JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Zhixia Wang
It has been shown that tropine-based ionic liquid surfactant (TILS) possesses exceptional biological, botanical, and pharmacological capabilities. Significantly, little research has been done on its essential characteristics, which are greatly influenced by its structural makeup. In this study, the essential properties, such as thermal stability, surface activity, foaming properties, and solubilization, were examined. The results demonstrate that the temperature stability of TILS was influenced by the nucleophilicity, coordination, and hydrophilicity of anions. Surface tension, solubility, and the HLB value of the TILS solution all worked together to affect the performance of the foam. The micellar and acid-base characteristics of TILS contributed to the solubilization of curcumin in its solution. The solubilization of curcumin in water was improved by TILS from 11 ng·mL −1 to more than 30 mgmmL −1 , an increase of at least 10 6 times. These positive and adaptable physical and chemical characteristics highlight TILS potential in a variety of industrial-related applications.
研究领域:
化学
·
生物学
·
药学
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Chaomeng Dai,Wang Kai Tong,Jia Jie Zou,Min-tian Gao,Yalei Zhang,Shuguang Liu,Tingzhu Li,Jixiang Li,Jiajun Hu
Micro-nanobubbles (MNBs) with their negatively charged surface and cationic surfactant with a positively charged hydrophilic head were designed to synergistically solubilize polycyclic aromatic hydrocarbons (PAHs). Through response surface method experimentation, the results showed that MNBs had no obvious solubilizing effect for the PAH, phenanthrene . However, MNBs and the cationic surfactant didodecyldimethylammonium bromide (DDAB) had a synergistic solubilization effect on phenanthrene. Through the analysis of physical and chemical factors, it could be inferred that the synergy was caused by a conversion in the structure of the vesicles formed by DDAB after the combination of DDAB and MNBs. This structure conversion improved the phenanthrene solubility. In addition to being amplified, this synergy was verified to be universal and could be strengthened. The synergy, which increased with increasing DDAB and MNB concentrations, could achieve up to about 3 times the solubilizing as that without MNBs. In addition to DDAB, MNBs could also synergistically solubilize phenanthrene with other cationic surfactants. Changing the gas source of MNBs from air to nitrogen or oxygen could increase the negative surface charge, which enhanced the synergistic effect between MNBs and cationic surfactants. These results demonstrate a novel method for synergistic solubilization of PAHs by surfactant and MNBs while it can decrease the excessive use of surfactants causing the pollution issues. The synergistic effect between cationic surfactants and MNBs has the potential to be widely used in environmental and medical fields.
研究领域:
环境科学
·
医学
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DOI
高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2015
·Vol. 44
·期 6
·1163-1176
·
IF 1.177
Long Jian,Tian Senlin,Li Guang,Li Lin
For the purpose of studying the potential of a novel nonionic switchable surfactant, 11-ferrocenylundecyl polyoxyethylene ether (FPEG), applied to surfactant-enhanced remediation (SER), the surface properties and micelle solubilization behavior of FPEG were investigated with different inorganic salts. With the addition of inorganic salts (NaCl and CaCl 2 ), the critical micelle concentration (CMC) of FPEG dropped from 15 to 12 and 8 mg·L −1 , respectively, due to the salting-out effect on the alkyl chain. Thermodynamic parameters based on the CMCs indicated that micelle formation was an entropy-driven process. Dynamic light scattering measurements verified that these inorganic salts can decrease the hydrodynamic diameters ( D
h ) of the micelles. Solubilization experiments with three typical polycyclic aromatic hydrocarbons (PAHs) demonstrated that the system of FPEG with NaCl shows the highest solubilization ability, and the molar solubilization ratio and micelle–water partition coefficient ( K
m
) values follow the order pyrene > phenanthrene > acenaphthene. After oxidation, PAHs can be released from the micelles through breaking up of the micelles, and the cumulative release efficiency of pyrene, phenanthrene and acenaphthene are 31.2, 42.8 and 44.6 %; the order of release efficiency is opposite to that of the reduced form for solubilization abilities. All the results suggest that the ferrocene-containing, redox-active surfactant FPEG has the potential to be recycled in SER technology through electrochemistry approaches.
