiang Chen,Guangzhou Liu,Yuanyuan Gao,Li Lai,Wenwen Dou
Microbiologically influenced corrosion (MIC) affects offshore production activities severely. Although adding biocides is a simple method, it can cause environmental damage over time. Using green biocide enhancers is a viable strategy to reduce the amount of biocides. In this study, four novel peptides, named Peptide T/Tc/Ts/Tcs, were designed by a natural peptide extracted from the Arctic sea squirt to enhance the efficacy of tetrakis hydroxymethyl phosphonium sulfate (THPS) in mitigating the biocorrosion of EH36 steel caused by Desulfovibrio ferrophilus . The combination of 40 ppm THPS and 100 nM Peptide T/Tc/Ts/Tcs reduced the corrosion rates of EH36 steel by 68 %, 71 %, 86 %, and 90 % after the 7-d incubation, respectively. Notably, 40 ppm THPS + 100 nM Peptide Ts/Tcs achieved similar antimicrobial and biocorrosion mitigation effects as 100 ppm THPS. It suggests that optimizing the cationic and hydrophobic properties of peptides could enhance the bactericidal properties of biocides.
研究领域:
材料科学
·
微生物学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 10
·107505
·
IF 3.721
Peijin Wang,Qian Wu,Caixia Wang,Yuxin Pu,Mao Zhou,Mingxiao Zhang
In this work, a sensitive polyethylenimine functionalized Perylene derivative PTC-PEI, S2O82− and 3D flower-like MoS2 (3D MoS2 NFs) ternary system was fabricated for quantitation of Methotrexate (MTX) based on the quenched electrochemiluminescence (ECL) signals. Specifically, the PTC-PEI was prepared via cross-linking Perylenetetracarboxylic acid (PTCA) and polyethylenimine (PEI). Then, the hybrid nanocomposite PTC-PEI-MoS2 was synthysized through electrostatic absorption effect between PTC-PEI and 3D MoS2 NFs. With the excellent catalytic effect of 3D MoS2 NFs towards the electrochemical reduction process of S2O82− thus resulting in generation of more sulfate radical anions (SO4·−), the ECL signal probe PTC-PEI-MoS2 exhibits higher luminous efficiency compared with PTC-PEI (3-fold enhancement). In addition, electrochemical regenerable property of Mo6+/Mo4+ active sites endows 3D MoS2 NFs excellent signal enhancement efficiency. Under the optimum conditions, a linear range from 10 μM to 1pM with the limit of detection down to 0.15 pM could be obtained in MTX determination. Notably, the proposed strategy provides a new idea for sensitive determination of MTX.
研究领域:
分析化学
·
纳米材料
·
电化学
·
生物传感器
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）