研究领域:
环境化学
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胶体与界面科学
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电化学
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污染物修复
·
功能材料
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DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Lu Shuo,Liu Yashuang,Dong Jinfeng,Li Xuefeng
Here are described the dilution-driven gel-sol-gel-sol transitions in aromatic hydrotrope/zwitterionic surfactant bi-component aqueous mixtures. Long and entangled wormlike micelles (WLMs) of concentrated erucyl dimethyl amidopropyl betaine (EAPB) solutions sequentially transform into hexagonal liquid crystal phase (H 1 ), highly concentrated spherical micelles (HCSMs), and finally hexagonal close packed micellar phase (HCP) upon gradual introducing an aromatic hydrotrope, sodium salicylate (NaSal). The HCP then successively converts into HCSMs, WLMs, and spherical micelles (SMs) upon further dilution with water, corresponding to a gel-sol-gel-sol transition. This dilution-induced HCSMs to WLMs transition results in an interesting thickening process, which is caused by a slow kinetic process, from the agglomeration and recombination of SMs to long and rigid WLMs via the intermediately formed rodlike micelles. In this work, the sustained adjustment of the competitive self-sorting and co-assembly between hydrotropes and surfactants by dilution was identified, benefitting the creation and application of WLMs fluids with switchable viscosity.
研究领域:
胶体化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
DRUG DEVELOPMENT RESEARCH
·
2025
·Vol. 86
·期 6
·e70143
·
IF 4.2
Qilong Wang,Xiaowen Wang,Qinyang Hua,Feng Shi,Xia Jiang,Minjie Gong,Tingyuan Li,Jiaying Li,Elmurat Toreniyazov,Jiangnan Yu,Michael Adu-Frimpong,Xia Cao,Ximing Xu
Liver cancer is the fourth most deadly cancer worldwide, but existing treatment options are insufficient, thus highlighting the urgent need for new therapeutic agents. Taxanes, known for their anticancer properties, provide a promising avenue for intervention. In this study, a tetracyclic taxane compound with antitumor activity (taxinine) was extracted and isolated from Taxus chinensis ( T. chinensis ) seeds. It was then formulated into liposomes using lecithin, cholesterol, and D- α -tocopheryl polyethylene glycol succinate (TPGS) as excipients to enhance its solubility and antitumor efficacy. The isolation of taxinine was achieved through ultrasound-assisted ethanol extraction, followed by silica gel column chromatography, MTT activity screening, and recrystallization. Afterward, the structure of taxinine was confirmed using nuclear magnetic resonance and mass spectrometry. Taxinine liposomes were prepared via the thin film dispersion method, while the particle size, polydispersity index, zeta potential, and encapsulation efficiency of the nanoliposomes were discovered to be 186.76 ± 0.08 nm, 0.226 ± 0.012, −44.34 ± 0.77 mV, and 93.75 ± 1.29%, respectively. They also showed good stability with a release rate of 85.77% ± 2.43% in phosphate-buffered solution (PBS, pH 7.4). Toxicity tests conducted on zebrafish larvae indicated that taxinine liposomes were safe in vivo. Tissue distribution study showed that the concentration of taxinine liposomes increased to varying degrees in tissues (especially liver). In vitro experiments demonstrated that taxinine liposomes significantly enhanced the inhibitory effect of taxinine on HepG2 cell growth. Overall, the nanoliposomal formulation improved the anti-liver cancer activity of taxinine, thus suggesting its potential as a therapeutic agent.
研究领域:
肿瘤学
·
药剂学
·
纳米医学
·
分子药理学
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药物代谢
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天然产物化学
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转化医学
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产品关联
DOI
PubMed
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2023
·
IF 7.8
Wei Zhang,Heng Li,Siqiang Xiao,Jianfei Wu,Chuanhu Wang,Xiaobin Liu,Qingbiao Li,Yanmei Zheng
Controllable delivery of persulfate (PS) and the enhancement of oxidative availability of pollutants in in-situ oxidative remediation of low-permeability polycyclic aromatic hydrocarbons (PAHs) contaminated soil are crucial. To tackle the above challenges, the coupling of Tween 80 solubilization enhanced oxidation of phenanthrene (PHE) in low-permeability soil under electrokinetic remediation (EKR) was proposed. Firstly, batch degradation experiments showed that the addition of Tween 80 significantly inhibited the degradation of PHE in soil under thermally activated PS, as the dosage of Tween 80 increased from 0 % to 1 % with the corresponding removal rate declining from 99.19 % to 40.90 %. Accordingly, in-situ electrokinetic delivery of Tween 80 and PS was regulated in further EKR, intending to reduce unproductive consumption. PS was more uniformly delivered to the whole remediation regions from the cathode chamber by electromigration , while Tween 80 was transported into the soil from the anode chamber by electroosmosis , which made Tween 80 solubilization and PS oxidation achieve synergistic effect . And the total removal rate of PHE reached 64.90 % under this strategy, which had increased by 415.90 % and 8.76 %− 130.14 % compared with only EKR or EKR coupling single enhanced technology , respectively. After further thermal activation of transported PS at 50 ℃ by electrical resistance heating, the total removal rate of PHE increased to 71.58 %. EPR spectrum indicated that SO 4 . - and OH . were responsible for the degradation of PHE.
研究领域:
环境科学
·
化学工程
·
土壤修复
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产品关联
DOI
高影响因子
DESIGNED MONOMERS AND POLYMERS
·
2018
·
IF 1.37
Yong-Fu Li,Hong-Tao Tang,Si-Jing Zhou
The β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using 60Co γ-ray irradiation method. The optimized preparation conditions for the CDM-AM copolymer are as follows: CDM:AM mass ratio of 1:1; irradiation dose of 4 kGy; and using 20 mL of DMF water solution. The yield rate of CDM-AM was 75% in grams using these synthetic conditions. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 13,446.06 M−1 and 2595.3 M−1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.
研究领域:
药学
·
高分子化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Chao Zheng,Xiaoyan Yu,Xiaoyi Chen,Mingming Chang
Poly(ethylene oxide)- b -poly(propylene oxide)- b -poly(ethylene oxide) (PEO-PPO-PEO) and acrylamide are both commercially available and widely used water-soluble substances. There are many situations that PEO-PPO-PEO coexist with acrylamide in industry applications, while little is known about the influence of acrylamide on cloud point of PEO-PPO-PEO aqueous solution. In this work, it reveals a universal solubilization of PEO-PPO-PEO by acrylamide. There is always an increase in cloud point with addition of acrylamide no matter what the molecular structure and concentration of PEO-PPO-PEO is. It is found the solubilization is more pronounced when PEO-PPO-PEO is with lower molecular weight or lower weight fraction of PPO segments. On the other hand, the cloud point of systems at lower concentration is more sensitive to addition of acrylamide. On the contrary, polyacrylamide exhibits an opposite impact on cloud point of PEO-PPO-PEO. Acrylamide/PEO-PPO-PEO solution changes from clear to cloudy after polymerization of acrylamide.
研究领域:
化学
·
材料科学
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产品关联
DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2022
·
IF 8.91
Bairen Yang,Jiajie Wang,Menglei Wu,Qingqing Shang,Hao Zhang
In this study, the effect of rhamnolipids (RL) on m -dichlorobenzene ( m -DCB) removal and biofilm was investigated in two biotrickling filters (BTF) (BTF1: blank control; BTF2: RL addition). The critical micelle concentration (CMC) value of RL was 75.6 mg L −1 , and the RL could significantly improve the solubilization of m -DCB. The results showed that the optimal concentration of RL was 180 mg L −1 . The removal efficiency (RE) of m -DCB dropped by 42.4% for BTF1 no fed with RL and only 28.2% for BTF2 fed with RL when the inlet concentration increased from 200 to 1400 mg m −3 at an empty bed time (EBRT) of 60 s. RL increased the secretion of extracellular polymers (EPS) and the ratio of Protein/Polysaccharide, which improved the mass transfer of m -DCB to the biofilm. RL also had a facilitating effect on catechol-1,2-dioxygenase (C 12 O) enzyme activity . Furthermore, RL increased Zeta potential and facilitated microorganisms to form biofilm . The dominant microorganisms of microbial community were increased and the application of RL promoted the enrichment of them.
研究领域:
环境工程
·
微生物学
·
生物技术
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Fan Wang,Jinling Zhan,Rongrong Ma,Yaoqi Tian
Bioactive compounds are frequently incorporated into polysaccharides (e.g., starch) to form active biodegradable films for food packaging, but some of them are water insoluble (e.g., curcumin , CUR) that will make the films have undesirable performance. Herein, CUR was successfully solubilized into the aqueous starch film solution by steviol glycoside (STE, a natural sweetener)-based solid dispersion. The mechanisms of solubilization and film formation were explored through molecular dynamic simulation and various characterization methods. The results showed that the amorphous state of CUR combined with micellar encapsulation of STE achieved the solubilization of CUR. STE and starch chains cooperated to form the film via hydrogen bonding , while CUR was uniformly and densely distributed within the film in the form of needle-like microcrystals. The as-prepared film exhibited high flexibility, great moisture barrier, and excellent UV barrier (UV transmittance : ∼0 %). Compared with the film containing CUR alone, the as-prepared film possessed higher release efficiency, antibacterial activity , and pH response sensitivity due to the assistance of STE. Hence, the introduction of STE-based solid dispersion can simultaneously improve the biological and physical properties of starch films, which provides a green, nontoxic, and facile strategy for the perfect integration of hydrophobic bioactive compounds and polysaccharide-based films.
研究领域:
食品科学
·
材料科学
·
生物技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Yu Yao,Xueming Qin,Yufeng Fu,Yeping Gao,Chengwu Zhang,Hui Zhang,Chuanyu Qin,Bing Qin,Liming Ren
Surfactant-enhanced aquifer remediation (SEAR) is an effective strategy for removing dense non-aqueous phase liquids (DNAPLs) from contaminated groundwater. While Gemini surfactants possess unique dimeric structures and excellent physicochemical properties, the role of hydrophobic chain length in governing their solubilization performance has not been systematically clarified. Here, five sugar-based anionic–nonionic Gemini surfactants (SANG 06, 08, 09, 10, and 13) with different hydrophobic chain lengths were synthesized and evaluated. The surface activity, hydrophilic–lipophilic balance, and micellar behaviors were characterized, and the relationship between chain length and DNAPL solubilization was systematically investigated. Results showed that increasing hydrophobic chain length significantly influenced micelle formation and solubilization behavior. Among them, SANG 13, with the longest chain, exhibited the most favorable characteristics, including an extremely low critical micelle concentration (0.086 g/L), an optimal HLB value (16.85), and ultra-low interfacial tension with PCE (0.6 mN/m). It also formed the largest micelles (26.80 nm) and the highest aggregation number (Nagg=15.98 at 10 CMC), resulting in superior solubilization and desorption efficiencies for DNAPLs. This study provides the first systematic evidence of how hydrophobic chain length regulates the physicochemical properties and solubilization mechanisms of Gemini surfactants. The findings offer new insights into surfactant structure–function relationships and provide theoretical support for optimizing SEAR technology in DNAPLs-contaminated groundwater remediation.
研究领域:
环境科学
·
化学工程
·
胶体与界面科学
·
地下水修复
·
有机化学
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产品关联
DOI
PubMed
高影响因子
Drug Design Development and Therapy
·
2023
·
IF 4.8
Qin Guo,Jie Cai,Pengyu Li,Dongling Xu,Xiaomin Ni,Hui Wen,Dan Liu,Suizhen Lin,Haiyan Hu
Androst-3β,5α,6β-triol (Triol) is a promising neuroprotective agent, but its poor solubility restricts its development into parenteral preparations. In this study, Triol is significantly solubilized by bile salt/phosphatidylcholine mixed micelles (BS/PC-MM). All BS/PC-MM systems are tested to remarkably improve the drug solubility with various stabilities after drug loading. Among them, the sodium glycocholate (SGC)/egg phosphatidylcholine (EPC) system with 2:1 ratio in weight and the total concentration of SGC and EPC of 100 mg/mL is proved to produce stable mixed micelles with high drug loading. It is found that the stability of drug-loaded mixed micelles is quite different, which might be related to the change in critical micelle concentration (CMC) after incorporating drugs. SGC/EPC and SGC/soya phosphatidylcholine (SPC) remain transparent under accelerated conditions and manifest a decreased CMC (dropping from 0.105 to 0.056 mg/mL and from 0.067 to 0.024 mg/mL, respectively). In contrast, swine bile acid-sodium salt (SBA-Na)/PC and sodium deoxycholate (SDC)/PC are accompanied by drug precipitation and reached the maximum CMC on the first and the third days, respectively. Interestingly, the variation of CMC under accelerated testing conditions highly matches the drug-precipitating event in the primary stability experiment. In brief, the bile salt/phosphatidylcholine system exists as a potential strategy of improving sterol drug solubility. CMC variation under accelerated testing conditions might be a simple and easy method to predict the stability of drug-loaded mixed micelles.
研究领域:
药剂学
·
药物化学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）